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Three-dimensional structural models,evolution and petroleum geological significances of transtensional faults in the Ziyang area,central Sichuan Basin,SW China

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Petroleum Exploration and Development 2024年第3期51卷 604-620页

作者： TIAN Fanglei guo Tonglou HE Dengfa GU Zhanyu MENG Xianwu WANG Renfu WANG Ying ZHANG Weikang lu guo School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Enrichment Mechanism Ministry of EducationBeijing 100083China Sinopec Southwest Oil and Gas Company Chengdu 610031China

With drilling and seismic data of Transtensional(strike-slip)Fault System in the Ziyang area of the central Sichuan Basin,SW China plane-section integrated structural interpretation,3-D fault framework model building,fault throw analyzing,and balanced profile restoration,it is pointed out that the transtensional fault system in the Ziyang 3-D seismic survey consists of the northeast-trending F_(I)19 and F_(I)20 fault zones dominated by extensional deformation,as well as 3 sets of northwest-trending en echelon normal faults experienced dextral shear *** them,the F_(I)19 and F_(I)20 fault zones cut through the Neoproterozoic to Lower Triassic Jialingjiang Formation,presenting a 3-D structure of an“S”-shaped *** before Permian and during the Early Triassic,the F_(I)19 and F_(I)20 fault zones underwent at least two periods of structural ***,the 3 sets of northwest-trending en echelon normal faults are composed of small normal faults arranged in pairs,with opposite dip directions and partially left-stepped *** before Permian,they had formed almost,restricting the eastward growth and propagation of the F_(I)19 fault *** F_(I)19 and F_(I)20 fault zones communicate multiple sets of source rocks and reservoirs from deep to shallow,and the timing of fault activity matches well with oil and gas generation *** there were favorable Cambrian-Triassic sedimentary facies and reservoirs developing on the local anticlinal belts of both sides of the F_(I)19 and F_(I)20 fault zones,the major reservoirs in this area are expected to achieve breakthroughs in oil and gas exploration.

关键词： transtensional(strike-slip)fault three-dimensional structural model structural evolution petroleum geological significance Ziyang area Sichuan Basin

Dynamics Modeling and Parameter Identification for a Coupled-Drive Dual-Arm Nursing Robot

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 243-257页

作者： Hao lu Zhiqiang Yang Deliang Zhu Fei Deng Shijie guo College of Electronic Information and Automation Tianjin University of Science and TechnologyTianjin 300222China Academy for Engineering&Technology Fudan UniversityShanghai 200433China Shanghai Engineering Research Center of AI&Robotics Shanghai 200433China School of Mechanical Engineering Hebei University of TechnologyTianjin 300130China

A dual-arm nursing robot can gently lift patients and transfer them between a bed and a *** its lightweight design,high load-bearing capacity,and smooth surface,the coupled-drive joint is particularly well suited for these ***,the coupled nature of the joint disrupts the direct linear relationship between the input and output torques,posing challenges for dynamic modeling and practical *** study investigated the transmission mechanism of this joint and employed the Lagrangian method to construct a dynamic model of its internal *** on this foundation,the Newton-Euler method was used to develop a dynamic model for the entire robotic arm.A continuously differentiable friction model was incorporated to reduce the vibrations caused by speed transitions to *** experimental method was designed to compensate for gravity,inertia,and modeling errors to identify the parameters of the friction *** method establishes a mapping relationship between the friction force and motor *** addition,a Fourier series-based excitation trajectory was developed to facilitate the identification of the dynamic model parameters of the robotic *** tracking experiments were conducted during the experimental validation phase,demonstrating the high accuracy of the dynamic model and the parameter identification method for the robotic *** study presents a dynamic modeling and parameter identification method for coupled-drive joint robotic arms,thereby establishing a foundation for motion control in humanoid nursing robots.

