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A novel intronic circular RNA,circGNG7,inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82

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Cancer Communications 2021年第11期41卷 1152-1172页

作者： Houyu Ju Zhenrong Hu Dongliang Wei Jinyun Huang Xinyi Zhang Mengyu Rui Zhi Li Xiaomeng Zhang Jingzhou Hu Wei Guo guoxin ren Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology National Clinical Research Center of StomatologyShanghai 200011P.R.China National Clinical Research Center of Stomatology Shanghai 200011P.R.China School of Stomatology Weifang Medical UniversityWeifangShandong 261053P.R.China Shanghai Key Laboratory of Stomatology Department of Oral and Maxillo-facial ImplantologySchool of MedicineShanghai Ninth People’s HospitalShanghai Jiao Tong UniversityShanghai 200011P.R.China

Background:There is increasing evidence that circular RNAs(circRNAs)play a significant role in pathological processes including *** contrast to exonic circRNAs,which are the most frequently reported circRNAs in cancer so far,the studies of intronic circRNAs have been greatly lagged ***,we aimed to investigate the regulatory role of intronic circRNAs in head and neck squamous cell carcinoma(HNSCC).Methods:We conducted whole-transcriptome sequencing with four pairs of primary tumor tissues and adjacent normal tissues from HNSCC ***,we characterized circGNG7 expression in HNSCC tissues and cell lines and explored its association with the prognosis of HNSCC *** also identified interactions between circGNG7 and functional proteins,which alter downstream signaling that regulate HNSCC ***:In this study,we identified a new intronic circRNA,circGNG7,and validated its functional roles in HNSCC ***7 was predominately localized to the cytoplasm,and its expression was downregulated in both HNSCC tissues andCAL27,CAL33,SCC4,SCC9,HN6,and HN30 *** expression of circGNG7 was significantly correlated with poor prognosis in HNSCC *** with this finding,overexpression of circGNG7 strongly inhibited tumor cell proliferation,colony formation,in vitro migration,and in vivo tumor ***,the expression of circGNG7 in HNSCC cells was regulated by the transcription factor SMAD family member 4(SMAD4).Importantly,we discovered that circGNG7 could bind to serine residues 78 and 82 of the functional heat shock protein 27(HSP27),occupying its phosphorylation sites and hindering its phosphorylation,which reduced HSP27-JNK/P38 mitogen-activated protein kinase(MAPK)oncogenic *** of circGNG7 expression in HNSCC increased HSP27-JNK/P38 MAPK signaling and promoted tumor ***:Our results revealed that a new intronic circRNA,circGNG7,functions as a strong tumo

关键词： circGNG7 head and neck squamous cell carcinoma heat shock protein 27(HSP27) intronic circular RNAs mitogen-activated protein kinase(MAPK)signaling phosphorylation tumor suppressor

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内窥镜辅助刮治颌骨囊性病变专家共识

实用口腔医学杂志 2024年第3期40卷 301-308页

作者：吴炜陈攀黄志权朱桂全何悦李春洁阮敏秦力铮闫冰王成胡镜宙孙志军任国欣尚伟杨凯李吉辰孙沫逸口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科西安710032 中山大学孙逸仙纪念医院口腔颌面外科口腔疾病防治全国重点实验室国家口腔医学中心国家口腔疾病临床医学研究中心四川大学华西口腔医院头颈肿瘤外科上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科首都医科大学附属北京口腔医院口腔颌面外科中山大学光华口腔医院口腔颌面外科武汉大学口腔医院颌面头颈肿瘤外科青岛大学附属医院口腔颌面外科重庆医科大学附属第一医院口腔颌面外科哈尔滨医科大学附属第一医院口腔医院口腔颌面外科

刮治术是颌骨囊性病变的主要治疗手段,但单纯的刮治术容易损伤周围结构如邻牙、神经等,且存在刮治不彻底、颌骨缺损较大等情况。而内窥镜(Endoscope)辅助下的刮治术,能够为术者提供良好的手术视野,在术中能更清晰的辨认出重要的解剖结构... 详细信息

刮治术是颌骨囊性病变的主要治疗手段,但单纯的刮治术容易损伤周围结构如邻牙、神经等,且存在刮治不彻底、颌骨缺损较大等情况。而内窥镜(Endoscope)辅助下的刮治术,能够为术者提供良好的手术视野,在术中能更清晰的辨认出重要的解剖结构,尽可能去除囊壁组织,减小损伤,降低病变复发率。该文就结合颌面外科的特点及临床治疗经验,总结国内外相关文献,经相关专家经共同讨论,以期对内窥镜辅助下刮治颌骨囊性病变的临床治疗提供参考。

关键词：内窥镜刮治颌骨囊性病变治疗专家共识

Clinical application of local ultrasound hyperthermia combined with systemic chemotherapy in oral maxillofacial-head and neck malignant tumors

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中国口腔颌面外科杂志 2008年第B5期6卷 185-186页

作者： guoxin ren Wei Guo Yazhu Chen Guofeng Shen Dongxia Ye Jingfeng Bai Department of Oral and Maxillofacial Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University Shanghai 200011 China Institute of Biomedical lnstrument College of Life Science & Biotechnology Shanghai Jiao Tong University Shanghai 200240China

Purpose: To investigate the effects and main side-effects of local ultrasound hyperthermia combined with systemic chemotherapy in oral maxillofacial-head and neck malignant tumors。Methods: From February 2003 to May 2006, 57 patients in our department were divided into two groups: hyperthermo-chemotherapy group (27 patients) and chemotherapy group (30 patients)。Two groups were performed standard systemic chemotherapy according their pathological diagnosis respectively。The combined therapy group was administered tertian concurrent local ultrasound hyperthermo-therapy in addition, which performed 5 times totally。Chi-square test was used to analyze the data using SAS 6.12 software package。Results: The index ofhyperthermia of the treatment group is: Tmax -41.35±0.43℃,T average=40.67±0.62℃,Tmin=39.57±0.55℃,F(42℃)(%)=0.49±0.22,average heated time =39.74±3.32 min。To evaluate the effects after 4 weeks of treatment。The total response of hyperthermo- chemotherapy group was 51.85% (CR 3,PR I I,SD 12,PDI)。and that the chemotherapy group was 23.33 % (CR I,PR 6,NC l 9,PD4)。The total response revealed significant differences in the two groups (P<0.05)。The main side-effects were bearable local low-grade skin bums (9/27) and 1 degree ache (10/27)。Conclusions: The local hyperthermia could improve the chemotherapy effect showing that they had synergic anti-tumor effect。The local hyperthermia was safety that no serious related side-effect was observed。

关键词：口腔癌头颈部肿瘤超声波化学疗法

Candidate therapeutic agents in a newly established triple wild-typemucosalmelanoma cell line

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Cancer Communications 2022年第7期42卷 627-647页

作者： Chaoji Shi Ziyue Gu Shengming Xu Houyu Ju Yunteng Wu Yong Han Jiayi Li Chuwen Li Jing Wu Lizhen Wang Jiang Li Guoyu Zhou Weimin Ye guoxin ren Zhiyuan Zhang Rong Zhou Department of Oral and Maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China National Clinical Research Center for Oral Diseases Shanghai 200011P.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology Shanghai 200011P.R.China Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghai 200011P.R.China Department of Oral Pathology Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200011P.R.China

