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International Journal of Ophthalmology(English edition) 2014年第2期7卷 205-210页

作者： Bing Sun Zhi-Wei Li Hai-Qun Yu Xiang-Chen Tao Yong Zhang guo-ying mu Department of Ophthalmology Provincial Hospital Affiliated to Shandong University Department of Ophthalmology Provincial Hospital Affiliated to Anhui Medical University Department of Ophthalmology Affiliated Hospital of Weifang Medical University

AIMTo evaluate the antimicrobial properties of ultraviolet A (UVA) (365 nm)/riboflavin against Candida albicans and Fusarium solani.

关键词： antimicrobial crosslinking fungal riboflavin ultraviolet A

Evaluation of corneal endothelium after UVA/riboflavin cross-linking in thin keratoconic corneas

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 321-322页

作者： Wei Chen Zhi-Wei Li Xiao-Min Zhao Wen -Wen Xu guo-ying mu Clinical College of Ophthalmology Tianjin Medical University Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University School of Nursing Binzhou Medical College

Dear Sir,UVA/riboflavin cross-linking （CXL） has been used clinically applied for the treatment of keratoconus and corneal edema via enhancement of corneal stiffness The safety of the corneal endothelium is of prime importance during CXL treatment. In clinical practice, a corneal thickness （CT） of 400um has traditionally been regarded as the minimum treatable thickness, thereby avoiding damage to the corneal endothelium Although CXL has been applied to thinner corneas, using a hypoosmotic solution onto cornea and inducing edema . CXL safety still needs further evaluation because of lower relative concentration of collagen in the hydrated stroma . This study aims to evaluate the changes of corneal endothelial density （ECD） in cases where the CT is 〈400 um before iatrogenic corneal swelling and CXL treatment.

关键词： UVA Evaluation of corneal endothelium after UVA/riboflavin cross-linking in thin keratoconic corneas

Therapeutic and inducing effect of corneal crosslinking on infectious keratitis

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1820-1823页

作者： Liang-Zhu Jiang Shi-Yan Qiu Zhi-Wei Li Xiao Zhang Xiang-Chen Tao guo-ying mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University Department of Ophthalmology the People's Hospital of Linyi Department of Pediatrics the People's Hospital of Linyi

The corneal crosslinking （CXL） with riboflavin and ultraviolet-A （UVA） is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis.

关键词： corneal crosslinking keratitis theraputic and inducing effect

Comparative study of visual acuity and aberrations after intralase femtosecond LASIK:small corneal flap versus big corneal flap

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 641-645页

作者： Ya-Li Zhang Lei Liu Chang-Xia Cui Ming Hu Zhao-Na Li Li-Jun Cao Xiu-Hua Jing guo-ying mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University Department of Ophthalmology the Second People's Hospital of Jinan Department of Health Examination Jinan Central Hospital Affiliated to Shandong University

AIM:To study the effects of different flap sizes on visual acuity,refractive outcomes,and aberrations after femtosecond laser for laser in situ keratomileusis(LASIK).METHODS:In each of the forty patients enrolled,1 eye was randomly assigned to receive treatment with a 8.1mm diameter corneal flap,defined as the small flap,while the other eye was treated with a 8.6mm diameter corneal flap,defined as the big *** errors,visual acuity,and higher-order aberrations were compared between the two groups at week 1,month 1 and 3 postoperatively. RESULTS:The postoperative refractive errors and visual acuity all conformed to the intended *** higher-order aberrations were increased,especially in spherical aberration(Z12) and vertical coma(Z7).There were no statistically significant differences between the two groups in terms of postoperative refractive errors,visual acuity,root mean square of total HOAs(HO-RMS),trefoil 30°(Z6),vertical coma(Z7),horizontal coma(Z8),trefoil 0°(Z9),and spherical aberration(Z12) at any point during the postoperative ***:Both the small and big flaps are safe and effective procedures to correct myopia,provided the exposure stroma meets the excimer laser *** personalized size corneal flap is feasible,as we can design the size of corneal flap based on the principle that the corneal flap diameter should be equal to or greater than the sum of the maximum ablation diameter and apparatus error.

