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Sending an SOS: Healing the Liver with the Bone Marrow

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Journal of Clinical and Translational Hepatology 2022年第1期10卷 1-3页

作者： gustavo Ayares Juan Pablo Arab Ashwani K.Singal Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de ChileSantiagoChile De-partment of Internal Medicine University of South Dakota Sanford School of MedicineSioux FallsSDUSA Division of Transplant Hepatology Avera Transplant InstituteSioux FallsSDUSA

Citation of this article:Ayares G,Arab JP,Singal *** an SOS:Healing the Liver with the Bone Marrow.J Clin Transl Hepatol 2022;10(1):***:10.14218/***,an end stage of any chronic liver disease is a form of impaired regeneration leading to progressive dif-fuse hepatic *** healthcare burden of cirrhosis is increasing,and it is currently the 13th leading cause of death *** progression of liver injury and fibrosis results in portal hypertension and hepatic insufficiency.

关键词： impaired Liver hepatic

Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy

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World Journal of Gastroenterology 2008年第7期14卷 1060-1066页

作者： Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker gustavo B Baretton Daniela E Aust Institute for Pathology University of TechnologyFetscherstr. 74D-01307 DresdenGermany Department of General Visceral and Transplantation SurgeryUniversity Medical Center of GttingenRobert-Koch-Str. 40D-37075 GttingenGermany

AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment ***: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading ***: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor ***: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes.

关键词： p53 Ki67 Neoadjuvant treatment Rectal cancer Thymidylate synthase

Ionic liquid passivated black phosphorus for stabilized compliant electronics

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Nano Research 2023年第5期16卷 7858-7866页

作者： Ravindra Mehta Misook Min Ridwan F.Hossain gustavo A.Saenz Gerardo Gamboa Anupama B.Kaul Department of Materials Science and Engineering PACCAR Technology InstituteUniversity of North TexasDentonTX 76207USA Department of Electrical Engineering University of North TexasDentonTX 76207USA

Black phosphorus(BP)is an attractive material for two-dimensional(2D)electronics and optoelectronics given its direct optical band gap in the ***,the vulnerability of BP to oxygen and moisture under ambient conditions has been a significant impediment for the adoption of this material towards practical *** vulnerability has also curtailed the development of additively manufactured,solution processed,ink-jet printed BP devices,which are cost-effective alternatives to lithographically patterned rigid electronics and optoelectronics based on *** this work,we have fabricated stable BP electronic devices on flexible and compliant substrates using low-cost,additive manufacturing techniques with ink-jet printing through scalable chemical exfoliation *** address the stability issues with BP,ionic liquids(ILs)were used as a passivation layer on the surface of the BP to minimize oxidative *** enhanced stability of BP was inferred through Raman spectroscopy and scanning probe microscopy techniques,where no observable changes in the A^(1)_(g)and A^(2)_(g)Raman vibrational modes were observed with time for the BP films passivated with ILs over a period of 168 h under ambient *** the other hand,a blue-shift in these Raman modes was evident for unpassivated *** probe microscopy measurements clearly revealed the difference in the surface characteristics through localized regions of degradation that intensified with time,which was clearly absent in IL/BP *** stability measurements were also conducted in electronic device platforms for IL coated BP devices,where the temperature T dependence of the I_(ds)-V_(ds)characteristic was measured from T~5.4 to 335 *** demonstrations of stabilized ILs/BP devices at ambient printed on flexible polyimide substrates were also *** irradiation with broadband radiation appears to have a significant influence on the electrical behavior of BP,evident through t

关键词： 2D materials black phosphorus ionic liquids ink-jet printing flexible electronics

Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hippocampal-related neurological disorders

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Neural Regeneration Research 2022年第3期17卷 469-476页

作者： Priscila Chiavellini Martina Canatelli-Mallat Marianne Lehmann Rodolfo G.Goya gustavo R.Morel Biochemistry Research Institute of La Plata(INIBIOLP)-Histology and Embryology B School of Medical SciencesNational University of La Plata(UNLP)La PlataBuenos AiresArgentina

