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中国有色金属学会会刊：英文版 2004年第z1期14卷 186-189页

作者： WANG Wei HOU Feng-yan guo He-tong School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Ni-ZrO2 nanocomposite coatings with monodispersed ZrO2 nanoparticles were prepared from the composite plating bath containing dispersant under DC electrodeposition condition. It is found that the morphology, orientation and hardness of the composite coating with monodispersed ZrO2 nanoparticles have lots of difference from the composite coating with agglomerated ZrO2 nanoparticles and pure nickel coating. Especially, the result of hardness shows that only a very low volume fraction (less than 1%) of monodispered ZrO2 nanoparticles in Ni-ZrO2 composite coatings will result in higher hardness of the coating. The hardness of Ni-ZrO2 nanocomposite coatings with monodispersed and agglomerated ZrO2 nanoparticles are HV 529 and HV 393, respectively. The hardness value of the former composite coatings is over 1.3 times higher than that of the later. All these composite coatings are 2 - 3 times higher than that of pure nickel plating (HV 207) prepared under the same conditions.

关键词： Nanocomposites electroplating coating metal matrix composites Ni-ZrO2

Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy

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Neural Regeneration Research 2023年第5期18卷 976-982页

作者： Lei Tang guo-tong Xu Jing-Fa Zhang Department of Ophthalmology of tongji Hospital Tongji Eye InstituteDepartment of Regenerative Medicineand Department of PharmacologyTongji University School of MedicineShanghaiChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease, is the leading cause of visual impairment in diabetic patients. Many clinical features observed in diabetic retinopathy, such as capillary occlusion, acellular capillaries and retinal non-perfusion, aggregate retinal ischemia and represent relatively late events in diabetic retinopathy. In fact, retinal microvascular injury is an early event in diabetic retinopathy involving multiple biochemical alterations, and is manifested by changes to the retinal neurovascular unit and its cellular components. Currently, intravitreal anti-vascular endothelial growth factor therapy is the firstline treatment for diabetic macular edema, and benefits the patient by decreasing the edema and improving visual acuity. However, a significant proportion of patients respond poorly to anti-vascular endothelial growth factor treatments, indicating that factors other than vascular endothelial growth factor are involved in the pathogenesis of diabetic macular edema. Accumulating evidence confirms that low-grade inflammation plays a critical role in the pathogenesis and development of diabetic retinopathy as multiple inflammatory factors, such as interleukin-1β, monocyte chemotactic protein-1 and tumor necrosis factor-α, are increased in the vitreous and retina of diabetic retinopathy patients. These inflammatory factors, together with growth factors such as vascular endothelial growth factor, contribute to blood-retinal barrier breakdown, vascular damage and neuroinflammation, as well as pathological angiogenesis in diabetic retinopathy, complicated by diabetic macular edema and proliferative diabetic retinopathy. In addition, retinal cell types including microglia, Müller glia, astrocytes, retinal pigment epithelial cells, and others are activated, to secrete inflammatory mediators, aggravating cell apoptosis and subsequent vascular leakage. New therapies, targeting these inflammatory molecules or relate

关键词： anti-inflammation therapy anti-vascular endothelial growth factor diabetic retinopathy hyperreflectivity foci inflammation inflammatory cells inflammatory cytokines leukostasis microglia Müller cells

Content subscribing mechanism in P2P streaming based on gamma distribution prediction

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1983-1989页

作者： guo tong-qiang WENG Jian-guang ZHUANG Yue-ting School of Computer Science Zhejiang University Hangzhou 310027 China

P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism （CSM） to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.

关键词： P2P streaming Gamma distribution Content subscribing mechanism (CSM)

A simplified three-dimensional extension of Hoek-Brown strength criterion

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第3期13卷 568-578页

作者： Hangzhou Li tong guo Yalin Nan Bo Han Department of Civil Engineering Xi’an Jiaotong UniversityXi’anShaanxi710049China Shaanxi Engineering Research Center of Soil Body China Electronic Research Institute of Engineering Investigation and DesignXi’anShaanxi710054China

The Hoek-Brown(HB)strength criterion has been applied widely in a large number of projects around the ***,this criterion ignores the intermediate principal stress *** evidences have demonstrated that the rock strength is dependent on *** it is necessary to extend the HB criterion into a three-dimensional(3D)*** this study,the effect of s2 on the strength of rocks is identified by reviewing the true triaxial tests of various rock types reported in the literature.A simple 3D strength criterion is *** modified criterion is verified by the true triaxial tests of 13 rock *** results indicate that the modified criterion can achieve a good fit to most of rock *** can represent a series of criteria as b *** comparisons,several existing 3D versions of the HB criterion are selected to predict the strengths of these rock *** is indicated that the proposed criterion works better than other criteria.A substantial relationship between parameter b and the unconfined compressive strength is established,which guarantees that the proposed criterion can still work well even in the absence of true triaxial test data.

