检索结果-南通市图书馆

The heterogeneity of tumor-associated macrophages and strategies to target it

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第3期48卷 363-378页

作者： HAO lv BO ZHU DEGAO CHEN Institute of Cancer Xinqiao HospitalThird Military Medical UniversityChongqing400037China Chongqing Key Laboratory of Immunotherapy Xinqiao HospitalThird Military Medical UniversityChongqing400037China

Tumor-associated macrophages(TAMs)are emerging as targets for tumor therapy because of their primary role in promoting tumor *** studies have been conducted to target TAMs by reducing their infiltration,depleting their numbers,and reversing their phenotypes to suppress tumor progression,leading to the development of drugs in preclinical and clinical ***,the heterogeneous characteristics of TAMs,including their ontogenetic and functional heterogeneity,limit their ***,in-depth exploration of the heterogeneity of TAMs,combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor *** review focuses on the heterogeneous ontogeny and function of TAMs,as well as the current development of tumor therapies targeting TAMs and combination strategies.

关键词： Tumor-associated macrophages Tissue-resident macrophages Heterogeneity Immune checkpoint therapy

Imaging a force field via an optically levitated nanoparticle array

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics B 2024年第9期33卷 179-184页

作者： Bihu lv Jiandong Zhang Chuang Li Research Center for Novel Computing Sensing and Intelligent Processing Zhejiang LaboratoryHangzhou 311121China School of Mathematics and Physics Jiangsu University of TechnologyChangzhou 213001China

Levitated optomechanical systems represent an excellent candidate platform for force and acceleration *** propose a force-sensing protocol utilizing an optically levitated nanoparticle *** our scheme,N nanoparticles are trapped in an optical cavity using holographic optical *** external laser drives the cavity,exciting N cavity modes interacting simultaneously with the N *** optomechanical interaction encodes the information of the force acting on each nanoparticle onto the intracavity photons,which can be detected directly at the output ports of the ***,our protocol enables real-time imaging of a force field.

关键词： optomechanics levitated nanoparticles force field detection

Enhancing AI System Privacy:An Automatic Tool for Achieving GDPR Compliance in NoSQL Databases

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第7期80卷 217-234页

作者： Yifei Zhao Zhaohui Li Siyi lv College of Cyber Science Nankai UniversityTianjin300350China

The EU’s Artificial Intelligence Act(AI Act)imposes requirements for the privacy compliance of AI *** systems must comply with privacy laws such as the GDPR when providing *** laws provide users with the right to issue a Data Subject Access Request(DSAR).Responding to such requests requires database administrators to identify information related to an individual ***,manual compliance poses significant challenges and is *** administrators need to write queries through time-consuming *** demand for large amounts of data by AI systems has driven the development of NoSQL *** to the flexible schema of NoSQL databases,identifying personal information becomes even more *** paper develops an automated tool to identify personal information that can help organizations respond to *** tool employs a combination of various technologies,including schema extraction of NoSQL databases and relationship identification from query *** describe the algorithm used by our tool,detailing how it discovers and extracts implicit relationships from NoSQL databases and generates relationship graphs to help developers accurately identify personal *** evaluate our tool on three datasets,covering different database designs,achieving an F1 score of 0.77 to *** results demonstrate that our tool successfully identifies information relevant to the data *** tool reduces manual effort and simplifies GDPR compliance,showing practical application value in enhancing the privacy performance of NOSQL databases and AI systems.

关键词： GDPR compliance NoSQL databases AI system privacy

Recent progress of in-situ characterization of LiNi_(1−x−y)Co_(x)Mn_(y)O_(2) cathodes for lithium metal batteries: A mini review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 1384-1401页

作者： Huanzhu lv Xiaoqi Zhu Jun Mei Yuanhua Xia Bin Wang Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Chengdu Development Center of Science and Technology China Academy of Engineering PhysicsChengdu 610200China Key Laboratory of Neutron Physics and Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics(CAEP)Mianyang 621999China

In the context of the gradual popularity of electric vehicles(EVs),the development of lithium battery systems with high energy density and power density is regarded as the foremost way to improve the range of ***_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)cathodes have been the focus of researchers due to their high energy density,excellent power performance,and low-temperature ***,the elaboration of the decay mechanism of NCM cathode based on lithium metal batteries(LMBs)is still being restricted to the primary *** the past decades,the development and application of advanced in-situ characterization tools have facilitated researchers'understanding of the internal operation mechanism of batteries during charging and *** this minireview,the latest progress of in-situ observation of the NCM cathode by X-ray diffraction(XRD),fourier transform infrared(FT-IR)spectroscopy,Raman spectroscopy,atomic force microscopy(AFM),transmission electron microscope(TEM),optical microscope,and other characterization tools is *** mechanisms of structural degradation,cathode-electrolyte interfaces(CEIs)composition,and dynamic changes of NCM,electrolyte breakdown,and gas production are ***,based on the existing research progress,the opportunities and challenges for future in-situ characterization technology in the study of the mechanism of LMBs are discussed in ***,the purpose of this minireview is to summarize recent work that focuses on the outstanding application of in-situ characterization techniques in the mechanistic study of LMBs,and pointing the way to the future development of high energy density and power density LMBs systems.

