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Wireless actuation and control of ionic polymer-metal composite actuator using a microwave link

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International Journal of Smart and Nano Materials 2012年第4期3卷 244-262页

作者： J.S.Lee W.Yim C.bae K.J.kim Department of Mechanical Engineering University of NevadaLas VegasUSA Department of Chemistry University of NevadaLas VegasUSA Department of Mechanical Engineering University of NevadaRenoUSA

The ionic polymer–metal composite(IPMC),a type of electroactive polymer(EAP)actuator,has created a unique opportunity to design robots that mimic the motion of biological systems due to its soft structure and operation at a low *** this polymer actuator has strong potential for a next-generation artificial muscle actuator,it has been observed by many researchers that supplying actuation voltages in multiple locations is *** robotic applications,a tethered operation is prohibited and the battery weight can be critical for actual *** this research,the remote unit can provide necessary power and control signals to the target mobile robot units actuated by *** research addresses a novel approach of using a wireless power link between the IPMC and a remote unit using microstrip patch antennas designed on the electrode surface of the IPMC for transmitting the *** modulation of the microwave is proposed to selectively actuate a particular portion of the IPMC where the matching patch antenna pattern is *** approach can be especially useful for long-term operation of small-scale locomotion units and avoids problems caused by complex internal wiring often observed in various types of biologically inspired robots.

关键词： ionic polymer-metal composite actuator microwave link wireless actuation robotic application biomimetic robot

A comparison of short-term postoperative outcomes including nutritional status between gastrectomy with simultaneous cholecystectomy and gastrectomy only in patients with gastric cancer

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Chinese Journal of Cancer Research 2019年第3期31卷 443-452页

作者： You Na kim Ji Yeong An Min-Gew Choi Jun Ho Lee Tae Sung Sohn Jae Moon bae Sung kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Korea Department of Surgery Korea University Anam HospitalKorea University School of MedicineSeoul 02841Korea

Objective: We aimed to evaluate the effect of simultaneous cholecystectomy on the short-term postoperative outcomes and nutritional status in patients with gastric ***: We retrospectively reviewed data from 4,820 patients with gastric cancer who underwent gastrectomy from January 2011 to December 2016. Patients who underwent only gastrectomy(N=4,578) were matched to those who underwent simultaneous cholecystectomy during gastrectomy(N=242) at a 1:1 ratio using propensity score matching analysis. The nutritional status and inflammatory responses preoperatively and postoperatively and postoperative outcomes were compared between the ***: The simultaneous cholecystectomy group showed more intraoperative blood loss and a longer operative time than the gastrectomy only group [150.0(100.0, 200.0) m L vs. 100.0(100.0, 200.0) m L, P=0.006;176.0(150.0,210.0) min vs. 155.0(128.0, 188.0) min, P<0.001, respectively]. Intraoperative event rate, postoperative complication rate, and postoperative recovery did not differ between the groups. All parameters including body weight, the hemoglobin level, absolute lymphocyte count, total protein level, albumin level, fasting glucose level,and prognostic nutritional index excluding the cholesterol level were not significantly different between the groups,and their changing patterns were similar. Although the cholesterol level was significantly lower in the simultaneous cholecystectomy group than in the gastrectomy only group at all follow-up points, the mean value of the decreased cholesterol level was within normal ***: In gastric cancer patients with gallbladder disease, simultaneous cholecystectomy is safe and not associated with additional nutritional loss.

