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Clonal immunoglobulin heavy chain and T-cell receptor γ gene rearrangements in primary gastric lymphoma

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World Journal of Gastroenterology 2013年第34期19卷 5727-5731页

作者： guo-dong shan feng-ling hu Ming Yang Hong-Tan chen Wen-guo chen Yun-Gui Wang li-hua chen You-Ming li guo-qiang xu Department of Gastroenterology the First Affiliate HospitalSchool of MedicineZhejiang University

AIM:To study the diagnostic value of immunoglobulin heavy chain(IgH)and T-cell receptorγ (TCR-γ)gene monoclonal rearrangements in primary gastric lymphoma(PGL).METHODS:A total of 48 patients with suspected PGL at our hospital were prospectively enrolled in this study from January 2009 to December *** patients were divided into three groups(a PGL group,a gastric linitis plastica group,and a benign gastric ulcer group)based on the pathological results(gastric mucosal specimens obtained by endoscopy or surgery)and *** ultrasonography(EUS)and EUSguided biopsy were performed in all the *** tissue specimens were used for histopathological examination and for IgH and TCR-γ gene rearrangement polymerase chain reaction ***:EUS and EUS-guided biopsy were successfully performed in all 48 *** the PGL group(n=21),monoclonal IgH gene rearrangements were detected in 14(66.7%)patients.A positive result for each set of primers was found in 12(57.1%),8(38.1%),and 4(19.0%)cases using FR1/JH,FR2/JH,and FR3/JH primers,***,12(75%)patients with mucosal-associated lymphoid tissue lymphoma(n=16)and 2(40%)patients with diffuse large B-cell lymphoma(n=5)were positive for monoclonal IgH gene *** patients in the gastric linitis plastica group(n=17)and only one(10%)patient in the benign gastric ulcer group(n=10)were positive for a monoclonal IgH gene *** TCRgene monoclonal rearrangements were *** sensitivity of monoclonal IgH gene rearrangements was 66.7%for a PGL diagnosis,and the specificity was96.4%.In the PGL group,8(100%)patients with stage IIE PGL(n=8)and 6(46.1%)patients with stage IE PGL(n=13)were positive for monoclonal IgH gene ***:IgH gene rearrangements may be associated with PGL staging and may be useful for the diagnosis of PGL and for differentiating between PGL and gastric linitis plastica.

关键词： Immunoglobulin heavy chain T-cell receptor γ Gene rearrangement Primary gastric lymphoma Endoscopic biopsy specimen

Double-balloon enteroscopy for obscure gastrointestinal bleeding: A single center experience in China

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World Journal of Gastroenterology 2010年第13期16卷 1655-1659页

作者： chen, li-hua chen, Wen-guo Cao, Hai-Jun zhang, Hong shan, guo-dong li, lin zhang, bing-ling xu, cheng-Fu Ding, Kai-li Fang, Ying cheng, Ying Wu, chen-Jiao xu, guo-qiang Zhejiang Univ Dept Gastroenterol Affiliated Hosp 1 Coll Med Hangzhou 310003 Zhejiang Peoples R China Zhejiang Univ Chinese Med Dept Gastroenterol Affiliated Hosp 1 Hangzhou 310003 Zhejiang Peoples R China dongyang Peoples Hosp 1 Dept Gastroenterol Jinhua 322100 Zhejiang Peoples R China Zhejiang Univ Dept Endoscopy Ctr Affiliated Hosp 1 Coll Med Hangzhou 310003 Zhejiang Peoples R China

AIM: To evaluate the diagnostic value of double-balloon enteroscopy (DBE) for obscure gastrointestinal bleeding (OGIB). METHODS: The data about 75 OGIB patients who underwent DBE in January 2007-June 2009 in our hospital were retrospectively analyzed. RESULTS: DBE was successfully performed in all 75 patients without complication. Of the 75 patients, 44 (58.7%) had positive DBE findings, 22 had negative DBE findings but had potential bleeding at surgery and capsule endoscopy, etc . These 66 patients were finally diagnosed as OGIB which was most commonly caused by small bowel tumor (28.0%), angiodysplasia (18.7%) and Crohn’s disease (10.7%). Lesions occurred more frequently in proximal small bowel than in distal small bowel (49.3% vs 33.3%, P = 0.047). CONCLUSION: DBE is a safe, effective and accurate procedure for the diagnosis of OGIB.

