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Cerebral furin deficiency causes hydrocephalus in mice

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Genes & Diseases 2024年第3期11卷 438-451页

作者： Shiqi Xie Xiaoyong Xie Jing Tang Biao Luo Jian chen Qixin Wen Jianrong Zhou guojun chen Nursing College Chongqing Medical UniversityChongqing 400016China Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Major Neurological and Mental DisordersChongqing Key Laboratory of NeurologyChongqing 400016China

Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory *** have previously reported that cerebral overexpres-sion of furin promotes cognitive functions in ***,by generating the brain-specific furin conditional knockout(ckO)mice,we investigated the role of furin in brain *** found that furin deficiency caused early death and growth *** resonance im-aging showed severe *** the brain of furin cko mice,impaired ciliogenesis and the derangement of microtubule structures appeared along with the down-regulated expres-sion of RAB28,a ciliary vesicle *** line with the widespread neuronal loss,ependymal cell layers were *** proteomics analysis revealed that cell adhesion molecules including astrocyte-enriched ITGB8 and BCAR1 were altered in furin cKO mice;and astrocyte overgrowth was accompanied by the reduced expression of sox9,indicating a disrupted differ-entiation into ependymal ***,whereas alteration of RAB28 expression correlated with the role of vesicle trafficking in ciliogenesis,dysfunctional astrocytes might be involved in ependymal damage contributing to hydrocephalus in furin ckO *** structural and mo-lecular alterations provided a clue for further studying the potential mechanisms of furin.

关键词： Astrocyte Ciliogenesis Conditionalknockout Ependymal Furin Hydrocephalus Proteomics

Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu chen chen Xiaoning chen Yuheng Yang Hao Lian Hao chen Xiaofeng cheng Zhitong chen guojun chen Chaoqun Liu Lanlan chen Yu He Zhaowei chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and BiologyCollege of ChemistryFuzhou UniversityFuzhou 350002China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Biomedical Engineering and the Rosalind&Morris Goodman Cancer Research Institute McGill UniversityMontreal QC H3A 1A3Canada School of Pharmacy Henan UniversityKaifeng 475004China Department of Chemistry University of HullHull HU67RXUK

Chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global ***,traditional disposal strategies have limitations,including high energy consumption,use of aggressive reagents and generation of toxic ***,inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments,we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide,CEES)under sweet *** exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase)and threeenzyme(invertase/glucose oxidase/chloroperoxidase)cascades,both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and>99% selectivity towards non-toxic *** found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination *** importantly,the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles,following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

Effects of zero-valent iron added in the flooding or drainage process on cadmium immobilization in an acid paddy soil

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Journal of Environmental Sciences 2024年第4期138卷 19-31页

作者： Hanbing Meng Shiwen Hu Zebin Hong Wenting Chi guojun chen Kuan cheng QiWang Tongxu Liu Fangbai Li Kexue Liu Yang Yang Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and ManagementInstitute of Eco-environmental and Soil SciencesGuangdong Academy of SciencesGuangzhou 510650China School of Resources and Planning Guangzhou Xinhua UniversityGuangzhou 510310China University of Chinese Academy of Sciences Beijing 100049China

Zero-valent iron(ZVI)is a promising material for the remediation of Cd-contaminated paddy ***,the effects of ZVI added during flooding or drainage processes on cadmium(Cd)retention remain ***,Cd-contaminated paddy soil was incubated for 40days of flooding and then for 15 days of drainage,and the underlying mechanisms of Cd immobilization coupled with Fe/S/N redox processes were *** addition of ZVI to the flooding process was more conducive to Cd *** potential available Cd was detected by adding ZVI before flooding,which may be due to the increase in paddy soil pH and newly formed secondary Fe ***,the reductive dissolution of Fe minerals promoted the release of soil colloids,thereby increasing significantly the surface sites and causing Cd ***,the addition of ZVI before flooding played a vital role in Cd retention after soil *** contrast,the addition of ZVI in the drainage phase was not conducive to Cd retention,which might be due to the rapid decrease in soil pH that inhibited Cd adsorption and further immobilization on soil *** findings of this study demonstrated that Cd availability in paddy soil was largely reduced by adding ZVI during the flooding period and provide a novel insight into the mechanisms of ZVI remediation in Cd-contaminated paddy soils.

