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Ghrelin inhibits autophagy mediated by AKT/mTOR pathway to ameliorate retinal angiogenesis induced by high glucose stress

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 785-793页

作者： Jiang-Li Fan Rong Li min Zhang Chao Chen guo-min Yao Ling-Xiao Zhou Department of Ophthalmology Gongshu District People’s Hospital of Integrated Traditional Chinese and Western MedicineHangzhou 310004Zhejiang ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of Endocrinology the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina Department of General Surgery the First Affiliated Hospital of Xi’an Medical UniversityXi’an 710077Shaanxi ProvinceChina

AIM:To observe the effect of ghrelin,a growth hormonereleasing peptide,on retinal angiogenesis in vitro under high glucose(HG)stress and to explore the possible mechanism of ***:Human retinal microvascular endothelial cells(HRMECs)were treated with high concentration of glucose alone or in combination with *** cell migration,tube formation and the expression of the autophagy-related proteins LC3-II/I,Beclin-1,p62,phosphorylated AKT(p-AKT)/AKT and phosphorylated mammalian target of rapamycin(p-mTOR)/mTOR were ***,to clarify the correlation between ghrelin effect and autophagy,AKT inhibitor VIII was adopted to treat HRMECs,and cell migration,tube formation as well as the protein expressions of LC3-II/I,Beclin-1 and p62 were ***:Under HG stress,ghrelin inhibited migration and tube formation of *** inhibited the increases in the protein levels of LC3-II/I,Beclin-1 and the decreases in the protein levels of p62,p-AKT/AKT and p-mTOR/mTOR induced by HG ***,under the action of AKT/mTOR pathway inhibitors,the effects of ghrelin on migration and tube formation were both *** addition,the expression of LC3-II/I and Beclin-1 were significantly up-regulated and the expression of p62 was ***:Retinal angiogenesis under in vitro HG stress can be inhibited by ghrelin through activating AKT/mTOR pathway to inhibit autophagy.

关键词： ghrelin retinal endothelial cell angiogenesis autophagy stress

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Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China

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Petroleum Science 2024年第3期21卷 1552-1568页

作者： Xiao-Lin Wang Xiao-min zhu Jin Lai Xing-Yue Lin Xiang Wang Yu-Shan Du Chao Huang Yu-Rui zhu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield SINOPECDongying257000ShandongChina

The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas *** sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine *** article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)***,the OM enrichment model was *** results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source *** source of OM is a mixture of lower bacteria,algae,and *** the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low *** the late sedimentary period,the climate became warmer and more *** a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous *** and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of *** warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic *** research results may have implications for the genetic mechanisms of organic matter *** will provide theoret

关键词： Elemental geochemical Paleoenvironment Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin

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Hemoglobin loss method calculates blood loss during pancreaticoduodenectomy and predicts bleeding-related risk factors

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 419-428页

作者： Chao Yu Yi-min Lin guo-Zhe Xian Department of Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND The common clinical method to evaluate blood loss during pancreaticoduoden-ectomy(PD)is visual inspection,but most scholars believe that this method is extremely subjective and ***,there is no accurate,objective me-thod to evaluate the amount of blood loss in PD *** retrospectively analyzed the clinical data of 341 patients who underwent PD in Shandong Provincial Hospital from March 2017 to February *** to different surgical methods,they were divided into an open PD(OPD)group and a laparoscopic PD(LPD)*** differences and correlations between the in-traoperative estimation of blood loss(IEBL)obtained by visual inspection and the intraoperative calculation of blood loss(ICBL)obtained using the Hb loss method were ***,IEBL and perioperative calculation of blood loss(PCBL)were compared between the two groups,and single-factor regression analysis was *** There was no statistically significant difference in the preoperative general patient information between the two groups(P>0.05).PD had an ICBL of 743.2(393.0,1173.1)mL and an IEBL of 100.0(50.0,300.0)mL(P200μmol/L(95%CI:7.09-644.26;P=0.045)were independent risk factors for *** ICBLs of the LPD group and OPD group were 767.7(435.4,1249.0)mL and 663.8(347.7,1138.2)mL,respectively(P>0.05).The IEBL of the LPD group 200.0(50.0,200.0)mL was slightly greater than that of the OPD group 100.0(50.0,300.0)mL(P>0.05).PCBL was greater in the LPD group than the OPD group[1061.6(612.3,1632.3)mL vs 806.1(375.9,1347.6)mL](P<0.05).CONCLUSION The ICBL in patients who underwent PD was greater than

