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Automatic test system development for digital beam position monitor of HEPS and BEPCII

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Radiation Detection Technology and Methods 2022年第3期6卷 330-338页

作者： Xuhui Tang Yaoyao Du Jianshe Cao Shujun Wei Zhi Liu Qiang Ye Huizhou Ma Jing Yang guodong gao Yukun Li Yanfeng Sui Junhui Yue University of Chinese Academy of Science Beijing 100049China Institute of High Energy Physics Chinese Academy of ScienceBeijing 100049China

Purpose Hundreds of digital beam position monitor processors(DBPM)are required to be produced during the construction of projects such as High Energy Photon Source(HEPS)and the upgrade project of the Beijing Electron Positron Collider(BEPCII),which brings great challenges to the test *** order to achieve accurate,fast,and complete mass production tests of DBPMs,an automatic test system(ATS)has been developed in this *** According to the test items of DBPM,the standardized testing softwareﬂow is designed based on virtual instru-ment program control technology and experimental physics and industrial control system(EPICS),which realize automatic adjustment of test parameters and automatic acquisition of test result *** and conclusions The ATS can realize one-button testing of channel coefﬁcients,channel linearity,attenuator linearity,beam current dependence(BCD)and sampling signal-to-noise ratio(SNR),and generate test *** total test time is less than 3 minutes,which is signiﬁcantly more efﬁcient compared to manual *** than 90 BEPCII DBPMs has been tested by this ATS in the *** test results proved that such a system could automatically recognize defective products and satisfy the requirements of mass testing.

关键词： Automatic test system Digital beam position monitor processor Program control Experimental physics and industrial control system Analog-to-digital converter

Transfusion of Ipscs-Derived Leukocytes to Kill Cancer

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Journal of Cancer Therapy 2010年第1期1卷 29-30页

作者： Jiang Li Ying Cui guodong gao Ti-Fei Yuan Department of Clinical Laboratory and Research center of Tang Du Hospital The Forth Military Medical University Xi’an China Department of Neurosurgery Tang Du Hospital The Fourth Military University Xi’an China

Here we propose that the rejuvenation of leukocytes with iPSC technology in vitro and transfusion of cancer cellresistant white blood cells back to human body provide a prospective therapy for cancer patients.

关键词： Ipscs Leukocytes Cancer

Strain data recorded in Xinjiang and their bearing on Tianshan’s uplift/shortening and Tarim basin’s rotation

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Geodesy and Geodynamics 2011年第1期2卷 21-28页

作者： Jiang Jingxiang Wu guodong Yin Guanghua gao Ge Wang Zaihua Li Jie Earthquake Administration of Xinjiang Uygur Autonomous Region Urumqi 830011 China

Based on the continuous strain data recorded in Xinjiang since 1985, we discuss the mechanisms of Tianshan＇ s uplift and Tarim basin＇ s clockwise rotation. The results indicate ： 1 ） The principal - compression directions in Tianshan are nearly NS, and their intersection angles with regional structures and mountains are nearly perpendicular, which is in accordance with Tianshan＇ s uplift and crustal shortening. 2）The principal compressions around Tarim basin tend to facilitate the regional faults＇ left-lateral strike-slip movements and the basin＇ s clockwise rotation. These phenomena of uplift/shortening and rotation are fundamentally the re- suits of India plate＇ s northward push on Euro-Asia plate, and the associated Pamir arc ＇ s rapid northward movement and regional blocks＇ interaction.

关键词： continuous borehole strain measurement principal-compression direction Tianshan uplift NScrustal shortening Tarim basin's clockwise rotation

Retrospective single center experience with the transversus abdominis muscle release procedure in complex abdominal wall reconstruction

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Retrospective single center experience with the transversus ...

Oxidation of survival factor MEF2D in neuronal death and Parkinson’s disease

2018年浙江省外科学学术年会

作者： Wang Ping Huang Yonggang Ye Jing gao guodong Zhang Fangjie Wu Hao 杭州市第一人民医院

Objective To investigate the clinical utility of the transversus abdominis muscle release(TAR) procedure in complex abdominal wall *** Retrospectively studied thirty-two cases of complex abdominal wall defect patients admitted to Hangzhou First People’s Hospital from January 2016 to December *** materials were collected and *** Among 32 cases of large incisional hernia patients,there were 19 males(59.4%) and 13 females(40.6%).Mean age were 64.41±12.11 years,BMI were 30.00±5.97 kg/*** width of abdominal defect were 11.34±1.82 ***-four cases were midline incisional hernias with one case of planed incisional hernia after severe pancreatitis,and three cases were *** cases were recurrent incisional *** the patients underwent retro-muscular mesh repair,and abdominal wall reconstruction using TAR *** operation time was 151.59±28.64 min,and estimated blood loss was 118.12±83.41 *** of hospital stay were 13.66±2.72 *** had two cases of superficial surgical site infection,five cases of type Ⅲ seroma,and one intestinal *** these postoperative complications were cured through non-surgical *** mesh infection,fistula,recurrence,and postoperative bulging were reported during the *** Posterior component separation via TAR is a reliable and effective technique for complex abdominal wall *** time follow-up is needed to expect potential recurrence.

