检索结果-南通市图书馆

Dynamics of Advantageous Mutant Spread in Spatial Death-Birth and Birth-Death Moran Models

Communications on Applied Mathematics and Computation 2024年第1期6卷 576-604页

作者： Jasmine Foo Einar Bjarki gunnarsson Kevin Leder David Sivakoff School of Mathematics University of MinnesotaTwin CitiesMN55455USA Department of Industrial and Systems Engineering University of MinnesotaTwin CitiesMN55455USA Departments of Statistics and Mathematics The Ohio State UniversityColumbusOH43210USA

The spread of an advantageous mutation through a population is of fundamental interest in population genetics. While the classical Moran model is formulated for a well-mixed population, it has long been recognized that in real-world applications, the population usually has an explicit spatial structure which can significantly influence the dynamics. In the context of cancer initiation in epithelial tissue, several recent works have analyzed the dynamics of advantageous mutant spread on integer lattices, using the biased voter model from particle systems theory. In this spatial version of the Moran model, individuals first reproduce according to their fitness and then replace a neighboring individual. From a biological standpoint, the opposite dynamics, where individuals first die and are then replaced by a neighboring individual according to its fitness, are equally relevant. Here, we investigate this death-birth analogue of the biased voter model. We construct the process mathematically, derive the associated dual process, establish bounds on the survival probability of a single mutant, and prove that the process has an asymptotic shape. We also briefly discuss alternative birth-death and death-birth dynamics, depending on how the mutant fitness advantage affects the dynamics. We show that birth-death and death-birth formulations of the biased voter model are equivalent when fitness affects the former event of each update of the model, whereas the birth-death model is fundamentally different from the death-birth model when fitness affects the latter event.

关键词： Spatial death-birth models Spatial birth-death models Spatial evolutionary models Spatial cancer models Evolutionary graph theory Stochastic processes Biased voter model Dual process Fixation probability Shape theorem

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

THE CERVICAL THICKNESS OF THE MANDIBULAR ALVEOLAR PROCESS AND SKELETAL BONE MINERAL DENSITY.

THE CERVICAL THICKNESS OF THE MANDIBULAR ALVEOLAR PROCESS AN...

引用

1st International Conference on Bone and Mineral Research

作者： Grethe Jonasson gunnarsson R Kiliaridis S Department of Orthodontics Gteborg University GothenborgSweden.

＜正＞In the present study we have examined the influence of skeletal bone mineral density on the shape and thickness of the mandibular alveolar *** objective was to find a simple and cheap method to detect individuals with low bone mass and risk of osteoporotic fractures that could be used by dentists in ordinary dental practices without special accommodations like panoramic and digital radiographs. The alveolar process of the mandible and the maxilla is highly dependent of the presence of *** newborn baby has no alveolar process and the alveolar bone decreases in size by resorption after extraction of *** is

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

腹股沟疝复发的时间分析

引用

中国实用外科杂志 2011年第4期31卷 336-340页

作者： Magnusson N Nordin P Hedberg M gunnarsson U Sandblom G Department of Surgery Mora HospitalMoraSweden Department of Surgery stersund HospitalstersundSweden CLINTEC Division of SurgeryKarolinska InstitutetStockholmSweden

目的假设不同术式疝修补术术后复发的发病过程是不同的,那么疝复发的时间也是不同的。该研究的目的是分析影响初次手术到复发后再次手术时间间隔的危险因素。方法研究数据来自瑞典疝登记注册系统。将5年随访期间的每一年的资料作为亚组... 详细信息

目的假设不同术式疝修补术术后复发的发病过程是不同的,那么疝复发的时间也是不同的。该研究的目的是分析影响初次手术到复发后再次手术时间间隔的危险因素。方法研究数据来自瑞典疝登记注册系统。将5年随访期间的每一年的资料作为亚组分列,后合为大组。对于每个危险因素以再次手术为研究终点,运用Cox回归分析复发时间与危险因素之间的关系。结果共分析了142578例,其中7.7%是女性,年龄平均59岁。5年总体复发率为4.3%。多因素分析显示复发疝修补后再次复发的时间较早(P<0.05);第一次手术后如果发生并发症,则发生复发也较早(P<0.05);缝合修补或腹腔镜修补后的复发要早于开放式补片修补者(P<0.05)。通过单因素分析提示,所有缝合修补的早期复发的危险要高于所有补片修补早期复发的危险(P<0.05)。结论不同术式疝修补术后复发的发病过程是不同的。腹腔镜修补、传统疝修补术(不应用补片)和复发疝修补术后早期复发率高可能是由于手术技术失误率较高。

