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Saline conducted electric coagulation (SCEC):original experience in experimental hepatectomy

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第3期13卷 186-191页

作者： guo-ping ding li-ping cao da-ren liu ri-sheng que Department of General Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective: To evaluate the feasibility and superiority of a new coagulating and hemostatic method named "saline conducted electric coagulation (SCEC)". Methods: The Peng's multifunction operative dissector (PMOD) was modified to enable saline to effuse persistently out of its nib at a constant speed. In a group of six New Zealand rabbits, two hepatic lobes of each rabbits were resected respectively by SCEC and conventional electric coagulation (EC). The features of SCEC were recorded by photo and compared with conventional EC. After 7 d, the coagulating depth was measured in each residual hepatic lobe. Hepatic tissue was dyed by hematoxylin and eosin (HE) and studied under a microscope. Results: The coagulating depth increased with the continuation of SCEC time. Hepatectomies were performed successfully, no rabbit died in the perioperative period. The incisal surface of SCEC was gray-white with no red bleeding point. There was a thick solidified layer at the margin and a thin red-white intermittent layer between the solidified layer and normal hepatic tissue at the vertical section of SCEC. The mean coagulating depth of SCEC was 1.8 cm vs. 0.3 cm of conventional EC. Pathological examination showed a mild inflammatory reaction by SCEC. Conclusions: SCEC is a feasible and safe method for surgical hemostasis. As a new technique for liver resection, SCEC shows better coagulating effect and milder inflammatory reaction than conventional EC. Our study shows bloodless liver resection can also be performed by SCEC, especially for liver malignant tumor.

关键词： Saline Electric coagulation Hepatectomy Hemostasis Bloodless liver resection

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Transumbilical single-port laparoscopic cholecystectomy using traditional laparoscopic instruments:a report of thirty-six cases

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 862-866页

作者： li-ping cao ri-sheng que Fan ZHOU guo-ping ding De-xi JING Department of Surgery the Second Affliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China

Objective:To evaluate the feasibility and safety of the operation of transumbilical single-port laparoscopic cholecystectomy (TSPLC) by traditional laparoscopic instruments and summarize the initial ***:Sixty subjects with cholelithiasis were divided into two *** group (36 cases) underwent TSPLC and the control group (24 cases) underwent traditional three-port laparoscopic cholecystectomy (LC).Postoperative complications were observed and operation time,hospital days,visual analogue scale (VAS) after 6 and 24 h of operation,and subject satisfaction score were ***:TSPLC and traditional LC were performed successfully in the two *** operation time in the TSPLC group was significantly longer than that in the control *** was no statistically significant difference in hospital stay and VAS between the TSPLC and control *** subject satisfaction score in the TSPLC group was 91.2,significantly higher than that in the control group (Plication occurred during the period of two weeks after ***:TSPLC is a feasible and safe method for cholecystectomy,although it may be more ***,it is welcomed by patients who are more concerned with cosmetic *** studies are needed to confirm its disadvantages and contraindications.

关键词： Laparoscopic cholecystectomy Single-incision laparoscopic cholecystectomy Minimally invasive surgery Traditional laparoscopic instruments

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Increasing the immune activity of exosomes: the effect of miRNA-depleted exosome proteins on activating dendritic cell/cytokine-induced killer cells against pancreatic cancer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第5期17卷 352-360页

作者： ri-sheng que Cheng liN guo-ping ding Zheng-rong WU li-ping cao Department of Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310020 China

Background： Tumor-derived exosomes were considered to be potential candidates for tumor vaccines because they are abundant in immune-regulating proteins, whereas tumor exosomal miRNAs may induce immune tolerance, thereby having an opposite immune function. Objective： This study was designed to separate exosomal protein and depleted exosomal microRNAs （miRNAs）, increasing the immune activity of exosomes for activating dendritic cell/cytokine-induced killer cells （DC/CIKs） against pancreatic cancer （PC）. Methods： PC-derived exosomes （PEs） were extracted from cultured PANC-1 cell supernatants and then ruptured; this was followed by ultrafiltered exosome lysates （UELs）. DCs were stimulated with lipopolysaccharide （LPS）, PE, and UEL, followed by co-culture with CIKs. The anti-tumor effects of DC/CIKs against PC were evaluated by proliferation and killing rates, tumor ne- crosis factor-a （TNF-a） and perforin secretion. Exosomal miRNAs were depleted after lysis and ultrafiltration, while 128 proteins were retained, including several immune-activating proteins. Results： UEL-stimulated DC/CIKs showed a higher killing rate than LPS- and PE-stimulated DC/CIKs. Conclusions： miRNA-depleted exosome proteins may be promising agonists for specifically activating DC/CIKs against PC.

