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Influence of antiviral drugs combined with antioxidant therapy on liver injury and fibrosis process in patients with chronic hepatitis B cirrhosis

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Journal of Hainan Medical University 2017年第11期23卷 39-42页

作者： guo-yun wan Hui Liu Department of Infectious Disease Hospital of China University of Petroleum in Shandong ProvinceDongying257061China Department of Infectious Disease Dongying Hospital for Infectious Diseases in Shandong ProvinceDongying257055China

Objective:To study the influence of antiviral drugs combined with antioxidant therapy on liver injury and fibrosis process in patients with chronic hepatitis B ***: A total of118 patients with chronic hepatitis B cirrhosis who were treated in Dongying Hospital for Infectious Diseases between May 2013 and February 2016 were retrospectively analyzed and divided into the control group (n=60) who underwent routine antiviral therapy and the observation group (n=58) who underwent antiviral drugs combined with antioxidant therapy. Serum levels of oxidative stress indexes, liver function indexes and liver fibrosis indexes were compared between two groups of patients before and after ***:Before treatment, there were no significant differences in serum oxidative stress indexes, liver function indexes and liver fibrosis indexes between two groups of patients. 3 months after treatment, serum oxidative stress index SOD level in observation group was higher than that in control group while AOPPs level was lower than that in control group;serum liver function indexes AST, ALT and TBIL levels in observation group were lower than those in control group while ALB level was higher than that in control group;serum liver fibrosis indexes HA,Ⅳ-C, PCIII and LN levels in observation group were lower than those in control ***:Antiviral drugs combined with antioxidant therapy can significantly reduce oxidative stress injury in patients with chronic hepatitis B cirrhosis so as to protect the liver function and inhibit the liver fibrosis process.

关键词： Chronic hepatitis B cirrhosis Antiviral Antioxidant Liver injury Fibrosis

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Recent advances of sonodynamic therapy in cancer treatment

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Cancer Biology & Medicine 2016年第3期13卷 325-338页

作者： guo-yun wan Yang Liu Bo-Wei Chen Yuan-Yuan Liu Yin-Song wang Ning Zhang Research Center of Basic Medical Science & School of Pharmacy Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics) Tianjin Medical University Laboratory of Cancer Cell Biology National Clinical Research Center for Cancer Tianjin Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and Hospital

Sonodynamic therapy(SDT) is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed *** this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.

关键词： Sonodynamic therapy sonosensitizer cancer ultrasound reactive oxygen species

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Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da wan Shuwei Tang Shulin Bai Xiaodong Li Peng Ai wanrong guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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华阳湖群鱼类功能群及其对围网养殖的响应

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生态学杂志 2018年第2期37卷 438-445页

作者：夏治俊蒋忠冠谢涵郭婉昀王朝安徽大学资源与环境工程学院合肥230601

本研究基于华阳湖群围网养殖区和非养殖区鱼类资源的周年调查(2016年1月、4月、8月、11月),从功能生态学的视角,选取与鱼类食性、体型、生态习性及生活史特征相关的功能性状通过聚类分析的方法划分和定义功能群,通过比较功能群的物种组... 详细信息

本研究基于华阳湖群围网养殖区和非养殖区鱼类资源的周年调查(2016年1月、4月、8月、11月),从功能生态学的视角,选取与鱼类食性、体型、生态习性及生活史特征相关的功能性状通过聚类分析的方法划分和定义功能群,通过比较功能群的物种组成和多样性状况,揭示鱼类功能群对围网养殖的响应。结果表明:华阳湖群65种鱼类隶属于6目12科41属,且可以划分为17种相互独立且有清晰生物学解释的功能群;围网养殖区G1、G3-G5、G11-G13和G15功能群鱼类的密度显著低于非养殖区(P<0.05),而G9-G10功能群鱼类的密度则显著高于非养殖区(P<0.05);与非养殖区相比,围网养殖区鱼类功能群的丰富度指数和Margalef多样性指数显著更低(P<0.05),而Pielou均匀度指数显著更高(P<0.05)。围网养殖在一定程度上造成了鱼类功能群的物种组成和多样性的改变。

关键词：围网养殖功能群功能群多样性鱼类华阳湖群

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan wan wang Bin wang Ju-yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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岭南篆刻艺术的徽派传承探析

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安徽理工大学学报（社会科学版） 2017年第1期19卷 82-86页