关键词： Hoek-Brown(HB)strength criterion Three-dimensional(3D)strength criterion Intermediate principal stress Failure envelope

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肝动脉灌注化疗在肝细胞癌治疗中研究进展

中国实用外科杂志 2024年第8期44卷 953-958页

作者：张炜浩高炜司同国邢文阁于海鹏陈璐天津医科大学肿瘤医院、国家肿瘤临床医学研究中心、天津市恶性肿瘤临床医学研究中心、天津市消化系统肿瘤重点实验室、药物成药性评价与系统转化重点实验室介入治疗科天津300060 天津医科大学肿瘤医院、国家肿瘤临床医学研究中心、天津市恶性肿瘤临床医学研究中心、天津市消化系统肿瘤重点实验室、药物成药性评价与系统转化重点实验室肝胆肿瘤科天津300060

以靶向、免疫治疗为代表的系统治疗是晚期肝细胞癌的标准治疗,但总体有效率并不高。肝动脉灌注化疗(HAIC)能够有效控制肝内肿瘤,且微创、安全性好。系统治疗联合HAIC能有效提高客观缓解率和疾病控制率,改善生活质量。目前文献报道,HAIC... 详细信息

以靶向、免疫治疗为代表的系统治疗是晚期肝细胞癌的标准治疗,但总体有效率并不高。肝动脉灌注化疗(HAIC)能够有效控制肝内肿瘤,且微创、安全性好。系统治疗联合HAIC能有效提高客观缓解率和疾病控制率,改善生活质量。目前文献报道,HAIC在外科术前降期、术后辅助和综合治疗中均有积极应用。但如何在病人初诊时筛选出优势人群,根据病人的病情特点做到个体化用药,仍需深入探讨。

关键词：肝细胞癌肝动脉灌注化疗分子靶向治疗免疫治疗

Effect of pyrolytic carbon interphase on mechanical properties of mini T800-C/SiC composites

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Journal of Advanced Ceramics 2021年第2期10卷 219-226页

作者： Donglin Zhao tong guo Xiaomeng Fan Chao Chen Yue Ma Science and Technology on Thermostructure Composites Materials Laboratory Northwestern Polytechnical UniversityXi’an710072China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai201203China

The effect of pyrolytic carbon(PyC) thickness on the tensile property of mini T800 carbon fiber reinforced SiC matrix composites(C/SiC) was studied. PyC interphase was prepared by chemical vapor infiltration(CVI) process using C3H6–Ar as gas source, the PyC thickness was adjusted from 0 to 400 nm, and then the SiC matrix was prepared by CVI process using methyltrichlorosilane(MTS)–H2–Ar as precursor and gas source. The results showed that the tensile strength of mini T800-C/SiC increased first and then decreased with the increase of the PyC thickness. When the thickness of PyC was 100 nm, the average strength reached the maximum value of 393 ± 70 MPa. The Weibull modulus increased from 2.0 to 8.06 with the increase of PyC thickness, and the larger the Weibull modulus, the smaller the dispersion, which indicated that the regulation of PyC thickness was conducive to improve tensile properties.

关键词： T800 carbon fiber C/SiC pyrolytic carbon(PyC)interphase tensile strength Weibull modulus

Accurate stress analysis on rigid central buckle of long-span suspension bridges based on submodel method

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Science China(Technological Sciences) 2009年第4期52卷 1019-1026页

作者： WANG Hao LI AiQun guo tong MA Shuang College of Civil Engineering Southeast UniversityNanjing 210096China

Runyang Suspension Bridge (RSB) with the main span of 1490 m is the longest bridge in China and the third longest one in the world. In this bridge the rigid central buckle is employed for the first time in the mid-span of the suspension bridge in China. For such a super-long-span bridge, the traditional finite element (FE) modeling technique and stress analysis methods obviously cannot satisfy the needs of conducting accurate stress analysis on the central buckle. In this paper, the submodel method is in- troduced and for the first time used in analyzing the stresses of the central buckle. After an accurate FE submodel of the central buckle was specially established according to the analysis results from the whole FE model, the connection technique between the two-scale FE models was realized and the ac- curate stresses of the central buckle under various vehicle load cases were then conducted based on the submodel method. The calculation results were testified to be accurate and reliable by the field measurements, which show the efficiency and reliability of the submodel method on analyzing the mechanical condition of the central buckle of long-span suspension bridges. Finally, the working be- havior and mechanical characteristics of the central buckle of the RSB under vehicle loads were ana- lyzed based on the calculation and measurement results. The results obtained in this paper can provide theoretic references for analyzing and designing the rigid central buckle in long-span suspension bridges in future.

