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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu guo-chao zhang Wu Ning Hai-Bin Liu Hua Yang chao-Feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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Primary advanced esophago-gastric melanoma:A rare case

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World Journal of Gastroenterology 2016年第11期22卷 3296-3301页

作者： Lin Wang Liang Zong Hidetsugu Nakazato Wen-Yue Wang chao-Feng Li Yan-Fen Shi guo-chao zhang Tao Tang Peking University China-Japan Friendship School of Clinical Medicine Beijing 100029China Department of Gastrointestinal Surgery Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Department of Surgery Okinawa Red Cross HospitalOkinawa 902-8588Japan Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China

Primary esophageal or gastric melanoma is a very rare disease with early metastasis. Due to its atypical symptom and less efficiency of chemotherapy and radiotherapy, the prognosis of esophageal or gastric melanoma is still very poor. Surgical resection remains the preferential treatment for esophageal or gastric melanoma. Here we present an extremely rare case of primary advanced esophago-gastric melanoma. Debulking surgery was performed without chemotherapy or radiotherapy. However, abdominal recurrence and hepatic metastases were found within one month by a postoperative follow-up computed tomography. Three and a half months after surgical resection, the patient died of extensive abdominal metastasis.

关键词： Malignant melanoma Esophago-gastric junction Surgery Chemotherapy Prognosis

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Distributed Space-Time Coding in LTE Systems

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ZTE Communications 2010年第1期8卷 21-25页

作者： Wei guo zhang chao Wang Lei Wireless Information Network Lab University of Science and Technology of China Hefei 230027 P. R. China

Relay is considered as one of the candidate key technologies of LTE-advanced for it brings broader cell coverage and higher system capacity. Distributed Space-Time Coding （DSTC） not only exploits the spatial diversity from the relay structure, but also brings some coding gains. According to the performances of existing DSTC schemes, the Demodulate-and-Forward （DMF） scheme is the best candidate for DSTC in LTE-Advanced system. Moreover, a threshold-based selective relaying scheme for DSTC is proposed to solve the error propagation of DMF. This scheme can achieve excellent performance gains at the cost of little system complexity.

关键词： error propagation key technologies performance gains structure coverage little DMF cell

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SCALE OPTIMIZATION FOR DISTORTED MODEL ON DIVERSION SYSTEM OF HYDROPOWER STATION

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Journal of Hydrodynamics 1999年第3期11卷 61-67页

作者： Huang guo fu, Wu chao, zhang Ting State Key Hydraulics Laboratory of High Speed Flows, Sichuan University, Chengdu 610065, P.R.China (Received Oct. 16, 1998)

Long diversion system of hydropower station, including surge tank, inlet tunnel and penstock, is an inseparable whole system. Scale effects of distorted model on the diversion system are studied in the present paper. Based on the concept of model scale correlation and the method of parameter expression of model scale, the model scale optimization can be realized. Furthermore, a quantitative criterion for the choice of distorted model or normal model is presented. The study shows that distorted model can simultaneously satisfy the similarity conditions derived from surge wave equations, water hammer equations and wave speed equation for the diversion system. In addition, an example for the design of a practical distorted model is provided.

关键词： scale optimization distorted model model test diversion system surge tank

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基于动态功率阈值降低PAPR的部分传输序列算法

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系统工程与电子技术 2017年第7期39卷 1620-1624页

作者：季策郭伟张超东北大学计算机科学与工程学院辽宁沈阳110169

为了改善正交频分复用(orthogonal frequency division multiplexing,OFDM)系统的峰均功率比(peak-to-average power ratio,PAPR)性能,提出了一种基于动态功率阈值的低复杂度部分传输序列(partial transmit sequences,PTS)方法。在新的PTS方法中,引入了基于功率的判别函数,并给出了一种基于功率合理选择阈值的方法。在选取最小的PAPR值进行传输时,只对Pn大于等于阈值的样本信号进行峰值功率的计算。与传统的PTS算法相比,本文提出的算法在保证PAPR性能和误码率的情况下,能够更有效地降低计算复杂度。

关键词：正交频分复用峰均功率比部分传输序列阈值

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Therapeutic options for intermediate-advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2011年第13期17卷 1685-1689页

作者： Zong-Ming zhang Jin-Xing guo Zi-chao zhang Nan ]iang Zhen-Ya zhang Li-Jie Pan Department of General Surgery Digestive Medical Center The First Affiliated Hospital Schoolof Medicine Tsinghua University Beijing 100016 China

Hepatocellular carcinoma (HCC) is one of the most common malignancies, ranking the sixth in the world, with 55% of cases occurring in China. Usually, patients with HCC did not present until the late stage of the disease, thus limiting their therapeutic options. Although surgical resection is a potentially curative modality for HCC, most patients with intermediate-advanced HCC are not suitable candidates. The current therapeutic modalities for intermediate-advanced HCC include: (1) surgical procedures, such as radical resection, palliative resection, intraoperative radiofrequency ablation or cryosurgical ablation, intraoperative hepatic artery and portal vein chemotherapeutic pump placement, two-stage hepatectomy and liver transplantation; (2) interventional treatment, such as transcatheter arterial chemoembolization, portal vein embolization and image-guided locoregional therapies; and (3) molecularly targeted therapies. So far, how to choose the therapeutic modalities remains controversial. Surgeons are faced with the challenge of providing the most appropriate treatment for patients with intermediate-advanced HCC. This review focuses on the optional therapeutic modalities for intermediateadvanced HCC.

