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超米兰标准肝细胞癌伴微血管侵犯患者肝移植前DEB-TACE疗效评估及预后分析

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影像诊断与介入放射学 2024年第4期33卷 271-277页

作者：叶兆丹曹国洪宋梦晨张景峰浙江中医药大学浙江杭州310053 浙江树人学院树兰国际医学院附属树兰(杭州)医院放射科浙江杭州310022 宁波市第二医院放射科浙江宁波315010

目的载药微球经导管肝动脉灌注化疗栓塞术(DEB-TACE)作为超米兰标准肝细胞癌(HCC)合并微血管侵犯(MVI)患者肝移植术前的新辅助治疗,探讨其安全性、疗效及对肝移植预后的影响。方法回顾性分析2016年5月—2022年12月树兰(杭州)医院141例... 详细信息

目的载药微球经导管肝动脉灌注化疗栓塞术(DEB-TACE)作为超米兰标准肝细胞癌(HCC)合并微血管侵犯(MVI)患者肝移植术前的新辅助治疗,探讨其安全性、疗效及对肝移植预后的影响。方法回顾性分析2016年5月—2022年12月树兰(杭州)医院141例超米兰标准HCC行肝移植患者资料,其中55例患者合并MVI纳入本研究,根据术前是否行DEB-TACE治疗分为DEB-TACE组(n=26)和对照组(n=29),对照组肝移植术前未行任何治疗。采用Kaplan-Meier法评估患者的肝移植术后总生存(OS)率和无复发生存(RFS)率,并用Log-rank检验。结果DEB-TACE术后客观缓解率(ORR)高达88%,术后不良反应以栓塞综合征为主。1、2、3年RFS率DEB-TACE组(88.5%、79.2%、73.9%)高于对照组(69%、50%、44.4%),两组间3年RFS率差异有统计学意义(χ^(2)=4.428,P=0.035)。1、2、3年OS率差异虽然无统计学意义(χ^(2)=3.224,P=0.073),但DEB-TACE组(100%、91.7%、82.6%)仍优于对照组(96.6%、82.1%、59.3%)。结论DEB-TACE可改善超米兰标准HCC合并MVI患者肝移植的预后。

关键词：肝细胞癌肝移植微血管侵犯载药微球经导管肝动脉灌注化疗栓塞

Two UV organic-inorganic hybrid antimony-based materials with superior optical performance derived from cation-anion synergetic interactions

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Chinese Chemical Letters 2024年第9期35卷 442-446页

作者： Pu Zhang Xiang Mao Xuehua Dong Ling Huang Liling cao Daojiang Gao guohong Zou College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China College of Chemistry Sichuan UniversityChengdu 610065China

Finding suitable strategies to effectively enhance the optical properties of materials are the goal being pursued by ***,cation-anion synergetic interactions strategy was proposed to develop two novel organic-inorganic hybrid antimony-based optical materials,(C_(3)H_(5)N_(2))Sb F_(2)SO_(4)(I)and(C_(5)H_(6)N)Sb F_(2)SO_(4)(Ⅱ),which were obtained by introducing Sb^(3+)cation containing stereochemically active lone-pair(SCALP)and organicπ-conjugated cations into sulphate *** synergistic interactions of the organicπ-conjugated cations,the inorganic[SbO_(2)F_(2)]^(3-)seesaw anions and the[SO_(4)]^(2-)distorted tetrahedra anions make their ultraviolet(UV)absorption edges approach 297 and 283 nm,respectively,and raise their birefringence up to 0.193@546 nm and 0.179@546 nm,***,although the two compounds have the same stoichiometric ratio and similar one-dimensional(1D)chain structure,they show opposite macroscopic symmetry,where the NCS compound(Ⅱ)exhibits a large secondharmonic generation(SHG)response(1.6 times that of KH_(2)PO_(4)).The two reported compounds are found to be promising UV optical materials in the experimental tests.

