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Retrievable puncture anchor traction method for endoscopic ultrasound-guided gastroenterostomy: A porcine study

World Journal of Gastroenterology 2020年第25期26卷 3603-3610页

作者： guo-xin wang Kai Zhang Si-Yu Sun Department of Gastroenterology Endoscopic CenterShengjing Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Endoscopic ultrasound-guided gastroenterostomy(EUS-GE)is an alternative method for the surgical treatment of gastric outlet obstruction,but it is regarded as a challenging technique for endoscopists as the bowel is highly mobile and can tent ***,the technique requires superb *** order to improve EUS-GE,we have developed a retrievable puncture anchor traction(RPAT)device for EUSGE to address the issue of bowel *** To evaluate the feasibility of RPAT-assisted EUS-GE using an animal *** Six Bama mini pigs each weighing between 15 and 20 kg underwent the RPATassisted EUS-GE *** was taken to ensure that the animals experienced minimal pain and *** days prior to the procedure the animals were limited to a liquid *** oral intake was allowed on the day before the procedure.A fully covered metal stent was placed between the stomach and the intestine using the RPAT-assisted EUS-GE *** in the animals was *** weeks after the procedure,a standard gastroscope was inserted into the pig’s intestine through a previously created fistula in order to check the status of the stents under *** pig was euthanized after *** The RPAT-assisted EUS-GE method allowed placement of the stents with no complications in all six *** the pigs tolerated a regular diet within hours of the *** animals were monitored for four weeks after the RPATassisted EUS-GE,during which time all of the animals exhibited normal eating behavior and no signs of infection were *** imaging performed four weeks after the RPAT-assisted EUS-GE showed that the stents remained patent and stable in all the *** tissue overgrowth or ingrowth was observed in any *** animal had a mature fistula,and the stents were removed without significant *** of all six pigs revealed complete adhesion between the intestine and the stomach *** The RPAT method

关键词： Retrievable puncture anchor Endoscopic ultrasound Endoscopic ultrasoundguided gastroenterostomy Gastric outlet obstruction Gastroenterostomy Electrocauteryenhanced delivery of lumen-apposing metal stents

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Composition operators on weighted Bergman spaces induced by doubling weights

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Science China Mathematics 2024年第7期67卷 1571-1598页

作者： xin guo Maofa wang School of Mathematics and Statistics Wuhan UniversityWuhan430072China

Given a doubling weightωon the unit disk D,let A_(ω)^(p) be the space of all the holomorphic functions f,where∥f∥A_(ω)^(p):=(∫_(D)|f(z)|_(p)ω(z)dA(z))^(1/p)<∞.We completely characterize the topological connectedness of the set of composition operators on A_(ω)^(p).As an application,we construct an interesting example which reveals that two composition operators on A_(α)^(p) in the same path component may fail to have a compact difference and give a negative answer to the Shapiro-Sundberg question in the(standard)weighted Bergman *** addition,we completely describe the central compactness of any finite linear combinations of composition operators on A_(ω)^(p) in three terms:a Julia-Carathéodory-type function-theoretic characterization,a power-type characterization,and a Carleson-type measure-theoretic characterization.

关键词： composition operator linear combination linearly connected weighted Bergman space doubling weight

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Effects of premedication with Pronase for endoscopic ultrasound of the stomach: A randomized controlled trial

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World Journal of Gastroenterology 2016年第48期22卷 10673-10679页

作者： guo-xin wang Xiang Liu Sheng wang Nan Ge Jin-Tao guo Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University

AIM To analyze the effects of premedication with Pronase for endoscopic ultrasound(EUS) examination of the *** This was a prospective, randomized and controlled clinical study. All patients were randomly assigned to either the Pronase group or placebo group. The pretreatment solution was a mixed solution of 20000 U of Pronase and 60 m L sodium bicarbonate solution in the Pronase group, while an equal amount of sodium bicarbonate solution was administered to the placebo group. All operators, image evaluators and experimental recorders in EUS did not participate in the preparation and allocation of pretreatment solution. Two blinded investigators assessed the obscurity scores for the EUS images according to the size of artifacts(including ultrasound images of the gastric cavity and the gastric wall). Differences in imaging quality, the duration of examination and the usage of physiological saline during the examination process between the Pronase group and the control group were *** No differences existed in patient demographics between the two groups. For the gastric cavity, the Pronase group had significantly lower mean obscurity scores than the placebo group(1.0476 ± 0.77 vs 1.6129 ± 0.96, respectively, P = 0.000). The mean obscurity scores for the gastric mucosal surface were significantly lower in the Pronase group than the placebo group(1.2063 ± 0.90 vs 1.7581 ± 0.84, respectively, P = 0.001). The average EUS procedure duration for the Pronase group was 11.60 ± 3.32 min, which was significantly shorter than that of the placebo group(13.13 ± 3.81 min, P = 0.007). Less saline was used in the Pronase group than the placebo group, and the difference was significant(417.94 ± 121.38 m L vs 467.42 ± 104.52 mL, respectively, P = 0.016).CONCLUSION The group that had Pronase premedication prior to the EUS examination had clearer images than the placebo group. With Pronase premedication, the examination time was shorter, and the amount of saline us

