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Neural network mapping of gelastic behavior in children with hypothalamus hamartoma

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World Journal of Pediatrics 2024年第7期20卷 735-745页

作者： Zhi‑hao guo Jian‑guo Zhang Xiao‑Qiu Shao Wen‑Han Hu Lin Sang Zhong Zheng Chao Zhang Xiu Wang Chun‑De Li Jia‑Jie Mo Kai Zhang Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityNo.119 South 4th Ring West RoadFengtai DistrictBeijing 100070China Department of Neurosurgery Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Fengtai HospitalBeijingChina

Background Hypothalamus hamartomas(HHs)are rare,congenital,tumor-like,and nonprogressive malformations resulting in drug-resistant epilepsy,mainly affecting *** seizures(GS)are an early hallmark of epilepsy with *** aim of this study was to explore the disease progression and the underlying physiopathological mechanisms of pathological laughter in *** We obtained clinical information and metabolic images of 56 HH patients and utilized ictal semiology evaluation to stratify the specimens into GS-only,GS-plus,and no-GS subgroups and then applied contrasted trajectories inference(cTI)to calculate the pseudotime value and evaluate GS *** logistic regression was performed to identify neuroimaging-clinical predictors of GS,and then voxelwise lesion network-symptom mapping(LNSM)was applied to explore GS-associated brain *** cTI inferred the specific metabolism trajectories of GS progression and revealed increased complexity from GS to other seizure *** was further validated via actual disease duration(Pearson R=0.532,P=0.028).Male sex[odds ratio(OR)=2.611,P=0.013],low age at seizure onset(OR=0.361,P=0.005),high normalized HH metabolism(OR=−1.971,P=0.037)and severe seizure burden(OR=−0.006,P=0.032)were significant neuroimaging clinical *** revealed that the dysfunctional cortico-subcortico-cerebellar network of GS and the somatosensory cortex(S1)represented a negative *** This study sheds light on the clinical characteristics and progression of GS in children with *** identified distinct subtypes of GS and demonstrated the involvement of specific brain regions at the cortical–subcortical–cerebellar *** valuable results contribute to our understanding of the neural correlates of GS.

关键词： Contrasted trajectories inference Gelastic seizure Hypothalamus hamartoma Lesion network-symptom mapping Neural basis

Characteristics and drivers of the soil multifunctionality under different land use and land cover types in the drylands of China

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Regional Sustainability 2024年第3期5卷 99-110页

作者： SONG Boyi ZHANG Shihang LU Yongxing guo hao guo Xing WANG Mingming ZHANG Yuanming ZHOU Xiaobing ZHUANG Weiwei College of Life Sciences Xinjiang Normal UniversityUrumqi830054China State Key Laboratory of Desert and Oasis Ecology Key Laboratory of Ecological Safety and Sustainable Development in Arid LandsXinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi830011China Xinjiang Key Laboratory of Biodiversity Conservation and Application in Arid Lands Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi830011China Xinjiang Field Scientific Observation Research Station of Tianshan Wild Fruit Forest Ecosystem Ili Botanical GardenXinjiang Institute of Ecology and GeographyChinese Academy of SciencesIli844900China University of Chinese Academy of Sciences Beijing100049China

The drylands of China cover approximately 6.6×106 km2 and are home to approximately 5.8×10^(8)people,providing important ecosystem services for human survival and ***,dryland ecosystems are extremely fragile and sensitive to external environmental *** use and land cover(LULC)changes significantly impact soil structure and function,thus affecting the soil multifunctionality(SMF).However,the effect of LULC changes on the SMF in the drylands of China has rarely been *** this study,we investigated the characteristics of the SMF changes based on soil data in the 1980s from the National Tibetan Plateau Data *** explored the drivers of the SMF changes under different LULC types(including forest,grassland,shrubland,and desert)and used structural equation modeling to explore the main driver of the SMF *** results showed that the SMF under the four LULC types decreased in the following descending order:forest,grassland,shrubland,and *** main driver of the SMF changes under different LULC types was mean annual temperature(MAT).In addition to MAT,pH in forest,soil moisture(SM)and soil biodiversity index in grassland,SM in shrubland,and aridity index in desert are crucial factors for the SMF ***,the SMF in the drylands of China is regulated mainly by MAT and pH,and comprehensive assessments of the SMF in drylands need to be performed regarding LULC *** results are beneficial for evaluating the SMF among different LULC types and predicting the SMF under global climate change.