Background:Mucosalmelanoma has characteristically distinct genetic features and typically poor *** lack of representativemucosal melanoma models,especially cell lines,has hindered translational research on this melanoma *** this study,we aimed to establish and provide the biological properties,genomic features and the pharmacological profiles of a mucosal melanoma cell line that would contribute to the understanding and treatment optimization of molecularly-defined mucosal melanoma ***:The sample was collected from a 67-year-old mucosal melanoma patient and processed into pieces for the establishment of cell line and patientderived xenograft(PDX)*** proliferation and tumorigenic property of cancer cells from different passageswere evaluated,andwhole-genome sequencing(WGS)was performed on the original tumor,PDX,established cell line,and the matched blood to confirm the establishment and define the genomic features of this cell *** was conducted to depict the architecture of amplified regions detected by ***-throughput drug screening(HTDS)assay including a total of 103 therapeutic agents was implemented on the established cell line,and selected candidate agents were validated in the corresponding PDX ***:A mucosal melanoma cell line,MM9H-1,was established which exhibited robust proliferation and tumorigenicity after more than 100 serial *** analysis of MM9H-1,corresponding PDX,and the original tumor showed genetic fidelity across genomes,and MM9H-1 was defined as a triple wild-type(TWT)melanoma subtype lacking well-characterized“driver mutations”.Instead,the amplification of several oncogenes,telomerase reverse transcriptase(TERT),v-Rafmurine sarcoma viral oncogene homolog B1(BRAF),melanocyte Inducing transcription factor(MITF)and INO80 complex ATPase subunit(INO80),via large-scale genomic rearrangement potentially contributed to oncogenesis of ***,HTDS identified proteasome

关键词： bortezomib cell line extrachromosomal DNA high-throughput drug screening mucosal melanoma patient derived tumor cells patient-derived xenograft whole-genome sequencing

基于纤维长度根数分布的精梳加工模拟及棉网质量预测

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纺织学报 2017年第6期38卷 23-27页

作者：贾国欣任家智冯清国河南工程学院纺织新产品开发河南省工程实验室河南郑州450007 河南省纺织服装协同创新中心河南郑州450007 中原工学院纺织学院河南郑州450007

为实现精梳质量的预测及精梳工艺的智能设计,采用Monte Carlo随机模拟的方法,对给定纤维长度分布(根数)的棉卷进行精梳加工计算机模拟,得到工作周期内不同阶段的棉丛形态及输出棉网根数不匀CV值。讨论了不同工艺参数下的模拟结果,结果表... 详细信息

为实现精梳质量的预测及精梳工艺的智能设计,采用Monte Carlo随机模拟的方法,对给定纤维长度分布(根数)的棉卷进行精梳加工计算机模拟,得到工作周期内不同阶段的棉丛形态及输出棉网根数不匀CV值。讨论了不同工艺参数下的模拟结果,结果表明:分离罗拉顺转定时为14.5、15.5分度时,输出棉网的不匀值较小;落棉隔距增大,输出棉网的不匀小幅度增长;给棉长度在4.7~5.9 mm之间增加时,输出棉网的不匀轻微恶化,模拟结果与此前的实验研究结论有良好的相关性,模拟加工的方法更适用于纤维长度分布(根数)经常变化的棉卷精梳过程研究。

关键词：纤维长度分布加工模拟棉网预测

口腔颌面部恶性肿瘤颈淋巴清扫术后肩臂综合征的评估与康复管理专家共识

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实用口腔医学杂志 2024年第5期40卷 597-607页

作者：李家存孙沫逸任皎洁郭伟李龙江唐瞻贵任国欣孙志军孟箭尚伟刘绍严张杰李吉辰何悦李春洁杨凯龚忠诚席庆韩冰麦华明陈彦平章杰吴亚东李超安常明孙传政袁华杨帆袁海光吴丹冬范帅李飞徐超魏伟口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院医疗康复科西安710032 口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科陕西省中医医院耳鼻喉科上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科四川大学口腔疾病国家重点实验室国家口腔疾病研究临床中心华西口腔医院头颈肿瘤外科中南大学湘雅口腔医院武汉大学口腔医学院徐州市中心医院青岛大学附属医院口腔颌面外科中国医学科学院肿瘤医院头颈外科北京大学口腔医学院口腔颌面外科哈尔滨医科大学附属第一医院重庆医科大学附属第一医院口腔颌面外科新疆医科大学口腔医学院解放军总医院第一医学中心口腔科吉林大学口腔医院口腔颌面外科广西医科大学附属口腔医院河北医科大学第四医院暨河北省肿瘤医院南昌大学第一附属医院口腔颌面外科贵州医科大学口腔医学院四川省肿瘤医院头颈外科国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院头颈外科昆明医科大学第三附属医院(云南省肿瘤医院)头颈外二科空军军医大学西京医院康复医学科陕西中医药大学附属医院针灸二科重庆医科大学附属第一医院康复医学科中南大学湘雅三医院康复科解放军总医院第一医疗中心康复医学科广西医科大学第一附属医院康复医学科滨州医学院附属烟台山医院康复医学科