关键词： femtosecond laser laser in situ keratomileusis refractive surgery flap visual acuity aberration

Inhibitory effect of polysulfated heparin endostatin on alkali burn induced corneal neovascularization in rabbits

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 234-238页

作者： Zhao-Na Li Zhong-Fang Yuan guo-ying mu Ming Hu Li-Jun Cao Ya-Li Zhang Lei Liu Ming-Xu Ge Department of Ophthalmology the Second People's Hospital of Jinan Department of Ophthalmology Jinan Central Hospital Affiliated to Shandong University Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University Department of Neurosurgery Shandong Provincial Hospital Affiliated to Shandong University

AIM: To investigate anti-angiogenic effects of polysulfated heparin endostatin(PSH-ES) on alkali burn induced corneal neovascularization(NV) in ***: An alkali burn was made on rabbit corneas to induce corneal NV in the right eye of 24 rabbits. One day after burn creation, a 0.2 m L subconjunctival injection of 50 μg/m L PSH-ES, 50 μg/m L recombinant endostatin(ES), or normal saline was administered every other day for a total of 14d(7 injections). Histology and immunohistochemisty were used to examine *** NV growth was evaluated as microvessel quantity and corneal vascular endothelial growth factor(VEGF)expression was measured by immunohistochemical ***: Subconjunctival injection of ES and PSHES resulted in significant corneal NV suppression, but PSH-ES had a more powerful anti-angiogenic effect than ES. Mean VEGF concentration in PSH-ES treated corneas was significantly lower than in ES treated and saline treated corneas. Histological examination showed that corneas treated with either PSH-ES or ES had significantly fewer microvessels than eyes treated with saline. Additionally corneas treated with PSH-ES had significantly fewer microvessels than corneas treated with ***: Both PSH-ES and recombinant ES effectively inhibit corneal NV induced by alkali ***, PSH-ES is a more powerful anti-angiogenic agent than ES. This research has the potential to provide a new treatment option for preventing and treating corneal NV.

关键词： polysulfated heparin endostatin corneal neovascularization chemical burns rabbits

A short-term study of corneal collagen cross-linking with hypo-osmolar riboflavin solution in keratoconic corneas

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 94-97页

作者： Shao-Feng Gu Zhao-Shan Fan Li-Hua Wang Xiang-Chen Tao Yong Zhang Chun-Qin Wang Ya Wang guo-ying mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University

AIM: To report the 3mo outcomes of collagen crosslinking(CXL) with a hypo-osmolar riboflavin in thin corneas with the thinnest thickness less than 400 μm without ***: Eight eyes in 6 patients with age 26.2±4.8y were included in the study. All patients underwent CXL using a hypo-osmolar riboflavin solution after its de-epithelization. Best corrected visual acuity, manifest refraction, the thinnest corneal thickness, and endothelial cell density were evaluated before and 3mo after the ***: The mean thinnest thickness of the cornea was 408.5 ±29.0 μm before treatment and reduced to369.8 ±24.8 μm after the removal of epithelium. With the application of the hypo-osmolar riboflavin solution, the thickness increased to 445.0 ±26.5 μm before CXL and recover to 412.5 ±22.7 μm at 3mo after treatment, P =0.659). Before surgery, the mean K-value of the apex of the keratoconus corneas was 57.6 ±4.0 diopters, and slightly decreased(54.7±4.9 diopters) after surgery(P =0.085). Mean best-corrected visual acuity was 0.55 ±0.23 logarithm of the minimal angle of resolution, and increased to 0.53±0.26 logarithm after surgery(P =0.879).The endothelial cell density was 2706.4 ±201.6 cells/mm2 before treatment, and slightly decreased( 2641. 2 ±218.2 cells/mm2) at last fellow up(P =0.002).CONCLUSION: Corneal collagen cross-linking with a hypo-osmolar riboflavin in thin corneas seems to be a promising treatment. Further study should be done to evaluate the safety and efficiency of CXL in thin corneas for the long-term.

