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Local prediction of the chaotic fh-code based on LS-SVM

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Journal of Systems Engineering and Electronics 2008年第1期19卷 65-70页

作者： Wang yi guo Wei National Key Lab of Communication Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

Support vector machine （SVM） is powerful to solve some problems such as nonlinear classification, function estimation and density estimation. To consider the chaotic fh （frequency hopping）-code＇s characters in chaotic dynamic system, the forecasting model of the support vector machine in combination with Takens＇ delay coordinate phase reconstruction of chaotic times is established and the least squares model for large-scale problems is used in local training for this model. Finally, a fh-code series generated by Logistic-Kent mapping is applied to verify the local prediction model. Simulation results show that the high accuracy and fault tolerant SVM model has an excellent performance in predicting the fh code, with a very low mean square error and a high relative coefficient.

关键词： support vector machine(SVM) fh code least squares(LS) prediction

Outlier Analysis for Gene Expression Data

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Journal of Computer Science & Technology 2004年第1期19卷 13-21页

作者： ChaoYan guo-LiangChen yi-FeiShen NationalHighPerformanceComputationalCenter UniversiLyofScienceandTechnologyofChinaHefei230027P.R.China

The rapid developments of technologies that generate arrays of gene dataenable a global view of the transcription levels of hundreds of thousands of genes *** outlier detection problem for gene data has its importance but together with the difficulty ofhigh dimensionality. The sparsity of data in high-dimensional space makes each point a relativelygood outlier in the view of traditional distance-based definitions. Thus, finding outliers in highdimensional data is more complex. In this paper, some basic outlier analysis algorithms arediscussed and a new genetic algorithm is presented. This algorithm is to find best dimensionprojections based on a revised cell-based algorithm and to give explanations to solutions. It cansolve the outlier detection problem for gene expression data and for other high dimensional data aswell.

关键词： gene expression data outlier analysis cell-based algorithm geneticalgorithm

Optimal Dividend and Dynamic Reinsurance Strategies with Capital Injections and Proportional Costs

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 505-524页

作者： yi-dong WU Jun-yi guo School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China School of Economics Yunnan UniversityKunming 650091China

We consider an optimization problem of an insurance company in the diffusion setting, which controls the dividends payout as well as the capital injections. To maximize the cumulative expected discounted dividends minus the penalized discounted capital injections until the ruin time, there is a possibility of （cheap or non-cheap） proportional reinsurance. We solve the control problems by constructing two categories of suboptimal models, one without capital injections and one with no bankruptcy by capital injection. Then we derive the explicit solutions for the value function and totally characterize the optimal strategies. Particularly, for cheap reinsurance, they axe the same as those in the model of no bankruptcy.

关键词： proportional reinsurance non-cheap optimal dividend capital injections

A novel low-voltage high precision current reference based on subthreshold MOSFETs

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 50-55页

作者： YU guo-yi ZOU Xue-eheng Department of Electronic Science ＆ Technology Huazhong University of Science and Technology Wuhan 430074 China

A novel topology low-voltage high precision current reference based on subthreshold Metal-Oxide-Semiconductor Field Effect Transistors （MOSFETs） is presented. The circuit achieves a temperature-independent reference current by a proper combination current of two first-order temperature-compensation current references, which exploit the temperature characteristics of integrated poly2 resistors and the 1- V transconductance characteristics of MOSFET operating in the subthreshold region. The circuit, designed with the 1 st silicon 0.35 μm standard CMOS logic process technology, exhibits a stable current of about 2.25 μA with much low temperature coefficient of 3 × 10^-4μA/℃ in the temperature range of-40-150 ℃ at 1 V supply voltage, and also achieves a better power supply rejection ratio （PSRR） over a broad frequency. The PSRR is about -78 dB at DC and remains -42 dB at the frequency higher than 10 MHz. The maximal process error is about 6,7% based on the Monte Carlo simulation. So it has good process compatibility.

关键词： Current reference Curvature-compensation Low voltage Subthreshold CMOS integrated circuit

Multi-channel blind deconvolution algorithm for multiple-input multiple-output DS/CDMA system

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Journal of Systems Engineering and Electronics 2007年第3期18卷 454-461页

作者： Cheng Hao guo Wei Jiang yi National Key Lab of Communication Univ. of Electronic Science and Technology Chengdu 610054 P. R. China

Direct sequence spread spectrum transmission can be realized at low SNR, and has low probabilityof detection. It is aly problem how to obtain the original users＇ signal in a non-cooperative context. In practicality, the DS/CDMA sources received are linear convolute mixing. A more complex multichannel blind deconvolution MBD algorithm is required to achieve better source separation. An improved MBD algorithm for separating linear convolved mixtures of signals in CDMA system is proposed. This algorithm is based on minimizing the average squared cross-output-channel-correlation. The mixture coefficients are totally unknown, while some knowledge about temporal model exists. Results show that the proposed algorithm can bring about the exactness and low computational complexity.

