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Open Journal of Internal Medicine 2023年第3期13卷 173-180页

作者： Pablo Sisiruca gustavo Adolfo Socorro Calderas Saint James School of Medicine Arnos Vale Saint Vincent and the Grenadines Jose Maria Vargas Medical School Faculty of Medicine Universidad Central de Venezuela Caracas Venezuela

Introduction: Thyroid states can be associated with psychiatric manifestations, be it hypothyroid, hyperthyroid or even euthyroid. The effect of depression is significant in subclinical hypothyroidism. Sometimes, its signs and symptoms are indistinguishable from Major Depressive Disorder. Our immunological system and early embryologic origins also play a role in the coexistence of other comorbidities like Pernicious Anemia. Case: A 35-year-old Hispanic female presented with significant low mood, somnolence, weight gain, increased hunger, cold intolerance and epigastric pain. It is important to note the variety of clinical manifestations of our hypothyroidism patient to understand its associations and help us with a better approach to treatment. Discussion: Standard approaches to treatment of Subclinical Hypothyroidism will depend mostly on laboratory findings such as TSH levels and free T4. Individualized therapy chosen for our patient was based on his mood symptoms, laboratory findings and coexistence of Pernicious Anemia. The use of daily 0.025 mg of levothyroxine, 10 mg of escitalopram oxalate and weekly injections of cyanocobalamin were treatments of choice. Conclusion: During follow up of our patient, we can conclude that Levothyroxine and Escitalopram Oxalate were able to improve hypothyroidism symptoms, reduce thyroglobulin and peroxidase antibodies and improve mood symptoms including cognitive functions. In addition to this, weekly cyanocobalamin injections were integrated into the management. As parietal cell antibodies decreased, gastrointestinal symptoms also disappeared. By addressing the concerns of our patient, we improved quality of care, and this is reflected in the patient’s wellbeing in physical and psychological.

关键词： Cyanocobalamin Escitalopram Oxalate Hashimoto’s Thyroiditis Levothyroxine Pernicious Anemia Polyglandular Syndrome

AT1 receptor downregulation:A mechanism for improving glucose homeostasis

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World Journal of Diabetes 2023年第3期14卷 170-178页

作者： Diana L Lopez Oscar E Casillas Hiram J Jaramillo Tatiana Romero-Garcia J.gustavo Vazquez-Jimenez Department of Internal Medicine General Hospital of MexicaliMexicali 21000Baja CaliforniaMexico Faculty of Medicine Autonomous University of Baja CaliforniaMexicali 21000Baja CaliforniaMexico Faculty of Sports Autonomous University of Baja CaliforniaMexicali 21289Baja CaliforniaMexico

There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-Ⅱ enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1receptor could have beneficial effects in treating metabolic syndrome and type 2diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.

关键词： Type 2 diabetes mellitus High blood pressure Insulin receptor Insulin signaling pathway AT1 receptor Angiotensin II signaling pathway

SUMOylation regulates p27^(Kip1) stability and localization in response to TGFβ

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分子细胞生物学报:英文版 2016年第1期8卷 17-30页

作者： Sara Lovisa Simona Citro Maura Sonego Alessandra Dall’Acqua Valentina Ranzuglia Stefania Berton Alfonso Colombatti Barbara Belletti Susanna Chiocca Monica Schiappacassi gustavo Baldassarre Division of Experimental Oncology 2 Centro di Riferimento Oncologico National Cancer InstituteAviano 33081Italy Department of Experimental Oncology European Institute of Oncology at the IFOM-IEO CampusMilan 20139Italy Department of Scienze e Tecnologie Biomediche MATI Center of ExcellenceUniversity of UdineUdine 33010Italy Present address:Department of Cancer Biology Metastasis Research CenterThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

Exposure of normal and tumor-derived cells to TGFbresults in different outcomes,depending on the regulation of key *** CDK inhibitor p27^(Kip1) is one of these TGFβ targets and is essential for the TGFβ-induced cell cycle *** treatment inhibits p27^(Kip1) degradation and induces its nuclear translocation,through mechanisms that are still *** evidences suggest that SUMOylation,a post-translational modification able to modulate the stability and subcellular localization of target proteins,critically modifies members of the TGFβ signaling ***,we demonstrate that p27^(Kip1) is SUMOylated in response to TGFβ *** different p27^(Kip1) point mutants,we identified lysine 134(K134)as the residue modified by small ubiquitin-like modifier 1(SUMO1)in response to TGFb ***β-induced K134 SUMOylation increased protein stability and nuclear localization of both endogenous and exogenously expressed p27^(Kip1).We observed thatSUMOylation regulated p27^(Kip1) binding to CDK2,thereby governing its nuclear proteasomal degradation through the phosphorylation of threonine ***,p27^(Kip1) SUMOylation was necessary for proper cell cycle exit following *** data indicate thatSUMOylation is a novel regulatory mechanism that modulates p27^(Kip1) function in response to TGFβ *** the involvement of TGFb signaling in cancer cell proliferation and invasion,our data may shed light on an important aspect of this pathway during tumor progression.