关键词：疝复发注册登记术后并发症网片

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Low-field-induced spin-glass behavior and controllable anisotropy in nanoparticle assemblies at a liquid-air interface

引用

Science China Materials 2022年第1期65卷 193-200页

作者： Xiaoqi Liao Seda Ulusoy Rui Huang Erik Wetterskog Klas gunnarsson Yu Wang Huawei Liang Yu-Jia Zeng German Salazar-Alvarez Peter Svedlindh College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Materials Science and Engineering Hanshan Normal UniversityChaozhou 521041China Solid State Physics Department of Materials Science and EngineeringAngstrom LaboratoryUppsala UniversityBox 3575103 UppsalaSweden MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Stacking nanoscale-building blocks into onedimensional(1D)assemblies with collective physical properties is a frontier in designing ***,the formation of 1D arrays using weak magnetic fields and an in-depth understanding of their magnetic properties remain ***,low-dimensional assemblies of iron oxide nanocubes with a disordered arrangement are fabricated at the diethylene-glycol/air interface in the presence of assembly fields(0/1/3/5/30/50 mT).Ring-shaped assemblies gradually transform as the assembly field increases from 0 to 50 mT,first to a porous network consisting of elongated assemblies and then to an aligned array of filaments,in which the aligned filaments are formed when the assembly field is≥3 mT and duration t>14 ***-glass characteristics and static(dynamic)anisotropy factors~2(3)are achieved by tuning the strength of the assembly *** the presence of a relatively weak assembly field,the interplay between dipolar interactions and disorder with respect to magnetic easy axis alignment leads to spin-glass *** alignment of the magnetic easy axes and the strength of the dipolar interactions increase with increasing assembly field,resulting in the disappearance of spin-glass characteristics and enhancement of the magnetic *** study presents a strategy for obtaining magnetic assemblies with spin-glass behavior and controllable anisotropy while shedding light on the magnetic interactions of low-dimensional assemblies.

关键词： magnetic nanoparticles assembly anisotropy spin glass

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Somatonorm治疗特发性生长激素缺乏儿童的初步经验

引用

中华内分泌代谢杂志 1989年第1期5卷 7-10页

作者：史轶蘩刘蓉鲍秀兰邓洁英高淑敏张苏萍 R.gunnarsson 北京协和医院内分泌科儿科 KibiVitrum Peptide AB S ockholm

本文报告用重组hGH治疗9例特发性hGH缺乏儿童的疗效。治疗1年,身高生长速率由2.6±0.2增至10.7±0.5cm/年。剂量每周0.7 IU/kg、分7日皮下注射者比每周0.5 IU/kg、分3日肌肉注射者疗效更好。用药后除3例血清T_4降低,2例有未妨碍生长速... 详细信息

本文报告用重组hGH治疗9例特发性hGH缺乏儿童的疗效。治疗1年,身高生长速率由2.6±0.2增至10.7±0.5cm/年。剂量每周0.7 IU/kg、分7日皮下注射者比每周0.5 IU/kg、分3日肌肉注射者疗效更好。用药后除3例血清T_4降低,2例有未妨碍生长速度的抗hGH抗体外,无其他副作用。

关键词：生长激素缺乏儿童侏儒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

五大IT变革,你准备好了吗?