颈淋巴清扫术(ND)是口腔颌面部恶性肿瘤治疗的主要方法之一。尽管颈清术式在不断改良,但术中因剥离、牵拉等损伤副神经、肌肉、肌膜、筋膜及韧带引起的肩臂综合征(SS),仍是患者术后常见并发症,加之放疗的影响,不仅会导致患者肩颈及手臂... 详细信息

颈淋巴清扫术(ND)是口腔颌面部恶性肿瘤治疗的主要方法之一。尽管颈清术式在不断改良,但术中因剥离、牵拉等损伤副神经、肌肉、肌膜、筋膜及韧带引起的肩臂综合征(SS),仍是患者术后常见并发症,加之放疗的影响,不仅会导致患者肩颈及手臂疼痛、僵硬、麻木、活动受限等功能障碍,更会对患者的生存质量和身心健康产生严重影响。目前,国内外针对口腔颌面部恶性肿瘤颈清术后SS的问题尚缺乏一个系统评估和康复管理方案。基于前期临床实践基础以及当前可获得的最佳证据,参考国内外相关文献,邀请颌面肿瘤外科和康复领域的专家根据相关临床经验共同讨论、修改,从SS的病因、评估、诊断与鉴别诊断、康复策略及预防等方面达成共识,以期为临床提供参考。

关键词：口腔颌面部肿瘤颈淋巴清扫术肩臂综合征康复管理

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生物钟在口腔医学研究中合理应用专家共识

实用口腔医学杂志 2024年第4期40卷 455-460页

作者：杨凯孙沫逸李龙江唐瞻贵任国欣郭伟祝颂松郑家伟张杰孙志军任杰郑佳雯吕晓强唐洪陈丹席庆黄欣武和明马洪尚伟孟箭李吉辰李春洁李一赵宁波谭雪梅杨轶昕吴亚东尹仕琳张志伟重庆医科大学附属第一医院口腔颌面外科 400016 口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科四川大学华西口腔医学院头颈肿瘤外科中南大学湘雅口腔医学院口腔颌面外科上海交通大学医学院附属第九人民医院口腔医学院口腔颌面-头颈肿瘤科四川大学华西口腔医院正颌及关节外科北京大学口腔医学院口腔颌面外科武汉大学口腔医学院口腔颌面头颈肿瘤外科重庆医科大学附属第一医院口腔科中国人民解放军总医院第一医学中心口腔科首都医科大学附属北京口腔医院口腔颌面头颈肿瘤科南京医科大学附属口腔医院口腔颌面外科贵州医科大学附属口腔医院口腔颌面外科青岛大学附属医院口腔颌面外科徐州市中心医院口腔颌面外科哈尔滨医科大学附属第一医院口腔颌面外科西安交通大学口腔医院种植科德阳市人民医院口腔科昆明医科大学附属口腔医院云南省口腔医学重点实验室

机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发... 详细信息

机体生物钟(也称昼夜节律)是地球上所有生物体能适者生存在地球自转环境中的基础。昼夜节律是生命活动最基本的调控机制,在维持人体正常生理生化稳态、疾病发生及治疗中均扮演关键角色。研究表明,生物钟在口腔组织发育生长、口腔疾病发生及治疗中具有重要作用。由于目前还没有包括口腔医学在内的生物钟研究方法的指导性文献,研究者主要基于已发表的参考文献进行探讨,致使口腔医学中有关生物钟的研究方法存在争议,如何合理应用昼夜节律的研究方法还存在诸多困惑。该共识在总结生物钟的作用特点以及分析目前生物钟在口腔医学研究中不足的基础上,组织相关专家归纳推荐了生物钟在口腔医学研究中合理实施的10条原则,为生物钟在口腔医学研究中的合理应用提供参考。

关键词：生物钟昼夜节律口腔医学医学专家共识