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Additional gastrectomy in early-stage gastric cancer after non-curative endoscopic resection:a meta-analysis

Gastroenterology Report 2019年第2期7卷 91-97,I0001页

作者： Run-Cong Nie Shu-Qiang Yuan Yuan-Fang Li Shi chen Yong-ming chen Xiao-Jiang chen guo-ming chen Zhi-Wei Zhou Ying-Bo chen Department of Gastric Surgery Sun Yat-sen University Cancer CenterGuangzhouGuangdongP.R.China State Key Laboratory of Oncology in South China GuangzhouGuangdongP.R.China Collaborative Innovation Center for Cancer Medicine GuangzhouGuangdongP.R.China Department of Gastric Surgery The 6th Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background and objective:The role of additional gastrectomy after non-curative endoscopic resection remains *** present meta-analysis aimed to explore the risk factors for early-stage gastric-cancer patients after non-curative endoscopic resection and evaluate the efficacy of additional ***:Relevant studies that reported additional gastrectomy after non-curative endoscopic resection were comprehensively searched in MedLine,Web of Science and *** first investigated the risk factors for residual tumor and lymph-node metastasis after non-curative endoscopic resection and then analysed the survival outcome,including 5-year overall survival(OS)and 5-year disease-free survival,of additional ***:Twenty-one studies comprising 4870 cases were included in the present *** found that residual tumor was associated with larger tumor size(>3 cm)(odds ratio[OR]=2.81,P3 cm)(OR=1.73,PSM1)(OR=2.68,P<0.001),lymphatic invasion(OR=4.65,P<0.001)and positive vertical margin(OR=2.30,P<0.001).Patients who underwent additional gastrectomy had longer 5-year OS(hazard ratio[HR]=0.34,P<0.001),5-year disease-free survival(HR=0.52,P=0.001)and 5-year disease-specific survival(HR=0.50,P<0.001)than those who did ***,elderly patients also benefited from additional gastrectomy regarding 5-year OS(HR=0.41,P=0.001).Conclusions:Additional gastrectomy with lymph-node dissectionmight improve the survival of early-stage gastric-cancer patients after non-curative endoscopic ***,risk stratification should be performed to avoid excessive treatment.

关键词： Early gastric cancer non-curative endoscopic resection gastrectomy

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Reconstruction of a muon bundle in the JUNO central detector

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Nuclear Science and Techniques 2022年第5期33卷 78-90页

作者： cheng-Feng Yang Yong-Bo Huang Ji-Lei Xu Di-Ru Wu Yong-Peng Zhang Wu-ming Luo Miao He guo-ming chen Si-Yuan Zhang School of Physical Science and Technology Guangxi UniversityNanning 530004China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China

The Jiangmen Underground Neutrino Observatory(JUNO)is a multi-purpose neutrino *** of the main goals is to determine the neutrino mass ordering by precisely measuring the energy spectrum of reactor *** the detection of reactor antineutrinos,cosmogenic backgrounds,such as^(9)Li/^(8)He and fast neutrons induced by cosmic muons,should be rejected carefully by applying muon veto cuts,which require good muon track *** a 20-kton liquid scintillator detector,the simulation shows the proportion of muon bundles(muon multiplicity≥2)to be approximately 8%in JUNO,whereas its reconstruction has been rarely discussed in previous *** study proposes an efficient algorithm for muon track reconstruction based on the charge response of a photomultiplier tube *** is the first reconstruction of muon bundles in a large-volume liquid scintillator *** addition,the algorithm shows good performance and potential for reconstruction for both a single muon and double muons(muon multiplicity=2).The spatial resolution of a single-muon reconstruction was20 cm,and the angular resolution was 0.5°.For doublemuon reconstruction,the spatial and angular resolutions could be 30 cm and 1.0°,***,this paper also discusses muon classification and the veto strategy.