关键词： Gastric cancer cholecystectomy nutritional status

Fluoropolymer-based organic memristor with multifunctionality for flexible neural network system

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npj Flexible Electronics 2021年第1期5卷 296-303页

作者： Min-Hwi kim Hea-Lim Park Min-Hoi kim Jaewon Jang Jin-Hyuk bae In Man Kang Sin-Hyung Lee School of Electrical and Computer Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea Department of Creative Convergence Engineering Hanbat National UniversityYuseong-guDaejeon 305-719Republic of Korea School of Electronics Engineering and School of Electronic and Electrical EngineeringKyungpook National University80 Daehak-roBuk-guDaegu 702-701Republic of Korea

In this study,we propose an effective strategy for achieving the flexible one organic transistor–one organic memristor(1T–1R)synapse using the multifunctional organic *** dynamics of the conductive nanofilament(CF)in a hydrophobic fluoropolymer medium is explored and a hydrophobic fluoropolymer-based organic memristor is *** flexible 1T–1R synapse can be fabricated using the solution process because the hydrophobic fluorinated polymer layer is produced on the organic transistor without degradation of the underlying *** developed flexible synapse exhibits multilevel conductance with high reliability and stability because of the fluoropolymer film,which acts as a medium for CF growth and an encapsulating layer for the organic ***,the synapse cell shows potential for high-density memory systems and practical neural *** effective concept for developing practical flexible neural networks would be a basic platform to realize the smart wearable electronics.

关键词： transistor network neural

Expression of Ki-67,p53,and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2005年第43期11卷 6765-6769页

作者： Seok Jeong Don Haeng Lee Jung Il Lee Jin-Woo Lee Kye Sook Kwon Pum-Soo kim Hyung Gil kim Yong Woon Shin Young Soo kim Young bae kim Division of Gastroenterology Department of Pathology

AIM： To examine surgical specimens of pancreas with either chronic pancreatitis or pancreatic cancer in order to study whether ductal hyperplasia and dysplasia in pancreas represent precursor lesions for pancreatic cancer. METHODS： We examined expression of Ki-67, CEA, p53, and K-ras, in the surgical specimens of pancreas with adenocarcinomas （n = 11） and chronic pancreatitis （n = 12）. Cellular proliferation was assessed by Ki-67 proliferation index using the proliferation marker Ki-67. In specimens with pancreas cancer, we divided pancreas epithelium into normal （n = 7）, ductal hyperplasia （n = 3）, dysplasia （n = 4）, and cancerous lesion （n = 11） after hematoxylin and eosin staining, Ki-67, and CEA immunohistochemical staining. In cases with chronic pancreatitis, the specimen was pathologically examined as in cases with pancreas cancer, and they were also determined as normal （n = 10）, ductal hyperplasia （n = 4）, or dysplasia （n = 5）. p53 and K-ras expression were also studied by immunohistochemical staining. RESULTS： In pancreatic cancer, the Ki-67 index was 3.73±3.58 in normal site, 6.62±4.39 in ductal hyperplasia, 13.47：1：4.02 in dysplasia and 37.03±10.05 in cancer tissue, respectively. Overall, p53 was positive in normal ducts, ductal hyperplasia, dysplasia, and carcinoma cells in 0 of 14 （0%）, 0 of 7 （0%）, 7 of 9 （78%）, and 10 of 11 （91%）, respectively, and K-ras was positive in 0 of 8 （0%）, 1 of 3 （33%）, 4 of 6 （67%）, 4 of 5 （80%）, respectively. CONCLUSION： Our results favorably support the hypothesis that ductal hyperplasia and dysplasia of the pancreas might be precursor lesions for pancreas cancer. Further evaluation of oncogenes by the molecular study is needed.

关键词： Ki-67 p53 K-ras Chronic pancreatitis Pancreatic ductal adenocarcinoma

Fundamental principles and development of proximity-field nanopatterning toward advanced 3D nanofabrication

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Nano Research 2021年第9期14卷 2965-2980页

作者： Sang-Hyeon Nam Gayea Hyun Donghwi Cho Seonggon Han Gwangmin bae Haomin Chen Kisun kim Youngjin Ham Junyong Park Seokwoo Jeon Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina School of Materials Science and Engineering Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea Department of Energy Engineering Convergence Kumoh National Institute of TechnologyGumiGyeongbuk 39177Republic of Korea KAIST Institute for NanoCentury(KINC) KAISTDaejeon 34141Republic of Korea

