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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen zhu Tingting guo Yiran Zhang Tingting Xing Peng Yin shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

Effect of diacylglycerol acyltransferase 2overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation

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Journal of Animal Science and Biotechnology 2014年第4期5卷 406-413页

作者： Zhiqi Zhang Gang Shu Xiaotong zhu Junming guo Han Cai Songbo Wang Lina Wang Ping Gao Qianyun Xi yongliang Zhang Li Yuan Qingyan Jiang ALLTECH-SCAU Animal Nutrition Control Research Alliance College of Animal ScienceSouth China Agricultural University College of life science Xiamen University

Background：Fatty acid（FA） composition is the most important parameter affecting the flavor and nutritional value of the *** final and the only committed step in the biosynthesis of triglycerides is catalyzed by diacylglycerol acyltransferase 2（DGAT2）.The role of DGAT2 in lipid accumulation has been demonstrated in adipocytes,However,little is known about the effect of DGAT2 on the FA composition of these ***：To investigate the role of DGAT2 in regulating lipid accumulation,FA composition and the expression of adipogenic genes,we cloned the open reading frame of the porcine DGAT2 gene and established 3T3-L1 cells that overexpressed *** were then cultured in differentiation medium（DM） without FA,with a mixture of FAs（FA-DM）,or containing a ^（13）C stable isotope-labeled FA mixture（IFA-DM）.The FA composition of adipocytes was analyzed by gas chromatography-mass spectrometry and gas chromatography-isotope ratio mass *** PCR and western blotting were employed to detect expression of adipogenic genes in 3T3-L1 adipocytes cultured with FA-DM for 12 ***：The triacylglyceride（TAG） content was significantly higher in 3T3-L1 adipocytes overexpressing DGAT2 than in control *** cultured in DM or FA-DM for 12 d,cells overexpressing DGAT2 showed a higher proportion of unsaturated FAs（C16：1 and C18：1）.However,when cells overexpressing DGAT2 were cultured with FA-DM for30 min,the FA composition was almost identical to that of ***,the proportion of stable isotope-labeled FAs were similar in 3T3-L1 adipocytes overexpressing DGAT2 and control cells cultured in IFA-DM for 12 *** results collectively indicate that the higher proportion of mono-unsaturated FAs,C16：1 and C18：1,may originate from de novo FA synthesis but not from the uptake of specific FAs from the *** hypothesis is further supported by evidence that both mRNA and protein expression of genes involved in FA synthesis（ACACA,FASN,SCD1,and A-FABP）w

关键词： DGAT2 Fatty acid composition Overexpressing Pig

Simulated effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region of the Northern Hemisphere

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Research in Cold and Arid Regions 2021年第1期13卷 18-29页

作者： Di Ma SiQiong Luo DongLin guo shihua Lyu XianHong Meng BoLi Chen LiHui Luo Key Laboratory for Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of ScienceLanzhouGansu 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhouGansu 730000China Nansen-zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China School of Atmospheric Sciences Plateau Atmosphere and Environment Key Laboratory of Sichuan ProvinceChengdu University of Information TechnologyChengduSichuan 610225China Changzhou Meteorological Bureau ChangzhouJiangsu 213000China State Key Laboratory of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China

Soil freeze-thaw process is closely related to surface energy budget,hydrological activity,and terrestrial *** this study,two numerical experiments(including and excluding soil freeze-thaw process)were designed to examine the effect of soil freeze-thaw process on surface hydrologic and thermal fluxes in frozen ground region in the Northern Hemisphere based on the state-of-the-art Community Earth System Model version *** show that in response to soil freeze-thaw process,the area averaged soil temperature in the shallow layer(0.0175−0.0451 m)decreases by 0.35℃in the TP(Tibetan Plateau),0.69℃in CES(Central and Eastern Siberia),and 0.6℃in NA(North America)during summer,and increases by 1.93℃in the TP,2.28℃in CES and 1.61℃in NA during winter,***,in response to soil freeze-thaw process,the area averaged soil liquid water content increases in summer and decrease in *** surface heat flux components,the ground heat flux is most significantly affected by the freeze-thaw process in both summer and winter,followed by sensible heat flux and latent heat flux in *** the TP area,the ground heat flux increases by 2.82 W/m2(28.5%)in summer and decreases by 3.63 W/m2(40%)in ***,in CES,the ground heat flux increases by 1.89 W/m2(11.3%)in summer and decreases by 1.41 W/m2(18.6%)in *** heat fluxes in the Tibetan Plateau are more susceptible to the freeze-thaw process compared with the high-latitude frozen soil *** freeze-thaw process can induce significant warming in the Tibetan Plateau in ***,this process induces significant cooling in high-latitude regions in *** frozen ground can prevent soil liquid water from infiltrating to deep soil layers at the beginning of thawing;however,as the frozen ground thaws continuously,the infiltration of the liquid water increases and the deep soil can store water like a sponge,accompanied by decreasing surface *** influence of the soil freeze-thaw pr

关键词： freeze-thaw effect hydrologic and thermal frozen ground Northern Hemisphere

A General Procedure for Surface Modification of Nano-alumina and Its Application to Dendrimers

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Journal of Wuhan University of Technology(Materials Science) 2007年第3期22卷 453-456页

作者：王斌郭朝霞 Institute of Polymer Science and Engineering Department of Chemical EngineeringSchool of Materials Science and EngineeringTsinghua University

A general procedure for surface modification of nano-alumina using N, N＇-dicyclohexyl- carbodiimide （DCC） mediated amidation is reported. Aliphatic and aromatic carboxylic acids reacted smoothly with nano-alumina pretreated with 3-aminopropyltriethoxysilane in the presence of DCC, giving modified aluminas having organic surfaces. The grafted aluminas have been characterized qualitatively by FT-IR or ^13C CPMAS NMR spectroscopy, and quantitatively by thermogravimetric analysis and elemental analysis. The procedure was applied to polyether dendrons bearing carboxyl groups at the focal points, giving successful grafting of dendrimers onto nano-alumina.

关键词： nano-alumina N, N'-dicyclohexyl-carbodiimide (DCC) surface modification dendrimers

Fundamental band gap and alignment of two-dimensional semiconductors explored by machine learning

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Chinese Physics B 2020年第4期29卷 327-335页

作者： Zhen zhu Baojuan Dong Huaihong guo Teng Yang Zhidong Zhang Materials Department University of CaliforniaSanta BarbaraCA 93106USA Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China College of Sciences Liaoning Shihua UniversityFushun 113001China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Two-dimensional(2D)semiconductors isoelectronic to phosphorene have been drawing much attention recently due to their promising applications for next-generation(opt)*** family of 2D materials contains more than 400members,including(a)elemental group-V materials,(b)binary III–VII and IV–VI compounds,(c)ternary III–VI–VII and IV–V–VII compounds,making materials design with targeted functionality unprecedentedly rich and extremely *** shed light on rational functionality design with this family of materials,we systemically explore their fundamental band gaps and alignments using hybrid density functional theory(DFT)in combination with machine ***,calculations are performed using both the Perdew–Burke–Ernzerhof exchange–correlation functional within the generalgradient-density approximation(GGA-PBE)and Heyd–Scuseria–Ernzerhof hybrid functional(HSE)as a *** find this family of materials share similar crystalline structures,but possess largely distributed band-gap values ranging approximately from 0 eV to 8 ***,we apply machine learning methods,including linear regression(LR),random forest regression(RFR),and support vector machine regression(SVR),to build models for the prediction of electronic *** these models,SVR is found to have the best performance,yielding the root mean square error(RMSE)less than 0.15 eV for the predicted band gaps,valence-band maximums(VBMs),and conduction-band minimums(CBMs)when both PBE results and elemental information are used as ***,we demonstrate that the machine learning models are universally suitable for screening 2D isoelectronic systems with targeted functionality,and especially valuable for the design of alloys and heterogeneous systems.

关键词： two-dimensional semiconductors machine learning

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聚吡咯/碳纤维纸电热复合材料的制备及性能

复合材料学报 2020年第6期37卷 1426-1433页

作者：汤龙其令旭霞王士华郭帅龙柱江南大学生态纺织教育部重点实验室无锡214122 连云港市工业投资集团有限公司连云港222002 连云港纤维新材料研究院有限公司连云港222002

在碳纤维纸(CPP)上采用气相聚合法使吡咯单体发生聚合生成聚吡咯(PPY),制备聚吡咯/碳纤维(PPY/CF)纸导电发热复合材料。通过FTIR、SEM、XRD对PPY/CF纸复合材料进行测试分析,并探究了CPP中CF的最佳质量分数及FeCl3的最优溶度,研究了PPY/C... 详细信息

在碳纤维纸(CPP)上采用气相聚合法使吡咯单体发生聚合生成聚吡咯(PPY),制备聚吡咯/碳纤维(PPY/CF)纸导电发热复合材料。通过FTIR、SEM、XRD对PPY/CF纸复合材料进行测试分析,并探究了CPP中CF的最佳质量分数及FeCl3的最优溶度,研究了PPY/CF纸复合材料的力学性能和电热性能。结果表明,成功制备了PPY/CF纸复合材料,且PPY主要附着在芳纶浆粕上;采用CF质量分数为10 wt%的CPP且FeCl3浓度为1.2 mol/L时,制备的PPY/CF纸复合材料具有最低的电阻率,为0.139Ω·cm;PPY/CF纸复合材料与CPP相比不仅力学性能大幅提高,而且在低电压下,PPY/CF纸复合材料具有导电性能稳定、发热效果显著、热稳定性好等优点。