关键词： Soil multifunctionality(SMF) Land use and land cover(LULC)changes Structural equation modeling(SEM) Climate change Dryland ecosystems

Clinical characteristics and risk factors of Talaromyces marneffei infection in human immunodeficiency virus-negative patients: A retrospective observational study

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World Journal of Emergency Medicine 2021年第4期12卷 281-286页

作者： Hong-yan Wei Wen-jie Liang Bin Li Ling-yu Wei An-qi Jiang Wei-dong Chen Peng-hao guo Jia Xu Department of Emergency Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Pulmonary and Critical Care Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Clinical Trial Unit the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine the First Affi liated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

BACKGROUND: To investigate the clinical characteristics and risk factors of human immunodeficiency virus(HIV)-negative patients with Talaromyces marneffei(T. marneffei) ***: We retrospectively collected the clinical information of HIV-negative patients with T. marneffei infection from January 1, 2010 to June 30, 2019, and analyzed the related risk factors of poor ***: Twenty-five cases aging 22 to 79 years were included. Manifestations of T. marneffei infection included fever, cough, dyspnea, chest pain or distress, lymphadenopathy, ear, nose, and throat(ENT) and/or skin lesions, bone or joint pain, edema and pain in the lower extremities, digestive symptoms, icterus, malaise, and hoarseness. Two cases had no comorbidity, while 23 cases suff ered from autoimmune disease, pulmonary disease, cancer, and other chronic diseases. Sixteen cases had a medication history of glucocorticoids, chemotherapy or immunosuppressors. Pulmonary lesions included interstitial infiltration, nodules, atelectasis, cavitary lesions, pleural effusion or hydropneumothorax, bronchiectasis, pulmonary fibrosis, pulmonary edema, and consolidation. The incidence of osteolytic lesions was 20%. Eight patients received antifungal monotherapy, and 11 patients received combined antifungal agents. Fifteen patients survived and ten patients were dead. The Cox regression analysis showed that reduced eosinophil counts, higher levels of blood urea nitrogen(BUN), alanine aminotransferase(ALT), aspartate aminotransferase(AST), lactic dehydrogenase(LDH), myoglobin(Mb), procalcitonin(PCT), and galactomannan were related to poor prognosis(hazard ratio [HR]>1, P<0.05).CONCLUSIONS: Bone destruction is common in HIV-negative patients with T. marneffei infection. Defective cell-mediated immunity, active infection, multiple system, and organ damage can be the risk factors of poor prognosis.

关键词： Talaromyces marneffei Human immunodeficiency virus Bone destruction Risk factors

The Synthesis of Aromatic Hydrazones as Nitrogen-Containing Prostaglandin Congeners

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Chinese Chemical Letters 1998年第6期9卷 529-531页

作者： guo hao XIE Yan Mei HE Yuan Liu WU(Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050) Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China

We synthesized a series of hydrazones, a novel type of nitrogen-containing prostaglandins, from different aromatic hydrazines and variant 2-substituted amino-3-hydroxy bicycle [3.2.0]hept-6-ones IV.

关键词： aromatic hydrazine hydrazone nitrogen-containing prostaglandin

Carbon neutrality:China's energy transition over the past decade

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China Geology 2024年第4期7卷 803-806页

作者： Li-qiong Jia Xi-jie Chen Zi-guo hao Development and Research Center China Geological SurveyMinistry of Natural ResourcesBeijing 100037China

China's energy transition is based on accelerating the construction of a clean,low-carbon,safe,and efficient new energy system(Fig.1),providing strong energy security for economic and social development;focusing on ecological civilization construction,and accelerating the formation of a new energy consumption model that is efficient,green,inclusive,and beneficial,while promoting carbon reduction,pollution reduction,expansion of green spaces,and economic growth.

关键词： transition energy neutral

Impact of Lycium Barbarum Polysaccharide and Danshensu on vascular endothelial growth factor in the process of retinal neovascularization of rabbit

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 59-61页

作者： Xue-Min Tian Rui Wang Bai-Ke Zhang Chun-Lei Wang hao guo Shi-Jin Zhang Department of Ophthalmology Department of Traditional Chinese Medicine People's Hospital of Zhengzhou

