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Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

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Journal of Pharmaceutical Analysis 2024年第6期14卷 914-925页

作者： Guiqin Ye xin sun Jiuzhou Li Yuanyuan Mai Ruilan Gao Jianbin Zhang Cancer Center Department of Medical OncologyKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou310014China Clinical Laboratory Yuhuan City HospitalTaizhouZhejiang317600China Hangzhou Medical College Hangzhou311300China Department of Neurosurgery Binzhou People's HospitalBinzhouShandong256600China Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China

Lung cancer ranks the top of malignancies that cause cancer-related deaths *** leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory *** previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully *** synthesized Moracin N(MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic *** and its probe exerted similar growth-inhibitory effect on human lung cancer *** proteomic results showed that MAN targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCR)signaling pathway,indicating its immune-regulatory ***-free surface plasmon resonance(SPR)results showed the direct interaction of MAN with PD-L1 *** docking analysis demonstrated that MAN bound to E158 residue of PD-L1 *** downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMR).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAN-treated A549 cells,resulting in the increase of CD8^(+)GZMB^(+)T cells and the decrease of CD8^(+)PD-1^(+)T *** suggested that MAN exerts anti-cancer effect through blocking the PD-L1/PD-1 *** vivo,MAN combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic *** together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung *** modulatory effect on tumor microenvironment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.

关键词： Moracin N Click chemistry PD-L1 T cell Lung cancer

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Observation of the failure mechanism in Ag10Ge15Te75-based memristor induced by ion transport

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Nano Research 2024年第9期17卷 8431-8437页

作者： Yuwei Xiong Kuibo Yin Weiwei sun Jingcang Li Shangyang Shang Lei xin Qiyun Wu Xiaoran Gong Yidong Xia Litao sun SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 210096China College of Engineering and Applied Sciences Nanjing UniversityNanjing 210093China

The solid-electrolyte-based memristors have attracted tremendous attention for the next-generation nonvolatile memory for both logic and neuromorphic ***,they encounter variability performance challenges which originated from the random ionic transport and conductive filaments ***,the electrochemical metallized mechanism associated with ion transport has been ***,the failure mechanism caused by ion transport during cycles is rarely ***,the five stages of failure in the Ag/Ag10Ge15Te75/W memristor are elucidated through ex-situ current-voltage measurements combined with in-situ transmission electron microscopy *** investigation reveals that the migration and enrichment of Ag ions result in the precipitation of Ag_(2)*** formation of Ag_(2)Te hinders the device's ability to maintain its bipolar characteristics and also decreases the resistance value of the high resistance state,thereby reducing the device's switching *** promising results provide important guidance for the future design of structures and the manipulation of ion transport for high-performance memristors.

关键词： Ag10Ge15Te75 in-situ transmission electron microscopy(TEM) failure mechanism

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Mechanical Property and Microstructure of Cement Mortar with Carbonated Recycled Powder

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 689-697页

作者：丁亚红张美香 YANG Xiaolin XU Ping sun Bo guo Shuqi Department of Civil Engineering Henan Polytechnic UniversityJiaozuo 454150China College of Architectural Engineering Xinyu UniversityXinyu 336500China

Carbonated recycled powder as cementitious auxiliary material can reduce carbon emissions and realize high-quality recycling of recycled *** this paper,microscopic property of recycled powder with three carbonation methods was tested through XRD and SEM,the mechanical property and microstructure of recycled powder mortar with three replacement rates were studied by ISO method and SEM,and the strengthening mechanism was *** results showed that the mechanical property of recycled powder mortar decreased with the increasing of replacement *** is suggested that the replacement rate of recycled powder should not exceed 20%.The strength index and activity index of carbonated recycled powder mortar were improved,in which the flexural strength was increased by 27.85%and compressive strength was increased by 20%at the *** powder can be quickly and completely carbonated,and the improvement effect of CH pre-soaking carbonation was the *** activity index of carbonated recycled powder can meet the requirements of Grade II technical standard for recycled *** results revealed the activation mechanism of carbonated recycled powder such as surplus calcium source effect,alkaline polycondensation effect and carbonation enhancement effect.

关键词： recycled powder carbonation activation compound carbonation activity index mechanical property microstructure

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Nanostructured AlFeO_(3) thin films as a novel photoanode for photoelectrochemical water splitting

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Nano Research 2024年第3期17卷 1075-1085页

作者： xin sun Min Wang Qi Geng Shuailin Chen Xiaojun Lv Xunlei Ding Meicheng Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources School of New EnergyNorth China Electric Power UniversityBeijing 102206China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China