关键词：碳纤维聚吡咯电阻率复合材料力学性能电热性能

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聚苯胺-碳纤维导电纸的制备

精细化工 2021年第1期38卷 147-154页

作者：令旭霞秦栋王士华郭帅龙柱江南大学生态纺织教育部重点实验室江苏无锡214122 连云港纤维新材料研究院有限公司江苏连云港222002

采用改良的分步液相原位聚合法使得聚苯胺均匀生长在碳纤维纸基体上。考察了碳纤维质量分数、引发剂过硫酸铵(APS)与苯胺用量,以及浸渍时间和反应时间对聚苯胺-碳纤维导电纸导电性能的影响。采用SEM观察导电纸的微观形貌,利用FTIR与EDS... 详细信息

采用改良的分步液相原位聚合法使得聚苯胺均匀生长在碳纤维纸基体上。考察了碳纤维质量分数、引发剂过硫酸铵(APS)与苯胺用量,以及浸渍时间和反应时间对聚苯胺-碳纤维导电纸导电性能的影响。采用SEM观察导电纸的微观形貌,利用FTIR与EDS分别表征其表面结构与元素变化。结果表明,当碳纤维质量分数为20%,引发剂APS浓度为0.375 mol/L,n(苯胺)∶n(盐酸,1 mol/L)=2∶1,反应时间为12 h,浸渍时间为1 min时,制备的导电纸(PANI-CP)的导电性能最佳。相对于碳纤维原纸(CP),制备的PANI-CP电导率为5.435 S/cm,导电性能提高250.0%,抗张指数为27.665N·m/g,抗张指数提高37.3%。相对于液相原位聚合法制备的导电纸(L-PANI-CP),PANI-CP导电性能提高85.9%,总色差值(DE)下降66.0%。

关键词：聚苯胺碳纤维物理强度均匀性导电纸有机电化学与工业

酸处理对干法纺甲纶聚酰亚胺纤维增强体性能的影响

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材料研究学报 2017年第2期31卷 96-101页

作者：陈乐龙柱王士华李志强郭帅王斌江南大学生态纺织教育部重点实验室无锡214122 华南理工大学制浆造纸工程国家重点实验室广州510640 连云港市工业投资集团有限公司连云港222002

以HCl为湿化学处理液,研究了HCl处理对聚酰亚胺纤维增强体浸润性能、微观形貌、热性能、细度及力学性能、化学结构和微观聚集态结构的影响,在分析纤维浸润性能改善的同时也分析了其他性能及结构的变化。结果表明:HCl处理后纤维表面凹凸... 详细信息

以HCl为湿化学处理液,研究了HCl处理对聚酰亚胺纤维增强体浸润性能、微观形貌、热性能、细度及力学性能、化学结构和微观聚集态结构的影响,在分析纤维浸润性能改善的同时也分析了其他性能及结构的变化。结果表明:HCl处理后纤维表面凹凸不平,粗糙度增加,局部发生了刻蚀,引入了活性基团,表面能提高,浸润性能改善。且随着HCl浓度或温度的提高、处理时间的延长浸润性能改善趋势加快,热性能保持较好,细度及力学性能略有降低。在H+的作用下纤维酰亚胺环少量开环水解为聚酰胺酸,化学结构变化不明显,微观聚集态结构发生改变,非结晶区比例上升。HCl处理能有效地对纤维表面进行功能化改性。

关键词：复合材料酸处理聚酰亚胺纤维浸润性能性能及结构

聚苯胺表面修饰芳纶浆粕及其纸基材料的导电性能

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高等学校化学学报 2020年第11期41卷 2553-2560页

作者：令旭霞龙柱王士华李志强郭帅张丹江南大学生态纺织教育部重点实验室无锡214122 连云港纤维新材料研究院有限公司连云港222002 连云港市工业投资集团有限公司连云港222002

通过在芳纶浆粕(AP)表面修饰聚苯胺(PANI)制备了聚苯胺-芳纶浆粕(PANI-AP),然后与碳纤维(CF)共混,采用湿法抄纸技术制备导电性能优异的纸基材料(PANI-AP/CP).对其形貌结构、导电性能及PANI分布均匀性进行了表征,并研究了环境湿度、温度... 详细信息

通过在芳纶浆粕(AP)表面修饰聚苯胺(PANI)制备了聚苯胺-芳纶浆粕(PANI-AP),然后与碳纤维(CF)共混,采用湿法抄纸技术制备导电性能优异的纸基材料(PANI-AP/CP).对其形貌结构、导电性能及PANI分布均匀性进行了表征,并研究了环境湿度、温度、pH值及放置时间对PANI-AP/CP导电性能的影响.研究结果表明,PANI-AP表面粗糙度增加,结晶度增加,出现含醌式结构的导电PANI的衍射峰,说明PANI成功修饰于AP表面.采用该方法制备的PANI-AP/CP导电性能与分布均匀性均得到提高,相对于碳纤维纸基材(CP),PANIAP/CP的电导率为3.937 S/cm,导电性能提高153.5%.与PANI原位生长于CP(AP/CP-PANI)相比,PANI-AP/CP的导电性能提高34.6%,总色差值(DE)降低74.9%.

关键词：聚苯胺芳纶浆粕导电性分布均匀性