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Synthesis and in vitro antibacterial activities of 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives

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Chinese Chemical Letters 2010年第1期21卷 55-58页

作者： Wang, Ju Xian guo, Qiang Chai, Yun Feng, Lian Shun guo, hui yuan Liu, Ming Liang Chinese Acad Med Sci Inst Med Biotechnol Beijing 100050 Peoples R China Peking Union Med Coll Beijing 100050 Peoples R China

A series of novel 7-(4-alkoxyimino-3-hydroxypiperidin-1-yl)quinolone derivatives were designed,synthesized and evaluated for in vitro antibacterial *** 8f,8g,8i and 8j with the potencies similar to or better than thos... 详细信息

关键词： Fluoroquinolone Synthesis Antibacterial activities

THE ROLE OF CONNECTIVE TISSUE GROWTH FACTOR, TRANSFORMING GROWTH FACTOR Β1 AND SMAD SIGNALING PATHWAY IN CORNEA WOUND HEALING

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Chinese Medical Journal 2006年第1期119卷 57-62页

作者： WU Xin-yi YANG Yong-mei guo hui CHANG yuan Department of Ophthalmology Qilu Hospital Shandong University Ji＇nan 250012 China

The cornea is a highly specialized and unique organ in the human body. Its main function is to project light from the external environment onto the retina, and it has a specific transparency to perform its function properly. The transparency and integrity of the cornea is of vital importance. The corneal wound, especially laceration deep to Bowman＇s membrane and stroma, which will inevitably cause scar formation, may cause the degeneration or even loss of sight.

关键词： cornea wound healing connective tissue growth factor, transforming growth factorβ1 Smad signafing pathway

The Secondary Structure of Heated Whey Protein andIts Hydrolysates Antigenicity

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光谱学与光谱分析 2011年第11期31卷 3055-3059页

作者： PANG Zhi-hua ZHU Jun WU Wei-jing WANG Fang REN Fa-zheng ZHANG Lu-da guo hui-yuan College of Food Science ＆ Nutritional Engineering China Agricultural University Key Laboratoryof Functional Dairy Ministry of Education Beijing 100083 China Beijing Higher Leaning Institution Engineering Research Center of Animal Product Beijing 100083 China College of Science China Agricultural University Beijing 100094 China

Fourier transform infrared spectroscopy(FTIR) and circular dichroism(CD) were used to investigate the conformational changes of heated whey protein(WP) and the corresponding changes in the hydrolysates immunoreactivity were determined by competitive enzyme-linked immunosorbent assay(ELISA).Results showed that the contents of α-helix and β-sheet of WP did not decrease much under mild heating conditions and the antigenicity was relatively high;when the heating intensity increased(70 ℃ for 25 min or 75 ℃ for 20 min),the content of α-helix and β-sheet decreased to the minimum,so was the antigenicity;However,when the WP was heated at even higher temperature and for a longer time,the β-sheet associated with protein aggregation begun to increase and the antigenicity increased *** was concluded that the conformations of heated WP and the antigenicity of its hydrolysates are related and the optimum structure for decreasing the hydrolysates antigeniity is the least content of α-helix and β-*** the relationship between the WP secondary structure and WP hydrolysates antigenicity is significant to supply the reference for antigenicity reduction by enzymolysis.

关键词： FTIR CD Whey protein Heat Treatment Antigenicity

FTIR Analysis of Protein Secondary Structure in Cheddar Cheese during Ripening

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光谱学与光谱分析 2011年第7期31卷 1786-1789页

作者： WANG Fang LIU Ai-ping REN Fa-zheng ZHANG Xiao-ying Stephanie Clark ZHANG Lu-da guo hui-yuan College of Food Science ＆ Nutritional Engineering China Agricultural University Key Laboratory of Functional Dairy Ministry of Education Beijing 100083 China Beijing Higher Institution Engineering Research Center of Animal Product Beijing 100083 China Department of Food Science and Human Nutrition Iowa State University Iowa 50011 USA College of Science China Agricultural University Beijing 100094 China

Proteolysis is one of the most important biochemical reactions during cheese *** on the secondary structure of proteins during ripening would be helpful for characterizing protein changes for assessing cheese *** transform infrared spectroscopy(FTIR),with self-deconvolution,second derivative analysis and band curve-fitting,was used to characterize the secondary structure of proteins in Cheddar cheese during *** spectra of the amide I region showed great similarity,while the relative contents of the secondary structures underwent a series of *** ripening progressed,the α-helix content decreased and the β-sheet content *** structural shift was attributed to the strengthening of hydrogen bonds that resulted from hydrolysis of *** summary,FTIR could provide the basis for rapid characterization of cheese that is undergoing ripening.

关键词： FTIR Cheddar cheese Ripening Protein secondary structure

Synthesis and in vitro Antimycobacterial Activity of Moxifloxacin Methylene and Ethylene Isatin Derivatives

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Chemical Research in Chinese Universities 2012年第1期28卷 61-66页

作者： FENG Lian-shun, LIU Ming-liang, WANG Shuo, CHAI Yun, LI Su-jie and guo hui-yuan Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China Chinese Acad Med Sci Inst Med Biotechnol Beijing 100050 Peoples R China

A series of novel moxifloxacin methylene and ethylene isatin derivatives with remarkable improvement in lipophilicity, compared to the parent moxifloxacin, was designed, synthesized and characterized by 1H NMR, MS and HRMS. These derivatives were initially evaluated for their in vitro antimycobacterial activity against M. smegmatis CMCC 93202. Compounds 3a―3f, 5a, 5f and 5j were chosen for the further evaluation of their in vitro activity against Mycobacterium tuberculosis（MTB） H37Rv ATCC 27294 and MDR-MTB 09710. All the target com pounds[minimum inhibitory concentration（MIC）： 0.39―〉16 μg/mL] were far more active than rifampin（MIC： 2.0―〉256 μg/mL）, but less active than moxifloxacin（MIC： 0.1―1.0 μg/mL） against the three tested strains. The most active compounds 3a and 3c were found to be 2―64 fold more potent than isoniazid and rifampin against M. smegmatis CMCC 93202, 2 fold more potent than rifampin against MTB H37Rv ATCC 27294, and 16―〉64 fold more potent than ethambutol, isoniazid and rifampin against MDR-MTB 09710.

关键词： Moxifloxacin derivative Antimycobacterial activity Isatin

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一种新的摄像机自定标的方法

机器人 1999年第6期21卷 431-435页

作者：邹国辉袁保宗北方交通大学信息所北京100044

本文给出一种由未定标图像进行摄像机自定标的方法．通过分析基础矩阵关系式及方差之间关系，得出一种新的计算摄像机内部参数及运动参数的准则．在计算中采用单个摄像机并且假设摄像机像主点的位置已知。

关键词：立体视觉自定标摄像机计算机视觉

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喹诺酮类抗感染药物的合成与有关化学

中国抗生素杂志 2000年第5期25卷 321-329,352页

作者：郭惠元田治明中国医学科学院中国协和医科大学医药生物技术研究所北京100050

本文将喹诺酮类抗感染药物的合成与有关化学中最具代表性的成果分两部分 ,即喹诺酮母环系的形成和取代基的引入进行了归纳、总结。

关键词：喹诺酮类抗菌剂合成化学喹诺酮母环系

甲磺酸加替沙星对小鼠特异性免疫的调节作用研究

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中国抗生素杂志 2005年第7期30卷 420-422页

作者：张慧芳林赴田郭惠元中国医学科学院中国协和医科大学医药生物技术研究所北京100050

目的考察甲磺酸加替沙星(GFLX)对小鼠特异性免疫防御的调节作用.方法用溶血分光光度法测定GFLX对小鼠抗绵羊红细胞(SRBC)抗体产生的影响;用MTT法测定GFLX对小鼠脾淋巴细胞转化的影响;用结晶紫染色法测定GFLX对小鼠腹腔巨噬细胞产生TNF... 详细信息

目的考察甲磺酸加替沙星(GFLX)对小鼠特异性免疫防御的调节作用.方法用溶血分光光度法测定GFLX对小鼠抗绵羊红细胞(SRBC)抗体产生的影响;用MTT法测定GFLX对小鼠脾淋巴细胞转化的影响;用结晶紫染色法测定GFLX对小鼠腹腔巨噬细胞产生TNF的影响;用足肿胀法测定GFLX对小鼠迟发型变态反应(DTH)的影响.结果GFLX能增加小鼠特异性抗SRBC抗体(溶血素)的产生;在0.05～40μg/ml范围内能协同刁豆蛋白(conA)或脂多糖(LPS)促进小鼠脾淋巴细胞转化;在0.01～10μg/ml范围内可抑制小鼠腹腔巨噬细胞产生TNF-α;促进小鼠DTH.结论GFLX有调节小鼠特异性免疫防御的作用.

关键词：甲磺酸加替沙星特异性免疫免疫调节作用

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基于量子点半导体光放大器全光波长变换特性

光子学报 2016年第11期45卷 97-105页

作者：管磊王卓然袁国慧林志远杨梦电子科技大学光电信息学院成都610051

从光电集成电路的角度出发,根据量子点半导体光放大器(QD-SOA)中载流子跃迁速率方程和光场传输方程,建立了QD-SOA等效电路模型,并通过电路仿真的方法对QD-SOA的增益谱、饱和增益特性等进行了仿真和分析;利用QD-SOA的交叉增益调制研究了... 详细信息

从光电集成电路的角度出发,根据量子点半导体光放大器(QD-SOA)中载流子跃迁速率方程和光场传输方程,建立了QD-SOA等效电路模型,并通过电路仿真的方法对QD-SOA的增益谱、饱和增益特性等进行了仿真和分析;利用QD-SOA的交叉增益调制研究了速率分别为40Gbps、100Gbps和160Gbps时的波长转换特性,并分析了不同的偏置电流、功率的信号光和探测光对输出信号消光比和Q值的影响,其转换速率可达到100Gbps,消光比ER约为10dB,Q值约为2.2.该研究对提高基于QD-SOA的交叉增益调制波长转换的性能具有指导意义.

关键词：集成光学波长转换等效电路量子点半导体光放大器交叉增益调制