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基于浮动车轨迹数据的干线信号协调配时优化

广西大学学报（自然科学版） 2024年第1期49卷 132-146页

作者：杨伟沈国栋龙光钱宇丁恒安徽省交通规划设计研究总院股份有限公司安徽合肥230088 合肥工业大学汽车与交通工程学院安徽合肥230009

为了提高城市干线的通行效率,缩短车辆在干线行驶时的平均延误,基于浮动车轨迹数据提出一种城市干线交通信号协调控制优化方法。该方法根据浮动车采集的时空轨迹数据,使用最大期望算法对混合车流(浮动车和其他车辆)到达率进行预测。结... 详细信息

为了提高城市干线的通行效率,缩短车辆在干线行驶时的平均延误,基于浮动车轨迹数据提出一种城市干线交通信号协调控制优化方法。该方法根据浮动车采集的时空轨迹数据,使用最大期望算法对混合车流(浮动车和其他车辆)到达率进行预测。结合信号状态,通过计算干线道路上、下行双向饱和度,以总延误最短为优化目标建立了干线协调配时优化算法,并采用遗传算法进行求解。以合肥市黄山路路段为例,比较无协调控制、传统定时协调控制和基于轨迹数据的信号协调控制。结果表明,所提供的方案可有效缩短干线交叉口车辆总延误,减少燃油消耗。

关键词：干线信号控制车辆轨迹数据车路协同协调控制最大期望算法

Recent Advances in Domino Synthesis of Fused Polycyclic N-Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis

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Chinese Journal of Chemistry 2023年第24期41卷 3751-3771页

作者： Zefeng Jin guodong shen Xin Lv Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhuaZhejiang321004 China School of Chemistry and Chemical Engineering Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell TechnologyLiaocheng UniversityLiaochengShandong252059 China

Fused polycyclic N-heterocycles are very important scaffolds in biomedicinal chemistry and materials *** alkyne hydroamination is a powerful method for the construction of *** the last two decades,copper-catalyzed domino reactions based on intramolecular alkyne hydroamination has emerged as a robust strategy for assembling various fused polycyclic *** progress has been achieved in this *** short review covers the advances made in copper-catalyzed domino synthesis of fused polycyclic N-heterocycles based on the strategy from 2008 to 2023,and will hopefully serve as an inspiration towards the exploration of new copper-catalyzed versions of the *** domino transformations are introduced and discussed from five aspects according to the different key processes involved in these reactions.

关键词： Domino reactions Polycyclic N-heterocycles Fused-ring systems Intramolecular hydroamination Alkynes Copper Cyclization Synthetic methods

1,1′-Binaphthyl-2,2′-diamine Dihydrochloride：an Efficient Ligand for the N-Arylation of Imidazole with Aryl/heteroaryl Halides Catalyzed by CuI

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Chemical Research in Chinese Universities 2016年第6期32卷 947-951页

作者： shen guodong ZHAO Lingyu BAO Weiliang School of Chemistry and Chemical Engineering Liaocheng University Liaocheng 252000 P. R. China Department of Chemistry Xi Xi Campus Zhejiang University Hangzhou 310028 P. R. China

Employing 1,1′-binaphthyl-2,2′-diamine（BINAM） dihydrochloride as an efficient and commerciallyavailable ligand, relatively mild and highly efficient copper-catalyzed coupling reactions of imidazole with aryl andhe... 详细信息

关键词： Copper-catalyzed N-arylation N-Arylimidazole Ullmarm-type coupling

距舟楔关节融合术中植骨与不植骨治疗Müller-Weiss病的比较研究

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中国修复重建外科杂志 2024年第3期38卷 309-314页

作者：邹保利白文博沈国栋张凯亭徐镜程朱永展广州中医药大学第八临床医学院广州510006 佛山市中医院足踝外科广东佛山528051

目的比较距舟楔关节融合术中髂骨植骨与不植骨治疗Müller-Weiss病(Müller-Weiss diseases,MWD)的临床疗效。方法回顾性分析2017年1月—2022年11月接受距舟楔关节融合术治疗且符合选择标准的44例(44足)MWD患者临床资料。其中25例术中... 详细信息