关键词： Artifacts Randomized controlled trial Endosonography Pronase Stomach

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Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology:Progress and updates

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 1-18页

作者： Fan Yang Si-Yu Sun Sheng wang Jin-Tao guo Xiang Liu Nan Ge guo-xin wang Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

Gastrointestinal(GI)tumors,including liver,pancreatic,gastric,and colorectal cancers,have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent *** and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors,but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug *** studies have shown that ferroptosis plays an important role in the onset and progression of GI *** is a new non-apoptotic form of cell death,which is iron-dependent,non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species(ROS).The activation of ferroptosis can lead to tumor cell ***,regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors,making it become a research *** studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ***,several studies have indicated that ferroptosis may be a new approach for the treatment of GI ***,we review current research progress on the mechanism of ferroptosis,current inducers and inhibitors of ferroptosis,and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors.

关键词： Ferroptosis Gastrointestinal oncology Hepatocellular carcinoma Pancreatic cancer Gastric cancer Colorectal cancer

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Preparation and Swelling Kinetic Analysis of Poly (HPMC-co-AA-co-AM) Super Absorbent Resin

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 790-799页

作者：马砺 wang xin LIU Xixi WEI Gaoming guo Ying School of Safety Science and Engineering Xi’an University of Science and TechnologyXi'an 710054China Key Laboratory of Coal Fire Disaster Prevention Xi’an University of Science and TechnologyXi'an 710054China School of Energy Engineering Xi’an Uni-versity of Science and TechnologyXi'an 710054China Yanzhou Coal Mining Co. Ltd.Zoucheng 237500China

Super absorbent resin(SAR)is prepared by aqueous high temperature polymerization using hydroxypropyl methylcellulose(HPMC)as monomer backbone material,acrylic acid(AA)and acrylamide(AM)as the graft copolymer monomer,potassium persulfate(KPS)as the initiator to generate free radicals,and N,N`-methylenebisacrylamide(MBA)as cross-linking agent for cross-linking ***,the influence of individual factors on the water absorption is investigated,and these factors are mainly AA,AM,KPS,MBA,HPMC,and reaction *** optimized conditions are obtained by the experiment repeating for several *** water absorption multiplicity and salt absorption multiplicity under the conditions are 782.4 and 132.5 g/g,***,the effects of different temperatures and salt concentrations on its water absorption,as well as the swelling kinetics of SAR are *** is indicated the water-absorbing swelling process is mainly caused by the difference in water osmotic pressure and Na+concentration inside and outside the cross-linked molecular structure of the resin,which is not only consistent with the quasi-secondary kinetic model,but also with the Fick diffusion model.

关键词： super absorbent resin swelling kinetics water absorption graft copolymerization hydroxypropyl methyl cellulose

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The Synthesis of 3-(2'-Hydroxybutyl) isobenzofuran-1 (3H)-one

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Chinese Chemical Letters 1999年第1期10卷 21-22页

作者： guo xin wang guo HSO XIE Yuan Liu WU xin Fu PAN(Laboratory of Applled Organic Chemistry，Institute of Organlc Chemistry． Lanzhou University，Lanzhou，730000)(Instltute ofMateria Medica, Chinese Academy of Medical Science，Beijing 100050)(Department of Lab. of Applied Organic Chemistry Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China Institute of Materia Medica Chinese Academy of Medical Science Beijing 100050 China

The synthesis of 3-(2'-hydroxybutyl）isobenzofuran-1(3H)-onel from phthalicanhydride via the intermediate 3-(2'-oxoethyl) isobenzofuran-1(3H)-one 6 was described．

关键词： Synthesis 3-(2'-hydroxybutyl)lsobenzofuran-1(3H)-one.