关键词： DS/CDMA signal non-cooperative MBD stochastic gradient algorithms for MBD.

Astrocyte polarization in glaucoma: a new opportunity

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Neural Regeneration Research 2022年第12期17卷 2582-2588页

作者： yi-Xin Liu Hao Sun Wen-yi guo Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1(neurotoxic)and A2(neuroprotective).Several studies on astrocyte polarization have focused mainly on neurodegenerative diseases,trauma,and ***,the role of astrocyte polarization in glaucoma,a neurodegenerative disease,has not been fully *** this review,we first describe the characteristics of astrocyte astrogliosis in glaucoma,including morphological,molecular,proliferative and functional *** then summarize understanding of astrocyte polarization in other diseases,and show that A1 astrocytes are involved in the death of retinal ganglion cells in glaucoma,and that their neurotoxins kill only damaged retinal ganglion *** on this,we propose new interesting conjecture on astrocyte polarization in glaucoma:(1)That the neurotoxin from A1 astrocytes is a product of the complement system(membrane-attacking complex),since this system is known to mediate synaptic elimination and the C3 expression is clearly increased in A1 astrocytes;(2)that reactive scar-forming astrocytes in the optic nerve head may be classified as A2 astrocytes since their ablation leads to a worse prognosis in ***,current therapeutic research progress on astrocyte polarization in other diseases is also *** of astrocyte polarization can be achieved by extracellular microglia-related and intracellular *** A1 or increased A2 astrocytes can rescue the *** example,glucagon-like peptide-1 receptor agonist rescues retinal ganglion cells by reducing A1 astrocytes via the extracellular microglia-related pathway in an ocular hypertension model,suggesting that regulation of astrocyte polarization as a therapeutic target in glaucoma is feasible.

关键词： astrocytes glaucoma heterogeneity microglia neurodegenerative disease neuroinflammation neuroprotection optic nerve retina therapy

Synthesis and properties of novel thermotropic liquid crystalline copoly(ester-imide)s

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Chinese Chemical Letters 2009年第12期20卷 1510-1513页

作者： guo Yao yi Gu State Key Laboratory of Polymer Materials Engineering of China College of Polymer Science and Engineering Sichuan University Chengdu 610065 China

Four novel copoly（ester-imide）s based on 3,3′,4,4′-biphenyltetracarboxylic dianhydride, bis（trimellitic acid anhydride） phenyl ester and di-p-aminophenyl ester of dicarboxylic acids were synthesized via two-step method in order to investigate whether two imide mesogenic units with different conformation and polarity could control the formation of LC-phase. Polarizes light microscopy （PLM） and differential scanning calorimetry （DSC） have shown that three polymers formed the nematic phase with ＂thread schlieren texture＂ and a polymer formed the nematic phase with ＂Inversion walls texture＂.

关键词： Copoly(ester-imide) Inversion walls texture Mesogenic unit Thermotropic liquid crystalline

Synthesis, Electrochemistry, Fluorescence and ECL of Ru （phen）₂ （dcbpy）（PF₆）₂

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Chinese Chemical Letters 1999年第3期10卷 255-256页

作者： Wang, Peng Yuan, yi Zhu, guo yi Lab. of Electroanalytical Chemistry Changchun Inst. of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

A new ECL-active species. Ru (phen)_2 (dcbpy) (PF_6)_2. has been designed andsynthesized. its structure was confirmed by means of IR. ESI-MS and 2D NMR. Also. itsproperties of electrochemistry. fluorescence and ECL are reported. which have suggested a goodhope of being used in electrochemiluminescent immunoassay and nucleic acid hybridization.

关键词： Ru (phen)_2 (dcbpy) (PF_6)_2 electrochernistry fluorescence electrochemiluminescence

iGMDR:Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 150-160页

作者： Xiang Chen yi guo Xin Chen Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital Department of Radiation Oncology Zhejiang University School of MedicineHangzhou 310058China Department of Polymer Science and Engineering and Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang UniversityHangzhou 310027China Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhou 310058China

Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticancer *** some of these models are of crucial importance and have been used in clinical practice,these very valuable models have not been well adopted into cancer research to promote the development of cancer therapies due to the lack of integration and standards for the existing data of the pharmacogenetic *** this purpose,we built a resource investigating genetic model of drug response(iGMDR),which integrates the models from in vitro and in vivo pharmacogenetic studies with different omics data from a variety of technical *** this study,we introduced a standardized process for all integrations,and described how users can utilize these models to gain insights into *** is freely accessible at https://***.

关键词： Genetic model Pharmacogenetics Anticancer drug Cancer Drug response