关键词： Pancreaticoduodenectomy Hemoglobin loss Calculated blood loss Estimated blood loss

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Collembolans maintain a core microbiome responding to diverse soil ecosystems

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Soil Ecology Letters 2024年第1期6卷 33-46页

作者： Zhe-Lun Liu Dong zhu Yi-Fei Wang Yong-Guan zhu min Qiao State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China

The unique gut habitat led to a core intestinal micro-biome in diverse soil *** collembolan guts may help eliminate soil ***-selection carried more weight on community assembly of gut *** invertebrates are widely distributed in the ecosystem and are essential for soil ecological ***-brate gut microbiome plays an important role in host health and has been considered as a hidden microbial ***,little is known about how gut microbiome in soil invertebrates respond to diverse soil *** on a laboratory microcosm experiment,we characterized the assembling of microbiome of soil collembolans(Folsomia candida)from six representative regions of the soil ecosystem which they *** showed that collembolan gut microbial communities differed significantly from their surrounding soil microbial communities.A dominant core gut microbiome was identified in gut *** analyses indicated that deterministic process dominated in the community assembly of collembolan gut *** results further demonstrate a dominant contribution of host selection in shaping gut *** is also worthy to mention that pathogens,such as common agricultural phytopathogenic fungi Fusarium,were involved in core microbiome,indicating that collembolans could act as vectors of *** results unravelled the existence of gut core microbiome of collembolans in soil ecosystems and provided new insights for under-standing the crucial role of gut microbiome of soil fauna in maintaining microbial biodiversity and stability of soil ecosystems.

关键词： gut microbiome collembolan core microbiome community assembly

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Experimental Study on Soot Suppression of Acetylene Diffusion Flame by Acoustic-Excited Oscillation in Rijke-Type Burner

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Journal of Thermal Science 2024年第1期33卷 235-248页

作者： zhu Yibin guo Hui SUO Yan'ge WU minle YE Yanghui LI guoneng ZHANG Zhiguo School of Mechanical and Energy Engineering Zhejiang University of Science and TechnologyHangzhou 310023China

This work reports that the flame oscillation induced by acoustic excitation can effectively suppress soot generation in Rijke-type *** the acoustic frequency is close to the natural frequency of the burner system,it can produce resonance resulting in intense oscillation of the *** relationship between the soot suppression efficiency and the acoustic field of standing wave at different flame positions is *** with that under self-excited oscillation,when there is external forced acoustic force introduced to the flame,oscillation combustion occurred in a lager zone in the glass *** fundamental cause of different soot suppression efficiency at different positions is that the standing wave acoustic field causes the particles to move at different speeds in different positions of the glass *** axial particle velocity difference results in the formation of acoustic vortexes and the change of the flame *** high particle velocity causes the air in the glass tube to turn into the turbulent condition and make the flame temperature *** results show that the surface growth rate of soot is reduced,while the oxidation rate of soot is enhanced,which result in the soot suppression under acoustic *** study can provide some reference for the practical application of oscillate combustion in soot suppression.