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Effect of M-EMS on the solidification structure of a steel billet

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 159-164页

作者： Hua-jie Wu Ning Wei Yan-ping Bao guo-xin wang Chao-ping Xiao Jin-jin Liu Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing100083 China

Effects of mold electromagnetic stirring （M-EMS） on the solidification structure of 45# steel billet were investigated by examination of interdendritic corrosion. The results show that the primary and secondary dendrite arm spacings increase from the edge of the billet to the center and decrease obviously with increasing electromagnetic torque, which will be beneficial to refine the solidification structure and enlarge the equiaxed crystal zone. The ratio of equiaxed crystal increases by 15.9% with the electromagnetic torque increasing from 230 to 400 cN·cm. The increase of stirring intensity can improve the cooling rate and the impact of M-EMS on it reduces from the edge of the billet to the central area, where the cooling rates are similar at different torques. The closer to the central area, the less the influence of M-EMS on the cooling rate is. The ratio of the primary to secondary dendrite arm spacing is approximately 2.0, namely, λ1≈2λ2, and is constant irrespective of the stirring intensity and position of the billet. Original position analysis （OPA） results indicate that the center segregation of the billet is greatly improved, and the more uniform and compact solidification structure will be obtained with the increase of stirring intensity.

关键词： continuous casting electromagnetic stirring dendrite arm spacing cooling rate solidification

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Seismic performance evaluation of water supply pipes installed in a full-scale RC frame structure based on a shaking table test

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 163-178页

作者： Wu Houli guo Endong wang Jingyi Dai xin Dai Chenxi Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China

As an important part of nonstructural components,the seismic response of indoor water supply pipes deserves much *** paper presents shaking table test research on water supply pipes installed in a full-scale reinforced concrete(RC)frame *** material pipes and different methods for penetrating the reinforced concrete floors are combined to evaluate the difference in seismic *** response spectra and pipe acceleration amplification factors based on test data are discussed and compared with code provisions.A seismic fragility study of displacement demand is conducted based on numerical *** acceleration response and displacement response of different combinations are *** results show that the combination of different pipe materials and different passing-through methods can cause obvious differences in the seismic response of indoor riser pipes.

关键词： water supply pipe different materials shaking table test amplification factor seismic fragility

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Delayed perforation after endoscopic resection of a colonic laterally spreading tumor:A case report and literature review

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World Journal of Clinical Cases 2020年第16期8卷 3608-3615页

作者： Ge-Yu-Jia Zhou Jin-Long Hu Sheng wang Nan Ge Xiang Liu guo-xin wang Si-Yu Sun Jin-Tao guo Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been widely used for the treatment of early gastrointestinal *** piecemeal mucosal resection(EPMR)is derived from the combination of EMR and *** perforation with peritonitis after colonic EPMR is a rare but severe complication,sometimes requiring *** are some associated risk factors,including patient-(location,diameter,and presence of fibrosis)and procedure-related *** recognition and timely treatment are crucial for its *** SUMMARY We report a case in which delayed perforation with peritonitis was treated using endoscopic closure.A 54-year-old man was diagnosed with a 30-mm-diameter laterally spreading tumor in the colonic hepatic *** hours after endoscopic resection,peritonitis caused by delayed perforation occurred and gradually *** treatment was ineffective and no obvious perforation was *** timely endoscopic closure,the patient was discharged on postoperative day *** In occasion of localized peritonitis aggravating without macroscopic perforation,endoscopic closure is an effective treatment for delayed perforation with stable vital signs in the early stage.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Endoscopic piecemeal mucosal resection Delayed perforation Endoscopic closure Case report

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Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2017年第47期23卷 8345-8354页

作者： Fan Yang Dong-Yan Liu Jin-Tao guo Nan Ge Ping Zhu Xiang Liu Sheng wang guo-xin wang Si-Yu Sun Endoscopy Center Shengjing Hospital of China Medical University Medical Research Center Shengjing Hospital of China Medical University

AIM To analyze the diagnostic value of a circular RNA(circR NA), circ-LDLRAD3, in pancreatic *** Expression levels of circ-LDLRAD3 were tested in both cells and clinical samples; the latter included 30 paired pancreatic cancer tissues and adjacent non-tumorous tissues, 31 plasma samples from patients with pancreatic cancer, and 31 plasma samples from healthy volunteers. Real-time quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR) was performed to measure expression levels of circ-LDLRAD3 in cells and clinical samples; then, the relationship between clinicopathological factors of patient samples and expression of circ-LDLRAD3 in pancreatic cancer was analyzed. The diagnostic value of circ-LDLRAD3 was verified by receiver operating characteristic(ROC) curve *** Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines(P < 0.01), pancreatic cancer tissues(P < 0.01), and plasma samples from patients with pancreatic cancer(P < 0.01). High expression of circLDLRAD3 was significantly associated with venous invasion, lymphatic invasion, and metastasis. The area under the ROC curve of circ-LDLRAD3 alone or combination with CA19-9 was 0.67 and 0.87, respectively, with a sensitivity and specificity of 0.5738(alone) and 0.7049(alone), and 0.8033(combination) and 0.9355(combination), *** These data suggest that circ-LDLRAD3 may be a biomarker in the diagnosis of pancreatic cancer.

关键词： Circular RNA Pancreatic cancer biomarker

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