Hippocampus serves as a pivotal role in cognitive and emotional processes,as well as in the regulation of the hypothalamus-pituitary *** is known to undergo mild neurodegenerative changes during normal aging and severe atrophy in Alzheimer's ***,dysregulation in the hippocampal function leads to epilepsy and mood *** the first section,we summarized the most salient knowledge on the role of glial cell-line-derived neurotrophic factor and its receptors focused on aging,cognition and neurodegenerative and hippocampal-related neurological diseases mentioned *** the second section,we reviewed the therapeutic approaches,particularly gene therapy,using glial cell-line-derived neurotrophic factor or its gene,as a key molecule in the development of neurological *** the third section,we pointed at the potential of regenerative medicine,as an emerging and less explored strategy for the treatment of hippocampal *** briefly reviewed the use of partial reprogramming to restore brain functions,non-neuronal cell reprogramming to generate neural stem cells,and neural progenitor cells as source-specific neuronal types to be implanted in animal models of specific neurodegenerative disorders.

关键词： aging Alzheimer's disease cell reprogramming epilepsy gene therapy glial cell line-derived neurotrophic factor hippocampus major depression

Spectral classification of water masses under the influence of the Amazon River plume

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Acta Oceanologica Sinica 2010年第3期29卷 1-8页

作者： gustavo Souto Fontes Molleri Milton Kampel Evlyn Mrcia Leo de Moraes Novo National Institute for Space Research-INPE Remote Sensing Division So Jos dos Campos

The large amount of dissolved and particulate material discharged by the Amazon River into the Equatorial Atlantic Ocean cause distinct spectral response of its waters as compared to the nearby ocean waters. This paper shows the application of K-means clustering algorithm for classifying water masses in the region under the Amazon River plume influence according to their spectral behavior. Salinity and temperature data from 67 oceanographic stations were related to Sea-viewing Wide Field-of-view Sensor （SeaWiFS） remote sensing reflectances values and the following bio-optical products：（i） chlorophyll-a concentration, （ii） water attenuation coefficient and （iii） absorption coefficient for dissolved and detrital material. Four different water masses were identified such as：（1） oceanic water, （2） intermediate oceanic water, （3） intermediate river plume water and （4） Amazon River plume water. The spectral behavior of these water masses allowed concluding that the main active optical component of the waters in the region is the colored dissolved organic matter originated mostly from the Amazon River.

关键词： ocean color remote sensing amazon river plume spectral behavior cluster analysis

Breeding bird density does not drive vocal individuality

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Current Zoology 2012年第5期58卷 765-772页

作者： Daniel T. BLUMSTEIN Douglas R. MCCLAIN Carrie DE JESUS gustavo ALARCON-NIETO The Rocky Mountain Biological Laboratory Box 519 Crested Butte CO 81224 USA Department of Ecology and Evolutionary Biology University of California Los Angeles 621 Charles E. Young Dr. South Los Angeles CA 90095-1606 USA

Many species produce individually specific vocalizations and sociality is a hypothesized driver of such individuality. Previous studies of how social variation influenced individuality focused on colonial or non-colonial avian species, and how so- cial group size influenced individuality in sciurid rodents. Since sociality is an important driver of individuality, we expected that bird species that defend nesting territories in higher density neighborhoods should have more individually-distinctive calls than those that defend nesting territories in lower-density neighborhoods. We used Beecher＇s information statistic to quantify individu- ality, and we examined the relationship between bird density （calculated with point-counts） and vocal individuality on seven spe- cies of passerines. We found non-significant relationships between breeding bird density and vocal individuality whether regres- sions were fitted on species values, or on phylogenetically-independent contrast values. From these results, we infer that while in- dividuality may be explained by social factors, breeding bird density is unlikely to be generally important in driving the evolution of individually-specific vocalizations [Current Zoology 58 （5）： 765-772, 2012].