关键词： Nursing-care robot Coupled-drive joint Dynamic modeling Parameter identification

A mix & act liposomes of phospholipase A2-phosphatidylserine for acute brain detoxification by blood‒brain barrier selective-opening

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1827-1844页

作者： Zinan Zhang Wenbin Cao Huanchun Xing Shuai guo Lijuan Huang lin Wang Xin Sui Kui lu Yuan luo Yongan Wang Jun Yang State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institutes of Pharmacology and ToxicologyBeijing 100850China Tianjin University of Science and Technology Tianjin 300222China Hebei University of Science and Technology Shijiazhuang 050018China

In the treatment of central nervous system disease,the blood-brain barrier(BBB)is a major obstruction to drug delivery that must be *** this study,we propose a brain-targeted delivery strat-egy based on selective opening of the *** strategy allows some simple bare nanoparticles to enter the brain when mixed with special opening material;however,the BBB still maintains the ability to completely block molecules from passing *** on the screening of BBB opening and matrix delivery mate-rials,we determined that phospholipase A2-catalyzed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine li-posomes can efficiently carry drugs into the brain *** an effective dose,this delivery system is safe,especially with its effect on the BBB being *** mix&act delivery system has a simple structure and rapid preparation,making it a strong potential candidate for drug delivery across the BBB.

关键词： Liposomes Phospholipase A2 Phosphoserine Blood-brainbarrier Selectively open Mix&act

Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1006-1018页

作者： Jun-Jun lin Ye-Cai lu Department of Gastrointestinal Surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one very usual tumor together with higher death ***-specific protease 21(USP21)has been confirmed to take part into the regulation of CRC progression through serving as a ***,the promotive function of USP21 has also discovered in the progression of ***1 has illustrated to be modulated by USP7,USP22 and USP51 in ***,the regulatory functions of USP21 on ZEB1 in CRC progression need more *** To investigate the relationship between USP21 and ZEB1 in CRC *** The mRNA and protein expressions were assessed through RT-qPCR,western blot and IHC *** interaction between USP21 and ZEB1 was evaluated through Co-IP and GST pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,USP21 and ZEB1 exhibited higher expression in CRC,and resulted into poor ***,the interaction between USP21 and ZEB1 was further *** was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,USP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that USP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing *** discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of CRC.

关键词： Ubiquitin-specific protease 21 ZEB1 Stemness Colorectal cancer

Methane adsorption effected by pore structure of overmature continental shale:Lower Cretaceous Shahezi Formation,Xujiaweizi Fault,Songliao Basin

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Frontiers of Earth Science 2024年第1期18卷 172-187页

作者： Pengfei ZHANG Shuangfang lu Nengwu ZHOU Zizhi lin Xiangchun CHANG Junjian ZHANG guo CHEN Yumao PANG Junjie WANG Hongsheng HUANG Qi ZHI College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025China School of Geoscience China University of Petroleum(East China)Qingdao 266580China College of Resources and Environment Yangtze UniversityWuhan 430100China

Overmature continental shale is commonly developed,but few studies have given insight into its pore structure and sorption *** techniques,including SEM,helium porosity and permeability,N_(2)/CO_(2)adsorption,MICP,and NMR,were used to detect the pore structure of shale from the Shahezi Formation,Xujiaweizi Fault,Songliao *** excess methane adsorption volumes were measured by the volumetric method and modeled by the Langmuir *** on the findings,the most developed pores are intraparticle pores in clay minerals,followed by the dissolution pores in feldspar,but organic pores are *** selected shales have low helium porosity(mean 1.66%)and ultralow permeability(mean 0.0498×10^(−3)μm^(2)).The pore throats are at the nanoscale,and the pore-throat size distributions are unimodal,with most less than 50 *** studied shales are characterized by the lower specific surface area(SSA)and pore volume(PV)but the larger average pore *** total SSA is contributed by the micro-and mesopores,while the PV is dominated by meso-and *** pore structures are more complex and controlled by multiple factors,such as mineral compositions and diagenesis,but organic matter is not *** maximum absolute adsorption methane volume(VL)is 0.97−3.58 cm^(3)/g(mean 1.90 cm^(3)/g),correlating well with the total SSA,SSA,and pore volume of micropores,which indicates that methane is mainly adsorbed and stored in micropores,followed by mesopores.