关键词： Pancreatic cancer Exosome Dendritic cell MicroRNAs

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Assessment of 188Re marked anti MHC class II antibody by peripheral blood mononuclear cells stimulated by donor alloantigen

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Chinese Medical Journal 2011年第16期124卷 2512-2516页

作者： ding guo-ping cao li-ping liu Jie liu da-ren que ri-sheng ZHU lin-hua ZHOU Yi-ming MAO Ke-jie HU Jun-an Department of Surgery Second Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou Zhejiang 310009China

Background Previous studies showed that anti MHC-II monoclone antibody （MAb） only had partial inhibiting effect of alloreactive mixed lymphocyte reaction （MLR） in vitro and it was unsteady and non-persistent. The aim of this research was to determine whether radioactive isotope 188Re marked MHC-II antibody could benefit the allograft acceptance in transplantation as compared to normal MHC-II antibody. Methods 188Re was incorporated to 2E9/13F（ab＇）2 which is against swine MHC class II antigen （MAb-~88Re）. Porcine peripheral blood mononuclear （PBMC） cells were examined for proliferation and cytokine mRNA expression after stimulation with MHC-II MAb or MAb-188Re. Results The proliferative response of recipient PBMCs in mixed lymphocyte reaction （MLR） to donor alloantigen showed that the stimulation index of MAb-188Re group was significantly lower than the MHC-II MAb group and control （P 〈0.05）. mRNA expression of interleukin 2, interferon y and tumor necrosis factor a （type 1 cytokines） was lower in MAb-188Re group than the MHC-II MAb group, while interleukin 10 （type 2 cytokines） was higher in MAb-~aSRe group in the first 24 hours. Conclusion MAb-188Re could help the graft acceptance by inhibiting T cell proliferation, lowering the expression of type 1 cytokines and elevating the type 2 cytokines produced by PBMC.

关键词： MHC class H antibody dendritic cells cytokine 188Re, acute rejection

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针状焦原料对热膨胀性能影响研究

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炭素技术 2024年第2期43卷 59-63页

作者：曹玉亭王路海刘银东李圣平祁传磊王佳冉王琪丁怡中国石油天然气股份有限公司石油化工研究院北京102206

热膨胀系数作为针状焦质量分级的主要依据之一,与原料有着密切的联系。本文通过核磁与喹啉不溶物的测定获得原料的芳烃组成和活性指数,并利用公式与催化油浆、乙烯焦油及其混合物的热膨胀系数相关联。除此之外,本文还依据芳香化合度计... 详细信息

热膨胀系数作为针状焦质量分级的主要依据之一,与原料有着密切的联系。本文通过核磁与喹啉不溶物的测定获得原料的芳烃组成和活性指数,并利用公式与催化油浆、乙烯焦油及其混合物的热膨胀系数相关联。除此之外,本文还依据芳香化合度计算公式,进一步将热膨胀系数与原料的性质关联。结果表明,针状焦原料的最佳密度在1.02~1.08 g/cm^(3)之间,且高芳烃含量与低热反应活性对应低热膨胀系数。

关键词：石墨电极针状焦热膨胀系数

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang guofu cao Jianshe cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen danping Chen Fuqing Chen Fusan Chen Gang Chen guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun dai Xinchen dai Xuwen dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille dalian Minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV damping ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and damping ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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成人原发性肝肉瘤四例诊治分析

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中华普通外科杂志 2009年第8期24卷 617-620页

作者：曹利平胡均安阙日升浙江大学医学院附属第二医院普外科杭州310009

目的探讨成人原发性肝肉瘤的临床特点、诊断及治疗。方法回顾性分析我院自1998年至2008年收治的4例原发性肝肉瘤患者的临床资料，总结其发病特点、检查结果、诊断、治疗及随访。结果4例患者中男3例，女1例，年龄25～65岁，分别因腹痛、... 详细信息

目的探讨成人原发性肝肉瘤的临床特点、诊断及治疗。方法回顾性分析我院自1998年至2008年收治的4例原发性肝肉瘤患者的临床资料，总结其发病特点、检查结果、诊断、治疗及随访。结果4例患者中男3例，女1例，年龄25～65岁，分别因腹痛、乏力、消瘦及体检发现肿块而就诊，无明显家族史，肝脏酶学检测正常或稍增高，CT表现大多见肝内较大肿块，囊实性为多，密度不均匀，边界欠清，增强后无明显强化或部分强化；分别误诊为肝囊肿、肝癌、肝腺瘤，均行肝叶切除术。术后病理学诊断分别为：恶性间叶瘤（未分化肉瘤）、癌肉瘤、平滑肌肉瘤、恶性纤维组织细胞瘤部分血管肉瘤。现存活3例（已分别为术后4、56、84个月），死亡1例（术中死亡），其中1例术后5年肝内复发。结论原发性肝肉瘤的诊断容易误诊，确诊需依赖术后病理及免疫组织化学检查。采用以手术治疗为主的综合治疗是延长患者生存期的主要手段。患者的预后与肿瘤的病理类型、分化程度、是否浸润转移及是否手术切除等密切相关。