关键词： Incisional hernia Transversus abdominis muscle release Posterior component separation Abdominal wall reconstruction TAR

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Oxidation of survival factor MEF2D in neuronal death and Par...

中国神经科学学会第十届全国学术会议

作者： Li gao Hua She Wenming Li Jinqiu Zhu Dean P Jones Zixu Mao guodong gao Qian Yang Department of Neurosurgery Tangdu HospitalThe Fourth Military Medical University Department of Pharmacology Emory University School of Medicine Department of Neurology Emory University School of Medicine Department of Medicine Emory University School of Medicine

Dysfunction of transcription factor myocyte enhancer factor 2D（MEF2D）,a key survival factor,underlies the pathogenic loss of dopaminergic neurons in Parkinson’s disease（PD）.Both genetic factors and neurotoxins associated with PD impair MEF2D function in vitro and in animal models of *** investigated whether distinct stress conditions may target MEF2D via converging *** show that exposure of DA neuronal progenitor cells to 6-hyroxydopamine（6-OHDA）,a neurotoxin associated with PD,caused direct oxidative modifications of MEF2D,including carbonyl formation and oxidization of cysteine *** MEF2D bound to a key regulator for chaperone-mediated autophagy（CMA）,heat-shock cognate protein 70 kDa（Hsc70）,at higher *** addition,oxidative stress also increased the level of lysosomal associated membrane protein 2A（LAMP2A）,a rate limiting receptor for CMA process,and stimulated CMA activity,resulting in accelerated degradation of ***,6-OHDA caused oxidation of MEF2D and increased LAMP2A in the SNc region of mouse *** importantly,the levels of oxidized MEF2D were much higher in the postmortem PD brains compared to ***,reducing the levels of either MEF2D or LAMP2A exacerbated 6-OHDA-induced death of DA neuronal progenitor cells while increasing the levels of a MEF2D mutant resistant to oxidative modification protected cells from oxidation-induced *** study establishes survival protein MEF2D as a direct target in oxidative stress-induced DA neuronal *** modification of survival factor MEF2D inhibits its function,is part of PD pathogenic process,and underlies neurotoxicity associated with the disease.

关键词： chaperone-mediated autophagy oxidative stress MEF2D Parkinson’s disease neuronal death

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一种简化的拟蒙特卡洛-高斯粒子滤波算法

电讯技术 2017年第4期57卷 457-462页

作者：高国栋林明江苏科技大学电子信息学院江苏镇江212003

提出了一种简化的拟蒙特卡洛-高斯粒子滤波(QMC-GPF)算法(SQMC-GPF),以解决将QMC方法应用于GPF时计算复杂度高、运算量大的问题。该算法中,在连续的迭代滤波过程开始之前,首先利用QMC采样产生单位拟高斯分布粒子集,然后用其线性变换产生... 详细信息

提出了一种简化的拟蒙特卡洛-高斯粒子滤波(QMC-GPF)算法(SQMC-GPF),以解决将QMC方法应用于GPF时计算复杂度高、运算量大的问题。该算法中,在连续的迭代滤波过程开始之前,首先利用QMC采样产生单位拟高斯分布粒子集,然后用其线性变换产生GPF算法中需要的高斯分布粒子集,省去了重新进行QMC采样步骤。该算法简化了新粒子集的产生过程,减少了运算量和滤波时间,增强了算法的实时性。将粒子滤波算法(PF)、GPF算法、QMC-GPF算法和SQMCGPF算法用于单变量非静态增长模型(UNGM)和二维纯角度跟踪模型(BOT)的仿真结果表明,SQMC-GPF算法的滤波性能与QMC-GPF算法的滤波性能相近,但有更为明显的速度优势,具有重要的实际应用价值。

关键词：高斯粒子滤波拟蒙特卡洛采样线性变换高斯分布

“肾虚湿瘀”理论下的慢性肾脏病中医证候学研究

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世界科学技术-中医药现代化 2021年第10期23卷 3474-3482页

作者：高国栋孙伟南京中医药大学附属医院南京210029

目的探究"肾虚湿瘀"理论下慢性肾脏病不同分期的中医证型分布有何特点,并运用数据挖掘技术探索常见证型的辨证要点。方法通过对中国肾脏病应用创新联盟大数据平台中2012年9月1日至2019年9月30日于江苏省中医院孙伟主任医师处就诊的2899... 详细信息