关键词： JUNO Liquid scintillatordetector Muon reconstruction Muon bundle Veto strategy

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Nonlinear dynamic analysis and fatigue damage assessment for a deepwater test string subjected to random loads

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Petroleum Science 2016年第1期13卷 126-134页

作者： Kang Liu guo-ming chen Yuan-Jiang Chang Ben-Rui Zhu Xiu-Quan Liu Bin-Bin Han Centre for Offshore Engineering and Safety Technology China University of Petroleum

The deepwater test string is an important but vulnerable component in offshore petroleum exploration,and its durability significantly affects the success of deepwater test *** the influence of random waves and the interaction between the test string and the riser,a time-domain nonlinear dynamic model of a deepwater test string is *** stress-time history of the test string is obtained to study vibration mechanisms and fatigue development in the test *** recommendations for reducing damage are *** results indicate that the amplitude of dynamic response when the string is subjected to random loads gradually decreases along the test string,and that the von Mises stress is higher in the string sections near the top of the test string and the flex *** addition,the fatigue damage fluctuates with the water depth,and the maximum damage occurs in string sections adjacent to the lower flex joint and in the splash *** measures are proposed to improve the operational safety of deepwater test strings：applying greater top tension,operating in a favorable marine environment,managing the order of the test string joints,and performing nondestructive testing of components at vulnerable positions.

关键词： string fatigue joints performing applying operations durability retrieval sections favorable

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Discrimination of pp solar neutrinos and^(14)C double pile-up events in a large-scale LS detector

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Nuclear Science and Techniques 2023年第9期34卷 69-81页

作者： guo-ming chen Xin Zhang Ze-Yuan Yu Si-Yuan Zhang Yu Xu Wen-Jie Wu Yao-Guang Wang Yong-Bo Huang School of Physical Science and Technology Guangxi UniversityNanning 530004China Institute of High Energy Physics Beijing 100049China University of Chinese Academy of Sciences Beijing 100049China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Department of Physics and Astronomy University of CaliforniaIrvineCAUSA

As a unique probe,the precision measurement of pp solar neutrinos is important for studying the sun’s energy mechanism as it enables monitoring the thermodynamic equilibrium and studying neutrino oscillations in the vacuum-dominated *** a large-scale liquid scintillator detector,a bottleneck for pp solar neutrino detection is the pile-up events of intrinsic14C *** paper presents a few approaches to discriminating between pp solar neutrinos and ^(14)C pile-up events by considering the differences in their time and spatial *** this study,a Geant4-based Monte Carlo simulation is *** analysis and deep learning technology are adopted to investigate the capability of ^(14)C pile-up *** BDTG (boosted decision trees with gradient boosting) model and VGG network demonstrate good performance in discriminating pp solar neutrinos and ^(14)C double pile-up *** the ^(14)C concentration assumption of 5×10-18g/g,the signal significance can achieve 10.3 and 15.6 using the statistics of only one *** this case,the signal efficiency for discrimination using the BDTG model while rejecting 99.18% ^(14)C double pile-up events is 51.1%,and that for the case where the VGG network is used while rejecting 99.81%of the ^(14)C double pile-up events is 42.7%.

关键词： Liquid scintillator detector pp solar neutrinos 14C pile-up Multivariate analysis Deep learning

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Progress in studies of tetrandrine against hepatofibrosis

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World Journal of Gastroenterology 1998年第5期4卷 14-16页

作者： LI Ding guo, LU Han ming and chen Ying Wei

Ｔｅｔｒａｎｄｒｉｎｅ（Ｔｅｔ）ｉｓｔｈｅｍａｉｎａｌｋａｌｏｉｄｉｓｏｌａｔｅｄｆｒｏｍｔｈｅｌｕｍｐｙｒｏｏｔｏｆＳｔｅｐｈａｎｉａｔｅｔｒａｎｄｒａｓ．Ｍｏｏｒｅ．ＩｔｓｍｏｌｅｃｕｌａｒｆｏｒｍｕｌａｉｓＣ３... 详细信息

