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A functional hydrogenase mimic that catalyzes robust H_(2) evolution spontaneously in aqueous environment

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Nano Research 2024年第5期17卷 3942-3949页

作者： Ningning Song zhanjun guo Shuo Wang Yongli Li Yunpeng Liu Meishuai Zou Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials Science&Engineering Beijing Institute of TechnologyBeijing 100081China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Although great progress has been made in improving hydrogen production,highly efficient catalysts,which are able to produce hydrogen in a fast and steady way at ambient temperature and pressure,are still in large ***,we report a[NiCo]-based hydrogenase mimic,NiCo_(2)O_(4) nanozyme,that can catalyze robust hydrogen evolution spontaneously in water without external energy input at room *** hydrogenase nanozyme facilitates water splitting reaction by forming a three-center Ni-OH-Co bond analogous to the[NiFe]-hydrogenase reaction by using aluminum as electron donor,and realizes hydrogen evolution with a high production rate of 915 L·h^(-1) per gram of nanozymes,which is hundreds of times higher than most of the natural hydrogenase or hydrogenase ***,the NiCo_(2)O_(4) nanozyme can robustly disrupt the adhesive oxidized layer of aluminum and enable the full consumption of electrons from *** contrast to the often-expensive synthetic catalysts that rely on rare elements and consume high energy,we envision that this NiCo_(2)O_(4) nanozyme can potentially provide an upgrade for current hydrogen evolution,accelerate the development of scale-up hydrogen production,and generate a clean energy future.

关键词： hydrogenase mimic nanozyme hydrogen evolution reaction aluminum activation water-splitting

Enhancing the peroxidase-like activity of MoS_(2)-based nanozymes by introducing attapulgite for antibacterial application and sensitive detection of glutathione

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Nano Research 2024年第8期17卷 7415-7426页

作者： Feng Feng Yihe Zhang Xiao Zhang Bin Mu Jiahe Zhang Wenjie Qu Wangshu Tong Minmin Liang Qi An zhanjun guo Lu Zhao Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Clay Mineral Applied Research of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Experimental Center of Advanced Materials School of Materials Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Nanozymes are next-generation of nanomaterials with enzyme-like *** particular,nanozymes with peroxidase(POD)-like activity have been utilized in various fields,including antibacterial,detection,degradation,***,their extensive applications were limited by their low catalytic activity ***,we have presented a composite nanozyme based on attapulgite(ATP)(Fe-ATP-MoS_(2)(FAM)),which exhibited enhanced POD-like activity(185.33 U·mg^(−1)),4.25 times higher than that of Fe-MoS_(2)(FM)(43.63 U·mg^(−1)).The density functional theory(DFT)calculations indicated that the addition of ATP increased the electron density of metal centers(Mo and Fe).More importantly,Michaelis–Menten kinetics revealed that the introduction of ATP significantly enhanced the binding affinities of substrates through the pores of ATP,forming a highly concentrated substrate microenvironment and thus promoting its POD-like ***,from molecular size and kinetic analysis,we proposed that the changes in substrate size before and after oxidation also significantly affected its Michaelis-constant(Km)***,we utilized FAM in the applications of highly effective antibacterial application and sensitive detection of glutathione(GSH).In conclusion,this work provides a novel approach for designing a highly efficient nanozyme based on natural mineral composites.

关键词： attapulgite peroxidase electron density affinity antibacterial

Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong zhanjun guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li Zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

Recent progress in single-atom nanozymes research

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Nano Research 2023年第2期16卷 1878-1889页

作者： Bing Jiang zhanjun guo Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom nanozyme(SAzyme)is the hot topic of the current nanozyme *** intrinsic properties,such as high activity,stability,and low cost,present great substitutes to natural ***,its fundamental characteristics,i.e.,maximized atom utilizations and well-defined geometric and electronic structures,lead to higher catalytic activities and specificity than traditional *** have been applied in many biomedical areas,such as anti-tumor therapy,biosensing,antibiosis,and anti-oxidation ***,we will discuss a series of representative examples of SAzymes categorized by their biomedical applications in this *** the end,we will address the future opportunities and challenges SAzymes facing in their designs and applications.

关键词： single-atom nanozymes natural enzymes enzyme-like activity biomedical applications

Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage

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Nano Research 2023年第8期16卷 10763-10769页

作者： Yue Yu Yinuo Zhang Yu Wang Wenxing Chen zhanjun guo Ningning Song Minmin Liang Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China Shanghai Synchrotron Radiation Facilities Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghai 201204China Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)***,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural *** MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic ***,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,***,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes.

关键词： MnO_(2)@graphene oxide(MnO_(2)@GO)nanozyme superoxide dismutase(SOD)-like activity activity specificity antioxidation

HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway

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Virologica Sinica 2023年第5期38卷 680-689页

作者： Baoxin Zhao Hongxiu Qiao Yan Zhao Zhiyun Gao Weijie Wang Yan Cui Jian Li zhanjun guo Xia Chuai Sandra Chiu Institute of Medical and Health Science Hebei Medical UniversityShijiazhuang050017China Department of Pathogen Biology Hebei Medical UniversityShijiazhuang050017China Department of Gastroenterology and Hepatology The Fourth Hospital of Hebei Medical UniversityShijiazhuang050000China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega ScienceChinese Academy of SciencesWuhan430207China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei230026China