关键词：肉瘤诊断治疗肝

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人工关节置换术后假体周围感染的研究进展

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解放军医学杂志 2020年第11期45卷 1196-1206页

作者：刘鹏曹国定常彦峰李鹏刘军李旭升甄平甘肃中医药大学临床医学院兰州730000 联勤保障部队第940医院关节骨科兰州730050

假体周围感染(PJI)是人工关节置换术后灾难性的并发症,其诊疗一直是关节外科领域的研究热点和难点。目前,PJI的治疗策略包括抗生素治疗、保留假体清创灌洗术、Ⅰ期翻修术、Ⅱ期翻修术、关节融合术、截肢以及生物治疗等。常规治疗不能取... 详细信息

假体周围感染(PJI)是人工关节置换术后灾难性的并发症,其诊疗一直是关节外科领域的研究热点和难点。目前,PJI的治疗策略包括抗生素治疗、保留假体清创灌洗术、Ⅰ期翻修术、Ⅱ期翻修术、关节融合术、截肢以及生物治疗等。常规治疗不能取得满意的疗效,而生物治疗作为一种新兴的治疗模式,在PJI治疗中具有独特的优势。该文就PJI的危险因素和感染源、诊断和分型,以及治疗策略进行综述,为临床PJI治疗方式的选择提供参考。

关键词：假体周围感染清创术 Ⅰ期翻修 Ⅱ期翻修生物治疗

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基于LS-SVM的航空发动机气路参数趋势在线预测

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吉林大学学报（工学版） 2008年第1期38卷 239-244页

作者：王旭辉黄圣国曹力施鼎豪舒平南京航空航天大学民航学院南京210016 中国民用航空总局安全技术中心航空安全研究所北京100028

将最小二乘向量机(LS-SVM)应用于航空发动机气路参数趋势在线预测。首先,分析了PATS系统所接收的空地数据链(ACARS)报文的特点,构建用于实时存储和解析的发动机报文并行处理系统,获取在线模型的训练样本;其次,针对实时样本,利用最终误... 详细信息

将最小二乘向量机(LS-SVM)应用于航空发动机气路参数趋势在线预测。首先,分析了PATS系统所接收的空地数据链(ACARS)报文的特点,构建用于实时存储和解析的发动机报文并行处理系统,获取在线模型的训练样本;其次,针对实时样本,利用最终误差预报准则(FPE)确定嵌入维数,采用直接搜索法优化LS-SVM建模参数,建立了基于LS-SVM的气路参数预测模型。与航路飞机建立ACARS链接,获取发动机实时气路数据,预测气路参数变化趋势。与已有神经网络预测模型相比,具有更高的一步预测和多步预测精度。该方法解决了发动机预诊断中的数据趋势预测问题。

关键词：航空航天推进系统航空发动机在线预测支持向量机气路参数

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创伤性关节炎及其姜黄素治疗作用机制的研究进展

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解放军医学杂志 2021年第1期46卷 76-83页

作者：刘鹏任莉甄平李鹏常彦峰曹国定李旭升张浩强刘军甘肃中医药大学临床医学院兰州730000 联勤保障部队第940医院关节骨科兰州730050 兰州理工大学医学技术学院兰州730050 西安交通大学附属第二医院(西北医院)骨科西安710004

创伤性关节炎(TA)是继发于关节创伤的一种骨关节炎,发病机制目前尚不明确,主要与多种细胞因子及相关信号通路介导的软骨细胞凋亡有关。姜黄素具有抗炎、抗氧化、抗凋亡等作用,其治疗TA主要与抑制氧化酶,清除自由基的抗氧化作用,抑制环... 详细信息

创伤性关节炎(TA)是继发于关节创伤的一种骨关节炎,发病机制目前尚不明确,主要与多种细胞因子及相关信号通路介导的软骨细胞凋亡有关。姜黄素具有抗炎、抗氧化、抗凋亡等作用,其治疗TA主要与抑制氧化酶,清除自由基的抗氧化作用,抑制环氧化酶、脂氧化酶和多种炎性介质的抗炎作用,以及作用于多种信号转导通路以保护软骨细胞有关。该文通过阐述姜黄素的部分生物功能,介绍其治疗TA的相关作用机制。

关键词：创伤性关节炎姜黄素软骨细胞关节软骨信号通路炎性因子

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