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Nuclear Science and Techniques 2024年第3期35卷 198-207页

作者： Yang Su Ze-Yu Li Li-Le Liu guo-xiang dong Xiao-Bao Wang Yong-Jing Chen China Nuclear Data Center China Institute of Atomic EnergyBeijing 102413China School of Science Huzhou UniversityHuzhou 313000China

Using the Skyrme density functional theory,potential energy surfaces of^(240)Pu with constraints on the axial quadrupole and octupole deformations(q_(20)and q_(30))were *** volume-like and surface-like pairing forces,as well as a combination of these two forces,were used for the Hartree–Fock–Bogoliubov *** in the least-energy fission path,fission barrier,pairing energy,total kinetic energy,scission line,and mass distribution of the fission fragments based on the different forms of the pairing forces were analyzed and *** fission dynamics were studied based on the timedependent generator coordinate method plus the Gaussian overlap *** results demonstrated a sensitivity of the mass and charge distributions of the fission fragments on the form of the pairing *** on the investigation of the neutron-induced fission of^(239)Pu,among the volume,mixed,and surface pairing forces,the mixed pairing force presented a good reproduction of the experimental data.

关键词： Nuclear fission Density functional theory Pairing force Potential energy surfaces Fission fragment distribution

基于自噬途径探讨银杏叶提取物对老年性聋大鼠的保护作用

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中成药 2024年第1期46卷 65-71页

作者：王青玲张梦娴周颍东康浩然郭向东王庆林河南中医药大学河南郑州450046 河南中医药大学第一附属医院河南郑州450000 河南医学高等专科学校河南郑州451191

目的探讨银杏叶提取物对老年性聋大鼠听功能、耳蜗组织形态学和自噬相关蛋白表达的作用。方法将45只大鼠随机分为对照组、模型组和银杏叶提取物低、中、高剂量组(10、20、30 mg/kg),每组9只,采用腹腔注射500 mg/kg D-半乳糖(D-gal)构建... 详细信息

目的探讨银杏叶提取物对老年性聋大鼠听功能、耳蜗组织形态学和自噬相关蛋白表达的作用。方法将45只大鼠随机分为对照组、模型组和银杏叶提取物低、中、高剂量组(10、20、30 mg/kg),每组9只,采用腹腔注射500 mg/kg D-半乳糖(D-gal)构建老年性聋模型。给药8周后,听性脑干诱发电位(ABR)检测大鼠听阈变化,HE染色观察耳蜗毛细胞、血管纹和螺旋神经节细胞形态变化,免疫荧光染色法检测耳蜗内外毛细胞数量变化,透射电子显微镜观察耳蜗毛细胞超微结构变化,Western blot法检测耳蜗组织中自噬相关蛋白表达。结果与对照组比较,模型组ABR阈值升高(P<0.01),耳蜗内外毛细胞、螺旋神经节细胞和血管纹损伤严重,血管纹厚度、螺旋神经节细胞数、内外毛细胞数和自噬小体数均降低(P<0.01),耳蜗组织Beclin1、LC3Ⅱ蛋白表达和LC3Ⅱ/LC3Ⅰ比值均降低(P<0.01),P62蛋白表达升高(P<0.01);与模型组比较,银杏叶提取物中、高剂量组ABR阈值均降低(P<0.01),耳蜗内外毛细胞及血管纹形态改善,螺旋神经节细胞形态趋向正常,血管纹厚度、螺旋神经节细胞数、内外毛细胞数和自噬小体数均增加(P<0.05,P<0.01),耳蜗组织Beclin1、LC3Ⅱ蛋白表达和LC3Ⅱ/LC3Ⅰ比值均升高(P<0.01),P62蛋白表达降低(P<0.01)。结论银杏叶提取物对老年性聋大鼠的听功能和耳蜗细胞具有保护作用,其机制可能与上调耳蜗组织Beclin1、LC3Ⅱ蛋白表达,下调P62蛋白表达有关。

关键词：银杏叶提取物老年性聋自噬毛细胞螺旋神经节细胞

藁本内酯通过抑制铁自噬延缓小鼠听皮层组织衰老

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中国药理学通报 2024年第3期40卷 455-461页

作者：周颖东张梦娴王青玲康浩然张治成王庆林刘亚敏郭向东河南中医药大学第一临床医学院河南郑州450046 河南中医药大学第一附属医院耳鼻喉科河南郑州450000 河南医学高等专科学校河南郑州451191 河南中医药大学药学院河南郑州450046

目的探究藁本内酯(ligustilide,LIG)延缓听皮层组织衰老,治疗中枢性老年性聋的机制。方法将40只13月龄C57BL/6J小鼠随机分为LIG低剂量组(L-LIG)、LIG中剂量组(M-LIG)、LIG高剂量组(H-LIG)和衰老组(Age),同品系2月龄小鼠10只作为对照组(C... 详细信息

目的探究藁本内酯(ligustilide,LIG)延缓听皮层组织衰老,治疗中枢性老年性聋的机制。方法将40只13月龄C57BL/6J小鼠随机分为LIG低剂量组(L-LIG)、LIG中剂量组(M-LIG)、LIG高剂量组(H-LIG)和衰老组(Age),同品系2月龄小鼠10只作为对照组(Ctrl)。听性脑干反应测试检测给药前后小鼠听阈值;检测血清SOD活力和MOD含量了解氧化应激水平;HE染色观察听皮层病理变化;透射电子显微镜观察铁死亡情况;Western blot法检测听皮层组织NCOA4、GPX4和ACSL4蛋白的表达水平;免疫荧光法观察铁自噬情况;普鲁士蓝染色观察听皮层铁蓄积水平。结果衰老组小鼠听阈值明显升高,并表现出明显的衰老与铁死亡特征。中、高剂量LIG干预降低小鼠听阈值,改善听皮层组织病理损伤,保护神经元线粒体形态结构,减少铁聚集颗粒细胞数量,抑制铁自噬,降低NCOA4、ACSL4蛋白表达,升高GPX4的蛋白表达。结论LIG可以通过抑制铁自噬,减少衰老小鼠听皮层神经元铁死亡,延缓听皮层衰老,提示LIG具有治疗中枢性老年性聋的作用。

关键词：中枢性老年性聋藁本内酯铁自噬铁死亡听皮层听阈值

Weighted Composition Operators That Preserve Frames On Weighted Hardy Spaces

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1645-1654页

作者： Ya Li dong Rui Liu guo xiang Lu School of Mathematical Sciences and LPMC Nankai UniversityTianjin300071P.R.China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan430073P.R.China

In this paper, we characterize weighted composition operators that preserve frames on the weighted Hardy spaces in the unit disk. In particular, we obtain the symbol properties of the bounded invertible weighted composition operators. Moreover, we establish the equivalence between bounded invertible operators and frame-preserving operators. Furthermore, we show that weighted composition operator preserves frames if and only if it preserves the Riesz bases property. Additionally,we investigate the weighted composition operators that preserve tight or normalized tight frames on the Dirichlet space.

关键词： Weighted composition operators Weighted Hardy spaces frames invertible

The structure of neutron-rich calcium isotopes studied by the shell model with realistic effective interactions

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Chinese Physics C 2019年第12期43卷 107-114页

作者： Xiao-Bao Wang Yu-Hang Meng YaTu guo-xiang dong School of Science Huzhou UniversityHuzhou 313000China School of Physics Science and Technology Shenyang Normal UniversityShenyang 110034China

We study the structure of neutron-rich calcium isotopes in the shell model with realistic *** CD-Bonn and Kuo-Brown(KB)interactions are *** these interactions do not include the three-body force,their direct use leads to poor *** tested whether the adjustment of the single particle energies(SPEs)would be sufficient to include the three-body correlations *** turns out that the CD-Bonn interaction,after the adjustment of SPEs,gives good agreement with the experimental data for the energies and *** the KB interaction,both the SPEs and monopole terms require ***,the monopole problem is less serious for mod?ern realistic interactions which include perturbations up to the third *** also tested the effect of the non-central force on the shell *** is found that the effect of the tensor force in the CD-Bonn interaction is weaker than in the KB interaction.

