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Chinese Journal of Integrative Medicine 1995年第1期1卷 87-90页

作者： guo sai-shan (郭赛珊) Liang Xiao-chun (梁晓春) Yin Feng-hua (殷凤华) Wang Xiang-ding (王香定) (Peking Union Medical College Hospital, Beijing )(100730)guo sai-qi(郭赛琪) (Clinic of China News Press, Beijing) Peking Union Medical College Hospital Beijing Clinic of China News Press Beijing

Blood flow in the lower leg was determined in 50 cases of non-insulin dependent diabetesmellitus using an XLJ-2 bipolar rheoencephalometry impedance rheogram. In patients with leg pain (85legsi and diabetic foat (15 legs3, the blood flow of the lower leg was decreased as compared withhealthy legs (P<0. 01￣0. 001) . The group with diabetic foot showed a bigger decrease compared withthe leg pain group (PMO. 051 . Atter treatment with the principle of vitalizing blood and solubilizing throm-bus, 22 cases with leg pain (32 legs) showed a significant increase of blood flow in the lower leg (P<0. 001). The group with diabetic foot failed to show any significant increase, indicating the importance ofearly treatment. This method of determining blood flow in the lower leg will help early discovery of abnor-mal changes of blood supply in the lower leg. Treatment with the principle of vitalizing blood and solubiliz-ing thrombus can help improve the conditions of the patients.

关键词： blood flow in the lower leg diabetic foot Qi-Yin deficiency with blood stasis deficien-cy of both Yin and Yang with blood stasis

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中西医结合治疗糖尿病的优势

中国中西医结合杂志 2005年第6期25卷 565-569页

作者：郭赛珊屈岭中国医学科学院中国协和医科大学北京协和医院北京100730

中西医结合治疗糖尿病的优势是多方面的,其中最主要的、也是最根本的是提高了临床疗效。已有许多学者从整体、细胞、亚细胞及分子水平中西医有机结合进行了临床研究,说明在控制高血糖、改善临床症状、改善胰岛素抵抗、治疗糖耐量低减、... 详细信息

中西医结合治疗糖尿病的优势是多方面的,其中最主要的、也是最根本的是提高了临床疗效。已有许多学者从整体、细胞、亚细胞及分子水平中西医有机结合进行了临床研究,说明在控制高血糖、改善临床症状、改善胰岛素抵抗、治疗糖耐量低减、恢复胰岛β细胞功能、治疗高糖高脂血症及糖尿病并发症等方面,中西医结合治疗优于单用西药和单用中药治疗,展示了独特的优势。本文就近10年来有关的文献报道进行了综述。

关键词：中西医结合治疗胰岛β细胞功能糖尿病并发症胰岛素抵抗糖耐量低减临床疗效临床研究有机结合分子水平临床症状高脂血症中药治疗单用西药文献报道亚细胞高血糖

ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期68卷 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming guo shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

关键词： spatial transcriptome histological images spatial resolution enhancement

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高脂饲料与胰岛素抵抗动物模型

中国药理学通报 2006年第3期22卷 267-269页

作者：田爱平郭赛珊申竹芳中国医学科学院.中国协和医科大学北京协和医院北京100730 中国医学科学院.中国协和医科大学药物研究所北京100050

高脂饮食是2型糖尿病及胰岛素抵抗综合征发病的重要环境因素,以高脂饲料诱发实验动物产生胰岛素抵抗,建立稳定可靠而且经济实用的动物模型,成为2型糖尿病及胰岛素抵抗相关研究的重要内容。高脂饲料是否成功地诱发实验动物产生胰岛素抵抗... 详细信息

高脂饮食是2型糖尿病及胰岛素抵抗综合征发病的重要环境因素,以高脂饲料诱发实验动物产生胰岛素抵抗,建立稳定可靠而且经济实用的动物模型,成为2型糖尿病及胰岛素抵抗相关研究的重要内容。高脂饲料是否成功地诱发实验动物产生胰岛素抵抗,与饲料脂肪构成,高脂饲料的加工方式,动物摄入总热量,动物模型形成时间,实验动物品系、性别差异以及有无化学物质辅助诱导等诸多因素有关。

关键词：高脂饮食胰岛素抵抗 2型糖尿病

高热量饲料诱发胰岛素抵抗动物模型的实验研究

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中国药学杂志 2006年第11期41卷 827-831页

作者：田爱平郭赛珊陈跃腾申竹芳中国医学科学院-中国协和医科大学北京协和医院北京100730 中国医学科学院-中国协和医科大学药物研究所北京100050

目的研究高热量饲料诱发胰岛素抵抗(IR)动物模型的特征以及影响因素。方法两种性别的SD大鼠随机分为正常组和由高蔗糖、高脂肪组成的高热量饲料喂养的模型组,模型组大鼠于高热量饲料喂养前腹腔注射小剂量链脲霉素。用胰岛素耐量、糖耐... 详细信息