AIM:To discuss the impact of Lycium Barbarum Polysaccharide (LBP) and Danshensu purified from Traditional Chinese Medicine (TCM) on vascular endothelial growth factor (VEGF) of rabbits with retinal neovascularization. METHODS:Forty rabbits were divided into normal control group, model control group, LBP group and Danshensu group. Animals in the normal control group were fed in the normal oxygen environment. Animals in the other three groups were put into the environment with 70% oxygen for 5 days in order to build the model of oxygen-induced vascular proliferation retinopathy. And then different TCM extract was injected into the abdominal cavities of these annimals. After 7 days, the VEGF content of in the serum of rabbit was measured by double antibody sandwich method. RESULTS:Data analysis indicated that VEGF content was as follows:Danshensu group was lower than model control group (12.92 ±3.84ng/L vs 19.32 ±4.15ng/L, P < 0.05); LBP group and normal control group were lower than model control group (12.92±3.84ng/L, 9.26±1.61ng/L vs 19.32±4.15ng/L, P<0.01); total blood viscosity, plasma viscosity, cholesterol content, fibrinogen content and triacylglycerol content after peritoneal injection of LBP and Danshensu were obviously lower than before injection. CONCLUSION:TCM extract-LBP and Danshensu can prominently reduce the content of VEGF in the process of vascular proliferative retinopathy of rabbit; can prevent the occurrence of retinal microvascular disease by improving partial oxygen -deficient environment or affecting all kinds of new growth factor.

关键词： Lycium Barbarum Polysaccharide Danshensu vascular endothelial growth factor retinal neovascularization rabbit

Development of mobile miniature natural gas liquefiers

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Frontiers in Energy 2020年第4期14卷 667-682页

作者： Yanxing Zhao Maoqiong GONG haocheng WANG hao guo Xueqiang DONG Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100039China

With increasing consumption of natural gas(NG),small NG reservoirs,such as coalbed methane and oil field associated gas,have recently drawn significant *** to their special characteristics(e.g.,scattered distribution and small output),small-scale NG liquefiers are highly ***,the mixed refrigerant cycle(MRC)is suitable for small-scale liquefaction systems due to its moderate complexity and power *** consideration of the above,this paper reviews the development of mobile miniature NG liquefiers in Technical Institute of Physics and Chemistry(TIPC),*** effectively liquefy the scattered NG and overcome the drawbacks of existing technologies,three main improvements,i.e.,low-pressure MRC process driven by oil-lubricated screw compressor,compact cold box with the new designed heat exchangers,and standardized equipment manufacturing and integrated process technology have been *** development pattern of"rapid cluster application and flexible liquefaction center"has been eventually *** small-scale NG liquefier developed by TIPC has reached a minimum liquefaction power consumption of about 0.35 kW.h/Nm^(3).It is suitable to exploit small remote gas reserves which can also be used in boil-off gas reliquefaction and distributed peak-shaving of pipe networks.

关键词： natural gas mobile miniature liquefiers mixed refrigerant cycle vapor liquid equilibrium heat transfer

IUGS released first 100 Geological Heritage Sites and China has seven in the list

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China Geology 2023年第1期6卷 177-182页

作者： Li-qiong Jia Xi-jie Chen Ting Jia Zi-guo hao Development and Research Center of China Geological Survey Ministry of Natural ResourcesBeijing 100037China

On October 26,2022,the International Union of Geological Sciences(IUGS)unveiled the First 100 IUGS Geological Heritage Sites in *** sites are located in56 countries,including 34 in the Americas,28 in Europe,15 in Africa and 23 in the Asia-Pacific-Middle East region(Table 1).The seven selected sites of China are introduced as follows(black font in Table 1).

关键词： Geological Middle Sites

The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection

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Protein & Cell 2017年第8期8卷 590-600页

作者： Xuyuan Zhang Pan Yang Nan Wang Jialong Zhang Jingyun Li hao guo Xiangyun Yin Zihe Rao Xiangxi wang Liguo Zhang Key Laboratory of Infection and Immunity Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China National Laboratory of Macromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Entero virus 71 （EV71） causes hand, foot, and mouth disease （HFMD） and occasionally leads to severe neurological complications and even death. Scavenger receptor class B member 2 （SCARB2） is a functional receptor for EV71, that mediates viral attachment, internalization, and uncoating. However, the exact binding site of EV71 on SCARB2 is unknown. In this study, we generated a monoclonal antibody （mAb） that binds to human but not mouse SCARB2. It is named JL2, and it can effectively inhibit EV71 infection of target cells. Using a set of chimeras of human and mouse SCARB2, we identified that the region containing residues 77-113 of human SCARB2 contributes significantly to JL2 binding. The structure of the SCARB2-JL2 complex revealed that JL2 binds to the apical region of SCARB2 involving a-helices 2, 5, and 14. Our results provide new insights into the potential binding sites for EV71 on SCARB2 and the molecular mechanism of EV71 entry.

关键词： SCARB2 EV71 monoclonal antibody,HFMD receptor