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Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China

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World Journal of Gastroenterology 2010年第47期16卷 6020-6025页

作者： guo-hong zhang Bo Huang Rui-Qin Mai Department of Pathology Medical College of Shantou University Shantou 515031 Guangdong Province China Department of Laboratory Medicine the FirstAfliated HospitalMedical CollegeShantou UniversityShantou 515041Guangdong ProvinceChina

AIM: To evaluate whether alcohol dehydrogenase-1B (ADH1B) His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu487Lys polymorphism is involved in the esophageal squamous cell carcinoma (ESCC) risk in Chinese Han population. METHODS: Seven studies of ADH1B and ALDH2 genotypes in Chinese Han population in 1450 cases and 2459 controls were included for meta-analysis. Stratified analyses were carried out to determine the genealcohol and gene-gene interaction with ESCC risk. Potential sources of heterogeneity between studies were explored, and publication bias was also evaluated. RESULTS: Individuals with ADH1B arginine (Arg)/Arg genotype showed 3.95-fold increased ESCC risk in the recessive genetic model [Arg/Arg vs Arg/histidine (His) + His/His: odds ratio (OR) = 3.95, 95% confidence in- terval (CI): 2.76-5.67]. Signif icant association was found in the dominant model for ALDH2 lysine (Lys) allele [glutamate (Glu)/Lys + Lys/Lys vs Glu/Glu: OR = 2.00,95% CI: 1.54-2.61]. Compared with the non-alcoholics, Arg/Arg (OR = 25.20, 95% CI: 10.87-53.44) and Glu/ Lys + Lys/Lys (OR = 21.47, 95% CI: 6.44-71.59) were found to interact with alcohol drinking to increase the ESCC risk. ADH1B Arg+ and ALDH2 Lys+ had a higher risk for ESCC (OR = 7.09, 95% CI: 2.16-23.33). CONCLUSION: The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption. The individuals carrying both risky genotypes have a higher baseline risk of ESCC.

关键词： Esophageal cancer Alcohol metabolizing enzyme genes Polymorphism Susceptibility

Evolution of Hydrogen Storage Alloys Prepared by Special Methods

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Journal of Rare Earths 2004年第Z1期22卷 222-227页

作者： guo hong zhang Ximin Jing Hai Li Chengdong Xu Jun National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China National Engineering and Technology Research Center for Non-Ferrous Metals Composites General Research Institute for Non-Ferrous Metals Beijing 100088 China

Microstructure characteristics and electrochemical properties of hydrogen storage alloys prepared by gas atomization, melt spinning and strip casting respectively were *** advantages, disadvantages and research development of the above methods for preparing hydrogen storage alloys were *** strip casting is a new special means for preparing AB5 rare earth hydrogen storage alloys of high performance and low cost, and the study of the strip casting for preparing hydrogen storage alloys is presented specially.

关键词： hydrogen storage alloys gas atomization melt spinning strip casting rare earths

Micromagnetism simulation on effects of soft phase size on Nd2Fe14B/α-Fe nanocomposite magnet with soft phase imbedded in hard phase

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Chinese Physics B 2018年第8期27卷 529-534页

作者： Yu-Qing Li Ming Yue Yi Pen hong-guo zhang College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China

In this study, micromagnetism simulation by using timte dltterence method is cameo out on the Ncl21-el415/a-Fe nanocomposite magnet with soft phase imbedded in hard phase. The effects of soft magnetic phase size （S） on the magnetic properties and magnetic reversal modes are systematically analyzed. As S increases from 1 nm to 48 nm, the remanence （Jr） increases, while the coercivity （Hci） decreases, leading to the result that the magnetic energy prod- uct [（BH）max] first increases slowly, and then decreases rapidly, peaking at S = 24 nm with the （BH）max of 72.9 MGOe （1 MGOe = 7.95775 kJ.m-3）. Besides, with the increase of S, the coercivity mechanism of the nanocomposite magnet changes from nucleation to pinning. Furthermore, by observing the magnetic moment evolution in demagnetization pro- cess, the magnetic reversal of the soft phase in the nanocomposite magnet can be divided into three modes with the increase of S： coherent rotation （S 〈 3 nm）, quasi-coherent rotation （3 nm≤S 〈 36 nm）, and the vortex-like rotation （S ≥36 nm）.

关键词： micromagnetism simulation magnetization dynamics, Nd2Fe14B/a-Fe nanocomposite magnets

Growth Kinetics of Proeutectoid Ferrite in an Fe-0.09C-1.5Mn-0.2Si Steel

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Journal of Iron and Steel Research International 2014年第10期21卷 964-968页

作者： Lin CHENG Kai-ming WU Xiang-liang WAN guo-hong zhang The State Key Laboratory of Refractories and Metallurgy Hubei Collaborative Innovation Center for Advanced SteelsInternational Research Institute for Steel TechnologyWuhan University of Science and Technology

Growth kinetics of proeutectoid ferrite, including grain boundary face nucleated ferrite, grain boundary edge nucleated ferrite allotriomorph and intragranular ferrite idiomorph, were experimentally measured in an Fe- 0.09C-1.5Mn-0.2Si steel and compared with theoretical calculation in local equilibrium and paraequilibrium modes. Grain boundary edge nucleated ferrite exhibited larger growth rate than grain boundary face nucleated ferrite and in- tragranular ferrite idiomorph. Experimental kinetics of proeutectoid ferrite was within the window defined by the lo- cal equilibrium and paraequilibrium limits. A transition of growth kinetics from paraequilibrium to local equilibrium was observed in the temperature range of 650--750 ℃, which can be explained in terms of solute drag.

关键词： steel proeutectoid ferrite kinetics solute drag

Dynamic impedance of piles in visco-elastic material considering axial loads

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Journal of Central South University of Technology 2005年第Z1期12卷 162-167页

作者： JIANG Jian-guo ZHOU Xu-hong zhang Jia-sheng School of Civil Engineering and Architecture Central South University Changsha 410075 China School of Civil Engineering and Architecture Chang''an University Xi''an 710064 China School of Civil Engineering and Architecture Central South University Changsha 410075 China

The dynamic impedance function of pile in visco-elastie material considering axial loads under lateral dynamic force was analyzed, and the beam dynamic differential equation was used to induce the dynamic impedance function. After analyzing the edge conditions, the dynamic impedance functions were deduced. Contrasted with the result that does not consider axial loads, the axial loads have obvious influence on the dynamic impedance *** the results show that the dimensionless prarmeter of the dynamic impedance will change from 6 % to 9 % when considering axial loads, and dimensionless prarmeter of the dynamic impedance of the coupling horizontal-sway will increase by 31 %.

关键词： impedance function dynamic analysis axial loads

Effect of 1,25-dihydroxyvitamin D3 on mast cells tryptase in asthmatic guinea pigs

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 493-496页

作者： Xiao-He Zheng Gui-Dong zhang guo-hong zhang Rui-Qin Mai Ling Shen Department of Respiratory Medicine 1st Affiliated Hospital of Medical College of Shantou University

Objective:To explore the effect of 1,25-dihydroxyvitamin D3 on the mast cell tryptase(MCT) in asthmatic guinea ***:A total of 60 male or female healthy guinea pigs were randomly divided into control group(group A),asthmatic group(group B).and 1,25-dihydroxyvitamin D3 group(group C),with 20 cases in each *** establish asthmatic guinea pig models,1ml peanut oil was tilled into stomach in the morning in group A and group *** 1 ml peanut oil with 1,25-dihydroxyvitamin D3 was filled into stomach in group *** resistance(Re) of asthmatic guinea pigs was detected,and the bronchoalveolar lavage fluid(BALF) cells were *** tissue with HE and MCT immunohistochemical staining were used to observe the pathological changes in lung tissue and the distribution of ***:After injection of different concentration of acetylcholine chloride,the Re in group B and group C were increased significantly compared with group A(P<0.05):compared with group *** Re in group C were decreased significantly(t=-5.385.-5.761.-6.184.-13.574.P<0.05):the total number of BALF cells and eosinophils were increased significantly in group B and C(t=19.618.9.598.10.854.5.388.P<0.05);compared with group *** total number of BALF cells and eosinophils in group C was decreased significantly(t=-5.555.-5.392.P<0.05):the number of tryptase positive cells in group B was increased significantly than that in group A(t=21.312,P<0.05),and in addition to the alveolar septum and submucosa,the cells were also distributed around blood vessels and outside the cells:the number of tryptase positive cells in group C was decreased significantly compared with group *** the difference was statistically significant(t=5.043.P<0.05).Conclusions:After the asthmatic guinea pigs arc treated with 1,25-dihydroxyvitamin D3,their *** degree of inflammatory cells in the trachea and lung tissue and airway inflammatory reaction are reduced significantly.1,25-dihydroxyvitamin D3 has a cert

关键词： 1,25-dihydroxyvitamin D3 Asthmatic guinea pigs Expiratory airway resistance Mast cell tryptase

Fine Mapping and Cloning of the Grain Number Per-Panicle Gene (Gnp4) on Chromosome 4 in Rice (Oryza sativa L.)

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Agricultural Sciences in China 2011年第12期10卷 1825-1833页

作者： zhang Zhan-ying LI Jin-jie YAO guo-xin zhang hong-liang DOU Hui-jing SHI hong-li SUN Xing-ming LI Zi-chao Key Laboratory of Crop Heterosis and Utilization Ministry of Agriculture/Beijing Key Laboratory of Crop Genetic Improvement ChinaAgricultural University Beijing 100193 P.R.China

Grain number per-panicle is one of the most important components for rice yield. Spikelets on the primary and secondary branches determine the grain number per-panicle in rice. In this study, we identified a natural mutant, gnp4, lack of lateral spikelet on the secondary branches in the field condition. In addition, the Gnp4 and Lax1-1 double mutant showed dramatically reduced secondary branches and spikelets in panicle at reproductive stage, and tillers at vegetative stage. By map-based cloning approach, and using four F2 segregating populations, the Gnp4 gene was finally mapped to a 10.7-kb region on the long arm of chromosome 4 in rice. In this region, only one gene was predicted, and genomic DNA sequencing of the 10.7-kb region showed no nucleotide differences between the mutant and wild type. Interestingly, we found that the methylation level of several cytosines in the promoter CpG islands region of the predicted gene in gnp4 were different from the wild type. Thus, we propose that the DNA methylation changes at these sites may induce to decrease expression level of Gnp4, consequently, resulting in phenotypic variation.

关键词： rice gnp4 laxl-1 grain number per-panicle methylation

Associations of sex hormone levels with body mass index(BMI)in men:a cross-sectional study using quantile regression analysis

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Asian Journal of Andrology 2023年第1期25卷 98-102页

作者： Xin Lv Yu-Ting Jiang Xin-Yue zhang Lei-Lei Li hong-guo zhang Rui-Zhi Liu Center of Reproductive Medicine and Center of Prenatal Diagnosis The First Hospital of Jilin UniversityChangchun 130021China

Body mass index(BMI)has been increasing globally in recent *** studies reported that BMI was associated with sex hormone levels,but the results were generated via linear regression or logistic regression,which would lose part of *** regression analysis can maximize the use of variable *** study compared the associations among different regression *** participants were recruited from the Center of Reproductive Medicine,The First Hospital of Jilin University(Changchun,China)between June 2018 and June *** used linear,logistic,and quantile regression models to calculate the associations between sex hormone levels and *** total,448 men were included in this *** average BMI was 25.7(standard deviation[s.d.]:3.7)kg m^(-2);29.7%(n=133)of the participants were normal weight,45.3%(n=203)of the participants were overweight,and 23.4%(n=105)of the participants were *** levels of testosterone and estradiol significantly differed among BMI groups(all P<0.05).In linear regression and logistic regression,BMI was associated with testosterone and estradiol levels(both P<0.05).In quantile regression,BMI was negatively associated with testosterone levels in all quantiles after adjustment for age(all P<0.05).BMI was positively associated with estradiol levels in most quantiles(≤80^(th))after adjustment for age(all P<0.05).Our study suggested that BMI was one of the influencing factors of testosterone and *** note,the quantile regression showed that BMI was associated with estradiol only up to the 80^(th) percentile of estradiol.

关键词： body mass index estradiol obesity overweight testosterone

Optimal Robust Estimation for Linear Uncertain Systems with Single Delayed Measurement

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自动化学报 2008年第2期34卷 202-207页

作者： ZHAO hong-guo zhang Huan-Shui zhang Cheng-Hui School of Control Science and Engineering Shandong University Jinan 250061 P.R. China

这份报纸与单个推迟的测量为线性不明确的系统处理最佳的柔韧的评价问题。最佳的柔韧的评估者基于重新组织的革新分析途径被导出。最佳的柔韧的评估者的计算涉及解决象原来的系统的一样的尺寸的二个 Riccati 差别方程和一个 Lyapunov ... 详细信息

这份报纸与单个推迟的测量为线性不明确的系统处理最佳的柔韧的评价问题。最佳的柔韧的评估者基于重新组织的革新分析途径被导出。最佳的柔韧的评估者的计算涉及解决象原来的系统的一样的尺寸的二个 Riccati 差别方程和一个 Lyapunov 方程。一个数字例子被给显示出建议途径的有效性。

关键词：最佳强估计线性不确定系统延时测量差分方程