关键词： continental shale pore structure methane adsorption Shahezi Formation Songliao Basin

Solar-and/or Radiative Cooling-Driven Thermoelectric Generators:A Critical Review

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Energy Engineering 2024年第10期121卷 2681-2718页

作者： Jinglong Wang lin lu Kai Jiao Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityHong Kong999077China

Thermoelectric generators(TEGs)play a critical role in collecting renewable energy fromthe sun and deep space to generate clean *** their environmentally friendly,reliable,and noise-free operation,TEGs offer diverse applications,including areas with limited power infrastructure,microelectronic devices,and wearable *** review thoroughly analyses TEG system configurations,performance,and applications driven by solar and/or radiative cooling,covering non-concentrating,concentrating,radiative cooling-driven,and dual-mode *** for solar absorbers and radiative coolers,simulation techniques,energy storage management,and thermal management strategies are *** integration of TEGs with combined heat and power systems is identified as a promising ***,TEGs hold potential as charging sources for electronic *** comprehensive review provides valuable insights into this energy collection approach,facilitating improved efficiency,reduced costs,and expanded *** also highlights current limitations and knowledge gaps,emphasizing the importance of further research and development in unlocking the full potential of TEGs for a sustainable and efficient energy future.

关键词： Thermoelectric generators solar energy radiative sky cooling applications

Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression

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Current Medical Science 2024年第1期44卷 144-155页

作者： lin WANG Qing-guang CHEN Hao lu Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic *** the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains *** study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and *** Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were *** sequencing was utilized to analyze differential gene expression and identify potential therapeutic *** vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 *** viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and *** expression levels were determined by Western blotting *** investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein *** The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in

关键词： Jianpi Qinghua formula diabetic cardiomyopathy AP-1 transcription factor apoptosis inflammation

A method for determining the layout of a yaw system based on the Delphi method and the analytic hierarchy process

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Clean Energy 2024年第4期8卷 49-60页

作者： ShuTing lin Lanxing lu Peng Zhang Hua Li School of Mechanical Engineering Sichuan UniversityChengdu 610065China

Wind power technology has been widely used due to its characteristics of environmental protection,sustainability and low *** yaw system plays a vital role in improving the energy capture efficiency of a wind ***,the method of layout determination is lacking in the yaw *** solve this problem,a method that combines the Delphi method and the analytic hierarchy process was proposed in this *** evaluation indexes,including transmission efficiency,ratio range,operating temperature range and others,were identified by screening 18 technical indicators using the Delphi ***,the evaluation system of the yaw system was ***,six configuration schemes were ***’scores of schemes were collected according to the evaluation system and the score matrix of evaluation indexes was *** hierarchical model of the evaluation indexes of the yaw system was established and the comprehensive weight was obtained by using the analytic hierarchy pro*** calculating the comprehensive evaluation score,the comprehensive evaluation result was *** 2Z-X(A)negative mechanism,which achieved the highest score of 0.9227,is the optimal scheme.A new method and specific process are provided for *** research gap in the scheme selection method for yaw systems is filled.

关键词： renewable energy generation wind power yaw system Delphi method analytic hierarchy process

Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification

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Nano Research 2024年第7期17卷 6475-6482页

作者： Jian lu Juan Gao Rui-Xuan Qian Shuai-Hua Wang Fa-Kun Zheng guo-Cong guo Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Fluorescence imaging can be employed in fields of medical treatment,astronomical exploration,and national defense *** fluorescence imaging often takes the single-photon techniques,which is vulnerable to background interference and ***,two-photon fluorescence imaging can achieve much higher-resolution fluorescence imaging for reducing scattering and deeper ***,by assembling the tetraphenylethylene backbones with nontoxic and non-noble K^(+)ions,compound 1([(Hdma)K(H_(2)ettc)]_(n),H_(4)ettc=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carboxylic acid)))with the crystallization-induced emissions exhibited charming fluorescence imaging under two-photon excitation microscopy(TPEM).Besides,luminescent powders based on compound 1 can achieve high-resolution fingerprint recognition,providing secure access control and identification for a novel authentication *** with the commercial fluorescent dyes coumarin-6,the as-synthesized compound 1 showed great solvent stability,indicating its durability against harsh ***,compound 1 shows mechanoluminescent properties for the perturbation of weak supramolecular interactions within ordered arrangements of the H_(2)ettc^(2−)*** novel compound has provided an important insight to the development of twophoton fluorescence imaging and advanced external-stimuli responsive materials.

关键词： crystallization-induced emission fluorescence imaging two-photon absorption fingerprint recognition mechanoluminescence