关键词： Double-balloon enteroscopy Capsule endoscopy Obscure gastrointestinal bleeding Diagnosis

Design of a high-dynamic-range prototype readout system for VLAST calorimeter

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Nuclear Science and Techniques 2023年第10期34卷 47-59页

作者： qiang Wan Jian-hua guo Xing xu Shen Wang Yong-qiang zhang Yi-Ming hu Yan zhang xu Pan Xiang li Chuan Yue Wei Jiang Yu-Xin Cui Deng-Yi chen Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China

In the future, the Very Large Area gamma-ray Space Telescope is expected to observe high-energy electrons and gamma rays in the MeV to TeV range with unprecedented acceptance. As part of the detector suite, a high-energy imaging calorimeter(HEIC) is currently being developed as a homogeneous calorimeter that utilizes long bismuth germanate(BGO) scintillation crystals as both absorbers and detectors. To accurately measure the energy deposition in the BGO bar of HEIC, a highdynamic-range readout method using a silicon photomultiplier(SiPM) and multiphotodiode(PD) with different active areas has been proposed. A prototype readout system that adopts multichannel charge measurement ASICs was also developed to read out the combined system of SiPMs and PDs. Preliminary tests confirmed the feasibility of the readout scheme, which is expected to have a dynamic range close to 10~6.

关键词： VLAST Calorimeter Readout system Front-end electronics Large dynamic range

Properties of theβDelayed Proton Decay of 147Er

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Chinese Physics Letters 2010年第6期27卷 59-61页

作者： MA Fei ZHOU Xiao-Hong ZHENG Yong xu Shu-Wei XIE Yuan-Xiang chen liang zhang Yu-hu li Zhan-Kui qiang Yun-hua LEI Xiang-guo guo Ying-Xiang guo Song DING bing WANG Hai-Xia li Guang-Shun ZHOU Hou-bing Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 Graduate University of Chinese Academy of Sciences Beijing 100049

The β-delayed proton decay of 147Er is studied experimentally using the 58 Ni＋92Mo reaction at a beam energy of 383 MeV. Based on a He-jet apparatus coupled with a tape transport system, the β-delayed proton radioactivities both from the vδl/2 ground state and the vh11/2 isomer in 147 Er are identified by proton-7 coincidence measurements. By analyzing the time distribution of the 4＋ → 2＋-γ transition in the grand-daughter nucleus 146Dy, a half-life of 1.6 ± 0.2s is determined for the Vh11/2 isomer in 147 Er. The half-life for the ground state of 147Er is estimated to be 3.2±1.2 s.

关键词： Tapes Transport Measurement

SAPT:a synchrotron-based proton therapy facility in shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou zhang De-Ming li li-Ren Shen Hai-Rong zhang Zhi-ling chen Han-Wen Du Ming Gu Rui li De-Kang liu Yue-hu Pu Jun-feng Yu Jian-feng chen Chu chen Chun-Long guo Hao guo Ge-Yang Jiang Zhi-qiang Jiang lin Jin Wen-Jing li Xiu-Fang li Ye lin Ming liu Yong-Hao liu Ya-Juan liu Ming Lv Qing-Ru Mi lian-hua Ouyang Wei-guo Shi Hang Shu Qi-Sheng Tang Kun Wang Zhi-shan Wang Jun Wu Xiao-bing Wu Jia-qiang xu Wen-Zhen xu Chong-Xian Yin cheng Yu Ren-Xian Yuan Qi-bing Yuan Hai-Qun zhang Miao zhang Wen-Zhi zhang li-Ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-dong Sun Zhen-Tang Zhao shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan cheng Hao Cai Shi chen Tian-Lu chen Xiang dong You-liang feng Qi Gao Quan-Bu Gou Yi-Qing guo Hong-Bo hu Ming-Ming Kang Hai-Jin li chen liu Mao-Yuan liu Wei liu Fang-Sheng Min Chu-cheng Pan bing-qiang Qiao Xiang-li Qian hui-Ying Sun Yu-Chang Sun Ao-Bo Wang xu Wang Zhen Wang Guang-Guang Xin Yu-hua Yao qiang Yuan Yi zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China Ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun Jian-Wei Zhao xue-Heng zhang li-Na Sheng Zhi-Yu Sun Isao Tanihata Satoru Terashima Yong Zheng li-hua Zhu li-Min Duan liu-Chun He Rong-Jiang hu Guang-Shuai li Wen-Jian lin Wei-Ping lin Chuan-Ye liu Zhong liu chen-Gui Lu Xin-Wen Ma li-Jun Mao Yi Tian feng Wang Meng Wang Shi-Tao Wang Jia-Wen Xia Xiao-dong xu hu-shan xu Zhi-guo xu Jian-cheng Yang Da-Yu Yin You-Jin Yuan Wen-Long Zhan Yu-hu zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

