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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping CHENG Jian WEI Chao yuan Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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莫西沙星类似物的合成及其体内外抗菌活性

中国抗生素杂志 2008年第11期33卷 674-677页

作者：王菊仙曹珏李素杰刘明亮郭慧元中国医学科学院中国协和医学院医药生物技术研究所北京100050

目的合成具有良好抗菌活性的莫西沙星类似物。方法以盐酸莫西沙星为原料,先与甲基乙烯酮发生加成反应生成N-(3-氧代-1-正丁基)莫西沙星(1),接着经氧化并重排及中和反应得到N-羟基莫西沙星(2)。测定化合物1和2的体内外抗菌活性。结果1的... 详细信息

目的合成具有良好抗菌活性的莫西沙星类似物。方法以盐酸莫西沙星为原料,先与甲基乙烯酮发生加成反应生成N-(3-氧代-1-正丁基)莫西沙星(1),接着经氧化并重排及中和反应得到N-羟基莫西沙星(2)。测定化合物1和2的体内外抗菌活性。结果1的体外活性与对照药莫西沙星基本相当,且优于2(P0.05),且优于2(P<0.05)。结论在莫西沙星7-位侧链的亚氨基上引入3-氧代-1-正丁基后其活性基本保持,但引入羟基后其活性明显降低。

关键词：氟喹诺酮莫西沙星莫西沙星类似物合成体内外抗菌活性

Lactobacillus salivarius REN菌株的产胺测定与抗生素耐药性评价

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甘肃农业大学学报 2013年第4期48卷 124-130页

作者：顾会咏甘伯中任发政郭慧媛张卫兵文鹏程甘肃农业大学食品科学与工程学院甘肃兰州730070 甘肃省功能乳品工程实验室甘肃兰州730070 中国农业大学教育部北京市共建功能乳品重点实验室北京100083

Lactobacillus salivarius REN是具有脱基因毒性的益生菌株,试验通过HPLC分析了该菌在脱羧酶培养基中的产胺情况,并利用药敏纸片评价了其抗生素耐药性.结果表明:该菌株可产生组胺、亚精胺和腐胺,合成量分别为68.83、2.11、8.94mg/L,精... 详细信息

Lactobacillus salivarius REN是具有脱基因毒性的益生菌株,试验通过HPLC分析了该菌在脱羧酶培养基中的产胺情况,并利用药敏纸片评价了其抗生素耐药性.结果表明:该菌株可产生组胺、亚精胺和腐胺,合成量分别为68.83、2.11、8.94mg/L,精胺和酪胺未检出.在所测定的15种抗生素中,测试菌株对喹诺酮类的3种抗生素以及糖肽类的2种抗生素均有耐药性;对青霉素G表现出耐药性;对利福平、红霉素表现出中度敏感;对其他7种抗生素均表现出敏感性.

关键词： Lactobacillus salivarius REN 体外安全性评价生物胺抗生素耐药性

Stochastic Augmented-Based Dual-Teaching for Semi-Supervised Medical Image Segmentation

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Computers, Materials & Continua 2025年第1期82卷 543-560页

作者： Hengyang Liu Yang yuan Pengcheng Ren Chengyun Song Fen Luo School of Computer Science and Engineering Chongqing University of TechnologyChongqing400054China College of Artificial Intelligence Chongqing Technology and Business UniversityChongqing400067China

