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Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441

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Research 2024年第1期2023卷 181-197页

作者： Wen-Juan Lin Wen-Pu Shi Wan-Yi Ge liang-liang Chen Wei-Hong guo Peng Shang Da-Chuan Yin Key Laboratory for Space Bioscience and Biotechnology School of Life SciencesNorthwestern Polytechnical University127 Youyixi RoadXi'an 710072ShaanxiPR China

The biological effects of magnetic fields(MFs)have been a controversial ***,in recent years,there has been increasing evidence that MFs do affect biological ***,the physical mechanism remains ***,we show that MFs(16 T)reduce apoptosis in cell lines by inhibiting liquid–liquid phase separation(LLPS)of Tau-441,suggesting that the MF effect on LLPS may be one of the mechanisms for understanding the“mysterious”magnetobiological *** LLPS of Tau-441 occurred in the cytoplasm after induction with *** phase-separated droplets of Tau-441 recruited hexokinase(HK),resulting in a decrease in the amount of free HK in the *** cells,HK and Bax compete to bind to the voltage-dependent anion channel(VDAC I)on the mitochondrial membrane.A decrease in the number of free HK molecules increased the chance of Bax binding to VDAC I,leading to increased Bax-mediated *** the presence of a static MF,LLPS was marked inhibited and HK recruitment was reduced,resulting in an increased probability of HK binding to VDAC I and a decreased probability of Bax binding to VDAC I,thus reducing Bax-mediated *** findings revealed a new physical mechanism for understanding magnetobiological effects from the perspective of *** addition,these results show the potential applications of physical environments,such as MFs in this study,in the treatment of LLPS-related diseases.

关键词： inhibited Apoptosis finding

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds

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Regenerative Biomaterials 2024年第1期3卷 119-131页

作者： Bowen Qiao Jiaxin Wang Lipeng Qiao Aziz Maleki Yongping liang Baolin guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran Department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatment of MRSA-infected wounds,the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-amino phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected *** hydrophilic antibiotic moxifloxacin(M)was directly loaded in the *** hydrophobic curcumin(Cur)with anti-inflammatory function was first mixed with Pluronic F127(PF)to form Cur-encapsulated PF micelles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of moxifloxacin and Cur and their different existing forms in the HPA hydrogel,the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflammatory,antioxidant property,and biocompatibility of hydrogels were ***,in the MRSA-infected mouse skin wound,the hydrogel-treated group showed faster wound closure,less inflammation and more collagen *** experiments further confirmed that the hydrogel promoted better repair by reducing inflammation(TNF-a)and promoting vascular(VEGF)*** conclusion,this HPA/M&CurPF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.

关键词： MRSA-infected wounds spatiotemporally sequential delivery antibacterial anti-inflammatory

Accurate and efficient remaining useful life prediction of batteries enabled by physics-informed machine learning

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Journal of Energy Chemistry 2024年第4期91卷 512-521页

作者： liang Ma Jinpeng Tian Tieling Zhang Qinghua guo Chunsheng Hu School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongWollongongNSW 2522Australia Department of Electrical and Electronic Engineering and Research Centre for Grid Modernization The Hong Kong Polytechnic UniversityKowloonHong Kong 999077China School of Electrical Computer and Telecommunications EngineeringUniversity of WollongongWollongongNSW 2522Australia School of Advanced Interdisciplinary Studies Ningxia UniversityYinchuan 750000NingxiaChina

The safe and reliable operation of lithium-ion batteries necessitates the accurate prediction of remaining useful life(RUL).However,this task is challenging due to the diverse ageing mechanisms,various operating conditions,and limited measured *** data-driven methods are perceived as a promising solution,they ignore intrinsic battery physics,leading to compromised accuracy,low efficiency,and low *** response,this study integrates domain knowledge into deep learning to enhance the RUL prediction *** demonstrate accurate RUL prediction using only a single charging ***,a generalisable physics-based model is developed to extract ageing-correlated parameters that can describe and explain battery degradation from battery charging *** parameters inform a deep neural network(DNN)to predict RUL with high accuracy and *** trained model is validated under 3 types of batteries working under 7 conditions,considering fully charged and partially charged *** data from one cycle only,the proposed method achieves a root mean squared error(RMSE)of 11.42 cycles and a mean absolute relative error(MARE)of 3.19%on average,which are over45%and 44%lower compared to the two state-of-the-art data-driven methods,*** its accuracy,the proposed method also outperforms existing methods in terms of efficiency,input burden,and *** inherent relationship between the model parameters and the battery degradation mechanism is further revealed,substantiating the intrinsic superiority of the proposed method.

