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Comprehensive management of malocclusion in maxillary fibrous dysplasia:A case report

World Journal of Clinical Cases 2021年第34期9卷 10671-10680页

作者： Harneet kaur Sujata Mohanty gulsheen kaur kochhar Shahid Iqbal Anjali Verma Ritasha Bhasin Anuraj Singh kochhar Department of Orthodontics and Dentofacial Orthopaedics Faculty of DentistryJamia Millia IslamiaDelhi 110025DelhiIndia Department of Oral and Maxillofacial Surgery Maulana Azad Institute of Dental SciencesDelhi 110002DelhiIndia Department of Pediatric and Preventive Dentistry National Dental College and HospitalDerabassi 140507PunjabIndia Faculty of Dentistry Jamia Millia IslamiaDelhi 110025DelhiIndia Faculty of Dentistry University of TorontoToronto M5G1G6OntarioCanada Department of Orthodontics and Dentofacial Orthopaedics Faculty of DentistryUniversity of TorontoToronto M5G0C1OntarioCanada

BACKGROUND Fibrous dysplasia(FD)is a developmental hamartomatous bone disease characterized by a blend of fibrous and osseous *** rarely malignant,the tumor can vary from being small and asymptomatic,to a fairly large sized lesion,progressing gradually,compromising occlusion and facial *** approach depends on the stage of skeletal *** primarily involves surgical management for stabilizing the disease ***-surgical comprehensive dental treatment is necessary for restoring form and function of the jaws and *** article describes comprehensive orthodontic management of severe malocclusion in a surgically operated case of FD *** SUMMARY A 19-year female presented with a chief complaint of excessive gingival display when *** history included swelling of gums around the upper right front teeth,diagnosed at the age of 15 as FD of the right anterior maxillary segment and treated with surgical recontouring of the dysplastic *** clinical and radiological examinations showed adequate post-surgical *** surgically treated dysplastic area presented with right canting of the maxillary anterior occlusal *** maxillary teeth were torqued palatally,with the root of the right maxillary canine exposed *** discuss sequential management of the associated malocclusion with comprehensive fixed orthodontics,along with special precautions taken to prevent reactivation of the quiescent and healed *** The adequate healing of fibro-dysplastic bone post-surgery must be allowed before initiating orthodontic tooth movement in the dysplastic *** follow-ups are needed to monitor stability of occlusion and any relapse of the lesion.

关键词： Craniofacial fibrous dysplasia Malocclusion Orthodontic tooth movement Jaw surgery Case report

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Cone beam computed tomographic evaluation of pharyngeal airway in North Indian children with different skeletal patterns

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World Journal of Radiology 2021年第2期13卷 40-52页

作者： Anuraj Singh kochhar Maninder Singh Sidhu Ritasha Bhasin gulsheen kaur kochhar Himanshu Dadlani Jagpreet Sandhu Bobby Virk Former Orthodontist Max HospitalGurgaon 122001India Department of Orthodontics Faculty of Dental SciencesSGT UniversityGurugram 122001India Faculty of Dentistry University of TorontoToronto M5G 1G6Canada Department of Pediatric and Preventive Dentistry National Dental College and HospitalDerabassi 140507PunjabIndia Department of Periodontology Kalka Dental CollegeUttar Pradesh 210507India Senior Consultant Department of Dental SurgeryMax HospitalGurgaon 122001Indi Formerly at Department of Orthodontics Genesis Institute of Dental SciencesPunjab 152001India Chief Orthodontist Smile With BracesPuyallupWA 98371United States

BACKGROUND In growing patients with skeletal discrepancies,early assessment of functional factors can be vital for the restoration of normal craniofacial *** To compare airway volumes in patients with mandibular retrognathism with the normal anteroposterior skeletal relationship,thereby assessing the association between cephalometric variables and airway *** Cone-beam computed tomography volume scans,and lateral cephalograms,3-dimensional airway volume and cross-sectional areas of 120 healthy children(54 boys and 66 girls mean age 15.19±1.28)which were done for orthodontic assessment were *** subjects were divided into 2 groups based on the angle formed between point A,Nasion and point B(ANB)values and cephalometric variables(such as anterior and posterior facial height,gonial angle etc.)airway volumes,and cross-sectional measurements were compared using independent t ***’s correlation coefficient test was used to detect any relationship of different parts of the airway and between airway volume and 2-dimensional cephalometric *** Means and standard deviations for cephalometric,cross-sectional,and volumetric variables were ***,mandibular body length and facial convexity were statistically highly significant(P<0.01)whereas condylion to point A,nasal airway and total airway volume(P<0.05)were statistically *** nasal airway volume and the superior pharyngeal airway volume had a positive correlation(P<0.01),nasal airway was correlated to middle(P<0.05)and total airway superior had a relation with middle(P<0.05),inferior and total airway(P<0.05),middle was related to all other airways;inferior was also related to all the airways except *** cephalometric values were positively correlated with the airway volume with Frankfurt Mandibular Plane Angle and facial convexity showed significant correlations with total airway volume(P<0.05).Additionally,ANB angle was significantly correlated wit

关键词： Pharyngeal airway Cone beam computed tomography Skeletal pattern Malocclusion Retrognathic Airway volume

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Preliminary Investigation on the Effect of <i>Lactobacillus</i>and Epidermal Growth Factor on Tight Junction Proteins in Experimental Clostridium <i>difficile</i>Infection

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Advances in Microbiology 2014年第8期4卷 425-435页

作者： Sukhminderjit kaur Chetana Vaishnavi Pallab Ray Malkit Singh Rakesh kochhar Departments of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India Departments of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India Medical Microbiology Postgraduate Institute of Medical Education and Research Chandigarh India

Clostridium difficile associated disease (CDAD) is the most common hospital acquired infection, due to exposure to various drugs. C. difficile toxins influence barrier function in intestinal epithelium. Biotherapeutic approaches, employing probiotic and epidermal growth factor (EGF) could help in barrier protein protection and aid in CDAD management. A preliminary investigation on the effect of Lactobacillus acidophilus and EGF on tight junction proteins in experimentally induced C. difficile infection was done. BALB/mice were divided into 5 groups. Group 1 was comprised of healthy controls, whereas animals in Groups 2 - 5 were sub-divided into 3 subgroups (a, b and c) each. Animals in Groups 2 - 5 received C. difficile inoculum either on day 1 (Group 2) or after pretreatment with ampicillin (Group 3), cyclosporine (Group 4) or lansoprazole (Group 5). Additionally animals in subgroups “b” and “c” also received L. acidophilus and EGF inocula respectively after C. difficile challenge. All animals were investigated for the presence of tight junction proteins (occludin, α-actinin and zonula occludens) in their colonic segments. Data were analyzed using the SPSS version 10 software. These three proteins were present in significantly less (P < 0.05) number of animals in the drug receiving animals, whereas they were found in significantly more (P < 0.05) number of animals receiving L. acidophilus and EGF after challenge with ampicillin, cyclosporine and lansoprazole, suggesting their role in protecting intestinal barrier function.

关键词： Antibiotic C. difficile Epidermal Growth Factor Immunosuppressive Drug Probiotic Tight Junction Proteins

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