目的探究"肾虚湿瘀"理论下慢性肾脏病不同分期的中医证型分布有何特点,并运用数据挖掘技术探索常见证型的辨证要点。方法通过对中国肾脏病应用创新联盟大数据平台中2012年9月1日至2019年9月30日于江苏省中医院孙伟主任医师处就诊的2899例患者中四诊信息齐全的慢性肾脏病人共计1445例进行证型分布、证型兼夹特点、四诊信息统计,并将相似症状进行规范合并,通过数据挖掘技术与名医经验结合探究常见证型辨证要点。结论脾肾气虚证是慢性肾脏病本虚证的核心;血瘀证、湿浊证、湿热证是慢性肾脏病的主要标实证,湿毒证只有在慢性肾脏病(Chronic Kidney Disease,CKD)5期有较多分布,其他各分期均少见。并得出这5个常见证型的辨证要点。

关键词：慢性肾脏病肾虚湿瘀中医证候学数据挖掘

Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy

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Science China(Life Sciences) 2024年第5期67卷 996-1009页

作者： Xiaowen Zhou Yang Li Xiangrui Zhang Beibei Li Shengzhe Jin Menghan Wu Xiuman Zhou Qingyu Dong Jiangfeng Du Wenjie Zhai Yahong Wu Lu Qiu guodong Li Yuanming Qi Wenshan Zhao Yanfeng gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

The immune checkpoint TIGIT/PVR blockade exhibits significant antitumor effects through activation of NK and CD8^(+)T cell-mediated *** checkpoint blockade(ICB)could induce tumor ferroptosis through IFN-γreleased by immune cells,indicating the synergetic effects of ICB with ferroptosis in inhibiting tumor ***,the development of TIGIT/PVR inhibitors with ferroptosis-inducing effects has not been explored *** this study,the small molecule Hemin that could bind withTIGIT to block TIGIT/PVR interaction was screened by virtual molecular docking and cell-based blocking *** could effectively restore the IL-2 secretion from Jurkat-hTIGIT *** reinvigorated the function of CD8^(+)T cells to secrete IFN-γand the elevated IFN-γcould synergize with Hemin to induce ferroptosis in tumor *** inhibited tumor growth by boosting CD8^(+)T cell immune response and inducing ferroptosis in CT26 tumor *** importantly,Hemin in combination with PD-1/PD-L1 blockade exhibited more effective antitumor efficacy in anti-PD-1 resistant B16 tumor *** summary,our finding indicated that Hemin blocked TIGIT/PVR interaction and induced tumor cell ferroptosis,which provided a new therapeutic strategy to combine immunotherapy and ferroptosis for cancer treatment.

关键词： cancer immunotherapy TIGIT/PVR small molecule Hemin ferroptosis

大鼠实验性短暂脑缺血血浆中cAMP相对浓度与血脑屏障变化之关系

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中风与神经疾病杂志 1999年第2期16卷 83-85页

作者：贾栋高国栋西安第四军医大学唐都医院神经外科

目的观察短暂脑缺血再灌流过程中血脑屏障超微结构及血浆中环腺苷酸（ｃＡＭＰ）相对浓度的变化。方法用改良ｐｕｌｓｉｎｅｌｉ法造成短暂脑缺血再灌流模型。用Ｈ３－ｃＡＭＰ放免分析药盒测定血浆中ｃＡＭＰ相对浓度，并观察血脑屏障... 详细信息

目的观察短暂脑缺血再灌流过程中血脑屏障超微结构及血浆中环腺苷酸（ｃＡＭＰ）相对浓度的变化。方法用改良ｐｕｌｓｉｎｅｌｉ法造成短暂脑缺血再灌流模型。用Ｈ３－ｃＡＭＰ放免分析药盒测定血浆中ｃＡＭＰ相对浓度，并观察血脑屏障中紧密连接的变化。结果在短暂缺血及再灌流早期，血浆中ｃＡＭＰ相对浓度及紧密连接紧密程度（闭锁小带长度、凸嵴数目）无明显变化，血管内皮中胞饮小泡数目明显增多。再灌注中期内皮细胞间紧密连接松弛，闭锁小带长度及凸嵴数目均减少。血浆中ｃＡＭＰ浓度亦降低。结论短暂脑缺血及再灌流早期血脑屏障通透性的改变，主要是由于内皮细胞中胞饮小泡数增多所致。血浆中ｃＡＭＰ相对浓度可以反映血脑屏障的开放程度。

关键词：脑缺血环腺苷酸血脑屏障再灌注损伤大鼠