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Migrated endoclip and stone formation after cholecystectomy:A new danger of acute pancreatitis

World Journal of Gastroenterology 2007年第47期13卷 6446-6448页

作者： Kemal Dolay Halil Alis Aliye Soylu gulum altaca Ersan Aygun Department of General Surgery1 and Gastroenterology 2 Endoscopy UnitBakirkoy Research and Training HospitalBakirkoyIstanbulTurkey

Endoclip migration into the common bile duct following laparoscopic cholecystectomy (LC) is an extremely rare complication. Migrated endoclip into the common bile duct can cause obstruction,serve as a nidus for stone formation,and cause cholangitis. We report a case of obstructive jaundice and acute biliary pancreatitis due to choledocholithiasis caused by a migrated endoclip 6 mo after LC. The patient underwent early endoscopic retrog-rade cholangiopancreatography (ERCP) with endoscopic sphincterotomy and stone extraction.

关键词：急性胰腺炎胆结石胆囊切除术胆汁内窥镜检查

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The Frequency of K-ras Mutation in Colorectal Adenocarcinomas with Absence of Distant Metastasis at Diagnosis

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Surgical Science 2012年第3期3卷 111-115页

作者： Ebru Demiralay Yaman Saglam gulum altaca Banu Bilezikci Handan Ozdemir Department of General Surgery School of Medicine Baskent University Istanbul Turkey Department of Pathology School of Medicine Baskent University Istanbul Turkey Medical Genetics Laboratory Goztepe Park Medical Hospital Istanbul Turkey

Purpose: K-ras mutations were reported to be in 40% - 60% of patients with sporadic colorectal cancers (CRCs). HER-2/neu oncogene that is important in breast carcinoma was reported in CRCs in several studies. The aims of our study are to determine;the frequency of K-ras mutation in CRC and positivity of HER-2/neu, the relation between K-ras mutation and HER-2/neu positivity, and also the relation between clinicopathological findings with K-ras mutation and HER-2/neu expression. Methods: Total of 35 colon resection specimen from patients without distant metastasis who were operated due to colorectal adenocarcinoma were included in the study. The sections were examined with light microscopy. Vascular and perineural invasions and pericolonic tumor deposits (PCTD) were investigated. HER-2/neu was applied immunohistochemically. DNA sample obtained from tumor paraffin block was screened for presence of 20 mutations in K-ras gene-codon 12, 13, 61 by AutoGenomics and Infinity Analyzer. Results: K-ras gene mutation was detected in 14 of 35 patients (40%). HER-2/neu positivity was detected in 7 cases (28.57%). There was not any significant correlation between HER-2/neu positivity, K-ras gene mutation and clinicopathological findings. There was direct correlation between PCTD and vascular invasion. Conclusions: There was not correlation between K-ras mutation and clinicopathological findings similar to several other studies. The relation between HER-2/neu expression and clinicopathological findings was not found.

关键词： Colon Adenocarcinoma K-ras HER-2/Neu

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