Ｔｅｔｒａｎｄｒｉｎｅ（Ｔｅｔ）ｉｓｔｈｅｍａｉｎａｌｋａｌｏｉｄｉｓｏｌａｔｅｄｆｒｏｍｔｈｅｌｕｍｐｙｒｏｏｔｏｆＳｔｅｐｈａｎｉａｔｅｔｒａｎｄｒａｓ．Ｍｏｏｒｅ．ＩｔｓｍｏｌｅｃｕｌａｒｆｏｒｍｕｌａｉｓＣ３３Ｈ４２Ｎ２Ｏ６ａｎｄｉｔｓｃｈｅ...

关键词： liver cirrhosis/therapy liver cirrhosis/pathology liver cirrhosis, experimental/therapy tetrandrine/therapeutic use

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Search for a lighter neutral custodial fiveplet scalar in the Georgi-Machacek model

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Chinese Physics C 2022年第8期46卷 114-121页

作者： Chu Wang Jun-Quan Tao M.Aamir Shahzad guo-ming chen S.Gascon-Shotkin Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institut de Physique des 2 Infinis de Lyon Universitéde LyonUniversitéClaude Bernard Lyon 1CNRS-IN2P3Villeurbanne 69622France

Many researches from both theoretical and experimental perspectives have been performed to search for a new Higgs Boson that is lighter than the 125 GeV Higgs boson,which was discovered at the LHC in *** this study,we explore the possibility of constraining a lighter neutral custodial fiveplet scalar H_(5)^(0) in the GeorgiMachacek(GM) model using the latest results of the search for a lighter Higgs boson decaying into two photons from LHC *** custodial-singlet mass eigenstate h or H is considered to be the LHC observed 125 GeV Higgs boson.A new set of constrained parameters that is favoured by low-mass H_(5)^(0) is proposed to generate events *** production of H_(5)^(0) from a scan based on the constrained parameters is compared to the latest results of the search for a lighter Higgs boson decaying into two photons by the CMS Collaboration after applying theoretical constraints from the GM model and constraints from all existing relevant experimental measurements,including the recent results of the Higgs boson searches by the *** analyses of the surviving GM parameter space are *** tendencies and correlations of the GM input parameters from phenomenological studies are *** addition,the discovery potential of the other interesting decay channels of this low-mass neutral custodial fiveplet scalar are discussed.

关键词： Georgi-Machacek model lighter neutral custodial fiveplet scalar phenomenological studies

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Cosmic-ray helium nuclei measurement with the calorimeter of the Alpha Magnetic Spectrometer

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Radiation Detection Technology and Methods 2022年第3期6卷 427-432页

作者： Feng-ze Zhang Zhi-cheng Tang Zu-Hao Li cheng Zhang Ze-Tong Sun Jia-Yu Hu Shang-Lin Li guo-ming chen He-Sheng chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose The distributions of energy responses of helium measured by the electromagnetic calorimeter(ECAL)of Alpha Magnetic Spectrometer(AMS-02)in Monte-Carlo do not agree with those in real data,thus using energy response matrix obtained from Monte-Carlo to measure the cosmic ray helium spectrum is not ***,the spectrum measured with ECAL based on raw Monte-Carlo would be different from the real *** purpose is to correct the response matrix to measure helium spectrum with *** The energy measured by ECAL of AMS-02 provides in-ﬂight correction for the energy response matrix in *** The spectrum based on corrected response matrix is consistent with the AMS collaboration published *** It is feasible to measure helium spectrum with ECAL with corrected energy response matrix.