The earth-abundant and robust aluminum ferrite,AlFeO_(3)(AFO),is mainly studied in the context of ***,we demonstrate that AFO can be used as a stable solar absorber in photoelectrochemical cells for solar water splitting,exhibiting attractive *** is the first report on the photoelectrochemical activity of *** thin-film photoelectrodes prepared by solution-processing methods are composed of vertically oriented thin nanosheets,featuring the rhombohedral symmetry(R3c)and n-type *** as-prepared AFO photoanodes generate a photocurrent density of+0.78 mA·cm^(-2) at 1.23 V *** hydrogen electrode(RHE)with the photocurrent _(onset) potential(U_(onset))close to the flat band potential of 0.5 V *** in the presence of hole ***,the U_(onset) of AFO for solar water splitting coincides with the flat band potential as well,which is rare in n-type inorganic *** also report other properties of AFO associated with photoelectrochemical *** films exhibit a band gap energy of 2.31 eV and positive band edges with low ***,the carrier lifetimes in AFO films are up to millisecond timescales under the mediation of defect *** on the photoelectrochemical behavior and optoelectronic properties,we believe that AFO has great potential for application in photoelectrochemical cells.

关键词： AlFeO_(3) photoanode nanosheets photoelectrochemistry onset potential

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Synergy of phosphorus vacancies and build-in electric field into NiCo/NiCoP Mott-Schottky integrated electrode for enhanced water splitting performance

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Chinese Chemical Letters 2024年第2期35卷 604-610页

作者： Xiaochen Zhang Hui Xue Jing sun Niankun guo Tianshan Song Jiawen sun Yi-Ru Hao Qin Wang College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

Vacancy engineering and Mott-Schottky heterostructure can accelerate charge transfer,regulate adsorption energy of reaction intermediates,and provide additional active sites,which are regarded as valid means for improving catalytic ***,the underlying mechanism of synergistic regulation of interfacial charge transfer and optimization of electrocatalytic activity by combining vacancy and Mott-Schottky junction remains ***,the growth of a bifunctional NiCo/NiCoP Mott-Schottky electrode with abundant phosphorus vacancies on foam nickel(NF)has been synthesized through continuous phosphating and reduction *** obtained NiCo/NiCoP heterojunctions show remarkable OER and HER activities,and the overpotentials for OER and HER are as low as 117 and 60 mV at 10 mA/cm^(2) in 1 mol/L KOH,***,as both the cathode and anode of overall water splitting,the voltage of the bifunctional NiCo/NiCoP electrocatalyst is 1.44 V at 10 mA/cm^(2),which are far exceeding the benchmark commercial *** theoretical calculation results confirm that the phosphorus vacancies and build-in electric field can effectively accelerate ion and electron transfer between NiCo alloy and NiCoP semiconductor,tailor the electronic structure of the metal centers and lower the Gibbs free energy of the ***,the unique self-supported integrated structure is beneficial to facilitate the exposure of the active site,avoid catalyst shedding,thus improving the activity and structural stability of NiCo/*** study provides an avenue for the controllable synthesis and performance optimization of Mott-Schottky electrocatalysts.

关键词： Mott-Schottky Build-in electric field Phosphorus vacancies Phosphides Overall water splitting

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Stimulated Brillouin interaction between guided phonons and photons in a lithium niobate waveguide

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 173-175页

作者： Yuan-Hao Yang Jia-Qi Wang Zheng-Xu Zhu xin-Biao Xu Qiang Zhang Juanjuan Lu Yu Zeng Chun-Hua Dong Luyan sun Guang-Can guo Chang-Ling Zou CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China

The Brillouin scattering is one of the strongest nonlinear optical effects in dielectrics[1].In particular,the backward Brillouin scattering(BBS)provides an efficient method to achieve low-noise optical gain for active photonics[2]and the coherent interconnects between 10 GHz phonons and photons[3].However,previous studies on BBS are primarily limited to the unconfined phonons[1]or phonon confined in suspended structures[4-6].

关键词： scattering waveguide Brillouin

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Coordinated Frequency Control for Isolated Power Systems with High Penetration of DFIG-Based Wind Power

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1399-1414页

作者： xin Ding Wei Lin Jian Xu Yuanzhang sun Liangzhong Yao Beilin Mao School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China Department of Electrical Engineering and Computer Science Case Western Reserve UniversityClevelandOH 44106 USA

This paper proposes a coordinated frequency control scheme for emergency frequency regulation of isolated power systems with a high penetration of wind *** proposed frequency control strategy is based on the novel nonlinear regulator theory,which takes advantage of nonlinearity of doubly fed induction generators(DFIGs)and generators to regulate the frequency of the power *** deviations and power imbalances are used to design nonlinear feedback controllers that achieve the reserve power distribution between generators and DFIGs,in various wind speed *** effectiveness and dynamic performance of the proposed nonlinear coordinated frequency control method are validated through simulations in an actual isolated power grid.

