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Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study

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Journal of Pharmaceutical Analysis 2021年第4期11卷 444-457页

作者： Seung-Hyun Jeong Ji-Hun Jang guk-yeo lee Seung-Jung Yang Hea-Young Cho Yong-Bok lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea National Development Institute of Korean Medicine 288 Udeuraendeu-gilAnyang-myeonJangheung-gunJeollanam-do59338Republic of Korea Department of Oriental Rehabilitation Medicine Dongshin University Gwangju Korean Medicine Hospital141 Wolsan-roNam-guGwangju61619Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-do13488Republic of Korea

Gumiganghwal-tang is a traditional herbal medicine widely used for its anti-inflammatory,analgesic,and antipyretic ***,the safety and efficacy of its active ingredients based on an in vivo pharmacokinetic(PK)study have yet been *** have established a sensitive and accurate UPLC-ESI-MS/MS method and conducted a PK study on 14 constituents of Gumiganghwal-tang through human plasma *** conditions were optimized according to the physicochemical properties of the 14 compounds to facilitate efficient separation and eliminate overlap or interference between ***-C18 and Inertsil-C8 columns were used as UPLC stationary phases,and acetonitrile and aqueous formic acid were used as mobile *** the analytes were quantified with a triple quadrupole mass spectrometer using electrospray ionization in multiple reaction monitoring *** chromatograms of 14 bioactive compounds showed excellent elution and sensitivity,and each peak was selectively separated and quantified without interference with each other or *** established analytical method was based on international guidelines and was successfully used to perform PK studies of 14 herbal ingredients in humans after oral administration with Gumiganghwal-tang *** oral absorption of most active components of Gumiganghwal-tang was relatively rapid and remained considerably long in the body to be quantified in plasma up to 48 h after administration.

关键词： Gumiganghwal-tang Fourteen bioactive ingredients Simultaneous analysis UPLC-ESI-MS/MS Pharmacokinetics Clinical study

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok Kim Bruno Rigo Gabriella Wong Yoon Jae lee Woon‑Hong yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim Dong guk Kang Hyeon Gyu lee Yen Hai Thi Tran Kihun An Junghyun Choi Kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu lee Shonit Nair Sharma Sung-Yu Hong Young-guk Ko Yangsoo Jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

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Joint member angle limits of composite beams and CFT square columns

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Journal of Central South University 2013年第1期20卷 199-206页

作者： lee Seung-Jo lee Kang-guk Department of Architecture Chosun College of Science & Technology Research Center for Urban Affair Kyungil University

This work aims to understand the relationship between the member angle limit and the energy ratio for 24 test samples of composite beams and CFT square steel tube columns. This work also compares the formula applicability for member angle limit with the previous test result to provide the basic data for the design of composite beam-CFT column. The evaluation of the member angle limit was performed with concrete compressive strength (fC =22.16 MPa, 30.49 MPa), breadth-to-thickness ratio (B/t=25.0, 33.3, 43.5), and axial capacity ratio (N/N0=0, 0.3, 0.4, 0.5) as the main variables of the test samples. For the relationship between the member angle limit (Ru) and the energy ratio (ES/EC ), the test result shows that the energy ratio becomes lower as the axial capacity ratio and the breadth-to-thickness ratio increase. The energy ratio is lower for the Type B test sample compared with that of Types A and C. For the formula suggested by SATO, the test samples are distributed evenly for comparison between test values and the member angle limit; however, other formulas indicate a deviation. Specifically, for the comparison between R u,cal and R u (Test), Maeda's formula shows severe deviation.

关键词： square steel tube axial capacity ratio member angle limit breadth-to-thickness ratio

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Characteristics of bifurcation and buckling load of space truss in consideration of initial imperfection and load mode

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第3期14卷 206-218页

作者： Su-deok SHON Seung-jae lee Kang-guk lee School of Architectural Engineering Korea University of Technology and Education1800 ChungjeolroCheonan ChungnamRepublic of Korea Research Center for Urban Affair Kyungil UniversityGyeongsan-city GyeongbukRepublic of Korea

This study investigated characteristics of bifurcation and critical buckling load by shape imperfection of space truss,which were sensitive to initial *** critical point and buckling load were computed by the analysis of the eigenvalues and determinants of the tangential stiffness *** two-free-nodes example and star dome were selected for the case study in order to examine the nodal buckling and global buckling by the sensitivity to the eigen buckling mode and the analyses of the influence,and characteristics of the parameters as defined by the load ratio of the center node and surrounding node,as well as rise-span ratio were *** sensitivity to the imperfection of the initial shape of the two-free-nodes example,which occurs due to snapping at the critical point,resulted in bifurcation before the limit point due to the buckling mode,and the buckling load was reduced by the increase in the amount of *** two sensitive buckling patterns of the numerical model are established by investigating the displaced position of the free nodes,and the asymmetric eigenmode greatly influenced the behavior of the imperfection shape whether it was at limit point or ***,the sensitive mode of the two-free-nodes example was similar to the in-extensional basis mechanism of a simplified *** star dome,which was used to examine the influence among several nodes,indicated that the influence of nodal buckling was greater than that of global buckling as the rise-span ratio was ***,global buckling is occurred with reaching bifurcation point as the value of load ratio was higher,and the buckling load level was about 50%-70% of load level at limit point.