关键词： Cosmic rays Helium spectrum Electromagnetic calorimeter Monte Carlo simulation Fig.1 a The structure of ECAL b The indication of PMTs in one superlayer

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Improvement of cosmic-ray protonmeasurement with the electromagnetic calorimeter of the Alpha Magnetic Spectrometer

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Radiation Detection Technology and Methods 2021年第1期5卷 90-94页

作者： Fei Zhao Zhi-cheng Tang Zu-Hao Li cheng Zhang Ze-Tong Sun Feng-Ze Zhang Jia-Yu Hu guo-ming chen He-Sheng chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose The energy response of protons measured by electromagnetic calorimeter(ECAL)of Alpha Magnetic Spectrometer(AMS-02)shows disagreement between Monte Carlo(MC)simulation and ***,using the response matrix from MC to apply the energy unfolding,which is crucial for cosmic-ray proton spectrum measurement,is *** a result,cosmic-ray proton spectrum measured by ECAL based on raw MC would be different from the published results(based on the momentum measurement)by *** purpose is tuning the response matrix to agree with *** The independent energy measurement by AMS-02 magnetic spectrometer provides in-flight calibration for *** distributions of proton energy measured by ECAL in MC are corrected after the *** The proton spectrum based on the tuned response matrix is consistent with the published *** The matrix tuning is effective for the energy unfolding for cosmic-ray proton spectrum measurement.

关键词： Cosmic rays Proton spectrum Electromagnetic calorimeter Monte Carlo simulation

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On-orbit equalization of the electromagnetic calorimeter of the Alpha Magnetic Spectrometer

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Radiation Detection Technology and Methods 2021年第3期5卷 430-433页

作者： Ze-Tong Sun Jia-Yu Hu Zhi-cheng Tang cheng Zhang Feng-Ze Zhang Shang-Lin Li Mei-Jun Liang Zu-Hao Li guo-ming chen He-Sheng chen Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Purpose The Alpha Magnetic Spectrometer(AMS-02)will continuously collect data for the lifetime of the International Space Station(ISS).On-orbit equalization must be performed to ensure the accuracy of the AMS energy measurement(~1%)by the electromagnetic calorimeter(ECAL).Methods The equalization is performed using the most probable value(MPV)of the cosmic-ray proton minimum ionizing particle(MIP).Kalman filter technique is used to improve the *** The precision of the equalization with proton MIP is(7.206±0.003)%and improved to(2.388±0.002)%after the Kalman *** the toy Monte Carlo(MC)simulation,the error of the energy reconstruction is about 1.4%and 0.5%due to the 7.2%and 2.4%equalization accuracy,*** About 1.4%error due to~7%equalization precision does not match the AMS *** the improvement from the Kalman filter,the energy reconstruction error from the equalization is reduced to 0.5%,which can fulfill the AMS requirement.

关键词： Equalization Electromagnetic calorimeter Kalman filter Proton MIP Energy resolution

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Improvements on the particle identification with dead cell and side leakage corrections for the electromagnetic calorimeter of the Alpha Magnetic Spectrometer

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Radiation Detection Technology and Methods 2018年第2期2卷 14-18页

作者： Shao-Wen Zhang Zu-Hao Li Xue-Qiang Wang cheng Zhang Zhi-cheng Tang Suzan Basegmez du Pree Fei Zhao Ze-Tong Sun guo-ming chen He-Sheng chen Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of ScienceBeijing 10049China University of Chinese Academy of Sciences Beijing 100049China

Background The electromagnetic calorimeter(ECAL)of the Alpha Magnetic Spectrometer(AMS-02)measures the energy of electrons/positrons and separates them from ***,there are five dead cells in the ECAL which affect the reconstructed energy of *** particle identification power of the ECAL decreases when particles pass through these dead cells or close to the ECAL *** To improve the ECAL particle identification for particles pass through these dead cells or close to the ECAL *** An improved ECAL particle identification estimator using the electromagnetic shower shape is developed with dead cell and side leakage *** For events passing through dead cells,with this new estimator,the proton rejection power is improved by a factor of 2.2 and positron purity is improved from 31 to 50%in the energy range of 500–800 *** The new estimator works well for event passing through dead cells or close to the ECAL border.

关键词： Electron/proton separation Electromagnetic calorimeter(ECAL) Boosted Decision Trees(BDT) Dead cell correction Side leakage correction

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