关键词： Paddy soil Zero-valent iron Cadmium Flooding and drainage Remediation

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共融机器人实验教学平台设计

实验室研究与探索 2024年第5期43卷 215-219,255页

作者：陈国军王宇陈巍杨雪郭铁铮南京工程学院工业中心南京211167

在为自动化专业学生开设的共融机器人控制系统实验中,设计了基于多传感器融合的共融机器人实验平台。该平台通过基于深度学习的视觉检测方法实现行人感知功能,利用激光雷达-深度相机-IMU的多传感器信息融合方法实现定位与建图功能。借... 详细信息

在为自动化专业学生开设的共融机器人控制系统实验中,设计了基于多传感器融合的共融机器人实验平台。该平台通过基于深度学习的视觉检测方法实现行人感知功能,利用激光雷达-深度相机-IMU的多传感器信息融合方法实现定位与建图功能。借助语音导航实现导航与避障功能,通过改进蚁群算法实现路径规划功能。通过共融机器人实验平台开展项目式教学,让学生深入掌握共融机器人关键技术,构建了“工程化环境、项目化载体、团队式指导、协作式学习”的项目教学组织形态。实践教学表明,通过设置阶梯式教学,教师项目引导,学生自主学习,强化了专业理论知识,提升了学生工程实践能力和创新能力。

关键词：人机共融自主导航共融机器人项目式教学

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原发性阴茎恶性黑色素瘤1例报告

中华泌尿外科杂志 2024年第8期45卷 633-634页

作者：陈峙橦黄龙陈小彬周晓峰陈爽程文龙陈国俊青海大学附属医院泌尿外科西宁810000 青海大学附属医院肝胆胰外科西宁810000 青海大学附属医院病理科西宁810000

本文报道青海大学附属医院收治的1例阴茎原发性恶性黑色素瘤患者,56岁,因发现阴茎肿物1个月入院。查体:尿道外口下方近系带处可见大小约1.5cm×2.0cm不规则菜花样肿物,表面覆盖黄色坏死组织,触痛阳性;左、右侧腹股沟区可触及数枚包块,... 详细信息

本文报道青海大学附属医院收治的1例阴茎原发性恶性黑色素瘤患者,56岁,因发现阴茎肿物1个月入院。查体:尿道外口下方近系带处可见大小约1.5cm×2.0cm不规则菜花样肿物,表面覆盖黄色坏死组织,触痛阳性;左、右侧腹股沟区可触及数枚包块,触痛阳性。实验室检查未见异常。头、胸部、腹部、盆腔CT检查未见明显异常。阴茎肿物活检病理提示恶性黑色素瘤。右侧腹股沟区淋巴结穿刺活检病理结果考虑局部炎症反应。结合患者病史、查体、影像学检查和淋巴结穿刺结果诊断为原发性阴茎恶性黑色素瘤。行阴茎部分切除术,术后病理诊断为恶性黑色素侵犯表皮伴溃疡。术后随访9个月无局部复发和转移。

关键词：黑色素瘤原发性阴茎恶性黑色瘤手术免疫组化

基于iHDODC-LinkNet网络的遥感图像道路提取方法

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光电子．激光 2024年第1期35卷 51-58页

作者：陈国军朱燕宁耿润田李子祥中国石油大学(华东)计算机科学与技术学院山东青岛266580

遥感图像的道路提取在推动城乡发展规划及建设方面具有重要意义。然而,目前传统方法对于遥感图像道路提取存在工程量大、效率低下的问题,基于深度学习的方法又存在复杂场景下提取精度不高和连通性差等问题。针对上述存在的问题,为提高... 详细信息

遥感图像的道路提取在推动城乡发展规划及建设方面具有重要意义。然而,目前传统方法对于遥感图像道路提取存在工程量大、效率低下的问题,基于深度学习的方法又存在复杂场景下提取精度不高和连通性差等问题。针对上述存在的问题,为提高不同地貌区域的道路提取精度,本文提出一种基于iHDODC-LinkNet网络的高分辨率遥感图像道路提取方法。该方法在语义分割模型D-LinkNet的基础上进行改进:一方面使用ResNeSt50重建D-LinkNet网络并添加预训练模型,提出一种混联深度过参数化扩张卷积(hybrid depthwise over-parameterized dilated convolution,HDODC)模块;另一方面采用迭代注意力特征融合(iterative attentional feature fusion,iAFF)机制替换原始的相加融合,从而使模型关注于道路的全局信息。最后,在马萨诸塞州道路数据集和某省高速公路场景数据集上进行训练并通过测试集的提取效果证明模型改进方法的有效性。根据实验模型分割效果表明,改进后的方法在测试集上F1达到71.66%,相比原始模型提升了10%,能够得到效果更好的分割结果。