关键词： shell model effective interactions tensor force three-body force

Abnormal odd-even staggering behavior around^132Sn studied by density functional theory

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Chinese Physics C 2020年第9期44卷 154-161页

作者： Haoqiang Shi Xiao-Bao Wang guo-xiang dong Hualei Wang School of Science Huzhou UniversityHuzhou 313000China School of Physics and Engineering Zhengzhou UniversityZhengzhou 450001China

In this work,we have performed Skyrme density functional theory(DFT)calculations of nuclei around^132Sn to study whether the abnormal odd-even staggering(OES)behavior of binding energies around N=82 can be *** the Skyrme forces SLy4 and SkM*,we tested the volume-and surface-type pairing forces and also the intermediate between these two pairing forces,in the Hartree-Fock-Bogoliubov(HFB)approximation with or without the Lipkin-Nogami(LN)approximation or particle number projection after the convergence of HFBLN(PLN).The Universal Nuclear Energy Density Function(UNEDF)parameter sets are also *** trend of the neutron OES against the neutron number or proton number does not change significantly by tuning the density dependence of the pairing ***,for the pairing force that is favored more at the nuclear surface,a larger mass OES is obtained,and vice *** appears that the combination of volume and surface pairing can give better agreement with the *** the studies of the OES,a larger ratio of surface to volume pairing might be ***,in most cases,the OES given by the HFBLN approximation agrees more closely with the experimental *** found that both the Skyrme and pairing forces can influence the OES *** mass OES calculated by the UNEDF DFT is explicitly smaller than the experimental *** UNEDF1 and UNEDF2 forces can reproduce the experimental trend of the abnormal OES around^*** neutron OES of the tin isotopes given by the SkM*force agrees more closely with the experimental one than that given by the SLy4 force in most *** SLy4 and SkM*DFT have difficulties in reproducing the abnormal OES around^*** the PLN method,the systematics of OES are improved for several combinations of Skyrme and pairing forces.

关键词： odd-even mass staggering pairing correlation density functional theory

Intelligent responsive self-assembled micro-nanocapsules: Used to delay gel gelation time

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Petroleum Science 2024年第4期21卷 2433-2443页

作者： Chuan-Hong Kang Ji-xiang guo dong-Tao Fei Wyclif Kiyingi Unconventional Petroleum Research Institute China University of Petroleum

In the application of polymer gels to profile control and water shutoff,the gelation time will directly determine whether the gel can "go further" in the formation,but the most of the methods for delaying gel gelation time are complicated or have low *** is an urgent need for an effective method for delaying gel gelation time with intelligent *** by the slow-release effect of drug capsules,this paper uses the self-assembly effect of gas-phase hydrophobic SiO2in aqueous solution as a capsule to prepare an intelligent responsive self-assembled *** capsule slowly releases the cross-linking agent under the stimulation of external conditions such as temperature and pH value,thus delaying gel gelation *** the pH value is 2 and the concentration of gas-phase hydrophobic SiO2particles is 10%,the gelation time of the capsule gel system at 30,60,90,and 120℃ is12.5,13.2,15.2,and 21.1 times longer than that of the gel system without containing capsule,*** with other methods,the yield stress of the gel without containing capsules was 78 Pa,and the yield stress after the addition of capsules was 322 *** intelligent responsive self-assembled micronanocapsules prepared by gas-phase hydrophobic silica nanoparticles can not only delay the gel gelation time,but also increase the gel *** slow release of cross-linking agent from capsule provides an effective method for prolongating the gelation time of polymer gels.

