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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei Zhu Zhiming Zhang Jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang Na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang guosheng yuan Mengya Zang Qi Li Xiaotao Jiang Yajing He Sha Wu Yukai He Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

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颈部超声弹性成像联合超声造影对脑梗死颈动脉粥样硬化的诊断价值分析

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临床研究 2024年第1期32卷 137-140页

作者：崔前辉郭元勋杨帆袁国胜郑州市第七人民医院超声科河南郑州450000 郑州市第七人民医院超声影像科河南郑州450000

目的探讨颈部超声弹性成像联合超声造影对脑梗死颈动脉粥样硬化(CAS)的诊断价值。方法选取2021年10月至2022年10月郑州市第七人民医院收治的320例脑梗死患者均进行常规超声、颈部超声弹性成像、超声造影检查,以数字减影血管造影为金标准... 详细信息

目的探讨颈部超声弹性成像联合超声造影对脑梗死颈动脉粥样硬化(CAS)的诊断价值。方法选取2021年10月至2022年10月郑州市第七人民医院收治的320例脑梗死患者均进行常规超声、颈部超声弹性成像、超声造影检查,以数字减影血管造影为金标准,比较斑块检出率、稳定性与不稳定性、斑块检查参数及诊断价值。结果320例脑梗死患者中共检出CAS斑块251例(78.44%);颈部超声弹性成像联合超声造影对CAS斑块检出率(98.41%)高于常规超声(87.65%)、颈部超声弹性(94.42%)、超声造影(94.82%);颈部超声弹性成像联合超声造影和超声造影对软斑块检出率(98.11%、95.60%)高于常规超声和颈部超声弹性成像(86.16%、89.31%);颈部超声弹性成像联合超声造影对硬斑块检出率(97.22%)显著高于常规超声(77.78%);稳定性斑块组斑块厚度、弹性评分、增强密度均小于不稳定性斑块组;斑块厚度、弹性评分、增强密度单项及联合诊断脑梗死CAS不稳定性斑块的AUC分别为0.888、0.973、0.774、0.995,发现联合诊断的敏感度、特异度较高,差异有统计学意义(P<0.05)。结论常规超声、颈部超声弹性成像、超声造影均可诊断脑梗死CAS,同时其检查参数斑块厚度、弹性评分、增强密度可有效评估脑梗死CAS斑块稳定性,联合诊断价值更高。

关键词：脑梗死颈动脉粥样硬化颈部超声弹性成像超声造影

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Social Forestry Program at Shouning County in Fujian Province

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Forestry and Society Newsletter 1995年第2期 6-8页

作者： $$$$yuan guosheng

ＳＯＣＩＡＬＦＯＲＥＳＴＲＹＰＲＯＧＲＡＭＡＴＳＨＯＵＮＩＮＧＣＯＵＮＴＹＩＮＦＵＪＩＡＮＰＲＯＶＩＮＣＥ￥ＢｙＹｕａｎＧｕｏｓｈｅｎｇ１．ＰｒｏｊｅｃｔＢａｃｋｇｒｏｕｎｄＳｈｏｕｎｉｎｇｉｓｓｉｔｕａｔｅｄｉｎｔ... 详细信息

ＳＯＣＩＡＬＦＯＲＥＳＴＲＹＰＲＯＧＲＡＭＡＴＳＨＯＵＮＩＮＧＣＯＵＮＴＹＩＮＦＵＪＩＡＮＰＲＯＶＩＮＣＥ￥ＢｙＹｕａｎＧｕｏｓｈｅｎｇ１．ＰｒｏｊｅｃｔＢａｃｋｇｒｏｕｎｄＳｈｏｕｎｉｎｇｉｓｓｉｔｕａｔｅｄｉｎｔｈｅｎｏｒｔｈｐａｒｔｏｆＦｕｊｉ...

关键词： Social Forestry Program at Shouning County in Fujian Province

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ROLE OF WOMEN IN SOCIAL FORESTRY PROJECT

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Forestry and Society Newsletter 1996年第1期 7-8页

作者： $$$$ yuan guosheng

ＲＯＬＥＯＦＷＯＭＥＮＩＮＳＯＣＩＡＬＦＯＲＥＳＴＲＹＰＲＯＪＥＣＴｂｙＹｕａｎＧｕｏｓｈｅｎｇＳｉｎｃｅｉｔｓｉｍｐｌｅｍｅｎｔａｔｉｏｎｉｎ１９９２，ｔｈｅＦｕｊｉａｎＳｈｏｕｎｉｎｇＳｏｃｉａｌＦｏｒｅｓｔｒｙ...

ＲＯＬＥＯＦＷＯＭＥＮＩＮＳＯＣＩＡＬＦＯＲＥＳＴＲＹＰＲＯＪＥＣＴｂｙＹｕａｎＧｕｏｓｈｅｎｇＳｉｎｃｅｉｔｓｉｍｐｌｅｍｅｎｔａｔｉｏｎｉｎ１９９２，ｔｈｅＦｕｊｉａｎＳｈｏｕｎｉｎｇＳｏｃｉａｌＦｏｒｅｓｔｒｙＰｒｏｊｅｃｔｇｏｖｅｒｎｍｅｎｔ...

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Robustness of the octupole collectivity in 144Ba within the cranking covariant density functional theory in 3D lattice

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Nuclear Science and Techniques 2024年第8期35卷 124-131页

作者： Ze‑Kai Li yuan‑yuan Wang Mathematics and Physics Department North China Electric Power UniversityBeijing 102206China Hebei Key Laboratory of Physics and Energy Technology North China Electric Power UniversityBaoding 071000China

The octupole deformation and collectivity in octupole double-magic nucleus 144Ba are investigated using the Cranking covariant density functional theory in a three-dimensional lattice *** reduced B(E3)transition probability is implemented for the first time in semiclassical approximation based on the microscopically calculated electric octupole *** available data,including the I-ωrelation and electric transitional probabilities B(E2)and B(E3)are well ***,it is shown that the ground state of 144Ba exhibits axial octupole and quadrupole deformations that persist up to high spins(I≈24h).

关键词： Octupole collectivity Cranking covariant density functional theory Rotational spectrum Electric transitional probabilities

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Formation and destruction processes of upper Sinian oil-gas pools in the Dingshan-Lintanchang structural belt, southeast Sichuan Basin, China

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Petroleum Science 2010年第3期7卷 289-301页

作者： Liu Shugen Zhang Zhijing Huang Wenming Wang Guozhi Sun Wei Xu guosheng yuan Haifeng Zhang Changjun Deng Bin State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of Technology Sichuan610059 China

The lower Cambrian Niutitang Formation hydrocarbon source rocks at the Dingshan- Lintanchang structure in the southeast Sichuan Basin were of medium-good quality with two excellent hydrocarbon-generating centers developed in the periphery areas, with a possibility of forming a medium to large-sized oil-gas field. Good reservoir rocks were the upper Sinian （Dengying Formation） dolomites. The mudstone in the lower Cambrian Niutitang Formation with a good sealing capacity was the cap rock. The widely occurring bitumen in the Dengying Formation indicates that a paleo oil pool was once formed in the study area. The first stage of paleo oil pool formation was maturation of the lower Cambrian source rocks during the late Ordovician. Hydrocarbon generation from the lower Cambrian source rocks stopped due to the Devonian-Carboniferous uplifting. The lower Cambrian source rocks then restarted generation of large quantities of hydrocarbons after deposition of the middle Permian sediments. This was the second stage of the paleo oil pool formation. The oil in the paleo oil pool began to crack during the late Triassic and a paleo gas pool was formed. This paleo gas pool was destroyed during the Yanshan-Himalayan folding, uplifting and denudation. Bitumen can be widely seen in the Dengying Formation in wells and outcrops in the Sichuan Basin and its periphery areas. This provides strong evidence that the Dengying Formation in the Sichuan Basin and its periphery areas was once an ultra-large structural-lithologic oil-gas field, which was damaged during the Yanshan-Himalayan period.

关键词： Sinian oil-gas pool Dingshan-Lintanchang structural belt Sichuan Basin

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Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang yuan Lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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MAUN:Memory-Augmented Deep Unfolding Network for Hyperspectral Image Reconstruction

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1139-1150页

作者： Qian Hu Jiayi Ma yuan Gao Junjun Jiang Yixuan yuan Electronic Information School Wuhan UniversityWuhan 430072China School of Computer Science and Technology Harbin Institute of TechnologyHarbin 150001China Department of Electronic Engineering Chinese University of Hong KongHong Kong 999077China