Chronic hepatitis B virus(HBV)infection is one of the leading causes of hepatocellular carcinoma(HCC).The HBV genome is prone to mutate and several variants are closely related to the malignant transformation of liver disease.G1896A mutation(G to A mutation at nucleotide 1896)is one of the most frequently observed mutations in the precore region of HBV,which prevents HBeAg expression and is strongly associated with ***,the mechanisms by which this mutation causes HCC are ***,we explored the function and molecular mechanisms of the G1896A mutation during HBV-associated HCC.G1896A mutation remarkably enhanced the HBV replication in ***,it increased tumor formation and inhibited apoptosis of hepatoma cells,and decreased the sensitivity of HCC to ***,the G1896A mutation could activate ERK/MAPK pathway to enhanced sorafenib resistance in HCC cells and augmented cell survival and ***,our study demonstrates for the first time that the G1896A mutation has a dual regulatory role in exacerbating HCC severity and sheds some light on the treatment of G1896A mutation-associated HCC patients.

关键词： HBV G1896A mutation Hepatocellular carcinoma(HCC) Proliferation Apoptosis ERK/MAPK

Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA and age-at-onset of patients with chronic kidney disease

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Chinese Medical Journal 2014年第17期127卷 3088-3091页

作者： Bai Yaling guo zhanjun Xu Jinsheng Zhang Junxia Cui Liwen Zhang Huiran Zhang Shenglei Ai Xiaolu Department of Nephrology the Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China Departments of Gastroenterologyand Hepatology the Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China

Background The mitochondrial displacement loop （D-loop） accumulates mutations and single nucleotide polymorphisms （SNPs） at a higher frequency than other regions of mitochondrial DNA （mtDNA）.We previously identified disease riskassociated SNPs in the D-loop of chronic kidney disease （CKD） patients; in this study,we investigated the association of age-at-onset and D-loop SNPs in CKD *** The D-loop region of mtDNA was sequenced in 119 CKD patients attending the Fourth Hospital of Hebei Medical University between 2002 and *** age-at-onset curve of the CKD patients was calculated using the KaplanMeier method at each SNP site,and compared using the log-rank *** The mean age of 119 CKD patients was （55.6±14.2） years,and 56.3% were *** mean estimated glomerular filtration rate （eGFR） was （81.2±12.4） ml·min^-1·1.73 m^-2,with 79.8% （n=95） of patients having an eGFR 〈60 ml·min^-1·1.73 m^-*** participants had an eGFR 〉30 ml·min^-1·1.73 m^-*** age-at-onset for CKD patients who smoked was significantly lower than that of non-smoking CKD *** SNP sites of nucleotides 150C/T were identified for their association with age-at-onset using the log-rank *** age-at-onset of patients with the minor allele T genotype was significantly lower than that of patients with the C genotype at the 150 SNP site （P=0.010）.Conclusions Genetic polymorphisms in the D-loop appear to be predictive markers for age-at-onset in CKD ***,the analysis of genetic polymorphisms in the mitochondrial D-loop may help identify CKD patient subgroups at high risk of early onset disease.

关键词： D-loop peptide chronic kidney disease single nucleotide polymorphism mitochondrial DNA

Multilocular Cystic Renal Cell Carcinoma:A Series of 8 Cases and Review of the Literature

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Chinese Journal of Clinical Oncology 2007年第2期4卷 133-136页

作者： Shuo Liu Guang Sun zhanjun guo Xiaodong Li Depertment of Urology Second Hospital of Tianjin Medical University Institute of Urology Tianjin 300211 China

OBJECTIVE To study the clinical,pathologic and imaging features of multilocular cystic renal cell carcinoma(MCRCC)and to review the diagnosis and treatment of this subtype of renal cell carcinoma(RCC). METHODS The data from 8 cases(mean age,49.4;5 men and 3 women) who had been treated from 2004 to 2006,were reviewed retrospectively. Radiologic and pathologic documents were *** treatments,radi- cal nephrectomy was conducted in 4 patients,partial nephrectomy in 2 and laparoscopic nephrectomy in 2. RESULTS Postoperative pathological findings confirmed the diagnosis of *** stage of al 8 cases was *** pathologic grade,7 cases were G1 and 1 case was *** patients available for follow-up had sur- vived tumor-free during the mean time of 8 months. CONCLUSION MCRCC is an uncommon subtype of RCC,it has a lower malignant potential and a better prognosis compared with other types of ***-sparing surgery may be an appropriate treatment options for MCRCC.

关键词：多囊性肾细胞癌诊断治疗文献综述

河南省国有鲁山林场加强森林资源保护的措施探析

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南方农业 2022年第22期16卷 67-70页

作者：郭占军河南省国有鲁山林场河南鲁山467300

森林资源保护是可持续发展战略要求下林业发展的重要工作,各省也针对林业资源保护出台了相关政策和指导建议,明确划分各部门责任义务,将森林保护纳入防灾减灾工作体系。为加强森林资源保护力度,以河南省国有鲁山林场为例,阐述了加强森... 详细信息

森林资源保护是可持续发展战略要求下林业发展的重要工作,各省也针对林业资源保护出台了相关政策和指导建议,明确划分各部门责任义务,将森林保护纳入防灾减灾工作体系。为加强森林资源保护力度,以河南省国有鲁山林场为例,阐述了加强森林资源保护的重要性,结合森林资源保护战略的提出背景,从加强林区林木培育、健全护林管理机制两方面对河南省国有鲁山林场采取的措施进行分析总结。

关键词：可持续发展林木培育护林防火森林资源保护河南省国有鲁山林场