关键词： soot suppression acetylene diffusion flame acoustic-excited oscillation standing wave

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MXene-based all-solid flexible electrochromic microsupercapacitor

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Microsystems & Nanoengineering 2024年第3期10卷 347-355页

作者： Shanlu guo Ruihe zhu Jingwei Chen Weilin Liu Yuxiang Zhang Jianmin Li Haizeng Li College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China Optics and Thermal Radiation Research Center Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen Research Institute of Shandong University Shenzhen 518000China State Key Laboratory of Featured Metal Materials and Life Cycle Safety for Composite Structures Guangxi UniversityNanning 530004China

With the increasing demand for multifunctional optoelectronic devices,flexible electrochromic energy storage devices are being widely recognized as promising platforms for diverse ***,simultaneously achieving high capacitance,fast color switching and large optical modulation range is very *** this study,the MXenebased flexible in-plane microsupercapacitor was fabricated via a mask-assisted spray coating *** adding electrochromic ethyl viologen dibromide(EVB)into the electrolyte,the device showed a reversible color change during the charge/discharge *** to the high electronic conductivity of the MXene flakes and the fast response kinetics of EVB,the device exhibited a fast coloration/bleaching time of 2.6 s/2.5 s,a large optical contrast of 60%,and exceptional coloration *** addition,EVB acted as a redox additive to reinforce the energy storage performance;as a result,the working voltage window of the Ti_(3)C_(2)-based symmetric aqueous microsupercapacitor was extended to 1 ***,the device had a high areal capacitance of 12.5 mF cm^(−2)with superior flexibility and mechanical stability and showed almost 100%capacitance retention after 100 bending *** as-prepared device has significant potential for a wide range of applications in flexible and wearable electronics,particularly in the fields of camouflage,anticounterfeiting,and displays.

关键词： capacitance kinetics exceptional

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Review of Electrical and Electronic Architectures for Autonomous Vehicles:Topologies,Networking and Simulators

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Automotive Innovation 2024年第1期7卷 82-101页

作者： Wenwei Wang Kaidi guo Wanke Cao Hailong zhu Jinrui Nan Lei Yu National Engineering Research Center of Electric Vehicles Beijing Institute of Technology(BIT)Beijing 100081China Shenzhen Automotive Research Institute Beijing Institute of Technology(BIT)Shenzhen 518000China State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationBeijing 100876China Purple Mountain Laboratories Nanjing 211111China Beijing Kawen New Energy Vehicle Co. LTDBeijing 102209China

With the rapid development of autonomous vehicles,more and more functions and computing requirements have led to the continuous centralization in the topology of electrical and electronic(E/E)*** certain Tier1 suppliers,such as BOSCH,have previously proposed a serial roadmap for E/E architecture development,implemented since 2015 with significant contributions to the automotive industry,lingering misconceptions and queries persist in actual engineering ***,there are concerns regarding the perspective of zone-oriented E/E architectures,characterized by zonal concentration,as successors to domain-oriented E/E architectures,known for functional *** these misconceptions and queries,this study introduces a novel parallel roadmap for E/E architecture development,concurrently evaluating domain-oriented and zone-oriented ***,the study explores hybrid E/E architectures,amalgamating features from both *** align with the evolution of E/E architectures,networking technologies must adapt *** networking mechanisms pivotal in E/E architecture design are comprehensively ***,the study delves into modeling and verification tools pertinent to E/E architecture *** conclusion,the paper outlines existing challenges and unresolved queries in this domain.

关键词： Autonomous vehicles Electrical and electronic architectures Topology Networking Domain-oriented Zone-oriented

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Pulsations of Three Rapidly Oscillating Ap Stars TIC 96315731, TIC72392575, and TIC 318007796

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Research in Astronomy and Astrophysics 2024年第8期24卷 159-170页

作者： Hai-Jian Zhong Dong-Xiang Shen Chun-Hua zhu He-Lei Liu Su-Fen guo guo-Liang Lü School of Physical Science and Technology Xinjiang University Xinjiang Astronomical Observatory National Astronomical ObservatoriesChinese Academy of Sciences