关键词： corneal collagen cross-linking keratoconus hypo-osmolar riboflavin thin corneas

Semaphorin 7a participants in pterygium by regulating vascular endothelial growth factor

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International Journal of Ophthalmology(English edition) 2019年第6期12卷 892-897页

作者： Yun-Fei Han Zhen Liu Bang Wang Wei Zhu Jing-Zhen Li Yue-Qin Qi Xiao-Jing Li Yan-Yun Xu Xiao-Xiao Dou guo-ying mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Aier Eye Hospital Group Hubin Aier Eye HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology the Second People’s Hospital of LiaochengLinqing 252600Shandong ProvinceChina Neonatal Intensive Care Unit Binzhou Medical University HospitalBinzhou 256600Shandong ProvinceChina Department of Ophthalmology Jinan Central Hospital Affiliated to Shandong UniversityJinan 250013Shandong ProvinceChina Department of Cardiovascular Medicine the Second Affiliated Hospital of Zhejiang University College of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM: To investigate the relationship between semaphorin 7a expression and cell proliferation and migration in pterygium fibroblasts. METHODS: Twenty-six patients with surgically diagnosed pterygium were enrolled, including 15 cases of primary pterygium and 11 cases of recurrent pterygium. In addition, 12 cases of normal conjunctival tissue were collected. The expression of semaphorin 7a in normal conjunctival tissue, primary pterygium and recurrent pterygium was detected by real-time polymerase chain reaction. Recurrent pterygium fibroblasts were isolated and cultured, and the expression of semaphorin 7a was silenced by small interfering RNA(siRNA) interference technique. Furthermore, the effects of si-semaphorin 7a interference on the mRNA and protein levels of β1-integrin, vascular endothelial growth factor A(VEGFA) and vascular endothelial growth factor receptor(VEGFR), and on fibroblast proliferation were analyzed. Transwell assay was used to detect the effect of semaphorin 7a interference on fibroblast migration. RESULTS: Semaphorin 7a was highly expressed in the primary pterygium and recurrent pterygium samples than that of the normal conjunctival tissue. Compared with the primary pterygium, the expression of semaphoring 7a in the recurrent pterygium samples was significantly increased(P<0.05). The mRNA and protein expression levels of β1-integrin, VEGFA and VEGFR were decreased after si-semaphorin 7a transfection, and as well as the cell proliferation and migration. CONCLUSION: Semaphorin 7a might play important roles in the pathogenesis of pterygium by affecting the expression of β1-integrin, VEGFA and VEGFR.

关键词： semaphorin 7a pterygium β1-integrin vascular endothelial growth factor fibroblast

ACIDITY OF ZnSM-2 CATALYST AND ITS EFFECTS ON PROPANE AROMATIZATION

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Journal of Energy Chemistry 1993年第1期 42-50页

作者： ZHAO Su-Qin WANG Rong-Hui LIANG Juan guo Wen-Gui ying mu-Liang XU Bo-Qing Dalian Institute of Chemical Physics Academia Sinica Dalian,Liaoning 116023

The effects of the modification by zinc exchange on the acidity ofSM-2(ZSM-5 type)zeolite catalyst were studied by TPAD and IR spectra ofadsorbed *** loading of zinc increased Lewis acidity of the catalystand generated more sites with medium acid *** the conversion ofpropane and the yield of aromatics were dependent on the zinc content in *** of the behavior of a fresh and a partly pyridine poisoned0.7ZnSM-2 catalyst for propane conversion showed that the role of zinc speciesmay be:(a)adjusting catalyst acidity to promote propane activation and(b)act-ing as dehydrogenation catalyst for aromatization of *** was shown thatZnSM-2 catalyst has good stability in propane aromatization reaction.

关键词： Pro ACIDITY OF ZnSM-2 CATALYST AND ITS EFFECTS ON PROPANE AROMATIZATION over SM ITS

Comparative study of visual acuity and aberrations after intralase femtosecond LASIK: small corneal flap versus big corneal flap

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International Journal of Ophthalmology(English edition) 2014年第5期7卷 1-1页

作者： Ya-Li Zhang Lei Liu Chang-Xia Cui Ming Hu Zhao-Na Li Li-Jun Cao Xiu-Hua Jing guo-ying mu Department of Ophthalmology Shandong Provincial Hospital Affiliated to Shandong University Department of Ophthalmology the Second People’s Hospital of Jinan Department of Health Examination Jinan Central Hospital Affiliated to Shandong University

EZH2-dependent myelination following sciatic nerve injury

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Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li mu Xi Xu Tianyi Huang ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of Nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection