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Paired quasi-periodic pulsations of hard X-ray emission in a solar flare

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Science China(Physics,Mechanics & Astronomy) 2023年第5期66卷 195-206页

作者： Hai-Sheng Zhao dong li Shao-lin Xiong yan-Qiu zhang yang su Wei Chen yi Zhao Xiao-Bo li Jia-Cong liu Wen-Xi Peng rui Qiao Xin-Qiao li Xiang-yang Wen li-Ming Song Shi-jie Zheng Xin-ying Song Xiao-Yun Zhao Yue Huang Shuang-nan zhang Shuo Xiao Ce Cai Zheng-Hua An Can Chen Gang Chen Wei Chen yan-Qi Du Min Gao Ke Gong dong-ya guo Zhi-Wei guo Jian-Jian He Bin li Chao li Chao-yang li Gang li Jian-Hui li Lu li Qing-Xin li yan-guo li jing liang Xiao-Hua liang Jin-Yuan liao Xiao-jing liu ya-Qing liu Qi Luo Xiang Ma Bin Meng Ge Ou dong-li Shi jing-yan Shi Gong-Xing sun Xi-Lei sun You-li Tuo Chen-Wei Wang Hui Wang Jin Wang Jin-Zhou Wang Ping Wang Wen-Shuai Wang hong Wu Sheng-Lun Xie yan-Bing Xu Yu-Peng Xu Wang-Chen Xue Sheng yang Min yao Jian-ying Ye Qi-Bin yi Chao-Yue zhang Da-li zhang Fan zhang Fei zhang hong-Mei zhang Kai zhang Peng zhang Xiao-Lu zhang Zhen zhang guo-ying Zhao Shi-yi Zhao Chao Zheng Xing Zhou Yue Zhu Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Beijing Normal UniversityBeijing 100875China School of Computing and Artificial Intelligence Southwest Jiaotong UniversityChengdu 611756China Physics and Space Science College China West Normal UniversityNanchong 637002China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Institute of Astrophysics Central China Normal UniversityWuhan 430079China School of Physics Changchun University of Science and TechnologyChangchun 130022China College of Physics and Engineering Qufu Normal UniversityQufu 273165China College of Physics Sciences&Technology Hebei UniversityBaoding 071002China

We investigate high time resolution data obtained by the Gravitational wave high-energy Electromagnetic Counterpart All-sky Monitor(GECAM)during the flare event on 2022 April 21 at 01:52 *** subpeaks with durations of 4-6 s have been detected in the hard X-ray precursor phase,and the key feature is that they appear in pairs and seem like double-peak *** subpeaks are rarely observed in hard X-ray band and confirmed by the microwave obtained by Nobeyama Radio Polarimeters(NoRP)and Radio Solar Telescope Network(RSTN).While an exponential function can describe the continuum component of the time profile from the precursor to part of the impulsive *** periods of quasi-periodic pulsations(QPPs)are detected to be about 7.3 and 12.8 s for the precursor and impulsive phase,respectively,with at least 95%confidence *** paired QPPs are assumed to be double-peak QPPs and then the scenario of current loop coalescence model is found to be in good agreement with our *** precursor phase can be interpreted as the oscillating coalescence of two islands,while the impulsive phase can be interpreted as more islands to coalesce one by one to form larger islands.

关键词： solar flare QPPs loop coalescence circular-ribbon flare

Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSNS Back‑n

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Nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le yang Zhen‑dong An Wei Jiang Xian‑Kai li Wei‑Wei Qiu Zheng‑Fa liao Zi‑Yue Zhuang Xiao‑Ping zhang Sheng‑li Chen Chen‑Chen guo Er‑Xi Xiao Xiao Fang Xin‑Xiang li Xin‑Rong Hu Bing Jiang Jin‑Cheng Wang jie Ren Wen Luo Zhi‑Chao Zhu Hao‑yang Lan Zong‑Wei Cao Xu Ma ying‑Du liu pu‑Sen Wang yi yang Ping su Xian‑Gai Deng Wan‑Bing He chun‑Wang Ma Yu‑Ting Wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang Tang Tao Zhou jing Wang Han yi Yue zhang Yong‑Hao Chen rui‑rui Fan Ke‑Qing Gao Qiang li Kang sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao jing jing‑Yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CNSA Macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of Nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and Nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation Neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoNiS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoNiS v1.0 recommended value.

关键词： Time-of-flight technique Neutron capture cross sections Maxwell average cross sections

Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China

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Biomedical and Environmental Sciences 2020年第12期33卷 893-905页

作者： MA yan ZHU dong Shan CHEN Ren Bo SHI nan nan liU Si hong FAN yi Pin WU Gui Hui yaNG pu Ye BAI Jiang Feng CHEN hong CHEN li ying FENG Qiao guo Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI liang JIN Hai Hao LEI Xiao li chun yan li Min Qing li Qun Tang li Xian Yong liU hong De liU Jin Ping liU zhang MA Yu Ting MAO ya MO liu Fen na Hui WANG jing Wei SONG Fang li sun Sheng WANG dong Ting WANG Ming Xuan WANG Xiao yan WANG yin Zhen WANG Yu dong WU Wei WU Lan Ping XIAO yan Hua XIE Hai Jun XU hong Ming XU Shou Fang XUE rui Xia yaNG chun yaNG Kai Jun YUAN Sheng li zhang Gong Qi zhang Jin Bo zhang lin Song ZHAO Shu Sen ZHAO Wan ying ZHENG Kai ZHOU ying chun ZHU Jun Teng ZHU Tian Qing zhang Hua Min WANG yan Ping WANG Yong yan 无 Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012ShandongChina Institute of Information on Traditional Chinese Medicine China Academy of Chinese Medical SciencesBeijing 100700China Department of Tuberculosis The Public Health Clinical Center of ChengduChengdu 610066SichuanChina Department of Infectious Disease Shaanxi Infectious Disease HospitalXi'an 610113ShaanxiChina Department of Infectious Disease Yulin Chinese Medicine HospitalYulin 719000ShaanxiChina President's Office The First Hospital of QiqiharQiqihar 161005HeilongjiangChina Department of Traditional Chinese Medicine Shangluo Central HospitalShangluo 726000ShaanxiChina Department of Traditional Chinese Medicine The People's Hospital of QitaiheQitaihe 154603HeilongjiangChina Department of Scientific Research Xianyang Central HospitalXianyang 712000ShaanxiChina Department of traditional Chinese medicine The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230012AnhuiChina Department of Infectious Disease Heping Hospital Affiliated to Changzhi Medical CollegeChangzhi 046000ShanxiChina Department of Traditional Chinese Medicine Langfang Hospital of Chinese MedicineLangfang 065000HeibeiChina Department of Traditional Chinese Medicine Xingtai Hospital of Chinese MedicineXingtai 054001HeibeiChina Department of Traditional Chinese Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 168600GuangxiChina Department of Traditional Chinese Medicine The First People'sHospital of FangchenggangFangchenggang 538001GuangxiChina Department of Traditional Chinese Medicine Mianyang Hospital of Traditional Chinese MedicineMianyang 621000SichuanChina Department of Traditional Chinese Medicine Liuzhou People's HospitalLiuzhou 545006GansuChina Department of Traditional Chinese Medici

Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains *** A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of *** Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two *** Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes.

关键词： Comorbidities COVID-19 Severity Gender Age Treatment outcome

Cancer metabolism and tumor microenvironment:fostering each other?