We analyze the frequencies of three known roAp stars,TIC 96315731,TIC 72392575,and TIC 318007796,using the light curves from the Transiting Exoplanet Survey *** TIC 96315731,the rotational and pulsational frequencies are 0.1498360 day-1and 165.2609 day-1,*** the case of TIC 72392575,the rotational frequency is 0.25551 *** detect a quintuplet of pulsation frequencies with a center frequency of135.9233 day-1,along with two signals within the second pair of rotational sidelobes of the quintuplet separated by the rotation *** two signals may correspond to the frequencies of a dipole *** TIC318007796,the rotational and pulsational frequencies are 0.2475021 day-1,192.73995 day-1,and196.33065 day-1,*** on the oblique pulsator model,we calculate the rotation inclination （i）and magnetic obliquity angle （b） for the stars,which provide the geometry of the pulsation *** the phases of the frequency quintuplets,the pulsation amplitude and phase modulation curves,and the results of spherical harmonic decomposition,we conclude that the pulsation modes of frequency quintuplets in TIC96315731,TIC 72392575,and TIC 318007796 correspond to distorted dipole mode,distorted quadrupole mode,and distorted dipole mode,respectively.

关键词： asteroseismology stars: chemically peculiar stars: oscillations (including pulsations) techniques: photometric

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Fight or flee,a vital choice for Clostridioides difficile

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mLife 2024年第1期3卷 14-20页

作者： Ji Zeng Sshuying Fang Jinquan guo min Dong guo-Bao Tian Liang Tao School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhouChina Department of Brest Surgery Panyu Central Hospital.GuangzhouChina Department of Microbiology Harvard Medical SchoolBostonMassachusettsUSA Department of Urology Boston Children's HospitalHarvard Medical SchoolBostonMassachusettsUSA Department of Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Advanced Medical Technology Center The First Affiliated HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhouChina Key Laboratory of Tropical Diseases Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina School of Medicine Xizang Minzu UniversityXianyangChina Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineWestlake UniversityHangzhouChina Research Center for Industries of the Future School of Life SciencesWestlake UniversityHangzhouChina

Clostridioides difficile is a leading cause of healthcare-associated infections,causing billions of economic losses every *** symptoms range from mild diarrhea to life-threatening damage to the *** and recurrence of *** infection(CDl)are mediated by the metabolically dormant spores,while the virulence of *** is mainly due to the two large clostridial toxins,TcdA and *** toxins or forming spores are two different strategies for *** to cope with harsh environmental *** is of great significance to understand the molecular mechanisms for *** to skew to either of the cellular ***,we summarize the current understanding of the regulation and connections between toxin production and sporulation in *** and further discuss the potential solutions for yet-to-be-answered questions.

关键词： C.difficile sporulation TcdA TcdB toxin production

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Malignant myopericytoma originating from the colon: A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1918-1925页

作者： Heng-Li Zhang min Zhang Jing-Qiang guo Fang-Nan Wu Jin-De zhu Chao-Yong Tu Xin-Liang Lv Kun Zhang Department of General Surgery The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Myopericytoma is a benign tumor that typically occurs within subcutaneous tissue and most often involves the distal extremities,followed by the proximal extremities,neck,thoracic vertebrae and oral *** resection is often *** myopericytoma is extremely rare and has a poor ***,we report for the first time a case of malignant myopericytoma originating from the *** SUMMARY A 69-year-old male was admitted to our hospital with right upper quadrant pain for five *** suggested a liver mass with hemorrhage.A malignant hepatic tumor was the initial *** resection was performed after a complete preoperative work *** postoperative pathology suggested that the mass was a malignant myoblastoma unrelated to the *** months after the first surgery,an enhanced computed tomography(CT)scan revealed a recurrence of the *** diagnosis of malignant myopericytoma derived from the colon was confirmed on histopathological examination of the specimen from the second *** patient did not return to the hospital regularly for *** first postoperative abdominal CT examination six months after the second surgery demonstrated multiple liver *** time between the diagnosis of the tumor to death was approximately one *** Malignant myopericytoma is a rare *** diagnosis may be *** to a lack of treatment options,prognosis is poor.

关键词： Malignant myopericytoma Liver tumor Colonic neoplasms Abdominal pain

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