关键词： Frequency control isolated power systems nonlinear feedback nonlinear regulator theory wind power

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Learning to represent 2D human face with mathematical model

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 54-68页

作者： Liping Zhang Weijun Li Linjun sun Lina Yu xin Ning Xiaoli Dong AnnLab Institute of SemiconductorsChinese Academy of SciencesBeijingChina Center of Materials Science and Optoelectronics Engineering School of Integrated CircuitsUniversity of Chinese Academy of SciencesBeijingChina Beijing Key Laboratory of Semiconductor Neural Network Intelligent Sensing and Computing Technology BeijingChina

How to represent a human face pattern?While it is presented in a continuous way in human visual system,computers often store and process it in a discrete manner with 2D arrays of *** authors attempt to learn a continuous surface representation for face image with explicit ***,an explicit model(EmFace)for human face representation is pro-posed in the form of a finite sum of mathematical terms,where each term is an analytic function ***,to estimate the unknown parameters of EmFace,a novel neural network,EmNet,is designed with an encoder-decoder structure and trained from massive face images,where the encoder is defined by a deep convolutional neural network and the decoder is an explicit mathematical expression of *** authors demonstrate that our EmFace represents face image more accurate than the comparison method,with an average mean square error of 0.000888,0.000936,0.000953 on LFW,IARPA Janus Benchmark-B,and IJB-C *** results show that,EmFace has a higher representation performance on faces with various expressions,postures,and other ***,EmFace achieves reasonable performance on several face image processing tasks,including face image restoration,denoising,and transformation.

关键词： artificial neural networks face analysis image processing mathematics computing

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Influence of Surface Ice Roughness on the Aerodynamic Performance of Wind Turbines

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Fluid Dynamics & Materials Processing 2024年第9期20卷 2029-2043页

作者： xin Guan Mingyang Li Shiwei Wu Yuqi Xie Yongpeng sun School of New Energy Shenyang Engineering CollegeShenyang110136China Shenyang Key Laboratory Clean Energy Fine Comprehensive Utilization and Scheduling Energy Storage Shenyang110136China

The focus of this research was on the equivalent particle roughness height correction required to account for the presence of ice when determining the performances of wind *** particular,two icing processes(frost ice and clear ice)were examined by combining the FENSAP-ICE and FLUENT analysis *** ice type on the blade surfaces was predicted by using a multi-time step ***,the influence of variations in icing shape and ice surface roughness on the aerodynamic performance of blades during frost ice formation or clear ice formation was *** results indicate that differences in blade surface roughness and heat flux lead to disparities in both ice formation rate and shape between frost ice and clear *** ice has a greater impact on aerodynamics compared to frost ice,while frost ice is significantly influenced by the roughness of its icy surface.

关键词： Wind turbine icing blade surface roughness aerodynamic characteristics airfoil

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Cr-assisted low-temperature densification of(Ti,Zr,Nb,Ta,Mo)C high-entropy carbides with ultrafine grain and enhanced hardness

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Journal of Advanced Ceramics 2024年第6期13卷 780-788页

作者： Yang Liu Jiaji Liang Weiming guo Shikuan sun Yu Tian Hua-Tay Lin School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China State Key Laboratory of High Performance Tools Guangdong University of TechnologyGuangzhou 510006China School of Material Science and Energy Engineering Foshan UniversityFoshan 528000China

While the use of low-melting-point metals as sintering aids for high-entropy carbide(HEC)ceramics has been well established,their existence can compromise hardness due to residual metallic *** study demonstrates an innovative strategy to meet this challenge,where(Ti,Zr,Nb,Ta,Mo)C high-entropy carbide ceramics with ultrafine grains and enhanced hardness are obtained through chromium(Cr)-metal-assisted spark plasma sintering(SPS)at a temperature as low as 1600℃.The results show that the addition of 5 vol%Cr promotes the formation of highly densified single HEC phase ceramics with a high relative density(98.4%)and an ultrafine-grained microstructure(0.17μm).This low-temperature densification mechanism can be attributed to Cr’s solid-solution effect within the matrix and the increased carbon vacancies generated during *** grain size of the(Ti,Zr,Nb,Ta,Mo)C ceramics with 5 vol%Cr metal addition is significantly smaller than that of Cr-free(Ti,Zr,Nb,Ta,Mo)C ceramics sintered at 2000℃(3.03μm)or via traditional low-temperature liquid-phase sintering(1.3–1.5μm).Importantly,the addition of 5 vol%Cr substantially increased the hardness of the ceramics,with a remarkable increase from 23.57 to 28.16 GPa compared to that of the pure(Ti,Zr,Nb,Ta,Mo)C ceramics,owing to the fine-grain strengthening and solid-solution strengthening *** work highlights the uniqueness of Cr metal as a sintering aid in achieving densification and hardness improvements in(Ti,Zr,Nb,Ta,Mo)C ceramics,offering a promising strategy for improving the properties of HEC materials for further development in the near future.

关键词： solid solution sinterability hardness enhancement (Ti,Zr,Nb,Ta,Mo)C high-entropy carbide(HEC)ceramics

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