Three-dimensional(3D)nanoarchitectures have offered unprecedented material performances in diverse applications like energy storages,catalysts,electronic,mechanical,and photonic *** outstanding performances are attributed to unusual material properties at the nanoscale,enormous surface areas,a geometrical uniqueness,and comparable feature sizes with optical *** the practical use of the unusual nanoscale properties,there have been developments for macroscale fabrications of the 3D nanoarchitectures with process areas over centimeter *** the many fabrication methods for 3D structures at the nanoscale,proximity-field nanopatterning(PnP)is one of the promising techniques that generates 3D optical holographic images and transforms them into material structures through a lithographic *** conformal and transparent phase masks as a key factor,the PnP process has advantages in terms of stability,uniformity,and reproducibility for 3D nanostructures with periods from 300 nm to several *** merits of realizing precise 3D features with sub-100 nm and rapid processes are attributed to the interference of coherent light diffracted by phase *** this review,to report the overall progress of PnP from 2003,we present a comprehensive understanding of PnP,including its brief history,the fundamental principles,symmetry control of 3D nanoarchitectures,material issues for the phase masks,and the process area expansion to the wafer-scale for the target ***,technical challenges and prospects are discussed for further development and practical applications of the PnP technique.

关键词： proximity-field nanopatterning three-dimensional(3D)nanostructures phase mask interference lithography

Large colonic lipoma with a laterally spreading tumor treated by endoscopic submucosal dissection:A case report

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世界临床病例杂志 2023年第26期11卷 6194-6199页

作者： Jun Yong bae Hun Kyu kim Yee Jin kim Se Woong kim Youngeun Lee Chang Beom Ryu Moon Sung Lee Internal Medicine and Digestive Disease Center Seoul Medical CenterSeoul 02053South Korea Department of Pathology Seoul Medical CenterSeoul 02053South Korea Internal Medicine and Digestive Disease Center and Research Institute Soon Chun Hyang University of School of MedicineBucheon 14584South Korea

BACKGROUND Since fat does not transmit electrical energy well,delayed perforation and postpolypectomy syndrome due to electrical thermal injury are concerns in the endoscopic removal of colonic *** endoscopic submucosal dissection(ESD)technique concentrates electrical energy conducts to the submucosa,not the adipose *** helps to minimize electrical thermal injury,especially in the case of large colonic *** rare cases,such as colonic lipomas accompanied by mucosal lesions,it is difficult for endoscopists to decide how to safely remove *** SUMMARY A 78-year-old man underwent colonoscopy for colorectal cancer *** colonoscopy,a yellowish submucosal tumor with positive cushion sign was observed in the ascending colon measuring about 4.5 cm.A nodular mucosal lesion of about 2.5 cm was observed on the mucosal surface of the *** lipoma was so large that it occupied much of the inside of the colon,making it difficult to see the entire laterally spreading tumor(LST)at *** LST was confined to the surface of the lipoma,which had a semipedunculated shape with a wide *** margin of the LST was not observed at the neck of the *** was performed and the colonic lipoma with the LST was successfully removed without *** 3 d of hospitalization,the patient was discharged without any *** final pathology report showed that the lesion consisted of submucosal lipoma and tubulovillous adenoma with lowgrade *** ESD is effective and safe for treating a large colonic lipoma with an LST by minimizing electrical thermal injury.

关键词： Colonic lipoma Endoscopic submucosal dissection Laterally spreading tumor Tubulovillous adenoma Electrical injury Case report

Nutritional risk index as a predictor of postoperative wound complications after gastrectomy

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World Journal of Gastroenterology 2012年第7期18卷 673-678页

作者： Cheong Ah Oh Dae Hoon kim Seung Jong Oh Min Gew Choi Jae Hyung Noh Tae Sung Sohn Jae Moon bae Sung kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine50 Irwon-dongGangnamguSeoul 135-710South Korea

AIM： To investigate the correlation between the nutri- tional risk index （NRI） and postoperative wound com- plications.

