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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao guo Hua guo Shou-Feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-Feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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秦岭山脉南北麓暴雨触发条件对比分析

高原气象 2025年第1期44卷 178-190页

作者：武麦凤乔舒婷郭大梅任小同渭南市气象局陕西渭南714000 陕西省气象台陕西西安710014

采用实况气象观测资料、FY-2G卫星云图资料、多普勒雷达资料和ERA50.25°×0.25°逐小时再分析资料,对2021年8月21-22日同时发生在秦岭南北麓的强等级暴雨过程进行对比分析,探讨秦岭南北麓暴雨触发条件的影响机制。结果表明:秦岭北麓流... 详细信息

采用实况气象观测资料、FY-2G卫星云图资料、多普勒雷达资料和ERA50.25°×0.25°逐小时再分析资料,对2021年8月21-22日同时发生在秦岭南北麓的强等级暴雨过程进行对比分析,探讨秦岭南北麓暴雨触发条件的影响机制。结果表明:秦岭北麓流场上,西风带系统在秦岭特殊地形作用下,对流层低层形成中尺度气旋性环流,通过热力作用触发暴雨,对流性降水持续时间短,强度小;湿斜压性增强是秦岭北麓暴雨开始的一个信号,当湿斜压性减弱以及中层比湿减小时,降水结束。对秦岭南麓而言,地形作用下对流层低层流场形成中尺度辐合线触发暴雨;降水释放的凝结潜热加热低层大气,与中低层入侵的冷空气共同构建对流不稳定结构,上升运动增强,降水增强和持续;对流云团在高温高湿的环境下迅速组织化合并发展,形成中尺度对流复合体(MCC),对流强度大,对流层结深厚,小时雨强大;中低层冷空气的入侵和扩散到地面的时间分别与秦岭南麓强降水的开始和结束时间对应。

关键词：秦岭地形暴雨动力作用热力作用

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The convexity about ultimate bearing hypersurfaces o structures

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 456-461页

作者： Chengxi guo Tingting guo College of Civil Engineering Institution of Architecture Design Xi'an University of Architecture and Technology Xi'an 710055China

The relationship between the convexity on the ultimate bearing surface of a structure and the second- order effects of loads is discussed. All of generalized non-overload forces acted on a structure forms a convex set when ignoring the second-order effects （coupling effects between the generalized forces）. It is true also when the Hessian matrix composed of the second-order partial derivatives on the hypersurface about the ultimate bearing of the structure is negative definite. The outward convexity is kept when the surface is expressed by certain dimensionless parameters. A series of properties based on the convexity are pointed out. Some applications in the analysis of bearing capacity of structures were illustrated with examples. The study shows that an evaluation about the bearing capacity state of a complex structure can be made on the basis of several points on the surface of the ultimate bearing of the structure.

关键词： service limit load ultimate bearing surface convexity generalized force generalized displacement frame structure

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Formulization of Three-Dimensional Stress and Strain Fields at Elliptical Holes in Finite Thickness Plates

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Acta Mechanica Solida Sinica 2019年第4期32卷 393-430页

作者： Wei guo Wcinlin guo State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016 China

Stress raisers such as holes are inevitable in structures at which stress concentration occurs and the static as well as fatigue strength of the structures can be significantly weakened. Therefore, to accurately evaluate the stress concentration factor and stress fields at holes is of essential importance for structure design and service life prediction. Although stress and strain concentration and fields at holes in finite thickness plates strongly change with and along the thickness, manuals of stress concentration for engineering design are mainly based on twodimensional theory and no explicit formula is available even for circular holes in finite thickness plates. Here we obtain for the first time a complete set of explicit formulae for stress and strain concentration factors and the out-of-plane constraint factor at circular as well as elliptical holes in finite thickness plates by integrating comprehensive three-dimensional finite element analyses and available theoretical solutions. The three-dimensional stress distributions ahead of holes can also be predicted by the obtained formulae. With their accuracy and the corresponding applicable range being analyzed and outlined in detail, the formulae can serve as an important fundamental solution for three-dimensional engineering structure design and guideline for developing threedimensional analytical methods.

关键词： Three-dimensional stress and strain concentration Stress field Elliptical holes Finite thickness plate Explicit solution

DAO媒介:驱动未来社会算法化与自组织的元媒介

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 132-141页

作者：喻国明苏健威北京师范大学新闻传播学院北京师范大学传播创新与未来媒体实验平台北京100875

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统... 详细信息

DAO媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统复杂性的关键机制,DAO媒介是支撑“自组织式”算法化的元媒介。DAO媒介与数字文明时代喷发的微粒个体、微资源、微价值、微需求、微场景等相匹配,能够深度匹配人的个性与自我,形成有效的趣缘连接,进而极大地释放数字文明的生产力。DAO媒介将深刻影响社会系统的构造,将微粒个体与相关社会要素“包裹”为闭环子系统,支持其准开放的系统边界、有效的异质性整合、可持续的规则重构、子系统与父级系统的持续分化和快速进化,等等。在数字文明时代,DAO媒介将使“重新部落化”的“地球村”变为现实,其驱动构筑的DAO社会将更加多元、更加富有创造力,不断拓展人类群体实践的自由度,使人类在高度异质性聚合基础上更加和谐有序地整合协同。