关键词： suspension bridge central buckle accurate stress submodel method field measurements

Field measurement on wind characteristic and buffeting response of the Runyang Suspension Bridge during typhoon Matsa

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Science China(Technological Sciences) 2009年第5期52卷 1354-1362页

作者： WANG Hao LI AiQun guo tong XIE Jing College of Civil Engineering Southeast UniversityNanjing 210096China

Field measurement on wind characteristic and buffeting response of existing bridge is of great value to the development of bridge wind engineering,and the structural health monitoring system(SHMS) em-ployed in many long-span bridges provide a research basis for the field *** order to pro-vide reliable basis for wind resistant evaluation of Runyang Suspension Bridge(RSB),two anemome-ters and 85 accelerometers were installed in the SHMS of *** August 2005,Typhoon Matsa crossed over Jiangsu,the SHMS timely recorded the typhoon and structural vibration *** this paper by using the time-frequency technique and statistical theory,the recorded data were analyzed to obtain the strong wind characteristics,the buffeting response characteristics of the cable and deck,and the variation of buffeting response RMS versus wind *** obtained in this study can be em-ployed to validate the credibility of current buffeting response analysis theory techniques,and provide reference values for wind resistant evaluation of other long-span bridges.

关键词： suspension bridges typhoons buffeting response field measurement structural health monitoring system(SHMS)

Analysis and assessment of bridge health monitoring mass data——progress in research/development of “Structural Health Monitoring”

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Science China(Technological Sciences) 2012年第8期55卷 2212-2224页

作者： LI AiQun DING YouLiang WANG Hao guo tong Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China

The "Structural Health Monitoring" is a project supported by National Natural Science Foundation for Distinguished Young Scholars of China(Grant No.50725828).To meet the urgent requirements of analysis and assessment of mass monitoring data of bridge environmental actions and structural responses,the monitoring of environmental actions and action effect modeling methods,dynamic performance monitoring and early warning methods,condition assessment and operation maintenance methods of key members are systematically studied in close combination with structural characteristics of long-span cable-stayed bridges and suspension *** paper reports the progress of the project as follows.(1) The environmental action modeling methods of long-span bridges are established based on monitoring data of temperature,sustained wind and *** action effect modeling methods are further developed in combination with the multi-scale baseline finite element modeling method for long-span bridges.(2) The identification methods of global dynamic characteristics and internal forces of cables and hangers for long-span cable-stayed bridges and suspension bridges are proposed using the vibration monitoring data,on the basis of which the condition monitoring and early warning methods of bridges are developed using the environmental-condition-normalization technique.(3) The analysis methods for fatigue loading effect of welded details of steel box girder,temperature and traffic loading effect of expansion joint are presented based on long-term monitoring data of strain and beam-end displacement,on the basis of which the service performance assessment and remaining life prediction methods are developed.

关键词： structural health monitoring bridge mass data condition assessment environmental action

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重复低强度红光疗法防控近视的研究进展

中国斜视与小儿眼科杂志 2024年第3期32卷 47-48页

作者：郭姿彤韩惠芳河北医科大学眼科教研室河北省眼科医院

近视发病率与日俱增,预防、管理近视的任务迫在眉睫。其中重复低强度红光疗法以其抑制眼轴增长的独特优势成为当今的新兴研究热点。本文就近视发病机制、红光疗法防控近视的机制、临床应用和视觉副作用进行综述,以期为近视防控策略的制... 详细信息

近视发病率与日俱增,预防、管理近视的任务迫在眉睫。其中重复低强度红光疗法以其抑制眼轴增长的独特优势成为当今的新兴研究热点。本文就近视发病机制、红光疗法防控近视的机制、临床应用和视觉副作用进行综述,以期为近视防控策略的制定及工作的开展提供新思路。

关键词：近视重复低强度红光机制副作用