Existing semi-supervisedmedical image segmentation algorithms use copy-paste data augmentation to correct the labeled-unlabeled data distribution ***,current copy-paste methods have three limitations:(1)training the model solely with copy-paste mixed pictures from labeled and unlabeled input loses a lot of labeled information;(2)low-quality pseudo-labels can cause confirmation bias in pseudo-supervised learning on unlabeled data;(3)the segmentation performance in low-contrast and local regions is less than *** design a Stochastic Augmentation-Based Dual-Teaching Auxiliary Training Strategy(SADT),which enhances feature diversity and learns high-quality features to overcome these *** be more precise,SADT trains the Student Network by using pseudo-label-based training from Teacher Network 1 and supervised learning with labeled data,which prevents the loss of rare labeled *** introduce a bi-directional copy-pastemask with progressive high-entropy filtering to reduce data distribution disparities and mitigate confirmation bias in *** the mixed images,Deep-Shallow Spatial Contrastive Learning(DSSCL)is proposed in the feature spaces of Teacher Network 2 and the Student Network to improve the segmentation capabilities in low-contrast and local *** this procedure,the features retrieved by the Student Network are subjected to a random feature perturbation *** two openly available datasets,extensive trials show that our proposed SADT performs much better than the state-ofthe-art semi-supervised medical segmentation *** only 10%of the labeled data for training,SADT was able to acquire a Dice score of 90.10%on the ACDC(Automatic Cardiac Diagnosis Challenge)dataset.

关键词： Semi-supervised medical image segmentation contrastive learning stochastic augmented

Wafer‑Scale Ag_(2)S‑Based Memristive Crossbar Arrays with Ultra‑Low Switching‑Energies Reaching Biological Synapses

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Nano-Micro Letters 2025年第3期17卷 328-339页

作者： yuan Zhu Tomas Nyberg Leif Nyholm Daniel Primetzhofer Xun Shi Zhen Zhang Division of Solid‑State Electronics Department of Electrical EngineeringUppsala University75121 UppsalaSweden Department of Chemistry Uppsala UniversityUppsalaSweden Department of Physics and Astronomy Uppsala UniversityUppsalaSweden State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China

Memristive crossbar arrays(MCAs)offer parallel data storage and processing for energy-efficient neuromorphic ***,most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor(CMOS)technology still suffer from substantially larger energy consumption than biological synapses,due to the slow kinetics of forming conductive paths inside the memristive *** we report wafer-scale Ag_(2)S-based MCAs realized using CMOS-compatible processes at temperatures below 160℃.Ag_(2)S electrolytes supply highly mobile Ag+ions,and provide the Ag/Ag_(2)S interface with low silver nucleation barrier to form silver filaments at low energy *** further enhancing Ag+migration in Ag_(2)S electrolytes via microstructure modulation,the integrated memristors exhibit a record low threshold of approximately−0.1 V,and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological *** low-temperature process also enables MCA integration on polyimide substrates for applications in flexible ***,the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training *** impressive accuracy of 92.6%in image recognition simulations is demonstrated with the MCAs after the *** demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag_(2)S films Reactive sputter Silver nucleation Ag^(+)migration Energy-efficient neuromorphic computing

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嗜冷菌对UHT乳品质的影响研究

中国奶牛 2014年第2期 30-34页

作者：李晓建吕阳郭慧媛蒙牛乳业(唐山)有限责任公司唐山064000 中国农业大学食品科学与营养工程学院食品质量与安全北京实验室北京100083

摘要：原料乳嗜冷菌污染是影响uHT乳保质期的重要原因之一，并且嗜冷菌分布具有地域特征性本研究对蒙牛8个牧场原料乳中的嗜冷菌进行了分离和鉴定，确定了牧场常见嗜冷菌种类及特性，并分析了其对uHT乳品质的影响．结果表明，从试验样... 详细信息