关键词： Profile control and water shutoff Polymer gel Delayed gelation time Intelligent response Self-assembled Micro-nanocapsules

Macrocyclic peptides:up-and-coming weapons to combat antimicrobial resistance

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1786-1787页

作者： Wen-Jing Wang xiang-Min dong guo-Bo L Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuanChina Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education Department of Medicinal ChemistryWest China School of PharmacySichuan UniversityChengduSichuanChina

Recently,two companion papers published in Nature reported a first-in-class tethered macrocyclic peptide antibiotic targeting carbapenem-resistant ***(CRAB)and unveiled their unique antibacterial mechanism,which invol... 详细信息

关键词： outer macrocyclic Macrocyclic

Effect of different bottom blowing elements on stirring characteristics of molten bath in converter

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Journal of Iron and Steel Research International 2024年第2期31卷 368-376页

作者： Ming Lv Shuang-ping Chen Hong-min guo Yi-jie Hao xiang-dong Xing School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Shaanxi Longmen Steel Company Hancheng715405ShaanxiChina

The bottom blowing element is the key equipment to ensure the bottom blowing effect of the *** types of bottom blowing elements,dispersive type(D1),double circular seam(D2)and straight cylinder type(D3),were built,and the effects of bottom blowing element type on molten bath flow,wall erosion and furnace bottom erosion were *** was found that when the bottom blowing elements of dispersive type(D1)and double circular seam(D2)were used,the dead zone area in the lower part of the molten bath was smaller,and the high-speed zone area was larger;therefore,the stirring effect on the bottom melt was *** the straight cylinder type(D3)bottom blowing element was used,the gas penetrated the molten bath at a faster rate to reach the surface of molten bath and failed to disperse in the bottom molten bath,and the wall shear stress near the nozzle outlet was *** argon was blown by three different bottom blowing elements,the area of the wall shear stress greater than 3 Pa was 4.8,5.6 and 8.7 cm2,respectively,within 0.2 m of the bottom blowing nozzle outlet.

关键词： Converter steelmaking Bottom blowing element Molten bath stirring Wall erosion

Stent fracture after transjugular intrahepatic portosystemic shunt placement using the bare metal stent/stent-graft combination technique

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World Journal of Gastrointestinal Surgery 2023年第10期15卷 2133-2141页

作者： Qi-Jia Liu Xiao-Feng Cao Yun Pei Xuan Li guo-xiang dong Chang-Ming Wang Department of Interventional Radiology and Vascular Surgery Peking University Third HospitalBeijing 100191China Department of Interventional Therapy Yangquan First People’s HospitalYangquan 045000Shanxi ProvinceChina

BACKGROUND A transjugular intrahepatic portosystemic shunt(TIPS)is widely placed to treat portal *** the Viatorr®stent(*** and Associates,Flagstaff,AZ,United States)is not available in all hospitals in China,the bare metal stent(BMS)/stent-graft combination technique is still popular for TIPS *** fracture is a complication after TIPS placement using this technique,with limited available literature focusing on *** To assess the incidence of stent fracture after TIPS placement using the BMS/stent-graft combination technique and to identify the risk factors for stent *** proposed technique modifications to improve the clinical results of TIPS placement with the BMS/stent-graft combination *** We retrospectively analyzed the computed tomography(CT)data of all patients with portal hypertension who underwent the TIPS procedure between June 2011 and December 2021 in a single *** implanted with the BMS/stent graft and had follow-up imaging data available were *** identified patients with stent fracture and analyzed their *** logistic regression was applied to identify the potential predictors of stent *** Of the 68 included patients,stent fracture occurred in seven(10.3%)*** on CT images,the stent fractures were categorized into three *** study consisted of four(57.1%)type I fractures,one(14.3%)type II fracture,one(14.3%)type IIIa fracture,and one(14.3%)type IIIb *** adjusting for covariates,multivariable logistic regression revealed that the risk factors for stent fracture were the implantation of a greater number of stents[adjusted odds ratio(aOR)=22.2,95%confidence interval(CI):1.2-415.4,P=0.038]and a larger proximal sagittal stent bending angle(aOR=1.1,95%CI:1.0-1.3,P=0.020).CONCLUSION Stent fracture occurred in approximately 10%of patients with portal hypertension who underwent TIPS with the BMS/stent-graft combination tec

关键词： Portal hypertension Transjugular intrahepatic portosystemic shunt Stent fracture Bare metal stent/stent-graft combination Risk factor Fracture types