Spectral compressive imaging has emerged as a powerful technique to collect the 3D spectral information as 2D *** algorithm for restoring the original 3D hyperspectral images(HSIs)from compressive measurements is pivotal in the imaging *** approaches painstakingly designed networks to directly map compressive measurements to HSIs,resulting in the lack of interpretability without exploiting the imaging *** some recent works have introduced the deep unfolding framework for explainable reconstruction,the performance of these methods is still limited by the weak information transmission between iterative *** this paper,we propose a Memory-Augmented deep Unfolding Network,termed MAUN,for explainable and accurate HSI ***,MAUN implements a novel CNN scheme to facilitate a better extrapolation step of the fast iterative shrinkage-thresholding algorithm,introducing an extra momentum incorporation step for each iteration to alleviate the information ***,to exploit the high correlation of intermediate images from neighboring iterations,we customize a cross-stage transformer(CSFormer)as the deep denoiser to simultaneously capture self-similarity from both in-stage and cross-stage features,which is the first attempt to model the long-distance dependencies between iteration *** experiments demonstrate that the proposed MAUN is superior to other state-of-the-art methods both visually and *** code is publicly available at https://***/HuQ1an/MAUN.

关键词： Deep folding iteration

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Gradient microstructure and superior strength-ductility synergy of AZ61 magnesium alloy bars processed by radial forging with different deformation temperatures

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Journal of Materials Science & Technology 2024年第3期170卷 65-77页

作者： Jingfeng Zou Lifeng Ma Yanchun Zhu Ling Qin yuan yuan School of Mechanical Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Heavy Machinery Engineering Research Center of the Ministry Education Taiyuan University of Science and TechnologyTaiyuan 030024China Department of Engineering University of HullCottingham RdHull HU67RXUK National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

Gradient microstructure modification is a cost-efficient strategy for high strength without compromising ductility,which is urgently needed in the fundamental science of engineering *** this study,heterogeneous structures of AZ61 alloy bars with anisotropic gradients(with different grain size distributions from the surface to the center)were observed to exhibit strong strength-ductility synergies under different deformation tem *** results reveal that the grain refinement process under mediumlow temperature deformation conditions(≤350℃)consists of four transition stages along the radial direction,i.e.,twin activations and deformation band formations,dislocation cells and pile-ups,ultrafine sub-grains,and randomly orientated quasi-micron *** deformation temperatures have a great influence on twin activations and deformation band formations,and the high temperature can easily provoke the initiation of non-basal *** deformation bands were determined as a primary nucleation site due to their highly unstable dislocation hindrance *** in combination with the Radial forging(RF)deformation process,the differences of dynamic precipitates can be attributed to microstructural difference and solubility limit of Al at different tem *** summarizing the tensile test results,the sample forged at 350℃exhibited the best strength-ductility synergy,exhibiting the highest elongation(EL)of 23.2%with a 251 MPa yield strength(YS)and 394 MPa ultimate tensile strength(UTS)in center region,and combined with the highest strength value of 256 MPa YS and 420 MPa UTS in the center region,while the EL was slightly degraded to 19.8%.

关键词： Gradient microstructure Radial forging Strength-ductility synergy Magnesium alloy Strengthening mechanism

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Pyrolysis Empirical Modeling of Polyester Glass Fiber Reinforced Plastics Using Sestak-Berggren Model Method

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Journal of Thermal Science 2024年第2期33卷 725-738页

作者： NAN Wei JI Wenhui yuan Yanping yuan Zhongyuan SUN Yong School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China CRRC Changchun Railway Vehicles Co. LtdChangchun130062China

Polyester Glass Fiber Reinforced Plastic(Polyester GFRP),a thermosetting plastic comprised of glass fiber and polyester polymer compounds,is extensively utilized in high-speed *** its pyrolysis mechanism is crucial as it significantly influences the combustion characteristics and fire safety ***,kinetic research on polyester GFRP primarily focuses on employing the Coats-Redfern method to derive a theoretical kinetic ***,the pyrolysis process of polyester GFRP is complex and the aforementioned theoretical model fails to accurately describe the pyrolysis ***,this study seeks to utilize the Sestak and Berggren(SB) model as a methodological approach to reveal the complex reaction mechanism during the pyrolysis *** on thermogravimetric analysis,the entire pyrolysis process of polyester GFRP is divided into two primary ***,model-free methods are employed to ascertain the activation energy and pre-exponential *** results show that the fitted empirical models of the two main pyrolysis stages are f(α)=(1-α)^(1.47)[-ln(1-α)]^(1.50) and f(α)=(1-α)^(1.77)[-ln(1-α)]^(1.72),*** predicted results are in good agreement with experimental data under different heating rates,which indicates that the empirical model can sufficiently describe the pyrolysis process of polyester GFRP.

关键词： polyester GFRP model-fitting methods empirical models pyrolysis

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