摘要：原料乳嗜冷菌污染是影响uHT乳保质期的重要原因之一，并且嗜冷菌分布具有地域特征性本研究对蒙牛8个牧场原料乳中的嗜冷菌进行了分离和鉴定，确定了牧场常见嗜冷菌种类及特性，并分析了其对uHT乳品质的影响．结果表明，从试验样品中分离出的嗜冷菌为假单胞菌属、微球菌属和产碱杆菌属；牧场原料乳的嗜冷菌数量与气温有关，1～3月份数量较高，6～9月份数量较低；原料乳嗜冷菌数越多，UHTqL货架期越短；原料乳中嗜冷菌数达到10^5 CFU／mL时，对uHT乳苦味值的影响显著（p〈（1．（15）；嗜冷菌脂肪酶活力达10IU／mL、蛋白酶活力为15Iu／mL、25IU／mL时对UHTSfL苦味值的影响显著（P〈0．05）；原料gLpH值为6．7和3.5％2冷藏条件下，蛋白酶、脂肪酶活性较高，不利于uHT乳长期贮存、综上研究，原料乳中嗜冷菌数过多会严重影响uHT乳品质和风味；低温贮藏条件下，嗜冷菌产生的脂肪酶和蛋白酶会破坏UHT乳品质，因此不建议长期低温保存uHT乳、

关键词：嗜冷菌 UHT乳乳品质影响

Unlocking the potential of spatial transcriptomics with custom microfluidic chips

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Science China Life Sciences 2025年

作者： Bingqi Wu yuan Gao China National Center for Bioinformation Beijing Institute of Genomics Chinese Academy of Sciences University of Chinese Academy of Sciences

Spatial transcriptomics technique detects RNA sequences (St?hl et al.,2016) and quantifies their expression in the positional context (Ke et al.,2013),which can provide important information such as cell heterogeneity,cell developmental trajectory,differential gene expression between tissue regions or *** date,it is becoming a powerful tool for exploring tumorigenesis (Ren et al.,2023),cerebral neurodevelopment (Shi et al.,2023),embryonic development(Arutyunyan et al.,2023),and other biological ***-dimensional(3D) spatial transcriptome typically requires stacking multiple tissue slices to obtain a 3D atlas (Schott et al.,2024);therefore it prefers a method that meets high throughput,large sample sizes,and affordable cost to cover large regions of the ***,the lack of a single method that meets all of these requirements limits large-scale application of 3D spatial transcriptomics.

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含有取代吲哚满二酮-1-乙基的加替沙星衍生物的合成与抗结核作用研究(英文)

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中国抗生素杂志 2011年第1期36卷 37-43页

作者：万志龙刘明亮冯连顺王博郑旭东郭慧元中国医学科学院北京协和医学院医药生物技术研究所北京100050

目的寻找具有优秀活性的喹诺酮类抗结核药物。方法设计合成脂溶性更大的含有取代吲哚满二酮-1-乙基的加替沙星衍生物，测定其体外抗分枝杆菌活性。结果共合成了14个新化合物，其结构经，***、MS和HRMS确证。目标物普遍具有良好的抗分枝... 详细信息

目的寻找具有优秀活性的喹诺酮类抗结核药物。方法设计合成脂溶性更大的含有取代吲哚满二酮-1-乙基的加替沙星衍生物，测定其体外抗分枝杆菌活性。结果共合成了14个新化合物，其结构经，***、MS和HRMS确证。目标物普遍具有良好的抗分枝杆菌活性（MIC为1．56-6．25μg／mL），但均弱于其母药加替沙星。其中，化合物3h对草分枝杆菌CMCC93201和耻垢分枝杆菌CMCC93202的活性分别是利福平的4倍和2倍。结论脂溶性并非决定喹诺酮类化合物抗分枝杆菌活性的唯一因素。

关键词：加替沙星衍生物合成抗分枝杆菌活性

Multi-Stage Voltage Control Optimization Strategy for Distribution Networks Considering Active-Reactive Co-Regulation of Electric Vehicles

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Energy Engineering 2025年第1期122卷 221-242页

作者： Shukang Lyu Fei Zeng Huachun Han huiyuMiao Yi Pan Xiaodong yuan Electric Power Research Institute State Grid Jiangsu Electric Power Co.Ltd.Nanjing211103China

The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution ***,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are ***,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the *** optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy ***,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time ***-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control *** results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution *** effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network.

关键词： Electric vehicle(EV) distribution network multi-stage optimization active-reactive power regulation voltage control