目的研究高热量饲料诱发胰岛素抵抗(IR)动物模型的特征以及影响因素。方法两种性别的SD大鼠随机分为正常组和由高蔗糖、高脂肪组成的高热量饲料喂养的模型组,模型组大鼠于高热量饲料喂养前腹腔注射小剂量链脲霉素。用胰岛素耐量、糖耐量及糖异生等试验评估模型动物的胰岛素敏感性。结果给予高热量饲料6周可诱发实验动物产生以腹型肥胖、糖耐量异常、胰岛素耐量异常、糖异生能力增强、肝脏脂质沉积等为特征的IR动物模型。高热量饲料的加工方式以及实验动物的性别影响IR动物模型的形成。结论高热量饲料可诱发IR动物模型,但受饲料的加工方式及动物性别因素的影响。

关键词：高热量饲料糖尿病糖耐量减低胰岛素抵抗

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li shan guo Zhuang Tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Solvation

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308例2型糖尿病中医临床证型调查分析

北京中医药大学学报 2008年第6期31卷 420-423页

作者：张晓阳郭赛珊张孟仁王景李颖中国医学科学院中国协和医科大学北京协和医院北京100730

目的了解当前糖尿病患者中医临床证及证型的构成情况。方法对308例2型糖尿病患者进行中医证候的横断面调查,应用计算机根据辨证分型标准对患者进行辨证分型。结果8个基本证中湿热证179例次、血瘀证155例次、阴虚证122例次、火旺证89例... 详细信息

目的了解当前糖尿病患者中医临床证及证型的构成情况。方法对308例2型糖尿病患者进行中医证候的横断面调查,应用计算机根据辨证分型标准对患者进行辨证分型。结果8个基本证中湿热证179例次、血瘀证155例次、阴虚证122例次、火旺证89例次、气虚证16例次、血热证2例次、阳虚证和血虚证0例;证型分布:单证型107例、两证相兼型115例、三证相兼型53例、四证相兼型2例、无证型31例。结论湿热证、血瘀证、阴虚证是构成糖尿病临床复杂证型的基础,湿热证已成为当今糖尿病最常见的临床基本证型。

关键词： 2型糖尿病辨证分型临床调查

活血化瘀法在糖尿病及其慢性微血管并发症治疗中的作用

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环球中医药 2009年第2期2卷 118-120页

作者：梁晓春郭赛珊北京协和医院中医科 100730

瘀血是糖尿病发展过程中的病理产物又是慢性并发症的致病因素和病理基础,自从祝谌予教授提出活血化瘀治疗糖尿病以来,糖尿病血瘀症及活血化瘀治疗糖尿病及其慢性并发症的研究领域异常活跃。本文就糖尿病血瘀证及活血化瘀治疗糖尿病的作... 详细信息

瘀血是糖尿病发展过程中的病理产物又是慢性并发症的致病因素和病理基础,自从祝谌予教授提出活血化瘀治疗糖尿病以来,糖尿病血瘀症及活血化瘀治疗糖尿病及其慢性并发症的研究领域异常活跃。本文就糖尿病血瘀证及活血化瘀治疗糖尿病的作用机制结合我们研究的结果,谈谈活血化瘀法在糖尿病及其并发症治疗中的作用。

关键词：糖尿病血瘀证活血化瘀

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li shan-shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Surface Integrity of Inconel 738LC Parts Manufactured by Selective Laser Melting Followed by High-speed Milling

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Chinese Journal of Mechanical Engineering 2023年第1期36卷 65-79页

作者： Guanhui Ren sai guo Bi Zhang Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen518055China Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials Shenzhen518055China Research and Development Department Shenzhen Xinjinquan Precision Techonology Co.Ltd.Shenzhen518055China School of Mechanical Engineering Shandong UniversityJinan250061China

This study is concerned with the surface integrity of Inconel 738LC parts manufactured by selective laser melting(SLM)followed by high-speed milling(HSM).In the investigation process of surface integrity,the study employs ultradepth three-dimensional microscopy,laser scanning confocal microscopy,scanning electron microscopy,electron backscatter diffractometry,and energy dispersive spectroscopy to characterize the evolution of material microstructure,work hardening,residual stress coupling,and anisotropic effect of the building direction on surface integrity of the *** results show that SLM/HSM hybrid manufacturing can be an effective method to obtain better surface quality with a thinner machining metamorphic ***-speed machining is adopted to reduce cutting force and suppress machining heat,which is an effective way to produce better surface mechanical properties during the SLM/HSM hybrid manufacturing *** general,high-speed milling of the SLM-built Inconel 738LC samples offers better surface integrity,compared to simplex additive manufacturing or casting.

关键词： Surface integrity Inconel 738LC Selective laser melting High-speed milling