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三塔悬索桥施工过程抗风稳定性研究

土木工程学报 2011年第12期44卷 58-63页

作者：张新军郭辉浙江工业大学浙江杭州310014

以目前世界首座跨度超千米的三塔悬索桥——泰州长江公路大桥为工程背景,分别模拟主梁从主跨跨中向两侧桥塔、从两侧桥塔向主跨跨中以及从两侧桥塔和主跨跨中同时向主跨四分点处对称拼装的施工顺序,采用三维非线性空气静力和动力稳定性... 详细信息

以目前世界首座跨度超千米的三塔悬索桥——泰州长江公路大桥为工程背景,分别模拟主梁从主跨跨中向两侧桥塔、从两侧桥塔向主跨跨中以及从两侧桥塔和主跨跨中同时向主跨四分点处对称拼装的施工顺序,采用三维非线性空气静力和动力稳定性分析方法,分析主梁拼装过程结构的空气静力和动力稳定性的演变规律,并从抗风稳定性角度提出三塔悬索桥适宜的主梁拼装施工顺序。结果表明:主梁从两侧桥塔向主跨跨中对称拼装施工时,结构的空气静力和动力稳定性最好,是大跨度三塔悬索桥一种适宜的主梁拼装施工顺序。

关键词：三塔悬索桥主梁拼装施工顺序空气静力稳定性空气动力稳定性

Color Vision Defects with Variation in the Exon 5 of Red and Green Pigment Genes

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眼科学报 1998年第3期14卷 130-133页

作者： Huangxuan Shen, Qingjiong Zhang, Xueshan Xiao, Shiqiang Li, Li guo, Futian JiangZhongshan Ophthalmic Center, Sun Yat-sen university of Medical Sciences , Guangzhou 510060, china Zhongshan Ophthalmic Center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose : To investigate correlation of variation in the exon 5 of red and green pigment genes with color vision *** : Exon 5 of the red and green pigment genes in 11 protans, 19 deutans and 38 normal controls were analyzed by heteroduplux-SSCP *** : In all 11 protans and 8 of the 19 deutans, defects of the red or green pigment gene could be identified. The C polymorphism (A/C at codon 283) in green pigment gene was present in 8 of 44 trichromats and 5 of 24 dichromats. Specific electrophoretic bands were found in 2 normal controls and a ***: Variation in the exon 5 of the red and green pigment genes is the most common cause for color vision defects. Heteroduplex-SSCP analysis is a suitable way in screening specific variation in visual pigment genes. Eye Science 1998; 14 : 130 - 133.

关键词：色觉缺陷视色素基因 SSCP 遗传多态性红色素绿色素

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan Wang Zhi-Shan Wu Antony Stalin guo-Liang Cheng Bing Li Chao Wu Zhi-Hong Huang Shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

市场信号如何提升竞价排名机制的经济效率?--基于搜索引擎平台数据的实证分析

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管理科学学报 2024年第3期27卷 39-57页

作者：蔡祖国李世杰海南大学国际商学院海口570228 南开大学经济学院天津300071

“魏则西事件”将网络搜索引擎平台的主要商业模式--竞价排名的经济效率问题推向风口浪尖.本文以搜索引擎平台企业为例,构造包括搜索引擎平台、销售商、消费者三方主体的博弈模型,考察在互联网信息非对称条件的市场环境下,搜索引擎平台... 详细信息

“魏则西事件”将网络搜索引擎平台的主要商业模式--竞价排名的经济效率问题推向风口浪尖.本文以搜索引擎平台企业为例,构造包括搜索引擎平台、销售商、消费者三方主体的博弈模型,考察在互联网信息非对称条件的市场环境下,搜索引擎平台竞价排名机制的消费者福利效应,进而探究销售商真实地报告产品质量的激励机制,解析市场信号提升竞价排名机制经济效率的作用机理;并结合产业实践数据进行实证检验.研究发现,信息不对称的市场环境下,竞价排名机制引致的销售商竞价均衡,完全不能协助消费者识别销售商产品质量,致使消费者福利因销售商逆向选择而遭受损失;在植入由销售商构建的市场信号后,竞价排名机制引致的销售商竞价均衡,可协助消费者识别最高付费位置的销售商产品质量,进而局部地改善竞价排名机制的消费者福利效应,从而将竞价排名机制经济效率提升至中等水平;但搜索引擎平台没有激励主动为销售商设计市场信号.据此建议,相关规制部门应当约束搜索引擎平台行为,使之完善市场信号识别机制;激励高质量销售商提高产品质量,竞争更优付费位置,进而提高市场信号向消费者传递产品质量信息的效果;同时,搜索引擎平台还应持续评估并优化自身的信誉评价机制.

