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MapReduce Based Parallel Bayesian Network for Manufacturing Quality Control

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1216-1226页

作者： Mao-Kuan Zheng Xin-guo ming Xian-Yu Zhang guo-ming li School of Mechanical Engineering Shanghai Jiao Tong University

Increasing complexity of industrial products and manufacturing processes have challenged conventional statistics based quality management approaches in the cir- cumstances of dynamic production. A Bayesian network and big data analytics integrated approach for manufacturing process quality analysis and control is proposed. Based on Hadoop distributed architecture and MapReduce parallel computing model, big volume and variety quality related data generated during the manufacturing process could be dealt with. Artificial intelligent algorithms, including Bayesian network learning, classification and reasoning, are embedded into the Reduce process. Relying on the ability of the Bayesian network in dealing with dynamic and uncertain problem and the parallel computing power of MapReduce, Bayesian net- work of impact factors on quality are built based on prior probability distribution and modified with posterior probability distribution. A case study on hull segment manufacturing precision management for ship and offshore platform building shows that computing speed accelerates almost directly pro- portionally to the increase of computing nodes. It is also proved that the proposed model is feasible for locating and reasoning of root causes, forecasting of manufacturing outcome, and intelligent decision for precision problem solving. The inte- gration ofbigdata analytics and BN method offers a whole new perspective in manufacturing quality control.

关键词： Bayesian network Big data analytics MapReduce Quality control

Reprogram to pluripotency: a new logic and a chemical cocktail

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National Science Review 2014年第1期1卷 6-7页

作者： Hongjun Song guo-li ming Institute for Cell Engineering Departments of Neurology and Neuroscience Johns Hopkins University School of Medicine

Somatic cells rom animals and humans can be reprogrammed into pluripotent stem cells by pluripotency *** Deng and colleagues discovered that pluripotency can also be induced with exogenous lineage speciiers via balancing competing diferentiation *** a related study they achieved,for the irst time,restoration of pluripotency in adult somatic cells using a chemical cocktail alone.

关键词： GATA Reprogram to pluripotency a new logic and a chemical cocktail PSCs SOX

Synthesis, Crystal Structure and Biological Activity of 2-Chloro-N-{2-fluoro-5-[N-(phenylsulfonyl) phenyl-sulfonamido]phenyl}benzamide

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Chemical Research in Chinese Universities 2008年第3期24卷 295-298页

作者： li Wen-ming WANG Jian-guo li Zheng-ming SONG Hai-bin Elemento-Organic Chemistry Institute State Key Laboratory of Elemento-Organic Chemistry National Pesticide Engineering Research Center Nankai University Tianjin 300071 P R. China

2-Chloro-N-{2-fluoro-5-[N-（phenylsulfonyl）phenylsulfonamido]phenyl}benzamide was synthesized and its crystal structure was also determined by X-ray single-crystal diffraction. The title compound（C25H18ClFN2O5S2） belongs to monoclinic, space group P21/n with a=0.7377（3） nm, b=1.2036（5） nm, c=2.6846（11） nm, β=90.895（9）°, V=2.3833（16） nm3, Mr=544.98, Z=4, Dc=1.519 g/cm3, μ=0.385 mm–1, F（000）=1120, R1=0.0632, and wR2=0.1438. Its crystal structure belongs to a novel class that has not been reported yet, and its preliminary herbicidal activity was also tested. Its inhibition rate to seedling growth of barnyard grass reaches 15.1% at 100 μg/mL.

关键词： X-ray diffraction Crystal structure Synthesis Biological activity

EFFECT OF DRILLPIPE ROTATION ON BOREHOLE CLEANING FOR EXTENDED REACH WELL

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Journal of Hydrodynamics 2009年第3期21卷 366-372页

作者： WANG Zhi-ming guo Xiao-le li ming HONG Yu-kui College of Oil and Gas Engineering China University of Petroleum Beijing 102249 China

Wellbore cleaning is a key technology for the Extended Reach Drilling （ERD）. The success of drilling extended reach wells depends directly upon the quality of wellbore cleaning. The rotation of the drillpipe, and hydraulic and rheological parameters, are the key factors for wellbore cleaning. In this study, Computational Fluid Dynamics （CFD） is applied to simulate solid-liquid two-phase flows in wellbore annulus. The annual flow field with the presence of drillpipe rotation is described through analyzing various rotation conditions. The results indicate that the quasi-spiral flow is the main flow pattern for liquid-solid transport in the horizontal annulus. The influence of rotation on the cuttings transport is also investigated, as the rotation of drillpipe increases the disturbance of liquid to solid in annulus. As a result, the solid flow becomes favorable and the solid volume is reduced. Comparisons with previously published results are also performed to prove the importance of drillpipe rotation in the wellbore clearing for the ERD.

关键词： Extended Reach Drilling (ERD) borehole cleaning solid-liquid two-phase flow drillpipe rotation simulation spiral flow

The Cysteine Pairs in CLV2 are Not Necessary for Sensing the CLV3 Peptide in Shoot and Root Meristems

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Journal of Integrative Plant Biology 2010年第9期52卷 774-781页

作者： Xiufen Song Peng guo Chen li Chun-ming liu Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China

Receptor-like proteins （RLPs） are involved in both plant defense and developmental processes. Previous genetic and biochemical studies show that the leucine-rich repeat （LRR） receptor-like protein CLAVATA2 （CLV2） functions together with CLAVATA1 （CLV1） and CORYNE （CRN） in Arabidopsis to limit the stem cell number in shoot apical meristem, while in root it acts with CRN to trigger a premature differentiation of the stem cells after sensing the exogenously applied peptides of CLV3p, CLE19p or CLE40p. It has been proposed that disulfide bonds might be formed through two cysteine pairs in the extracellular LRR domains of CLV1 and CLV2 to stabilize the receptor complex. Here we tested the hypothesis by replacing these cysteines with alanines and showed that depletions of one or both of the cysteine pairs do not hamper the function of CLV2 in SAM maintenance. In vitro peptide assay also showed that removal of the cysteine pairs did not affect the perception of CLV3 peptides in roots. These observations allow us to conclude that the formation of disulfide bonds is not needed for the function of CLV2.