关键词： Lithium-ion batteries Remaining useful life Physics-informed machine learning

Identification of FIR systems under difference-driven scheduled quantized observations

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Control Theory and Technology 2024年第2期22卷 163-172页

作者： Dong liang Ruizhe Jia Fengwei Jing Yong Song Jin guo School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China Key Laboratory of Knowledge Automation for Industrial Processes Ministry of EducationBeijing100083China National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China

In networked system identification,how to effectively use communication resources and improve convergence speed is the focus of ***,there is an inherent contradiction between the two *** this paper,the event-driven communication is used to save communication resources for the identification of finite impulse response systems,and the input design is carried out to meet the requirements of convergence ***,a difference-driven communication is ***,the performance of the communication mechanism is analyzed,and the calculation method of its communication rate is *** that,according to the communication rate and the convergence rate of the identification algorithm,the input design problem is transformed into a constrained optimization problem,and the algorithm for finding the optimal solution is *** addition,considering the case that the output is quantized by multiple thresholds,the way to calculate its communication rate is given and the influence of threshold number on communication rate is ***,the effectiveness of the algorithm is verified by simulation.

关键词： System identification FIR system Difference-driven Quantized observation

Experimental Study on Impingement Processes of Fuel Sprays on Biomimetic Structured Surfaces

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Journal of Bionic Engineering 2024年第1期21卷 362-373页

作者： Yanling Chen liang guo Wanchen Sun Yuying Yan Rong Xuan Junfeng Zhang State Key Laboratory of Automotive Simulation and Control Jilin UniversityChangchun 130025China Faculty of Engineering University of NottinghamNottingham NG72RDUK

To improve the controllability of the wall-wetting process after the fuel spray-wall impingement in internal combustion engines,the methods of laser etching,chemical etching and surface free energy modification are used to prepare biomimetic structured surfaces with different *** impingement processes of diesel and n-butanol sprays on the walls under different conditions are experimentally *** the surface oleophilicity increases,the spreading radius of wall-impinging sprays *** about 5 s after the fuel injections,the fuel spray droplets hit the walls for the first time,and the secondary breakup and rebound *** mixture concentrations of different fuels hitting the various walls reach the peak *** a higher surface temperature,the peak value of the mixture concentration is mainly related to the heat flux to the fuel droplets in different boiling regimes from the metal *** concentration of the air–fuel mixture in the near wall region increases with increasing surface oleophilicity,increasing wall temperature and decreasing ambient *** with diesel,n-butanol presents a higher air–fuel mixture concentration in the near wall region.

关键词： Spray-wall impingement Morphological development Air-fuel mixture concentration Surface wettability Wall temperature:Ambient pressure

Regulation of Ti(C,N)deposition on hot surface of refractory in blast furnace hearth

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Journal of Iron and Steel Research International 2024年第6期31卷 1423-1435页

作者： Jian Cao Cui Wang Jjan-liang Zhang Ke-xin Jiao guo-hua Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

Ti(C,N)concentration was found to be lower on the hearth sidewall of a blast furnace and increased gradually toward the bottom of the blast *** Ti(C,N)protective layer in a blast furnace is ***,the formation of a Ti(C,N)protective layer was promoted by studying the heterogeneous nucleation principle of titanium compounds on different substances and regulation measures for the deposition process of titanium compounds on refractories or *** lattice disregistry between the titanium compounds and the main components in the refractory or the main impurities in the protective layer was calculated using a two-dimensional disregistry equation to study the heterogeneous nucleation principle of titanium *** results revealed that in refractory materials,the heterogeneous nucleation of carbonitride is weak when C,SiO_(2),and Al_(2)O_(3) are used as heterogeneous nucleation substrates,and the heterogeneous nucleation of carbonitride is strong when TiO_(2) and SiC are used as heterogeneous nucleation *** nucleation phases,TiC,TiN,Ti(C_(0.3),N_(0.7)),and Ti(C_(0.5),N_(0.5))have similar heterogeneous nucleation ability in single component refractory,and the type of carbonitride has little effect on the lattice *** impurities in the protective layer as the substrate phases are not conducive to the heterogeneous nucleation of *** CaS was used as the substrate phase,the heterogeneous nucleation ability of carbonitride was the *** carbon and alumina were not conducive to the heterogeneous nucleation of carbonitride,but carbon was more unfavourable than alumina.