关键词： Antimony-based crystals Cation-anion synergetic interactions Large birefringence Short UV absorption edge Organic-inorganic hybrid Ionothermal synthesis

Mirroring Smartphones for Good:A Feasibility Study

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ZTE Communications 2011年第1期9卷 9-14页

作者： Bo Zhao Zhi Xu Caixia Chi Sencun Zhu guohong cao Department of Computer Science and Engineering The Pennsylvania State University Bell Laboratories AlcateI-Lucent Technologies

An increasing number of applications and functions are being *** smartphones, but smartphones have limited computation ability and battery resources. To enhance smartphone capacity, cloud computing and virtualization techniques can be used to shift the workload from smartphone to computational infrastructure. In this paper, we propose a new framework in which a mirror is kept for each smartphone on a computing infrastructure in the telecom network. With mirrors, the workload can be greatly reduced, and smartphone resources can be virtually expanded. The feasibility of deploying this framework in telecom networks is demonstrated in the protocol design, a synchronization study, and a scalability test. Two applications are introduced to show how computational workload on the smartphone and traffic in the telecom network are signiScantly reduced using our techniques.

关键词： mirror cloud computing smartphone

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民间鱼纹剪纸生命意象溯源

民族艺术研究 2010年第4期23卷 160-163页

作者：曹国洪重庆文理学院美术学院

在我国民间剪纸中,以鱼为表现题材的剪纸历史悠久,形式多样,内容丰富,但不管其形式与内容怎样变化,其造型特征与文化内涵都能够在中国传统艺术中找到同宗同源的例证。民间鱼纹剪纸始终围绕最基本的主题——生命意识,通过图腾崇拜、生殖... 详细信息

在我国民间剪纸中,以鱼为表现题材的剪纸历史悠久,形式多样,内容丰富,但不管其形式与内容怎样变化,其造型特征与文化内涵都能够在中国传统艺术中找到同宗同源的例证。民间鱼纹剪纸始终围绕最基本的主题——生命意识,通过图腾崇拜、生殖繁衍、吉祥瑞福等生命意象,表达人类最朴素的情感和愿望。

关键词：鱼纹剪纸生命意象溯源

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接发列车仿真教学系统软件设计与实现

城市轨道交通研究 2013年第12期16卷 147-150页

作者：曹国红南京铁道职业技术学院南京副教授210031

针对教学中缺乏对学生进行接发列车操作实训的有效手段,设计了一套符合铁路相关技术标准的车站接发列车与调车作业仿真系统。详细介绍了该系统软件的功能、架构以及基于组件实现的关键技术。通过该仿真系统可使学生课后在实际场景中学... 详细信息

针对教学中缺乏对学生进行接发列车操作实训的有效手段,设计了一套符合铁路相关技术标准的车站接发列车与调车作业仿真系统。详细介绍了该系统软件的功能、架构以及基于组件实现的关键技术。通过该仿真系统可使学生课后在实际场景中学习、演练车站接发列车和调车作业,提高学生的实际操作能力。

关键词：接发列车调车作业仿真

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单线接发列车仿真教学系统设计与实现

城市轨道交通研究 2013年第11期16卷 130-133页

作者：曹国红南京铁道职业技术学院运输学院南京副教授210031

针对教学中单线接发车实训缺乏有效手段的现状,采用计算机模拟和沙盘模型相结合的方式,设计了一个符合铁路相关技术标准的单线接发列车与车站调车仿真教学系统。详细介绍了系统的结构、功能和特点。在实训中,通过该教学系统可使学生在... 详细信息

针对教学中单线接发车实训缺乏有效手段的现状,采用计算机模拟和沙盘模型相结合的方式,设计了一个符合铁路相关技术标准的单线接发列车与车站调车仿真教学系统。详细介绍了系统的结构、功能和特点。在实训中,通过该教学系统可使学生在实际场景中学习、演练,培训学生的实际操作能力。

关键词：接发列车模拟仿真沙盘实训

Limosilactobacillus reuteri CCFM1132 Modulates Gut Microbiota and Alleviates Hyperuricemia: A Randomized， Double-Blind， Placebo-Controlled Trial

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Food Science and Human Wellness 2024年