关键词： p^(27kip1) SUMOylation TGFβ

Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion

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World Journal of Gastroenterology 2014年第32期20卷 11406-11414页

作者： Gilmara Pandolfo Zabot gustavo Franco Carvalhal Norma Possa Marroni Renata Minuzzo Hartmann Vinícius Duval da Silva Henrique Sarubbi Fillmann Department of Surgery School of Medicine Pontifical Catholic University of Rio Grande do Sul Porto Alegre RS 90610-000 Brazil Department of Gastroenterology School of Medicine Federal University of Rio Grande do Sul Porto Alegre RS 90035-903 Brazil Department of Pathology School of Medicine Pontifical Catholic University of Rio Grande do SulPorto Alegre RS 90610-000 Brazil

AIM: To evaluate preventative effects of glutamine in an animal model of gut ischemia/reperfusion (I/R).

关键词： Ischemia-reperfusion Glutamine Lipid peroxidation Superoxide dismutase Nuclear factor-kappa beta Interleukin 6

On the Relationship between the Pure Delay and the Natural Period of Oscillation

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Applied Mathematics 2016年第6期7卷 504-507页

作者： Daniel Chuk gustavo Rodriguez Medina Facultad de Ingeniería Universidad Nacional de San Juan San Juan Argentina

This paper provides a proof of the well-known relationship between the pure delay and the natural period of oscillation in industrial systems.

关键词： Pure Delay Period of Oscillation First Order Systems PID Control

Environmental and Durability Perspective of the Use of Curaua Fiber Treated in Mortars

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Journal of Renewable Materials 2022年第9期10卷 2409-2429页

作者： Afonso R.G.de Azevedo Marcelo Nascimento Dirlane do Carmo Markssuel T.Marvila gustavo de C.Xavier Sergio Neves Monteiro UENF-State University of the Northern Rio de Janeiro LECIV-Civil Engineering LaboratoryCampos dos GoytacazesBrazil UFF-Federal Fluminense University TER-Department of Agricultural EngineeringNiteróiBrazil UENF-State University of the Northern Rio de Janeiro LAMAV-Advanced Materials LaboratoryCampos dos GoytacazesBrazil IME-Military Institute of Engineering Department of Materials ScienceRio de JaneiroBrazil

The use of natural lignocellulosic fibers(NLFs)as a reinforcement mechanism for cementitious composites,such as mortar,has been investigated in the last ***,their application has often been restricted to technological evaluation research.A NLF with great potential the curaua,which after treatment with NaOH solution,proved to be technologically feasible for mortars reinforcement based on cement and *** objective of this research was the comparative evaluation between a traditional mortar,based on cement and lime,with 1:1:6:0.8 ratio of cement:lime:sand:water,and a modified mortar with addition of 2 wt.%treated curaua fiber in cement mass by evaluating environmental and durability *** a curing time for 28 days,environmental assessments were carried out and durability methodologies were *** tests performed were:(i)attack by chlorides and sulfate,(ii)the wetting and drying cycles,and(iii)slake durability *** results showed that the mortar with the addition of curaua fiber presented a similar behavior to the reference mixture,both in terms of environmental and durability *** modified mortar is able to be used in internal and external environments,the latter with some ***,it also contributes to the promotion of sustainable use of curaua fiber.

关键词： Natural lignocellulosic fibers curaua mortar durability environmental aspects

Thoracic aorta thickness and histological changes with aging: an experimental rat model

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Journal of Geriatric Cardiology 2019年第7期16卷 580-584页

作者： Giulio Cesar Gequelim Djanira Aparecida da Luz Veronez gustavo Lenci Marques Camila Harumi Tabushi Ronaldo da Rocha Loures Bueno Master’s Degree Student in Postgraduate Program of Internal Medicine Federal University of Paraná(UFPR)Medical Resident in Cardiology in Hospital de Clínicas UFPRCuritiba-PRBrazil Department of Anatomy School of MedicineUFPRCuritiba-PRBrazil Master’s Degree in Internal Medicine Adjunct ProfessorDepartment of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Medical Student Department of Internal MedicineSchool of MedicineUFPRCuritiba-PRBrazil Department of Internal Medicine School of MedicineUFPRCuritiba-PRBrazil

The three main components of the media layer of the aorta are elastic fibers,collagen fibers and smooth muscle cells(SMC).[1]This layer’s elastic properties are major determinants of its biomechanics in health and disease states.[2,3]Age-related changes in such elastic properties are associated with altered hemodynamic parameters,such as systolic hypertension,[4,5]and end-organ damage,[6,7]and are thought to result from changes of its main components.