关键词： Ti(C,N) Lattice disregistry Lattice constant Heterogeneous nucleation Regulation measure

Highly selective and eco-friendly dihydroisoquinoline synthesis via Cu/Co synergistic catalysis in Cu NPs@MOFs catalyst under mild conditions

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Science China Chemistry 2024年第5期67卷 1561-1568页

作者： Peng-Fei guo Ze-Long liang Yue-E Jiao Hang Xu Bin Zhao Key Laboratory of Advanced Energy Material Chemistry Renewable Energy Conversion and Storage CenterDepartment of ChemistryNankai UniversityTianjin 300071China

3,4-Dihydroisoquinoline(DHIQ)is an important precursor used in the production of drugs for treating cancer,HIV,Alzheimer's disease,*** studies on DHIQ synthesis show low catalytic selectivity due to the susceptible over-oxidation feedstock of1,2,3,4-tetrahydroisoquinoline(THIQ),which often requires alkali ***,it is desirable yet challenging to explore a highly selective and efficient oxydehydrogenation capacity for DHIQ synthesis under eco-friendly reaction ***,a novel framework 1 was synthesized,exhibiting 1D channels with the size of 4.6 A×9.6 A and high solvent/p H/thermal stability.A stable framework allows it to encapsulate Cu nanoparticles(NPs)to form Cu NPs@1-x(x=1,2,3,and 4)with varying loading amounts of Cu NPs at 2.0 wt%,3.0 wt%,4.0 wt%,and 6.0 wt%,*** NPs@1-3 could selectively catalyze the reaction from THIQ to DHIQ with a high selectivity of 98%and a recorded turnover frequency(TOF)of 22.1 h-1under eco-friendly mild *** corresponding catalytic activity can maintain at least five recyclings and can be further applied to gram-scale ***,the efficient preparation of DHIQ catalyzed by Cu NPs@1-3 could be realized even under air ***,the anticancer molecule precursor synthesis of 6,7-dimethoxy-3,4-dihydroisoquinoline was also selectively catalyzed by Cu NPs@*** investigations revealed that high catalytic performance can be attributed to the stable framework and the synergistic catalytic effect of the loaded Cu NPs and Co metal *** importantly,this work represents the first example of MOF catalysts for selectively thermo-catalytic DHIQ synthesis and demonstrates a simple approach to obtain efficient catalysts for selective oxydehydrogenation in the production of unsaturated compounds.

关键词： metal-organic frameworks Cu NPs@MOFs 3 4-dihydroisoquinoline selective oxydehydrogenation synergistic catalysis

Attaining synergetic equilibrium of electrical conductivity and tensile strength in GQDs@GN/Cu composites through multi-scale intragranular and intergranular reinforcements

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Rare Metals 2024年第1期43卷 366-379页

作者： Shuang-Yin Zhang liang Liu Rui Bao Jian-Hong Yi Sheng-Da guo Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and TechnologyKunming 650093China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

The configuration and quality of reinforcements, as well as the robustness of interfacial bonding,holding a critical significance in determining the concurrence between electrical conductivity and mechanical strength in metal matrix composites. In this study, citric acid was employed as the precursor for synthesizing multiscale carbon nanomaterials(graphene quantum dots and graphene, abbreviated as GQDs and GN). The GQDs@GN/Cu composites were fabricated through a segmented ball milling process in conjunction with subsequent spark plasma sintering(SPS). The intragranular GQDs and intergranular GQDs@GN had synergistically reinforced Cu composites through Orowan strengthening, load transfer strengthening and refinement strengthening. Furthermore,the robust interface bonding between GQDs@GN and Cu effectively mitigated interfacial impedance stemming from electron-boundary scattering. The yield strength and ultimate tensile strength of the GQDs@GN/Cu composites were recorded as 270 and 314 MPa, respectively, representing an improvement of 92 and 28% over pure Cu, while maintaining electrical conductivity at a level comparable to that of pure Cu. This study advances the understanding of the possibility of realizing a synergistic compatibility between electrical conductivity and mechanical strength in Cu composites.

关键词： Cu matrix composites Interface bonding Mechanical property Graphene quantum dots(GQDs) Electrical conductivity

Global existence and large-time behavior for primitive equations with the free boundary

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Science China Mathematics 2024年第10期67卷 2303-2330页

作者： Hai-liang Li Chuangchuang liang School of Mathematical Sciences Capital Normal University Academy for Multidisciplinary Studies Capital Normal University College of Mathematics and Statistics Chongqing University

In the present paper, the primitive equations, which can be used to simulate the large-scale motion of the ocean and atmosphere, are considered in the three-dimensional domain bounded below by a fixed solid boundary and above by a free-moving boundary. The global existence and uniqueness of strong solutions are established, and the long-time convergence to the equilibrium state is shown to be either at an exponential rate for the horizontal periodic domain or at an algebraic rate for the horizontal whole space.

关键词： primitive equations the free boundary value problem global well-posedness large-time behavior

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