目的比较距舟楔关节融合术中髂骨植骨与不植骨治疗Müller-Weiss病(Müller-Weiss diseases,MWD)的临床疗效。方法回顾性分析2017年1月—2022年11月接受距舟楔关节融合术治疗且符合选择标准的44例(44足)MWD患者临床资料。其中25例术中行自体髂骨结构性植骨(植骨组),19例不植骨(未植骨组)。两组患者年龄、性别构成、身体质量指数、病程、侧别、Maceira分期以及术前美国矫形足踝协会(AOFAS)评分、疼痛视觉模拟评分(VAS)、正/侧位Meary角、Pitch角等基线资料比较,差异均无统计学意义(P>0.05)。记录两组手术时间、手术费用及术后相关并发症发生情况;采用AOFAS评分、VAS评分评价患足功能及疼痛程度;基于X线片测量正/侧位Meary角以及Pitch角,术后观察关节骨性融合情况。计算上述指标手术前后差值(变化值)进行组间比较,评价疗效差异。结果两组手术均顺利完成,术后切口均Ⅰ期愈合。植骨组手术时间及手术费用均多于未植骨组,差异有统计学意义(P0.05)。末次随访时两组AOFAS评分较术前提高、VAS评分下降,正/侧位Meary角以及Pitch角均改善,差异有统计学意义(P0.05)。两组均无骨延迟愈合、骨不连发生,末次随访时均达到关节骨性融合。结论距舟楔关节融合术治疗MWD时,联合自体髂骨植骨或不植骨处理的临床疗效和影像学改善程度无明显差异。但不植骨处理可缩短手术时间及手术费用,并且可以避免因自体取骨引发的取骨供区并发症。

关键词： Müller-Weiss病距舟楔关节融合术髂骨植骨

Cell-Mediated Immunity Imbalance in Patients with Intrahepatic Cholestasis of Pregnancy

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Cellular & Molecular Immunology 2007年第1期4卷 71-75页

作者： Bin Ling Fengqiu Yao Ying Zhou Zhengzheng Chen guodong shen Yuanyuan Zhu Department of Obstetrics and Gynecology Anhui Provincial HospitalHefei China Anhui Provinical Key Laboratory of Molecular Medicine Hefei China

Decidual lymphocytes may mediate fetal trophoblast recognition and regulate maternal immune reaction and play an essential role in the maintenance of normal pregnancy. The aim of this study was to compare the percentage of T cells, natural killer （NK） cells and natural killer T （NKT） cells within decidual parietalis of normal pregnant controls （NP） and patients with intraheptic cholestasis of pregnancy （ICP）, and to investigate the production of interleukin-4 （IL-4）, interferon-γ （IFN-γ） in the culture supernatant of decidual parietalis mononuclear cells （DPMCs）. Compared with controls, the decidua parietalis from ICP were characterized with significant increased percentages of CD3^＋CD56^＋ cells, CD3^＋CD56^＋ cells, CD56^＋CD16＋ cells, CD56^＋CD16^＋ cells, CD56^＋NKG2D＋ ceils, and the significant decreased percentages of CD3^＋ cells, CD3^＋CD4^＋ cells. There were no differences found for the percentage of CD3^＋CD8^＋ cells, CD56^＋NKG2A^＋ cells between control and study group. In addition, the enhanced concentration of IFN-γ was presented in culture supernatant of DPMCs from ICP. It was suggested that the increased NK cells, NKT cells and the decreased T cells in the decidual parietalis and over-secretion of IFN-γ could be correlated with the pathophysiology of ICP patients. Cellular ＆ Molecular Immunology. 2007;4（1）：71-75.

关键词： NK cell IFN-γ ICP

Ball-milling Synthesis of Tetrahydroquinolines via 'One-pot' Three-component Diels-Alder Reaction Catalyzed by Phosphotungstic Acid

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Chemical Research in Chinese Universities 2020年第5期36卷 835-842页

作者： WANG Zeyou shen guodong HUANG Xianqiang GONG Shuwen YANG Bingchuan SUN Zhenzhen ZHANG Zuhao LIU Wanxing School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252000P.R.China Department of Chemistry Liaocheng Chemical Institute of Industrial ScienceLiaocheng 252000P.R.China

We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by phos-photungstic acid at room *** this reaction,a simple 'one-pot'ball-milling operation was conducted,readily available starting materials were employed,'one-pot'conditions were applied,and the most important was to use inexpensive and environmentally friendly catalyst phosphotungstic *** tetrahvdroquinolines,which might be potentially applicable in the pharmaceutical and biochemical areas,were conveniently synthesized in moderate to excellent yields.

关键词： Ball-milling Diels-Alder reaction Phosphotungstic acid Tetraliydroquinoline

富含血小板血浆联合自体骨移植治疗骨缺损的临床研究

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武警医学 2024年第6期35卷 506-510页

作者：董海蛟沈国栋郝岩杜爱翠杜彬火箭军特色医学中心输血科北京100088 东部战区总医院秦淮院区输血科南京210002 火箭军特色医学中心骨科北京100088

目的探讨富含血小板血浆(PRP)联合自体骨移植治疗骨缺损的疗效及其影响因素。方法选择2023-01至2023-12在火箭军特色医学中心骨科门诊及住院的骨缺损患者60例作为研究对象,依据随机数字表法分为试验组(30例)和对照组(30例)。试验组采用... 详细信息