关键词： Individuality Sociality Birdsong Breeding bird density

Comparison between the theoretical models and experimental structures of some oc tacoordinated Ln(Ⅲ)-bis-dipyridyl-bis-dichloroacetato-diaquo complexes and their phenanthroline analogues

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Journal of Rare Earths 2010年第S1期28卷 83-85页

作者： S. P. SINHA Alfredo M. SIMAS gustavo L. C. MOURA SRD 6565 Willowick Pl.DaytonOHIO 45459-3005U.S.A. Departamento de Quimica Fundamental CCENUniversidade Federal de Pernambuco50590-470Recif ePEBrazil

The title complexes were modeled using the semiempirical MOPAC and the newly developed SPARKLE paramerters of the lanthanides. The calculated bond dis tances and angles agreed well with those found from crystal structure measuremen ts. This technique allows us to screen a large number of molecules and get struc tural information within a very short time.

关键词： lanthanide complex theoretical models octacoordination dipyridyl p henanthroline MOPAC SPARKLE rare earths

Effect of Lepidium meyenii(maca)roots on spermatogenesis of male rats

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Asian Journal of Andrology 2001年第3期3卷 231-233页

作者： gustavo F.Gonzales Ana Ruiz Carla Gonzales León Villegas Amanda Cordova Department of Physiological Sciences Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura.Universidad Peruana Cayetano Heredia.Postal Office 1843.LimaPeru

Aim:To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii(maca)on spermatogenesis in adult male ***;Male rats received an aqueous extract of the root(66.7 mg in onemL)twice a day for 14 consecutive ***:Treatment with Lepidium meyenii resulted in an increase in theweights of testis and epididymis but not the seminal vesicle *** length and frequency of stages IX-XIV seminif-erous tubules,where mitosis occurred,were increased and stages I-VI were reduced in rats treated with ***;The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initialstages(IX-XIV).

关键词： spermatogenesis Lepidium meyenii maca transillumination

Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2007年第31期13卷 4242-4248页

作者： Silvia Sookoian gustavo Castao Carolina Gemma Tomas Fernández Gianotti Carlos Jose Pirola Instituto de Investigaciones Medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina Consejo de Investigación GCBA Buenos Aires Argentina Instituto de Investigaciones Medicas A. Lanari. Universidad de Buenos Aires CONICET Combatiente de Malvinas 3150 1427-Ciudad Autonoma de Buenos Aires Argentina

To investigate the role of gene variants and derived haplotypes of the CLOCK transcription factor in nonalcoholic fatty liver disease （NAFID） and their relation with the disease ***： A total of 136 patients with NAFLD and 64 healthy individuals were studied. Liver biopsy was performed in 91 patients. Six tag SNPs showing a minor allele frequency 〉 10% （rs1554483 C/G; rs11932595 A/G; rs4580704 C/G; rs6843722 A/C; rs6850524 C/G and rs4864548 A/G） encompassing 117 kb of chromosome 4 and representing 115 polymorphic sites （P 〉 0.8） were genotyped. RESULTS： rs11932595 and rs6843722 showed significant associations with NAFLD （empiric P = 0.0449 and 0.023, respectively）. A significant association was also observed between clinical or histologic spectrum of NAFLD and rs1554483 （empiric P = 0.0399）, rs6843722 （empiric P = 0.0229） and rs6850524 （empiric P = 0.00899） and between fibrosis score and rs1554483 （empiric P = 0.02697）, rs6843722 （empiric P = 0.01898） and rs4864548 （empiric P = 0.02697）. Test of haplotypic association showed that CLOCK gene variant haplotypes frequencies in NAFLD individuals significantly differed from those in controls （empiric P = 0.0097）.CONCLUSION： Our study suggests a potential role of the CLOCK polymorphisms and their haplotypes insusceptibility to NAFLD and disease severity.

关键词： Circadian rhythm Circadian Iocomoter outputcycles protein kaput Gene variants Haplotypes Fattyliver Liver disease Obesity Nonalcoholic steatohepatitis