作者：郭守运区婉仪华南师范大学城市文化学院广东佛山528225

岭南地区的篆刻流派——粤派,由安徽人黄牧甫创立,并在南粤大地上广为流传,影响深远。粤派篆刻在风格、刀法、印法、观念、结构上全面学习徽派技法且独具特色,成为近现代中国篆刻极其重要的构成,共同推动了中国篆刻艺术的现代化传承和... 详细信息

岭南地区的篆刻流派——粤派,由安徽人黄牧甫创立,并在南粤大地上广为流传,影响深远。粤派篆刻在风格、刀法、印法、观念、结构上全面学习徽派技法且独具特色,成为近现代中国篆刻极其重要的构成,共同推动了中国篆刻艺术的现代化传承和国际化发展。

关键词：篆刻粤派徽派黄牧甫

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用计算机模拟探讨上冲量的传递规律

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计量学报 1985年第2期 99-103页

作者：郭允晟苏皖生

本文用计算机模拟的方法分析了带有上冲量的测试脉冲通过无冲的线性二端口网络的传递规律。文中计算了各种有关因素的影响。这些规律对于检定脉冲波形参数或示波器瞬态特性是很有意义的。

关键词：示波器瞬态特性脉冲波形上冲计算机模拟计算机仿真传递规律阻尼振荡

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自动时域测试系统

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计量学报 1987年第4期 249-253页

作者：郭允晟苏皖生

本文介绍中国计量科学研究院研制的脉冲参数国家标准——自动时域测试系统(ATDMS)。其测量上升时间的不确定度,在20ps～10ns量程内为±(1％+5ps);测量脉冲幅度的不确定度,在50mV～50V量程内为±(0.5％+1mV)。该系统还开发了自动检定测... 详细信息

本文介绍中国计量科学研究院研制的脉冲参数国家标准——自动时域测试系统(ATDMS)。其测量上升时间的不确定度,在20ps～10ns量程内为±(1％+5ps);测量脉冲幅度的不确定度,在50mV～50V量程内为±(0.5％+1mV)。该系统还开发了自动检定测试多种脉冲仪器的功能,效率显著。该系统的频域参数测试功能正在开发和试用中。

关键词：取样示波器上升时间不确定度时域测试系统示波器校准仪

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靶向MAPK信号通路调控脂肪细胞分化的microRNAs

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畜牧兽医学报 2016年第11期47卷 2159-2166页

作者：张秀秀郭云涛黄万龙李嫒苗向阳中国农业科学院北京畜牧兽医研究所北京100193

脂肪细胞分化是一个多能间充质干细胞(MSCs)逐渐向成熟脂肪细胞分化的复杂过程,该过程受很多转录因子、激素以及信号通路相关分子的严格调控。体内外的试验表明,microRNAs(miRNAs)也参与了脂肪细胞分化的调节,且可以靶向转录因子和信号... 详细信息

脂肪细胞分化是一个多能间充质干细胞(MSCs)逐渐向成熟脂肪细胞分化的复杂过程,该过程受很多转录因子、激素以及信号通路相关分子的严格调控。体内外的试验表明,microRNAs(miRNAs)也参与了脂肪细胞分化的调节,且可以靶向转录因子和信号通路中的关键分子发挥作用。丝裂原活化蛋白激酶(MAPK)信号通路是真核细胞将胞外信号转导至胞内引起细胞反应的一类重要信号系统,研究证明,miRNAs可以靶向MAPK信号通路中的某些基因,影响该通路的信号转导,参与脂肪细胞分化的调控。因此本文总结了近几年有关miRNA改变MAPK信号转导,实现调控脂肪细胞分化功能的研究,以期为深入了解脂肪细胞分化的机制,为治疗脂肪型疾病提供新的思路。

关键词： microRNA MAPK信号通路靶基因脂肪细胞分化

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Induced Chern-Simons Term at High Temperature in Intrinsic Regularization

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Chinese Physics Letters 1998年第5期15卷 321-322页

作者： guo Han-ying ZHAO wan-yun Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

By perturbative calculations of the high temperature ground-state axial current in intrinsic regularization,an anomalous Chern-Simons topological mass term is induced in the three-dimensional effective *** anomaly in three dimensions appears just in the ground-state current rather than in the divergence of ground-state *** the abelian case,the contribution comes only from the vacuum polarization graph,whereas in the nonabelian case,contributions come from the vacuum polarization graph and the two triangle graphs.

关键词： vacuum dimensions triangle

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