关键词： lithium metal batteries(LMBs) In-situ characterization LiNi_(1-x-y)Co_(x)Mn_(y)O_(2)(NCM)

Random change point model with an application to the China Household Finance Survey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第10期67卷 2373-2386页

作者： Meng Li Lingxi Gao Guangming lv Xingwei Tong School of Statistics Beijing Normal UniversityBeijing 100875China

We consider a linear model with a change point according to the unknown random threshold of a covariate. We give the expectation-maximization(EM) estimations of the regression and change point parameters. The existence of the random change point is detected by the supremum(SUP) test of score statistics. Theoretically, we establish the convergence and asymptotic distribution of the estimation and show that the EM estimates converge in distribution to a normal distribution. In addition, the numerical performance of the proposed approach is demonstrated through simulation studies. Finally, applying our methodology to household financial decisions, we see that the average debt tolerance of Chinese households is estimated to be 1.1364 times the sum of total household income and financial assets. The effect of assets and income on consumption shows a rapid decline if the household exceeds the average debt tolerance.

关键词： random change point EM algorithm SUP test debt nancial vulnerability

Minmax Common Due-Window Assignment Scheduling with Deteriorating Jobs

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of the Operations Research Society of China 2024年第3期12卷 681-693页

作者： Dan-Yang lv Jing Xue Ji-Bo Wang School of Mechatronics Engineering Shenyang Aerospace UniversityShenyang110136LiaoningChina

This paper investigates the common due-window assignment scheduling problem with deteriorating jobs on a single machine in which the processing time of a job is a proportional function of its starting *** goal is to minimize the maximum value of earliness and tardiness penalties,as well as due-window location cost,and size *** on whether the location and size of due-window are known,this paper studies three relevant cases,all of which are solvable in polynomial time.

关键词： Scheduling Single machine Deteriorating jobs Common due-window Earliness Tardiness

Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第8期14卷 3295-3311页

作者： Ao Wang Yi Zhang Xinting lv Guang Liang Department of Pharmacy and Institute of Inflammation Zhejiang Provincial Affiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China Key Laboratory of Natural Medicines of the Changbai Mountain Ministry of EducationYanbian UniversityYanji 133002China Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China

Protein tyrosine phosphorylation is a post-translational modification that regulates protein structure to modulate demic organisms’homeostasis and *** physiological process is regulated by two enzyme families,protein tyrosine kinases(PTKs)and protein tyrosine phosphatases(PTPs).As an important regulator of protein function,PTPs are indispensable for maintaining cell intrinsic physiology in different systems,as well as liver physiological and pathological *** of PTPs has been implicated in multiple liver-related diseases,including chronic liver diseases(CLDs),hepatocellular carcinoma(HCC),and liver injury,and several PTPs are being studied as drug therapeutic ***,given the regulatory role of PTPs in diverse liver diseases,a collated review of their function and mechanism is ***,based on the current research status of targeted therapy,we emphasize the inclusion of several PTP members that are clinically significant in the development and progression of liver *** an emerging breakthrough direction in the treatment of liver diseases,this review summarizes the research status of PTP-targeting compounds in liver diseases to illustrate their potential in clinical ***,this review aims to support the development of novel PTP-based treatment pathways for liver diseases.

关键词： Tyrosine phosphorylation PTPs Signal transduction CLDs HCC Allosteric inhibitor PROTACs Drug development

Visible-light-induced Synthesis of Organic Peroxides via Decarboxylative Couplings of Carboxylic Acids,Alkenes and tert-Butyl Hydroperoxide

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第5期40卷 863-873页

作者： HUANG Qiuwei LOU Chenhao lv Leiyang LI Zhiping Key Laboratory of Advanced Light Conversion Materials and Biophotonics School of Chemistry and Life ResourcesRenmin University of ChinaBeijing100872P.R.China

Herein,we present a photoinduced,CeCl_(3)-catalyzed three-component decarboxylative reaction that couples carboxylic acids,alkenes and tert-butyl hydroperoxide for the formation of various organic *** ligand-to-metal charge transfer(LMCT)excitation mode allows the decarboxylative alkylation-peroxidation reaction to occur under mild conditions,and is well applicable to primary,secondary and tertiary carboxylic acids and styrene derivatives.

关键词： Visible-light catalysis Difunctionalization Carboxylic acid Alkene Organic peroxide

Exceptional reversed yield strength asymmetry in a rare-earth free Mg alloy containing quasicrystal precipitates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第2期12卷 687-699页

作者： Qiang Yang Shuhui lv Zixiang Yan Zefeng Xie Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China

This work reports an exceptional reversed yield strength asymmetry at room temperature for a rare-earth free magnesium alloy containing a mass of fine dispersed quasicrystal(I-phase)*** exhibiting traditional basal texture,it owns an exceptional CYS/TYS as high as~*** back-scattered diffraction(EBSD)and transmission electron microscopy(TEM)examinations indicate pyramidal and prismatic dislocations plus tensile twinning being activated after immediate yielding in compression while basal and non-basal dislocations in tension.I-phase particles transferred the concentrated stress by self-twinning to provide the driving force for tensile twin initiating in neighboring grains,thereby significantly increasing the critical resolved shear stress of tensile twinning to possibly the level of pyramidal slip,finally leading to the dominance of pyramidal slip plus tensile twinning in texture *** results in a higher contribution on yield strength by~55 MPa in compression than in tension,which reasonably agrees with the experimental yield strength difference(~38 MPa).It can be concluded that I-phase particles influence deformation modes in tension and in compression,finally result in reversed yield strength asymmetry.

关键词： Magnesium alloy Reversed yield strength asymmetry Transmission electron microscopy(TEM) Twinning Dislocations