作者： Lei Sun Yang cao Feng Hang Dongbo Yuan Honglun Wang Jianxin Zhao Gang Wang guohong Qiao Liyun Wang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Department of Biostatistics， Harvard T.H.Chan School of Public Health National Engineering Research Center for Functional Food， Jiangnan University (Yangzhou) Institute of Food Biotechnology， Jiangnan University Department of Clinical Laboratory， Yixing People's Hospital， Affiliated to Jiangsu University Qinghai Provincial Key Laboratory of Tibetan Medicine Research Department of Endocrine Metabolism， Yixing People's Hospital， Affiliated to Jiangsu University

This randomized， double-blind， placebo-controlled trial evaluated the uric acid （UA）-lowering effect of Limosilactobacillus reuteri CCFM1132 in young males with hyperuricemia. Participants received 1×1010CFU of L. reuteri CCFM1132 （n=34） or placebo （n=31） daily for 8 weeks. After the intervention， serum UA concentration significantly decreased， along with a reduction in xanthine oxidase （XOD） activity compared to the placebo group （P < 0.01）. Indicators of liver （aspartate transaminase and alanine transaminase） and renal （urea and creatinine） functions improved. Short-chain fatty acid （SCFA） concentrations significantly increased， with an upregulated abundance of SCFA producers （Fusicatenibacter， Ruminococcaceae UCG＿014， and Ruminococcus 1） in the gut. Additionally， correlation analysis revealed that concentrations of SCFAs， particularly acetate and butyrate， were strongly negatively correlated with UA concentration and XOD activity. These findings suggest that L. reuteri CCFM1132 relieves hyperuricemia by enhancing the abundance of SCFA producers in the gut to promote SCFA production and by suppressing XOD activity. This study provides a valuable reference for developing new treatments for hyperuricemia.

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Changes of long noncoding RNA expression in bleomycin-induced lung fibrosis

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Changes of long noncoding RNA expression in bleomycin-induce...

ASb(SO_(4))_(2)(A=Rb,Cs):Two short-wave UV antimony sulfates exhibiting large birefringence

中华医学会呼吸病学年会——2013（第十四次全国呼吸病学学术会议）

作者： guohong cao Jinjin Zhang Meirong Wang Xiaodong Song Wenbo Liu Cuiping Mao Changjun Lv Medicine Research Center Binzhou Medical UniversityYantai Department of Respiratory Medicine Affiliated Hospital to Binzhou Medical UniversityBinzhou

Recent developments suggest that long noncoding RNAs(IncRNAs) are more involved in human diseases than previously realized.A growing body of evidence links IncRNA mutation and dysregulation to diverse human ***,the association of IncRNAs with the pathogenesis of lung fibrosis remains poorly *** this study,we detected changes in hydroxyproline,collagen,and the ultrastructure of lung tissue to develop a rat model of lung *** differentially expressed IncRNA and mRNA profiles

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Chinese Chemical Letters 2024年第1期35卷 514-517页

作者： Yang Lan Jinxuan Ren Pu Zhang Xuehua Dong Ling Huang Liling cao Daojiang Gao guohong Zou College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China College of Chemistry Sichuan UniversityChengdu 610065China

Herein,two antimony sulfates,named RbSb(SO_(4))_(2)(1)and CsSb(SO_(4))_(2)(2),have been successfully synthesized with the introduction of Sb^(3+)cation with stereochemically active lone pairs(SCALP)into sulfates by the conventional hydrothermal *** two compounds endow short ultraviolet(UV)absorption edges(281 nm and 278 nm,respectively)and large birefringence(0.171@546 nm and 0.174@546 nm,respectively),which means that they are promising short-wave UV optical ***,though both of the two compounds exhibit similar 1D chained structures,and possess the same functional moieties including SbO4 seesaws and SO4 tetrahedral groups,they exhibit significantly opposite macroscopic symmetries,i.e.,compound 1 crystallizes in a centrosymmetric(CS)manner(P2_(1)/n)and compound 2 in a noncentrosymmetric(NCS)manner(P2_(1)2_(1)2_(1)),due to the size of cations[r(Rb+)=1.56 A˚,r(Cs+)=1.67 A˚]affects the orientation of SCALP of the adjacent Sb^(3+).

关键词： Antimony sulfates Birefringent crystals Large birefringence Short UV absorption edge Stereochemically active lone pair