关键词： Hepatocellular carcinoma Intermediateadvanced Surgical procedure Interventional treatment Molecularly targeted therapy

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Collision tumor of the esophagus:a report of five cases

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Chinese Medical Journal 2020年第19期133卷 2386-2388页

作者： guo-chao zhang Bing-Zhi Wang Li-Yu Wang Ya-Long Wang Wei guo Nan Sun Shu-Geng Gao Qi Xue Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

To the Editor:Collision tumors are rare neoplasms comprising two cell populations that develop in juxtaposition to one another with minimal to no areas of intermingling.[1]The most common sites at which collision tumors occur have been reported to include the lungs,cranium,rectum,liver,uterus,bladder,and testis.[2,3]However,the biologic behavior of esophageal collision tumors remains largely unknown,with only a small number of studies originating from case reports having been *** study reports five cases of esophageal collision tumors to provide evidence-based recommendations for the care of future patients.

关键词： cases neoplasms bladder

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The EST Analysis of A Suppressive Subtraction cDNA Library of Chinese Wild Vitis pseudoreticulata Inoculated with Uncinula necator

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Agricultural Sciences in China 2010年第2期9卷 233-241页

作者： SHI Jiang-li, WANG Yue-jin, ZHU Zi-guo and zhang chao-hong Key Laboratory of Horticultural Plant Germplasm Utilization in Northwest China, Ministry of Agriculture/Shaanxi Key Laboratory of Molecular Biology for Agriculture/College of Horticulture, Northwest A&F University, Yangling 712100, P.R.China [a] Key Laboratory of Horticultural Plant Germplasm Utilization in Northwest China Ministry of Agriculture/Shaanxi Key Laboratory of Molecular Biology for Agriculture/College of Horticulture Northwest A&F University Yangling 712100 P.R. China

Uncinula necator is a worldwide serious fungus disease causing annual heavy lost on grapevine production. In order to get more informations on defense related EST sequences and help breeding program, we constructed and characterized a suppression subtractive hybridization cDNA library with artificially inoculated leaves and control Chinese wild Vitis pseudoreticulata clone Baihe-35-1, which is highly resistant to powdery mildew. In the library, the length of 58 EST fragments known as putative functions varied from 130 to 800 bp, and 60% of the ESTs exhibited high similarity to known sequences in database of GenBank with BLASTX analysis. These genes were involved in stress/defense response, detoxification, signal transduction, disease defense, and etc., and 14 ESTs remained unknown or hypothetical proteins, which may be new genes. The experiment provided an important basis for studying the disease-resistance mechanism and obtaining the genes for the aim of improving grapevine powdery mildew resistance.

关键词： Chinese wild Vitis pseudoreticulata disease resistance SSH cDNA library EST sequence

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Numerical Simulations of 3D Inviscid/Viscous Flow Fields on Cartesian/Unstructured/Prismatic Hybrid Grids

Numerical Simulations of 3D Inviscid/Viscous Flow Fields on ...

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第四届亚洲计算流体力学会议

作者： zhang Laiping guo chao Yang Yongjian zhang Hanxin Gao Shuchun(China Aerodynamics Research and Development Center Mianyang Sichuan China 621000 )

＜正＞ In this paper, a Cartesian/unstructured hybrid grid technique is presented for numerical simulation of three-dimensional inviscid flow fields over complex configurations. The hierarchy Cartesian tessellation is employed to cover the almost entire area of interest, whereas unstructured elements only closing to solid wall for describing complex geometries without staircasing effects. To simulate boundary layer effects on solid wall for three-dimensional viscous flow fields, a Cartesian/unstructured/prismatic hybrid grid technique is developed also. A cell-centered finite volume scheme is presented for arbitrary shapes of elements. The numerical results demonstrate the capability of simulating complex flow fields with complicate boundaries accurately, efficiently and robustly.

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DETERMINATION OF ORGANIC ACID IN HAW BY MICROTITRATION

DETERMINATION OF ORGANIC ACID IN HAW BY MICROTITRATION

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40th IUPAC Congress

作者： Ling-shuang Cai,Mao Chen,Zhen-guo zhang,Ji-chao zhang,Yin Xie(College of Chemistry & Molecular Sciences,Wuhan University,Wuhan 430072)

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