关键词： Space truss Geometric nonlinearity Initial imperfection Snap-through Bifurcation Global buckling

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Thermal-environment characteristics and comfort of combined radiant-floor (Korean heating system ondol) and convective cooling system

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Journal of Central South University 2013年第12期20卷 3589-3603页

作者： lee Kang-guk HONG Won-Hwa School of Architecture Kyungpook National University

The thermal-environment characteristics of the existing forced-convection cooling system were compared with those of the convective cooling system, which combined the radiant-floor cooling system using floor-heating panel typically applied to apartments in South Korea with the forced-convection cooling system using improved fan coil unit. The subjective warm/cool-feeling responses to the combined radiant-floor and convective cooling system in the questionnaire survey conducted among the test subjects were analyzed to establish the basic data for the combined cooling system. The results show that in the thermal-equilibrium condition, the vertical air temperature difference in the model living room is larger in the forced-convection-cooling condition. Most of the subjects feel a proper warm/cool feeling on their entire body, but they feel colder on the foot and lower body in the combined-cooling condition.

关键词： convection cooling temperature ondol thermal comfort fan coil unit combined cooling system

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Smooth cutting pattern generation technique for membrane structures using geodesic line on subplane and spline interpolation

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Journal of Central South University 2013年第11期20卷 3131-3141页

作者： SHON Su-deok lee Seung-jae lee Kang-guk School of Architectural Engineering Korea University of Technology and Education Research Center for Building safety Kyungpook National University

Practical techniques for smooth geodesic patterning of membrane structures were *** the geodesic search,adjustment of the subplane of the extracted elements series was proposed,and various spline approximation methods were used to flatten the strip for the generation of a smooth *** search approach is very simple,and the geodesic line could be easily attained by the proposed method without the need for a difficult computation *** cutting patterning can also be generated by spline approximation without the noise in discrete nodal ***,the geodesic cutting pattern saved about 21%of the required area for the catenary model due to the reduction of the curvature of the planar pattern seam line.

关键词： membrane structures cutting pattern generation geodesic line spline interpolation triangular mesh sub-plane

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Analyses on performances of heat and multilayer reflection insulators

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Journal of Central South University 2012年第6期19卷 1645-1656页

作者： lee Moo-jin lee Kang-guk SEO Won-duck School of Architecture Kyungil UniversityGyeongsan 702701Korea Research Center for Urban Affair Kyungil UniversityGyeongsan 702701Korea Department of Architectural Design Joongbu UniversityGeumsan-gun 701140Korea

This research was conducted to study the performances of the heat and multilayer reflection insulators used for buildings in South Korea to realize eco-friendly, low-energy-consumption, green construction, and to contribute to energy consumption reduction in buildings and to the nation＇s greenhouse gas emission reduction policy （targeting 30% reduction compared to BAUCousiness as usual） by 2020）. The heat insulation performance test is about the temperatures on surfaces of test piece. The high air temperature and the low air temperature were measured to determine the overall heat transfer coefficient and thermal conductivity. The conclusions are drawn that the heat transmission coefficients for each type of existing reflection insulator are： A-1 （0.045 W/（m-K））, A-2 （0.031 W/（m.K））, A-3 （0.042 W/（m.K））, A-4 （0.078 W/（m.K））, and the average heat conductivity is 0.049 W/（m-K）; The heat conductivity for each type of Styrofoam insulator are 0.030 W/（m.K） for B-l, 0.032 W/（m-K） for B-2, 0.037 W/（m＇K） for B-3, 0.037 W/（m.K） for B-4, and the average heat conductivity is 0.035 W/（m＇K） regardless of the thickness of the insulator; The heat conductivity values of the multilayer reflection insulators are converted based on the thickness and type C-1 （0.020 W/（m.K））, C-2 （0.018 W/（m.K））, C-3 （0.016 W/（m.K））, and C-4 （0.012 W/（m.K））; The multilayer reflection insulator keeps the indoor-side surface temperature high （during winter） or low （in summer）, enhances the comfort of the building occupants, and conducts heating and moisture resistance to prevent dew condensation on the glass-outer-wall surface.

关键词： heat reflection insulator multilayer reflection insulator overall heat transfer coefficient thermal conductivity nonflammability vapor permeability eco-friendly construction

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Sensitivity to electricity consumption in urban business and commercial area buildings according to climatic change

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Journal of Central South University 2012年第3期19卷 770-776页

作者： lee Kang-guk KIM Sung-bum HONG Won-hwa Research Center for Urban Affair Kyungil University School of Architecture Kyungpook National University

Recently, urban high temperature phenomenon has become a problem which results from human activities, the increase in energy consumption, and land-cover change in urban areas. As extremely hot weather caused by urban high temperature continues, demand for power is increased and results in the degradation of electricity reserves. The current trend in climate change, regardless of the summer and winter power demand, is likely to have much effect on the power demand. Thus, sensitivity to electricity consumption in urban areas due to climate change was researched. The results show that, 1） the basic unit of the sensitivity to electricity consumption in the target areas is 1.25-1.58W/（m2.℃）; 2） The maximum sensitivity is recorded at around 8：00 pm in the area crowded with commercial and business area. And in the business area, electricity consumption load is even from 9：00 am to 6：00 pm.

关键词： electricity consumption electricity load electricity reserves energy

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