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Science China(life Sciences) 2022年第2期65卷 236-279页

作者： yiyuan Yuan Huimin li Wang pu Leilei Chen dong guo hongfei Jiang Bo He Siyuan Qin Kui Wang na li jingwei Feng jing Wen Shipeng Cheng yaguang zhang Weiwei yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng zhang Ping Gao Peng Jiang Shicheng su Bing sun Shi-Min Zhao Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200438China State Key Laboratory of Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Molecular and Cell Biology Lab Institutes of Biomedical Sciences and School of Life SciencesFudan UniversityShanghai 200032China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China West China School of Basic Medical Sciences&Forensic Medicine Sichuan Universityand State Key Laboratory of Biotherapy and Cancer CenterWest China Hospitaland Collaborative Innovation Center for BiotherapyChengdu 610041China Department of Biochemistry and Molecular Cell Biology Shanghai Key Laboratory of Tumor Microenvironment and InflammationShanghai Jiao Tong University School of MedicineShanghai 200025China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China School of life Science and Technology ShanghaiTech UniversityShanghai 201210China CAS Centre for Excellence in Cell and Molecular Biology the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China School of Medicine Institutes for Life SciencesSouth China University of TechnologyGuangzhou 510006China Tsinghua University School of life Sciences and Tsinghua-Peking Center for Life SciencesBeijing 100084China

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells *** reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental *** evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling *** cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor *** cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of *** conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer ***,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer *** metabolic,microRnas,and ncRnas alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as *** them,cancer microenvironmental cells are immune cells which exert profound effects on cancer *** of all these processes is a prerequisite for the development of a more effective strategy to contain cancers.

关键词： cancer metabolism cancer microenvironment epigenetics cancer immunology

SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou zhang De-Ming li li-Ren Shen Hai-Rong zhang Zhi-ling Chen Han-Wen Du Ming Gu rui li De-Kang liu Yue-Hu pu Jun-Feng Yu Jian-Feng Chen Chu Chen chun-Long guo Hao guo Ge-yang Jiang Zhi-Qiang Jiang lin Jin Wen-jing li Xiu-Fang li Ye lin Ming liu Yong-Hao liu ya-Juan liu Ming Lv Qing-Ru Mi lian-Hua Ouyang Wei-guo Shi Hang Shu Qi-Sheng Tang Kun Wang Zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun zhang Miao zhang Wen-Zhi zhang li-ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-dong sun Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the national Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-yi su sun-Bin ling Qiao-nan Shan Xu-Yong Wei rui Wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo sun Guang-Ming li Tai-Shi Fang nan Jiang Kun zhang Zhao-jie su Zhi-Hai Peng Ren Lang Tao Jiang Qiang He lin-Sen Ye yang yang Yu-Ting He Wen-Zhi guo liu-Gen Lan Xu-Yong sun dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-Hua Shi Bo Wang Jiang liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-yin yang pu-Sen Wang lin Zhong jing-Sheng Ma Qi-Gen li Sheng-dong Wu Chang-Jiang Lu Cai-De Lu dong-Hua zhang Xuan Wang Zi-Qiang li Mu-Jian Teng Jun-jie li Wen-Tao Jiang Jian-Hua li Quan-Bao zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-Hua Song Zhi-Ren Fu Wei Qiu guo-Yue Lv rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou Gang Chen ying-Peng Zhao li li Ze-Min Hu Qi-jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion

A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism

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Journal of Molecular Cell Biology 2022年第2期14卷 56-71页

作者： lianju Qin jing zhang Yujie Xiao Kang liu Yugui Cui Fangyan Xu Wenkai Ren yanggang Yuan chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan li Guang yang Shaowen Tang Zhihong zhang Juncheng Dai jing guo Qiang Wang Bin sun yifei Ge chun Ouyang Xueqiang Xu jing Wang yaoyu Huang hongqing Cui jing Zhou Meilian Wang Zhonglan su yan Lu Di Wu jingping Shi Wei liu li dong yinbing Pan Baiqiao Zhao ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen jie Wang Meng Cao Qian Cui li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang yanyan Pan ling Wang Xianrong Xu jing Zhao Xiuqin Wang Cuiping liu Ningxia liang Changying Xing Jiayin liu Ningning Wang State Key Laboratory of Reproductive Medicine Center of Clinical Reproductive MedicineThe First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Cardiology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Rheumatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Dermatology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Burn and Plastic surgery The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nuclear Medicine The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Infection The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Anesthesiology and Pain Management The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Nephrology The First People’s Hospital of LianyungangLianyungang 222061China Department of Nephrology Northern Jiangsu People’s HospitalYangzhou 225001China Department of General Medicine Geriatric Hospital of Nanjing Medical UniversityNanjing 210024China Department of Nephrology BenQ Medical CenterThe Affiliated BenQ Hospital of Nanjing Medical Uni

Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven ***,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified *** of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was *** release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were *** further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude *** the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the *** followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear *** biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged *** infusion or local treatment-related adverse events ***,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity.

关键词： calciphylaxis chronic kidney disease vascular calcification multidisciplinary rescue human amnion-derived mesenchymal stem cells preclinical research regenerative medicine

Diagnostic Guidelines for Infertility

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Reproductive and Developmental Medicine 2020年第1期4卷 11-17页

作者： Zi-Jiang Chen Jia-yin liu He-Feng Huang jie Qiao Can-Quan Zhou guo-Ning Huang ying-pu sun dong-Zi yang Xiao-yan liang Qi Yu Yun sun Zheng li li-Qing Fan Cong-Jian Xu Yuan-Hua Huang Xue-hong zhang jing yang Shao-Ming Lu lin-lin Cui Jun-Hao yan Jin-Fang lin Center for Reproductive Medicine Shandong UniversityJinan 250000China Clinical Center for Reproductive Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 211129China Department of Reproductive Medicine International Peace Maternity and Child Health HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Chongqing City Institute of Reproduction and Genetics Chongqing 400010China Center for Reproductive Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Obstetrics and Gynecology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Reproductive Medicine Center The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510655China Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Center for Reproductive Medicine Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Sperm Bank of Reproductive and Genetic Hospital of CITIC-XIANGya Changsha 410008China Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Reproductive Medicine Center The First Affiliated Hospital of Hainan Medical UniversityHaikou 570120China Department of Reproductive Medicine The First Hospital of Lanzhou UniversityLanzhou 730000China Center for Reproductive Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China

Infertility seriously endangers the reproductive health of women at childbearing *** is defined as the failure to achieve successful pregnancy after 1 year or more of regular unprotected *** defined,infertility includes two aspects-failure to conceive or have a live *** guideline only addressed content relevant to the *** was proposed by the gynecological endocrine group of the Chinese Society of Obstetrics and Gynecology,Chinese Medical Association,based on relevant guidelines of the World Health Organization,the American Society for Reproductive Medicine,the national Institute for Health and Clinical Excellence,as well as the clinical practice in *** guideline was reviewed by experts and doctors from medical institutions at all levels,which is applicable to the diagnosis of infertility by physicians in obstetrics,gynecology,and andrology at various medical institutions nationwide.

关键词： Diagnostic Guidelines Etiological Classification Infertility Evaluation

短效达必佳两种降调节方案在控制性超排卵中的效果比较

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生殖与避孕 2010年第1期30卷 32-36页

作者：赵红岩孙莹璞苏迎春郭艺红张轶乐孔慧娟李刚董悦芝郑州大学第一附属医院生殖医学中心郑州450052

目的:比较短效达必佳2种降调节方案在控制性超排卵(COH)中的效果。方法:回顾性分析比较本中心接受COH降调节方案的261个周期,根据达必佳用量及用法的不同分成A组:部分半量方案,95个周期;B组:半量方案,166个周期,比较组间的超促排卵情况... 详细信息

目的:比较短效达必佳2种降调节方案在控制性超排卵(COH)中的效果。方法:回顾性分析比较本中心接受COH降调节方案的261个周期,根据达必佳用量及用法的不同分成A组:部分半量方案,95个周期;B组:半量方案,166个周期,比较组间的超促排卵情况及妊娠结局。结果:A组Gn用量(75IU/支)、Gn总天数、IVF受精率和优质胚胎率均较B组高(P<0.05);Gn启动日FSH水平和hCG注射日LH水平较B组低(P<0.05);着床率、临床妊娠率、继续妊娠率A组与B组比差异无统计学意义(P<0.05),但有增高趋势。结论:黄体中期短效达必佳0.1mg/d×14d降调节效果比0.05mg/d降调节好。

关键词：达必佳垂体降调节控制性超促排卵