A practical community-based response strategy to interrupt Ebola transmission in sierra Leone, 2014–2015

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Infectious Diseases of Poverty 2016年第1期5卷 670-679页

作者： Zhong-Jie li Wen-Xiao Tu Xiao-Chun Wang guo-Qing Shi Zun-dong Yin Hai-Jun Su Tao Shen Da-Peng zhang Jian-dong li shan Lv Chun-li Cao Rui-Qian Xie Hong-Zhou Lu Rong-Meng Jiang Zheng Cao Zhi-Jie An Lei-Lei li Jie xu Yan-Wen Xiong Wei Zang Wei zhang Hong-Wei zhang Wen-Sen chen hua ling Wen xu Jian Cai huan-Jin Luo xue-Sheng Xing Can-Jun Zheng qiang Wei Xin-xu li Mei li Hai Jiang li-Quan Deng Ming-Quan chen Xiang huo feng xu xue-hui Lai Xi-chen Bai Long-Jie Ye Jian-Yi Yao Wen-Wu Yin Jiao-Jin Sun lin Xiao Fu-qiang liu Xiao-qiang liu Hong-Wei Fan Zeng-qiang Kou Ji-Kun Zhou Hao zhang Da-Xin Ni Thomas TSamba Qun li Hong-Jie Yu Yu Wang Xiao-feng liang Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijingChina Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Chinese Field Epidemiology Training Program Chinese Center for Disease Control and PreventionBeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Bureau of Disease Prevention and Control National Health and Family Planning Commission of the People’s Republic of ChinaBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina National Institute of Parasitic Disease Chinese Center for Disease Control and PreventionShanghaiChina Chinese Center for Health Education BeijingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterShanghaiChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Health News BeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Training Chinese Center for Health EducationBeijingChina Center for Infectious Diseases Beijing Youan HospitalCapital Medical UniversityBeijingChina Infection Management The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Chongqing Municipal Center for Disease Control and Prevention ChongqingChina Yunnan Provincial Center for Disease Control and Prevention KunmingChina Division of Infectious Disease Control and Prevention Zhejiang Provincial Center for Disease Control and PreventionHangzhouChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouChina Division of Acute Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and PreventionW

Background:The Ebola virus disease spread rapidly in West Africa in 2014,leading to the loss of thousands of *** engagement was one of the key strategies to interrupt Ebola transmission,and practical community level measures needed to be explored in the field and tailored to the specific context of ***:First,community-level education on Ebola virus disease(EVD)prevention was launched for the community’s social mobilizers in six districts in Sierra Leone beginning in November ***,from January to May of 2015,in three pilot communities,local trained community members were organized to engage in implementation of EVD prevention and transmission interruption measures,by involving them in alert case report,contact tracing,and social *** epidemiological indicators of transmission interruption in three study communities were ***:A total of 6016 community social mobilizers from 185 wards were trained by holding 279 workshops in the six districts,and EVD message reached an estimated 631680 *** three pilot communities,72 EVD alert cases were reported,with 70.8%of them detected by trained local community members,and 14 EVD cases were finally *** tracing detected 64.3%of EVD *** median duration of community infectivity for the cases was 1 *** secondary attack rate was 4.2%,and no third generation of infection was *** health worker was infected,and no unsafe burial and noncompliance to EVD control measures were *** community-based measures were modeled to reduce 77 EVD cases,and the EVD-free goal was achieved four months earlier in study communities than whole country of Sierra ***: The community-based strategy of social mobilization and community engagement was effective in casedetection and reducing the extent of Ebola transmission in a country with weak health system. The successfullypractical experience to reduce the risk of Ebola transmission in the

关键词： Ebola virus disease Community engagement Health education Outbreak control

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan shan xu-Yong Wei Rui Wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan Jiang Kun zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao Jiang qiang He lin-Sen Ye Yang Yang Yu-Ting He Wen-Zhi guo liu-Gen Lan xu-Yong Sun dong chen Zhi-Shui chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin Yang Pu-Sen Wang lin Zhong Jing-Sheng Ma Qi-Gen li Sheng-dong Wu Chang-Jiang Lu Cai-De Lu dong-hua zhang xuan Wang Zi-qiang li Mu-Jian Teng Jun-Jie li Wen-Tao Jiang Jian-hua li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He qiang Xia Shao-hua Song Zhi-Ren Fu Wei Qiu guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang chen Ying-Peng Zhao li li Ze-Min hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong guo Shu-Sen Zheng Xiao xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion