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Role of transforming growth factor-beta1-smad signal transduction pathway in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第4期12卷 644-648页

作者： guo-zhong ji Xue-Hao Wang Lin Miao Zheng Liu Ping Zhang Fa-Ming Zhang jian-Bing Yang Department of Gastroenterology Second Affiliated Hospital of Nanjing Medical University Nanjing 210011 Jiangsu Province China Department of Hepatic Surgery First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China Qidong Liver Cancer Institute Qidong 226200 Jiangsu Province China

AIM： To explore the role of transforming growth factorbeta1 （TGF-β1）-smad signal transduction pathway in patients with hepatocellular carcinoma. METHODS： Thirty-six hepatocellular carcinoma specimens were obtained from Qidong Liver Cancer Institute and Department of Pathology of the Second Affiliated Hospital of Nanjing Medical University. All primary antibodies （polyclonal antibodies） to TGF-β1, type H Transforming growth factor-beta receptor （TβR-Ⅱ）, nuclear factor-kappaB （NF-KB）, CD34, smad4 and smad7, secondary antibodies and immunohistochemical kit were purchased from zhongshan Biotechnology Limited Company （Beijing, China）. The expressions of TGF-β1, TβR-Ⅱ, NF- KB, smad4 and smad7 proteins in 36 specimens of hepatocellular carcinoma （HCC） and its adjacent tissue were separately detected by immunohistochemistry to observe the relationship between TGF-β1 and TβR-Ⅱ, between NF-KB and TGF-β1, between smad4 and smad7 and between TGF-β1 or TβR-Ⅱ and microvessel density （MVD）. MVD was determined by labelling the vessel endothelial cells with CD34. RESULTS： The expression of TGF-β1, smad7 and MVD was higher in HCC tissue than in adjacent HCC tissue （P〈0.01, P〈0.05,P〈0.01 respectively）. The expression of TβR-Ⅱ and smad4 was lower in HCC tissue than in its adjacent tissue （P〈0.01, P〈0.05 respectively）. The expression of TGF-β1 protein and NF-KB protein was consistent in HCC tissue. The expression of TGF-β1 and MVD was also consistent in HCC tissue. The expression of TIER- Ⅱ was negatively correlated with that of MVD in HCC tissue. CONCLUSION： The expressions of TGF-IB1, TβR- Ⅱ, NF-KB, smad4 and smad7 in HCC tissue, which are major up and down stream factors of TGF-β1-smad signal transduction pathway, are abnormal. These factors are closely related with NVD and may play an important role in HCC angiogenesis. The inhibitory action of TGF-β1 is weakened in hepatic carcinoma cells because of abnormality of TGF-β1 receptors （such as TIBR- Ⅱ） and postreceptors （such as

关键词： TGF-β1, TβR-Ⅱ Smad4, Smad7, NF-kB,MVD, Hepatocellular carcinoma, Signal transduction

Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events

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World Journal of Clinical Cases 2020年第14期8卷 2988-2999页

作者： Fatema Tabak Hui-Shan Wang Quan-Peng Li Xian-Xiu Ge Fei Wang guo-zhong ji Lin Miao Institute of Digestive Endoscopy and Medical Centre for Digestive Disease Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is a valuable therapeutic technique for pancreatobiliary diseases,and its application in the elderly is no longer ***,a higher incidence of procedure difficulty and periprocedural adverse events might be expected in elderly patients due to the presence of other medical disorders and the poor general condition of this *** To evaluate the incidence,causes,and management of difficult biliary cannulation during ERCP in elderly patients and the role of difficult cannulation as a risk factor for adverse *** A total of 614 patients who underwent ERCP during the study period were prospectively studied and divided into two groups based on their *** hundred and forty-six patients were aged 80 years or older and 468 patients were aged less than 80 *** primary outcome measurements were cannulation difficulty,cannulation success rate,ERCP procedure time,and related adverse *** There was no difference in the incidence of difficult cannulation among the two groups(32.9%vs 34.4%,P=0.765),as well as in the cannulation success rate(96.6%vs 96.8%,P=0.54).The cannulation techniques were shown to be safe and efficient in achieving successful *** regression analysis showed that patients aged 80 years or older were not associated with increased adverse events;however,difficult cannulation cases[adjusted odds ratio(AOR)=3.478;95%confidence interval(CI):1.877-6.442;P<0.001]and patients with Charlson Comorbidity Index≥2(AOR=1.824;95%CI:0.993-3.349;P=0.045)were more likely to develop adverse *** contrast,other factors including age≤65(AOR=3.460;95%CI:1.511-7.922;P=0.003),female gender(AOR=2.362;95%CI=1.089-5.124;P=0.030),difficult cannulation(AOR=4.527;95%CI:2.078-9.860;P<0.001),and patients with cholangitis(AOR=3.261;95%CI:1.204-8.832;P=0.020)were strongly associated with a higher rate of post-ERCP *** Advanced age has not been prove

关键词： Endoscopic retrograde cholangiopancreatography Difficult cannulation Cannulation techniques Elderly Adverse events Post-endoscopic retrograde cholangiopancreatography pancreatitis

Fecal microbiota transplantation and prednisone for severe eosinophilic gastroenteritis

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World Journal of Gastroenterology 2014年第43期20卷 16368-16371页

作者： Yi-Xuan Dai Chuan-Bing Shi Bo-Ta Cui Min Wang guo-zhong ji Fa-Ming Zhang Department of Digestive Endoscopy and Medical Center for Digestive Diseases Second Affiliated Hospital of Nanjing Medical University

Eosinophilic gastroenteritis is a rare disease of unknown etiology. It is characterized by patchy or diffuse eosinophilic infiltration of the bowel wall to a variable depth and various gastrointestinal manifestations. We describe a case of severe eosinophilic gastroenteritis presenting as frequent bowel obstruction and diarrhea in a 35-year-old man. The patient was misdiagnosed and underwent surgery because of intestinal obstruction when he was first admitted to a local hospital. Then he was misdiagnosed as having Crohn’s disease in another university teaching hospital. Finally, the patient asked for further treatment from our hospital because of the on-going clinical trial for treating refractory Crohn’s disease by fecal microbiota transplantation. Physical examination revealed a slight distended abdomen with diffuse tenderness. Laboratory investigation showed the total number of normal leukocytes with neutrophilia as 90.5%, as well as eosinopenia, monocytopenia and lymphocytopenia. Barium radiography and sigmoidoscopy confirmed inflammatory stenosis of the sigmoid colon. We diagnosed the patient as having eosinophilic gastroenteritis by multi-examinations. The patient was treated by fecal microbiota transplantation combined with oral prednisone, and was free from gastrointestinal symptoms at the time when we reported his disease. This case highlights the importance of awareness of manifestations of a rare disease like eosinophilic gastroenteritis.

关键词： Eosinophilic gastroenteritis Bowel obstruction Diarrhea Fecal microbiota transplantation Prednisone

Association between body mass index and erosive esophagitis:A meta-analysis

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World Journal of Gastroenterology 2012年第20期18卷 2545-2553页

作者： Nan cai guo-zhong ji Zhi-Ning Fan Yan-Feng Wu Fa-Ming Zhang Zhi-Fei Zhao Wei Xu Zheng Liu Department of Digestive Endoscopy and Medical Center for Digestive Diseases the Second Affiliated Hospital of Nanjing Medical University 121 Jiangjiayuan Road Nanjing 210011 Jiangsu Province China Department of Neurology the Second Affiliated Hospital of Nanjing Medical University 121 Jiangjiayuan Road Nanjing 210011 Jiangsu Province China

AIM:To conduct a meta-analysis to estimate the determinants of the association between erosive esophagitis (EE)and body mass index(BMI). METHODS:We identified the studies using PubMed. Studies were selected for analysis based on certain inclusion and exclusion *** were extracted from each study on the basis of predefined *** were performed to verify the risk factors,such as obesity and gender. RESULTS:Twenty-one studies were included in this systematic *** studies demonstrated an association between increasing BMI and the presence of EE[95%confidence interval(CI):1.35-1.88,overweight,odds ratio(OR)=1.60,P value homogeneity =0.003,95%CI:1.65-2.55,obese,OR=2.05,P< 0.01].The heterogeneity disappeared by stratifying for *** publication bias was observed in this metaanalysis by the Egger method. CONCLUSION:This analysis demonstrates a positive association between BMI and the presence of EE,especially in *** risk seems to progressively increase with increasing weight.

关键词： Erosive esophagitis Gastroesophageal reflux disease Obesity Body mass index Meta-analysis

Fecal microbiota transplantation cured epilepsy in a case with Crohn's disease: The first report

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World Journal of Gastroenterology 2017年第19期23卷 3565-3568页

作者： Zhi He Bo-Ta Cui Ting Zhang Pan Li Chu-Yan Long guo-zhong ji Fa-Ming Zhang Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University Key Lab of Holistic Integrative Enterology Nanjing Medical University

Fecal microbiota transplantation(FMT)is a promising strategy that involves reconstruction of gut ***,it has been considered as a treatment of Crohn’s disease(CD)and certain neurological ***,to the best of our knowledge,we report the first case that used FMT to achieve remission of intestinal and neurological symptoms in a girl with CD and a 17-year history of *** the 20 mo of follow-up,FMT has proved its efficacy in preventing relapse of seizures after withdrawing the antiepileptic ***,this finding highlights the role of microbiota-gut-brain axis and inspires a novel treatment for epilepsy through remodeling gut microbiota.

关键词： Fecal microbiota transplantation Epilepsy Crohn's disease Gut microbiota Brain-gut axis

Aortoesophageal fistula caused by descending aortic pseudoaneurysm:one case report

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Chinese Medical Journal 2007年第23期120卷 2149-2150页

作者： XIA Min guo ji-zhong ZHAN Qiang YAN jie Department of Digestive Diseases Wuxi First Hospital Nanjlng Medical University Wuxi 214002 China

Aortoesophageal fistula （AOF） is a rare（0.01%-0.08%）, but life threatening cause of upper gastrointestinal haemorrhage. Early diagnosis and surgical intervention are mandatory for survival. We report a case of an aortoesophageal fistula due to a descending aortic pseudoaneurysm and review the causes, clinical manifestations, diagnosis and treatment of this uncommon but often fatal cause of upper gastrointestinal haemorrhage.

关键词： FISTULA REPAIR ANEURYSM

A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

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Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： Yi-Xuan Li Liang-Ying Wu Yan Yang Yao-zhong Lu zhong-Ying ji Yu-Xiong guo Xiao-Long Wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability

In situ anchoring in carbon matrix of Bi_(2)O_(2)CO_(3) as a high-performance anode material for Li-ion batteries

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Rare Metals 2024年第8期43卷 3634-3646页

作者： Pu-Qiang He Jun guo Hui Huang zhong-Cheng guo Faculty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Research Center of Metallurgical Electrode Materials Engineering Technology Kunming 650106China Kunming Hendera Science and Technology Co. Ltd.Kunming 650106China

Bismuth-based anode materials have been regarded as promising Li-ion batteries due to their high theoretical ***,their low conductivity and associated volume expansion inhabited their *** this work,Bi_(2)O_(2)CO_(3)@C composites were successfully synthesized by in situ anchoring of flower-like Bi_(2)O_(2)CO_(3) nanosheets on a carbon-based substrate via *** unique composited structure of Bi_2O_(2)-CO_(3)@C leads to a stable specific capacity of 547 mAh·g^(-1)after 100 cycles at a current density of 0.1 A·g^(-1).Notably,it demonstrates excellent rate capability with a specific capacity of 210 mAh·g^(-1)at 5 A·g^(-1).After 550 cycles at a current density of 0.5 A·g^(-1),a high reversible capacity of nearly 400 mAh·g^(-1)was ***,in situ X-ray diffraction measurements clearly demonstrate the conversion between Bi and Li_(3)Bi during alloying/dealloying,confirming the good electrochemical reversibility of the materials for Li *** reaction kinetics of Bi_(2)O_(2)CO_(3)@C were further investigated using galvanostatic intermittent titration ***,Bi_2O_(2)-CO_(3)@C exhibited excellent long-term stability,maintaining its high reversible capacity for over 200 cycles at a current density of 0.5 A·g^(-1)in a full cell configuration using Li_(1.20)Mn_(0.54)Ni_(0.13)Co_(0.13)O_(2) as the cathode *** result further underscores its promising potential for lithium-ion *** work may provide inspiration for the design of alloy-type negative electrode materials for high-performance rechargeable batteries.

关键词： Bi_(2)O_(2)CO_(3) Composite materials Anode materials Full batteries

Multiple exciton generation effect in photocatalytic overall water splitting

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Science China Chemistry 2024年第2期67卷 424-425页

作者： Xiaolei guo ji-Jun Zou Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin300072China

This highlight is based on recent research published in Nature Energy by Li and co-workers [1] from Northwestern Polytechnology University, reporting an exceeding 100% internal quantum efficiency(IQE) in photocatalytic overall water splitting. This breakthrough promises a bright future for efficient photocatalyst design by utilizing the multiple exciton effect(MEG).

关键词： splitting effect utilizing