关键词： DAO 数字媒介算法自组织社会系统

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Buried interface bridging for inverted cesium-formamidinium triiodide perovskite solar cells with long operational stability

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Science China Chemistry 2025年第1期 163-173页

作者： Chenhui Zhang Chunjun Liang Fulin Sun Ting Zhu Xinghai Huang Yuzhu guo Xinyu guo Kunyang Ge Dan Li Fangtian You Zhiqun He Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic TechnologyBeijing Jiaotong University Department of Physics School of Physical Science and Engineering Beijing Jiaotong University

In the field of perovskite solar cells(PSCs), the research on defects in the buried interface has been relatively limited due to its non-exposure; however, this interface significantly impacts the performance enhancement of inverted PSCs. This study employs phenylethylammonium chloride(PEACl) molecules as a buffer layer to modify the buried interface of p-i-n structured PSCs,aiming to enhance the uniformity of self-assembled monolayers(SAMs) and facilitate the uniform nucleation and growth of perovskite films on the substrate. Furthermore, the introduction of the PEACl buffer layer effectively passivates defects at the bottom of the perovskite layer and notably enhances the crystal quality of the perovskite film by mitigating residual stress,thereby reducing nonradiative recombination loss. Following these optimizations, the MA-free PSCs treated with PEACl achieve a power conversion efficiency(PCE) of 24.11%, with significant improvements in storage, thermal stability, and operational stability. Particularly noteworthy is the device's performance in an unencapsulated state, whereas after 1,500 hours of continuous light operation stability testing, it retains 97% of its original efficiency. This study not only enriches the systematic understanding of the characteristics of the buried interface in PSCs but also contributes significantly to advancing the commercial production of perovskite photovoltaic technology.

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ImSpiRE: image feature-aided spatial resolution enhancement method

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Science China Life Sciences 2025年第1期 272-283页

作者： Yuwei Hua Yizhi Zhang Zhenming guo Shan Bian Yong Zhang State Key Laboratory of Cardiovascular Diseases and Medical Innovation Center Institute for Regenerative MedicineDepartment of NeurosurgeryShanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji University

The resolution of most spatially resolved transcriptomic technologies usually cannot attain the single-cell level, limiting their applications in biological discoveries. Here, we introduce ImSpiRE, an image feature-aided spatial resolution enhancement method for in situ capturing spatial transcriptome. Taking the information stored in histological images, ImSpiRE solves an optimal transport problem to redistribute the expression profiles of spots to construct new transcriptional profiles with enhanced resolution, together with extending the gene expression profiles into unmeasured regions. Applications to multiple datasets confirm that ImSpiRE can enhance spatial resolution to the subspot level while contributing to the discovery of tissue domains, signaling communication patterns, and spatiotemporal characterization.

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Light People:Professor Cheng Zhang

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Light(Science & Applications) 2023年第11期12卷 2281-2290页

作者： Siqiu guo Light Publishing Group Changchun Institute of OpticsFineMechanics and PhysicsChinese Academy of Sciences3888 Dong Nan HuRoadChangchun 130033China

Editorial Nanophotonics has emerged as a cutting-edge interdisciplinary research field *** primary objective is to leverage the interaction between light and matter at the wavelength and sub-wavelength scales,with the purpose of designing and manufacturing miniaturized,multifunctional,and high-performance optical devices and *** Cheng Zhang from Huazhong University of Science and Technology has dedicated his career to nanophotonic device *** work encompasses a wide range of areas,including plasmonic devices,optical metamaterials,and *** the design of innovative artificial electromagnetic structures and the exploration of emerging nanofabrication techniques,Professor Cheng Zhang has effectively achieved versatile control over various properties of electromagnetic waves,including amplitude,phase,and polarization ***,his research extends to the continuous exploration of novel optical phenomena,aimed at realizing high-performance engineering *** this edition of Light People,we will take you deep into the world of Professor Cheng Zhang,a young scientist exemplifying the spirit of innovation,relentless improvement,and unwavering pursuit of *** will discover how he has overcome numerous challenges in the realm of nanophotonic research.

关键词： overcome versatile pursuit

Light People:Professor Fan Wang

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Light(Science & Applications) 2023年第10期12卷 2007-2014页

作者： Siqiu guo Light Publishing Group Changchun Institute of OpticsFineMechanics and PhysicsChinese Academy of SciencesChangchunChina

My first encounter with *** Wang left a profound impression on me.I felt that he was exactly the gentle and courteous scholar depicted in books,well-read in poetry and literature,and exceptionally *** my interactions with *** Wang,I deeply sensed his passion for academia and pursuit of knowledge,as well as his warm hospitality,kindness,and gentle demeanor.

关键词： gentle exceptional pursuit