关键词：竞价排名信息不对称搜索引擎平台市场信号

基于ECT模型修正及算法优化的超音速分离流场图像重建

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化工进展 2024年第8期43卷 4222-4229页

作者：王世伟王超郭琪丁红兵天津大学电气自动化与信息工程学院天津300072 淮南师范学院机械与电气工程学院安徽淮南232038 天津市特种设备监督检验技术研究院国家市场监管重点实验室(特种设备数字孪生共性技术)天津300192

超音速分离器内流场参数的准确测量对其结构与性能优化至关重要,电容层析成像(electrical capacitance tomography,ECT)能够实现非侵入式参数测量,其逆问题求解的数学模型主要通过线性化近似得到,忽略了非线性、“软场”效应等对结果的... 详细信息

超音速分离器内流场参数的准确测量对其结构与性能优化至关重要,电容层析成像(electrical capacitance tomography,ECT)能够实现非侵入式参数测量,其逆问题求解的数学模型主要通过线性化近似得到,忽略了非线性、“软场”效应等对结果的影响,使得当场域内介质分布的介电常数差异较大时,图像重建质量不高。针对上述问题,本文通过引入模型推导误差对ECT逆问题数学模型修正,在此基础上,根据目标函数的可分离特性,设计结合正则化与Split Bregman(RASB)的求解算法,分别对模型误差和待重构介质进行交叉迭代求解。最后通过仿真和实验手段对比分析了RASB算法、Tikhonov正则化算法、L1正则化算法和Landweber算法重建图像效果,结果表明所提算法RASB可以减小线性化近似产生的误差,削弱噪声对图像重建结果的影响,重构的介质分布更加准确,图像中伪影更少。RASB算法对几种模型重建图像的平均相关系数为0.8964,高于Tikhonov正则化算法的0.8353、L1正则化算法的0.8496和Landweber算法的0.8681。

关键词：超音速分离器电容层析成像模型推导误差正则化与SplitBregman 交叉迭代

Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco

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Plant Communications 2024年第6期5卷 154-172页

作者： Geng Chen Zhaokuan guo Yanyu Shu Yan Zhao Lei Qiu Shaofeng Duan Yuan Lin Simei He Xiaobo Li Xiaolin Feng Guisheng Xiang Bo Nian Yina Wang Zhiyuan Li Chongkang Yang Yang Shi Yingchun Lu Guanze Liu Shengchao Yang Guanghui Zhang Bing Hao State Key Laboratory of Conservation and Utilization of Bio-resources in yunnan The Key Laboratory of Medicinal Plant Biology of Yunnan ProvinceNational&Local Joint Engineering Research Center on Germplasms Innovation&Utilization of Chinese Medicinal Materials in Southwest ChinaYunnan Agricultural UniversityKunming 650201China yunnan Characteristic Plant Extraction Laboratory KunmingYunnan 650106China

Cucurbitacin IIa is a triterpenoid isolated exclusively from Hemsleya plants and a non-steroidal anti-inflammatory drug that functions as the main ingredient of prescription Hemslecin capsules and tablets in *** biology provides new strategies for production of such valuable cucurbitacins at a large scale;however,the biosynthetic pathway of cucurbitacin IIa has been unknown,and the heterologous production of cucurbitacins in galactose medium has been expensive and low *** this study,we characterized the functions of genes encoding two squalene epoxidases(HcSE1-2),six oxidosqualene cyclases(HcOSC1-6),two CYP450s(HcCYP87D20 and HcCYP81Q59),and an acyltransferase(HcAT1)in cucurbitacin IIa biosynthesis by heterologous expression in Saccharomyces cerevisiae and Nicotiana *** achieved high-level production of the key cucurbitacin precursor 11-carbonyl-20b-hydroxy-Cuol from glucose in yeast via modular engineering of the mevalonate pathway and optimization of P450 expression *** resulting yields of 46.41 mg/l 11-carbonyl-20b-hydroxy-Cuol and 126.47 mg/l total cucurbitacin triterpenoids in shake flasks are the highest yields yet reported from engineered ***,production of 11-carbonyl-20b-hydroxy-Cuol by transient gene expression in tobacco resulted in yields of 1.28 mg/g dry weight in *** work reveals the key genes involved in biosynthesis of prescription cucurbitacin IIa and demonstrates that engineered yeast cultivated with glucose can produce high yields of key triterpenoid *** describe a low-cost and highly efficient platform for rapid screening of candidate genes and high-yield production of pharmacological triterpenoids.