关键词：语义分割连通性混联深度过参数化扩张卷积(HDODC) 注意力特征融合

Progress of transition metal-catalyzed cross-coupling mediated by PyBroP

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Chinese Science Bulletin 2014年第17期59卷 1942-1949页

作者： guojun chen Jianshi Du College of Science Changchun Institute of Technology Vascular Surgery The Third Hospital of Jilin University

In the transition metal-catalyzed cross-coupling reactions,phenol and enol derivatives activated by phosphorus groups are very important *** kind of compounds has the advantages of easy preparation,great stability,and producing more benign phosphorus *** present work provides a comprehensive review of the advances made over the past several decades in this ***-coupling reactions mediated by PyBroP are first surveyed,then two types of recently developed transition metal-catalyzed reactions,i.e.,Pd-catalyzed and Nicatalyzed reactions,and the corresponding mechanisms are ***,future directions are analyzed.

关键词：过渡金属催化介导交叉偶联反应联通亲电试剂催化反应衍生物化合物

不同视线诱导系统下高速公路隧道入口减速行为试验研究

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隧道建设（中英文） 2024年第9期44卷 1863-1873页

作者：强伟杰陈国俊杜志刚陈伟锋余亮贝润钊武汉理工大学交通与物流工程学院湖北武汉430063 广东省公路建设有限公司江罗分公司广东广州510699

为分析驾驶人在隧道入口区域的减速行为特征,并定量评价不同视线诱导设施的调节作用,开展模拟试验,基于日间自由流状态构建场景1(行业标准、对照组)、场景2(2.5 m立面标记)、场景3(环形立面标记)、场景4(多层次视线诱导系统)4组试验场景... 详细信息

为分析驾驶人在隧道入口区域的减速行为特征,并定量评价不同视线诱导设施的调节作用,开展模拟试验,基于日间自由流状态构建场景1(行业标准、对照组)、场景2(2.5 m立面标记)、场景3(环形立面标记)、场景4(多层次视线诱导系统)4组试验场景,采用开始减速位置、减速度变化率、油门开度变化率等指标进行分析。试验结果如下:1)驾驶人速度变化呈现“平稳—下降—较平稳”趋势;2)在行业标准下开始减速位置较近,导致需采取较大减速度、较少减速阶段实现车速下降,行车舒适度低于、操纵危险度大于其他场景;3)2.5 m立面标记与环形立面标记均能使驾驶人提前辨识洞门,行车舒适区间占比有所提升;4)多层视线诱导系统表现最优,开始减速位置提前65%,行车舒适区间提升最大(13.1%),且其采用的控制油门减速策略,平均油门开度最大(0.095)、油门操纵危险度最小(0.13),是入口区域较适宜的减速模式。试验结果表明:隧道入口洞门采用环形立面标记、增设多层次视线诱导系统有利于驾驶人早发现、早减速、缓减速,能显著提升隧道入口区域行驶安全性与舒适性。

关键词：高速公路隧道交通安全隧道入口区域减速行为视线诱导系统

Lego architecture:Research on a temporary building design method for post-disaster emergency

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Frontiers of Architectural Research 2021年第4期10卷 758-770页

作者： Daoyuan chen Guoen Wang guojun chen School of Urban Design Wuhan UniversityWuhan430072China

Disasters are becoming the norm in this world,which also poses challenges to *** needs to build temporary buildings may occur at the same time randomly around all over the *** an efficient and economical solution is the motivation of this *** a comprehensive review of all past related researches and architectural practices,“convenience”and“recyclability”have been identified as two important features of temporary buildings in the post-pandemic *** this article,we carry on a novel research of discrete *** on the design paradigm of discrete architecture,this research uses the three main components of S/U/P to develop a Lego Architecture design method by combining with the Grasshopper plug-in under the Rhino platform to write a program that automatically generates the target ***,a typical design scheme for physical construction verification and structural optimization is selected to ensure landing and *** from the thinking of productization,this research attempts to package the design methods and related knowledge into a systematic solution,relying on an open construction system framework to achieve a rapid,simple and safe construction of temporary buildings after disasters.

关键词： Discrete architecture Lego architecture Temporary buildings Portable buildings Recyclable