关键词： Aging Collagen Elastic fibers Smooth muscle cells

Femoral positioning influences ipsi-and contralateral anterior cruciate ligament rupture following its reconstruction:Systematic review and meta-analysis

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World Journal of Orthopedics 2017年第8期8卷 644-650页

作者： gustavo Constantino de Campos Paulo Eduardo Portes Teixeira Alex Castro Wilson de Mello Alves Junior Department of Orthopaedics Campinas’s State University (UNICAMP) Instituto Wilson Mello Research and Study Center

AIM To systematically review the incidence of ipsilateral graft re-rupture and contralateral anterior cruciate ligament(ACL) rupture following its reconstruction, with special attention to the femoral drilling technique. METHODS Systematic review and meta-analysis of high-level prospective studies searched in MEDLINE database following PRISMA statement. The rate of ipsilateral graft re-rupture and contralateral rupture in patients submitted to either transtibial(TT) technique(isometric) or anteromedial(AM) technique(anatomic) was compared. RESULTS Eleven studies met the criteria and were included in final analysis. Reconstructions using the AM technique had a similar chance of contralateral ACL rupture when compared to the chance of ipsilateral graft failure(OR = 1.08, P = 0.746). In reconstructions using TT technique, the chance of contralateral ACL rupture was approximately 1.5 times higher than ipsilateral graft failure(OR = 1.49, P = 0.048). Incidence of contralateral lesions were similar among the techniques TT(7.4%) and AM(7.0%)(P = 0.963), but a trend could be noticed with a lower incidence of lesion in the ipsilateral limb when using the TT technique(4.9%) compared to the AM technique(6.5%)(P = 0.081).CONCLUSION ACL reconstruction by TT technique leads to lower incidence of graft re-injury than contralateral ACL lesion. There is no difference between the chance of re-injury after AM technique and the chance of contralateral ACL lesion(native ligament) with either technique.

关键词： Anterior cruciate ligament Anterior cruciate ligament reconstruction Arthroscopy Graft survival

Dynamics of the ruminal microbial ecosystem, and inhibition of methanogenesis and propiogenesis in response to nitrate feeding to Holstein calves

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Animal Nutrition 2021年第4期7卷 1205-1218页

作者： Abimael Ortiz-Chura Jose Gere Gisela Marcoppido gustavo Depetris Silvio Cravero Claudia Faverin Cesar Pinares-Patino Angel Cataldi d Maria E.Ceron-Cucchi Institute of Pathobiology CICVyA National Institute of Agricultural TechnologyIPVetUEDD INTA-CONICETHurlinghamC1686Argentina Engineering Research and Development Division National Technological University(UTN)National Scientific and Technical Research Council(CONICET)Buenos AiresC1179Argentina Agricultural Experimental Station of Balcarce National Institute of Agricultural Technology(INTA)BalcarceB7620Argentina Institute of Agrobiotechnology and Molecular Biology IABIMONational Institute of Agricultural Technology(INTA)National Scientific and Technical Research Council(CONICET)HurlinghamC1686Argentina The Agribusiness Group Lincoln UniversityPO Box 85016Lincoln7674New Zealand

It is known that nitrate inhibits ruminal methanogenesis,mainly through competition with hydrogenotrophic methanogens for available hydrogen(H2)and also through toxic effects on the ***,there is limited knowledge about its effects on the others members of ruminal microbiota and their *** this study,we investigated the effects of dietary nitrate inclusion on enteric methane(CH4)emission,temporal changes in ruminal microbiota,and fermentation in Holstein *** animals were maintained in individual pens for 45 *** were randomly allocated to either a control(CTR)or nitrate(NIT,containing 15 g of calcium nitrate/kg dry matter)*** emissions were estimated using the sulfur hexafluoride(SF6)tracer *** microbiota changes and ruminal fermentation were evaluated at 0,4,and 8 h *** this study,feed dry matter intake(DMI)did not differ between dietary treatments(P>0.05).Diets containing NIT reduced CH4 emissions by 27%(g/d)and yield by 21%(g/kg DMI)compared to the CTR(P0.05)but differed with time,and post-feeding(P<0.05).Increases in the concentrations of ruminal ammonia nitrogen(NH3-N)and acetate were observed,whereas propionate decreased at 4 h post-feeding with the NIT diet(P<0.05).Feeding the NIT diet reduced the populations of total bacteria,total methanogens,Ruminococcus albus and Ruminococcus flavefaciens,and the abundance of Succiniclasticum,Coprococcus,Treponema,Shuttlewortia,Succinivibrio,Sharpea,Pseudobutyrivibrio,and Selenomona(P<0.05);whereas,the population of total fungi,protozoa,Fibrobacter succinogenes,Atopobium and Erysipelotrichaceae L7 AE11 increased(P<0.05).In conclusion,feeding nitrate reduces enteric CH4 emissions and the methanogens population,whereas it decreases the propionate concentration and the abundance of bacteria involved in the succinate and acrylate pathways.D

关键词： Methane emission Nitrate Microbiota Ruminal fermentation