关键词： cucurbitacin IIa oxidosqualene cyclase OSC 11-carbonyl-20b-hydroxy-Cuol Saccharomyces cerevisiae Nicotiana benthamiana Hemsleya chinensis

硫化杜仲胶改性沥青的微观结构及热解过程分析

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建筑材料学报 2024年第8期27卷 720-726页

作者：崔世超郭乃胜张军褚召阳大连海事大学交通运输工程学院辽宁大连116026

以天然植物基杜仲胶(EUG)为原料,制备了硫化杜仲胶改性沥青(VEUGMA),并对其微观结构和热解过程进行了研究.结果表明:与基质沥青相比,VEUGMA具有更小的针入度、更高的软化点、更大的延度和黏度,以及较好的高温抗变形和低温抗裂能力;与基... 详细信息

以天然植物基杜仲胶(EUG)为原料,制备了硫化杜仲胶改性沥青(VEUGMA),并对其微观结构和热解过程进行了研究.结果表明:与基质沥青相比,VEUGMA具有更小的针入度、更高的软化点、更大的延度和黏度,以及较好的高温抗变形和低温抗裂能力;与基质沥青相比,VEUGMA蜂型结构数量更多且尺寸更小,均方根粗糙度更小,黏附力更大,热解温度更高,以及CO_(2)和CO释放量更小;在基质沥青中加入6%EUG和3.5%硫磺(以EUG质量计)取得的改性效果最佳.

关键词：硫化杜仲胶改性沥青交联网络微观结构热重-傅里叶红外联用热解

WPA1 encodes a vWA domain protein that regulates wheat plant architecture

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The Crop Journal 2024年第4期12卷 992-1000页

作者： Yongxing Chen Huixin Xiao Yuange Wang Wenling Li Lingchuan Li Lingli Dong Xuebo Zhao Miaomiao Li Ping Lu Huaizhi Zhang Guanghao guo Keyu Zhu Beibei Li Lei Dong Peng Chen Shuming Wu Yunbo Jiang Fei Lu Chengguo Yuan Zhiyong Liu Yusheng Zhao Qiuhong Wu Institute of Biotechnology Xianghu LaboratoryHangzhou 311231ZhejiangChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China College of Advanced Agricultural Sciences University of Chinese Academy of SciencesBeijing 100049China Hebei Gaoyi Stock Seeds Farm Gaoyi 051330HebeiChina

Plant height,spike,leaf,stem and grain morphologies are key components of plant architecture and related to wheat yield.A wheat(Triticum aestivum L.)mutant,wpa1,displaying temperaturedependent pleiotropic developmental anomalies,was *** WPA1 gene,encoding a von Willebrand factor type A(vWA)domain protein,was located on chromosome arm 7DS and isolated by map-based *** functionality of WPA1 was validated by multiple independent EMS-induced mutants and gene *** analysis revealed that WPA1 is monocotyledon-specific in higher *** identification of WPA1 provides opportunity to study the temperature regulated wheat development and grain yield.

关键词： Wheat plant architecture Map-based cloning vWA Environmental temperature

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不同水底介质浅水爆炸载荷特性试验研究

中国造船 2024年第4期65卷 180-188页

作者：许江陈涛王立志郭君哈尔滨工程大学船舶工程学院哈尔滨150001 中国船舶及海洋工程设计研究院上海200011

沉底装药水下爆炸冲击波受不同水底介质的影响而呈现不同的载荷特性。对比分析不同水底介质对浅水爆炸载荷特性的影响和确定海底反射系数,设计了底部介质为砾石、黏土和钢板3种工况下的浅水爆炸试验。试验结果表明,由于水底边界的影响,... 详细信息

沉底装药水下爆炸冲击波受不同水底介质的影响而呈现不同的载荷特性。对比分析不同水底介质对浅水爆炸载荷特性的影响和确定海底反射系数,设计了底部介质为砾石、黏土和钢板3种工况下的浅水爆炸试验。试验结果表明,由于水底边界的影响,爆炸冲击波载荷呈现水底反射现象。其中钢板工况的冲击波压力峰值反射系数最大,为1.185,砾石和黏土工况分别为1.069和1.055。

关键词：浅水爆炸海底反射系数水底介质