关键词： Nutritional risk index Wound complication Gastric cancer

Association between Helicobacter pylori status and metachronous gastric cancer after endoscopic resection

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World Journal of Gastroenterology 2016年第44期22卷 9794-9802页

作者： Sung Bum kim Si Hyung Lee Seung Il bae Yo Han Jeong Se Hoon Sohn Kyeong Ok kim Byung Ik Jang Tae Nyeun kim Department of Internal Medicine Yeungnam University College of Medicine

AIM To investigate the effect of Helicobacter pylori(H. pylori) status test and H. pylori eradication on the occurrence of metachronous gastric cancer(MGC) after endoscopic submucosal dissection(ESD) of early gastric cancer(EGC) and risk factors of MGC. METHODS The authors retrospectively reviewed the medical records of 433 patients(441 lesions) who underwent ESD for EGC from January 2005 to January 2015 in Yeungnam University Hospital. Patients were categorized into two groups; the H. pylori tested group(n = 257) and the H. pylori non-tested group(n = 176) based on performance of H. pylori status test after ESD of EGC. The H. pylori tested group was further categorized into three subgroups based on H. pylori status; the H. pylori-eradicated subgroup(n = 120), the H. pylori-persistent subgroup(n = 42), and the H. pylori-negative subgroup(n = 95). Incidences of MGC and risk factors of MGC were *** Median follow-up duration after ESD was 30.00 mo(range, 6-107 mo). Total 15 patients developed MGC during follow-up. MGC developed in 11 patients of the H. pylori tested group(7 in the H. pylori-negative subgroup, 3 in the H. pylori-eradicated subgroup, and 1 in the H. pylori-persistent subgroup) and 4 patients of the H. pylori non-tested group(P > 0.05). The risk factors of MGC were endoscopic mucosal atrophy in the H. pylori tested group and intestinal metaplasia in all patients. CONCLUSION H. pylori eradication and H. pylori status test seems to have no preventive effect on the development of MGC after ESD for EGC. The risk factors of MGC development were endoscopic mucosal atrophy in the H. pylori tested group alone and intestinal metaplasia in all patients.

关键词： Metachronous gastric cancer Endoscopic submucosal dissection Helicobacter pylori

Perforation of the colon by invading recurrent gastrointestinal stromal tumors during sunitinib treatment

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World Journal of Gastroenterology 2008年第39期14卷 6096-6099页

作者： Hoon Hur Ae Ryoung Park Sung bae Jee Seung Eun Jung Wook kim Hae Myung Jeon Department of Surgery College of Medicinethe Catholic University of KoreaSeoul 150-713South Korea Department of Pharmacy St. Mary's HospitalSeoul 150-713South Korea Department of Radiology College of Medicinethe Catholic University of KoreaSeoul 150-713South Korea

The molecular targets of sunitinib are receptor tyrosine kinases (RTKs),and this drug has also been known to exert blocking effects on the activation of KIT,which is similar to the mechanism of action of imatinib. Moreover,sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation. We report here a 70-year-old patient diagnosed with a recurrent gastrointestinal stromal tumor (GIST),which invaded the transverse colon and led to a perforation during sunitinib treatment. A computed tomography scan and 3-dimensional reconstruction showed necrosis of the recurrent hepatic mass and perforation of the invaded transverse colon. After percutaneous drainage of the intraperitoneal abscess,antibiotic treatment and restricted diet,the condition of the patient improved. The present case is the first to report that sunitinib,which is administered to treat GIST resistant to imatinib,can cause unexpected colon perforation and subsequent peritonitis.

关键词： Gastrointestinal stromal tumors Recurrence Sunitinib Intestinal perforation