引用

软件和集成电路 2016年第2期 70-70,72,74页

作者： Dan Matthews Martin gunnarsson 艾菲诗软件(IFS)

毋庸置疑,IT领域正在发生一系列重大变革,未来几年也是该产业激动人心的时刻。下一个令人期待的创新是什么？它如何从预测变为现实？2015年初,权威咨询公司Gartner发布十大IT趋势预测,提到这些策略性科技趋势,可能在未来3年对企业产生... 详细信息

毋庸置疑,IT领域正在发生一系列重大变革,未来几年也是该产业激动人心的时刻。下一个令人期待的创新是什么？它如何从预测变为现实？2015年初,权威咨询公司Gartner发布十大IT趋势预测,提到这些策略性科技趋势,可能在未来3年对企业产生重大影响。随着2016新年的来临,艾菲诗软件（IFS）就预测的几个重大趋势进行了仔细研究,让我们回顾这些预测内容是否都已成现实,同时也一起来看看2016年,乃至未来的行业发展将会何去何从。

关键词： IT领域 Gartner 咨询公司预测策略性权威企业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

付结核分枝杆菌抗原的分析

引用

吉林畜牧兽医 1980年第S1期 61-63页

作者： gunnarsson 张鹏程

用交叉免疫电泳(ClE)及交叉线形免疫电泳(CLlE)对不同的付结核分枝杆菌菌株及其变种的抗原作了比较,同时还研究了其中一个菌株与禽结核杆菌及BCG之间的交叉反应。供试验的牛型付结核杆菌4个实验室菌株的每一株都具有44种抗原。与山羊变... 详细信息

用交叉免疫电泳(ClE)及交叉线形免疫电泳(CLlE)对不同的付结核分枝杆菌菌株及其变种的抗原作了比较,同时还研究了其中一个菌株与禽结核杆菌及BCG之间的交叉反应。供试验的牛型付结核杆菌4个实验室菌株的每一株都具有44种抗原。与山羊变种(M、Ptb、CN)呈现交叉反应的有39种抗原,与绵羊变种(M、Ptb、oI)呈现交叉反应的有31种抗原,与禽结核分枝杆菌(M、avium)呈现交叉反应的有27种抗原,与卡介苗(BCG)呈现交叉反应的有24种抗原。

关键词：结核分枝杆菌抗原实验室抗原结构分枝杆菌免疫电泳沉淀素试验抗血清

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Use of Acellular Fish Skin for Dura Repair in an Ovine Model: A Pilot Study

引用

Open Journal of Modern Neurosurgery 2015年第4期5卷 124-136页

作者： Hilmar Kjartansson Ingvar Hakon Olafsson Sigurbergur Karason Hjalti Thorisson Baldur Tumi Baldursson Eggert gunnarsson Einar Jorundsson Gudmundur Fertram Sigurjonsson Kerecis Limited Reykjavik Iceland The National University Hospital of Iceland Reykjavik Iceland Domus Radiology Center Reykjavik Iceland The Institute for Experimental Pathology University of Iceland Reykjavik Iceland

Recently the use of biologic materials as dura mater repair patches has been increasing. The purpose of this study is to assess the basis for efficacy and safety of using a novel fish derived acellular dermis (Kerecis Omega3 DuraTM). In an ovine model a craniotomy under general anaesthesia was performed. A defect was produced in the dural covering of approximately 1 × 2 cm and closed with an onlay technique, with Kerecis Omega3 Dura. The bone defect was covered with the bony flap and the overlying tissues closed in layers. At 2, 5, 8 and 11 weeks the sheep underwent MRI scanning followed by euthanasia, necropsy and histological assessment. MRI images taken at 2, 5, 8 and 11 weeks showed initially moderate inflammatory response, which diminished over time, and at 11 weeks no evidence of inflammation existed. There was evidence of cerebrospinal fluid leakage at no time point. Necropsy revealed some adhesions at 5 and 8 weeks, in particular at 5 weeks, but at 11 weeks there were no adhesions found. From 2 - 11 weeks, there was evidence of initially an inflammatory reaction followed by neodura formation at the defect site through cellular ingrowth and remodeling of the acellular fish skin. Histology showed a histiocytic foreign body reaction initially that subsided over time. As early as 8 weeks there was evidence of neodura formation and by 11 weeks there was a minimal inflammatory response with an intact neodura formed. In this pilot study the Kerecis Omega3 Dura patches performed in a safe and efficacious manner. This new material needs to be fully assessed and compared with other products that are currently on the market in a larger scale animal study.