目的探讨富含血小板血浆(PRP)联合自体骨移植治疗骨缺损的疗效及其影响因素。方法选择2023-01至2023-12在火箭军特色医学中心骨科门诊及住院的骨缺损患者60例作为研究对象,依据随机数字表法分为试验组(30例)和对照组(30例)。试验组采用PRP联合自体骨移植治疗,对照组采用单纯自体骨移植治疗,比较两组患者的骨愈合时间、骨愈合率、骨密度、骨强度、骨形态评分、美国下肢功能评分(LEFS评分)和疼痛视觉模拟评分(VAS评分),采用多元线性回归和多元logistic回归分析影响骨愈合的因素。结果试验组的骨愈合时间、骨愈合率、骨密度、骨强度和骨形态评分均明显优于对照组,差异均有统计学意义(P<0.05),且无严重的术后并发症发生。多元回归分析显示,PRP治疗是骨愈合时间和骨愈合率的独立影响因素(P<0.05)。结论PRP联合自体骨移植是一种安全、有效、可行的治疗骨缺损的方法,能够促进骨缺损的愈合和修复,提高骨愈合质量和患者的生活质量。

关键词：富含血小板的血浆自体骨移植骨缺损骨修复

Self-assembly of three Ag-polyoxovanadates frameworks for their efficient construction of C–N bond and detoxification of simulant sulfur mustard

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Chinese Chemical Letters 2022年第5期33卷 2605-2610页

作者： Xianqiang Huang Yanan Cui Jinhong Zhou Yalin Zhang guodong shen Qingxia Yao Jikun Li Zechun Xue Guoping Yang Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry&Chemical EngineeringLiaocheng UniversityLiaocheng 252059China College of Chemistry and Chemical Engineering Taishan UniversityTaian 271021China Jiangxi Province Key Laboratory of Synthetic Chemistry Jiangxi Key Laboratory for Mass Spectrometry and InstrumentationEast China University of TechnologyNanchang 330013China

Three imidazole-modified Ag-polyoxovanadates frameworks(APFs)with a controllable molar ratio of Ag+to polyoxovanadates(POVs)[Ag(IM)_(2)]_(2)V_(4)O_(12)·2Ag(IM)_(2)(APF-1),[Ag_(2)(1-eIM)_(4)]_(2)[Ag(1-eIM)_(2)]_(3)·2Ag(1-eIM)_(2)·3(1-HeIM)[V_(10)O_(28)]_(2)(APF-2)and[Ag(1-pIM)_(2)]_(3)[HV_(10)O_(28)]·2Ag(1-pIM)_(2)·2H_(2)O(APF-3)(IM=imida-zole;1-eIM=1-ethylimidazole and 1-pIM=1-propylimidazole)have been successfully achieved by self-assembly of POVs,Ag+cations,and three different imidazole ***,the molar ratios of Ag+to POVs vary from 4:1,4.5:1 to 5:1 by changing the vanadium resources and imidazole ***,the coordination environment of Ag+cations and the structure of POVs in the APFs are also ***,for APF-1,the four Ag atoms adopt three-coordinated and four-coordinated geometries,respectively,and Ag-imidazole complexes and[V_(4)O 1_(2)]_(4)−cluster form the one-dimensional polymeric *** Ag atoms in APF-2 and APF-3 exhibit two-,four-and five-coordinated geome-tries for APF-2,four-,five-and six-coordinated geometries for APF-3,*** Ag+cations and decavanadate clusters are assembled into the 2D supramolecular structure through the Ag-O bonds and Ag…Ag argentophilic ***,thus-obtained APF-2 can serve as powerful efficient hetero-geneous catalyst for construction of C–N bond and detoxification of simulant sulfur mustard(yields up to 99%),which enable successful recycling for three cycles with remained catalytic activities and structure stability.

关键词： Ag-polyoxovanadates Crystal engineering Controllable synthesis Bifunctional catalysts Heterogeneous reaction

A WNT7B-m^(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis

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Signal Transduction and Targeted Therapy 2021年第3期6卷 571-573页

作者： Qian Gao Liuyang Yang Aolin shen Yang Li Yongxiang Li Shilian Hu Runhuai Yang Xiangting Wang Xuebiao Yao guodong shen Department of Geriatrics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Genetics School of Life ScienceAnhui Medical UniversityHefeiAnhui 230032China Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy HefeiAnhui 230001China Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Biomedical Engineering Anhui Medical UniversityHefeiAnhui 230032China M0E Key Laboratory for Membrane-less Organelles and Cellular Dynamics University of Science and Technology of ChinaHefeiAnhui 230027China

Dear Editor,Signal transduction takes the responsibility of translating extracellular information into specific cellular activities,enabling cells,including cancer cells,to respond exquisitely to extracellular guidance cues.N6-methyladenosine(m^(6)A),the most pervasive and abundant modification within eukaryotic mRNAs,is known to have specific effects on cellular activities relevant to cancer.1 Despite the fact that m^(6)A methylation is a dynamic event involving a series of enzymes,it remains unknown whether signal transduction,much less extracellular signaling molecules,uses m^(6)A methylation as an effector mechanism in cancer.

关键词： metastasis cancer 6