关键词： Proteins Protein products Roots Stems Shoots Cells Rooting Senses Peptides Cysteine

Loss of chromatin modulator Dpy30 compromises proliferation and differentiation of postnatal neural stem cells

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Journal of Molecular Cell Biology 2020年第1期12卷 2-3页

作者： Ting Zhao Yan Hong guo-li ming Hongjun Song Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Epigenetic regulation via chromatin modulation plays pivotal roles in regulating neural stem cells(NSCs)both during embryonic development and in adult neurogenesis(Yao et al.,2016).One classic epigenetic mechanism is covalent post-translational modifications to histone proteins,including methylation,phosphorylation,acetylation,ubiquitination,and *** particular,methylation of histone H3 at K4 and K27 positions act antagonistically to maintain active and repressed gene expression states,*** it is established that gene expression regulated by H3K27 methylation is one of the major determinants of the capacity of NSCs for either self-renewal or lineage differentiation,little is known about the role of H3KA methylation in NSC regulation(Albert and Huttner,2018).

关键词： neural modulator maintain

Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in vitro

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World Journal of Gastroenterology 2006年第8期12卷 1303-1307页

作者： lian-Sheng Wang Ying-Wei Chen Ding-guo li Han-ming Lu Digestive Disease Laboratory Xinhua Hospital Shanghai Second Medical University Shanghai 200092 China

AIM： To investigate the effect of arg-gly-asp-mannose-6 phosphate （RGD-M6P） on the activation and proliferation of primary hepatic stellate cells in vitro. METHODS： Hepatic steUate cells （HSCs） were isolated from rats by in situ collagenase perfusion of liver and 18% Nycodenz gradient centrifugation and cultured on uncoated plastic plates for 24 h with DMEM containing 10% fetal bovine serum （FBS/DMEM） before the culture medium was substituted with 2% FBS/DMEM for another 24 h. Then, HSCs were cultured in 2% FBS/DMEM with transforming growth factor 131, M6P, RGD, or RGD- M6P, respectively. Cell morphology was observed under inverted microscope, smooth muscle α-actin （α-SMA） was detected by immunocytochemistry, type Ⅲ procollagen （PCⅢ） in supernatant was determined by radioimmunoassay, and the proliferation rate of HSCs was assessed by flow cytometry. RESULTS： RGD-M6P significantly inhibited the morphological transformation and the α-SMA and PC Ⅲ expressions of HSCs in vitro and also dramatically prevented the proliferation of HSCs in vitro. Such effects were remarkably different from those of RGD or M6R CONCLUSION： The new compound, RGD-M6P, which has a dramatic effect on primary cultured HSCs in vitro, can inhibit the transformation of HSCs in culture caused by TGFβ1, suppresses the expression of PCIII and decreases proliferation rate of HSC. RGD-M6P can be applied as a selective drug carrier targeting at HSCs, which may be a new approach to the prevention and treatment of liver fibrosis.

关键词： RGD Mannose-6-phosphate Hepatic stellate cell liver fibrosis

Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders

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Frontiers in Biology 2012年第3期7卷 179-188页

作者： Kimberly M. CHRISTIAN Hongjun SONG guo-li ming Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA The Solomon Snyder Department of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Cellular reprogramming allows for the de novo generation of human neurons and glial cells from patients with neurological and psychiatric disorders. Crucially, this technology preserves the genome of the donor individual and thus provides a unique opportunity for systematic investigation of genetic influences on neuronal pathophysiology. Although direct reprogramming of adult somatic cells to neurons is now possible, the majority of recent studies have used induced pluripotent stem cells （iPSCs） derived from patient fibroblasts to generate neural progenitors that can be differentiated to specific neural cell types. Investigations of monogenic diseases have established proof-of-principle for many aspects of cellular disease modeling, including targeted differentiation of neuronal populations and rescue of phenotypes in patient iPSC lines. Refinement of protocols to allow for efficient generation of iPSC lines from large patient cohorts may reveal common functional pathology and genetic interactions in diseases with a polygenic basis. We review several recent studies that illustrate the utility of iPSC-based cellular models of neurodevelopmental and neurodegenerative disorders to identify novel phenotypes and therapeutic approaches.

关键词： reprogramming iPSCs neurodevelopment neurodegeneration

Numerical simulation study of the influence on stability of slope by underground mining under opencast coal mine slope

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Journal of Coal Science & Engineering(China) 2011年第4期17卷 397-400页

作者： liU Ting-ting LU guo-bin TONG li-ming School of Mining Liaoning Technical University Fuxin 123000 China

In view of the study on mining transferred from open-pit to underground, the research on the problem of the stabil- ity of slope is less. This article combined the actual situation of the Gaohai Coal Mine in Fuxin City and set up a three-dimensional model of the part of Huizhou open-pit slope by the finite difference software. Through the three-dimensional numerical simulation study of the influence on the stability of slope by underground mining, the basic characteristics of the open-pit slope deformation and the situation of basic stability were discussed. The simulation results of the mining slope of the displacement and deformation analysis of the state for mining provide a reference to the slope stability research.

关键词： numerical simulation slope stability open-pit mine pit mining