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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients

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Virologica Sinica 2024年第2期39卷 319-330页

作者： guixin li Danli Yang Xin liu Ting Zhang Hui liu Jun Zou Zimeng Xu Xiangmei Chen lizhong Dai Hongsong Chen Fengmin Lu Peking University People's Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijing100044China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking UniversityBeijing100191China Baruch S.Blumberg Institute DoylestownPA18901USA Shenzhen Sanyuansheng Biotechnology Co. LtdShenzhen518000China Precision Medicine Center of Zhengzhou University Academy of Medical SciencesZhengzhou UniversityZhengzhou450001China Peking University-Sansure Biotech Joint Laboratory of Molecular Medicine Sansure Biotech Co.LtdChangsha410205China

Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative ***,the replicative capacity of HBV with PC/BCP mutations remains ***,meta-analysis showed that,only under HBeAg-negative status,the serum HBV DNA load in patients with PC mutation was 7.41-fold higher than those without the *** PC mutation alone and BCPþPC mutations promoted HBV replication in cell and hydrodynamic injection mouse *** human hepatocyte chimeric mouse model,BCPþPC mutations led to elevated replicative capacity and intrahepatic core protein ***,preC RNA harboring PC mutation could serve as mRNA to express core and P proteins,and such pgRNA-like function favored the maintenance of cccDNA pool under HBeAg-negative ***,BCPþPC mutations induced more extensive and severe human hepatocyte damage as well as activated endoplasmic reticulum stress and TNF signaling pathway in livers of chimeric *** study indicates that HBeAg-negative patients should be monitored on HBV mutations regularly and are expected to receive early antiviral treatment to prevent disease progression.

关键词： Hepatitis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress

Achromatic metasurface lens at visible wavelengths

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Science Bulletin 2018年第6期63卷 333-335页

作者： guixin li Department of Materials Science and Engineering Shenzhen Institute for Quantum Science and Engineering Southern University of Science and Technology

Lenses,such as optical lens,electron lens,acoustic lens and so on,are devices that can focus waves to form an *** the invention of telescopes and objectives,optical lenses play important roles in observing objects from molecular to astronomical levels,and high-resolution lithography using optical,electron or X-ray *** improve the imaging quality,usually,the

关键词：电子透镜无色波长平版印刷术高分辨率成像质量望远镜

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中医药防治放射性肺损伤研究进展

光明中医 2024年第9期39卷 1893-1897页

作者：冉朝阳李贵新山东中医药大学第一临床医学院潍坊市中医院保健二科

临床研究表明，化疗、放疗和全身治疗是各种胸部恶性肿瘤的主要治疗手段并且疗效可观，然而在治疗的同时也会产生一些不良反应，如可能危及生命的放射性肺损伤。放射性肺损伤是胸部恶性肿瘤放射治疗常见的并发症之一，严重者可影响患者... 详细信息

临床研究表明，化疗、放疗和全身治疗是各种胸部恶性肿瘤的主要治疗手段并且疗效可观，然而在治疗的同时也会产生一些不良反应，如可能危及生命的放射性肺损伤。放射性肺损伤是胸部恶性肿瘤放射治疗常见的并发症之一，严重者可影响患者的生存质量。中医药在放疗中的干预能有效降低放射性肺损伤的发生并减轻相关的症状，具有良好的防治效果。此文主要对中医经方、自拟方与中成药在预防和治疗放射性肺损伤中所起的作用加以综述，为中医药在临床防治放射性肺损伤的具体应用提供依据。

关键词：肺痿放射性肺损伤经方中成药

Optical metasurfaces:fundamentals and applications

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Photonics Research 2023年第5期11卷 I0004-I0006页

作者： THOMAS PERTSCH SHUMIN XIAO ARKA MAJUMDAR guixin li Friedrich-Schiller-Universität Jena 07737 JenaGermany Harbin Institute of Technology(Shenzhen) Shenzhen 518055China University of Washington SeattleWashington 98195USA Southern University of Science and Technology Shenzhen 518055China

Optical metasurfaces are currently an important research area all around the world because of their wide application opportunities in imaging,wavefront engineering,nonlinear optics,quantum information processing,just to name a *** feature issue“Optical Metasurfaces:Fundamentals and Applications”in Photonics Research allows for archival publication of the most recent works in optical metasurface and provides for broad dissemination in the photonics community.

关键词： surfaces optics quantum

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养阴清肺汤联合化疗治疗肺癌研究进展

光明中医 2024年第5期39卷 1026-1029页

作者：刘博文李贵新山东中医药大学山东济南250013 潍坊市中医院保健二科山东潍坊261041

近年来,肺癌已逐渐成为全球范围内病发率和病死率最高的恶性肿瘤之一。在西医治疗方法上,根据肺癌分期,多包括放疗、化疗、靶向治疗或和手术治疗等,中医治疗则需要根据其病因病机辨证论治、对症治疗,二者在临床上相辅相成,有利于更好地... 详细信息

近年来,肺癌已逐渐成为全球范围内病发率和病死率最高的恶性肿瘤之一。在西医治疗方法上,根据肺癌分期,多包括放疗、化疗、靶向治疗或和手术治疗等,中医治疗则需要根据其病因病机辨证论治、对症治疗,二者在临床上相辅相成,有利于更好地提高治疗效果,改善患者生活质量。文章围绕养阴清肺汤联合化疗在治疗肺癌时的优势展开,阐述养阴清肺汤在肺癌患者化疗时的应用。

关键词：肺积肺癌养阴清肺汤化疗中医药疗法

PEI-Ru@SiO_(2)-Au@Pt复合材料的制备与电化学发光性能

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当代化工 2024年第5期53卷 1026-1030,1105页

作者：程高兴王春李桂新新疆师范大学新疆乌鲁木齐830054

采用化学氧化法合成了聚乙烯亚胺-联吡啶钌@二氧化硅-金@铂(PEI-Ru@SiO_(2)-Au@Pt)发光功能化纳米复合材料;构建灵敏稳定的响应界面,制备了精准高效的固相增强型电化学发光纳米复合材料。通过透射电子显微镜(TEM)、紫外-可见吸收光谱(UV... 详细信息

采用化学氧化法合成了聚乙烯亚胺-联吡啶钌@二氧化硅-金@铂(PEI-Ru@SiO_(2)-Au@Pt)发光功能化纳米复合材料;构建灵敏稳定的响应界面,制备了精准高效的固相增强型电化学发光纳米复合材料。通过透射电子显微镜(TEM)、紫外-可见吸收光谱(UV-Vis)、傅里叶变换红外光谱(FTIR)、电化学阻抗谱(EIS)、循环伏安法(CV)和双电位阶跃法对合成的纳米复合材料进行了表征和性能测试。研究了PEI-Ru@SiO_(2)-Au@Pt纳米复合材料的形貌和结构以及电化学发光性能(ECL)。结果表明:PEI-Ru@SiO_(2)-Au@Pt纳米复合材料具有优异ECL性能,加入Au@Pt后,PEI-Ru@SiO_(2)-Au@Pt纳米复合材料的ECL强度是PEI-Ru@SiO_(2)的5倍。

关键词：电化学发光发光功能复合材料金核铂壳聚乙烯亚胺-联吡啶钌@二氧化硅

Reversible switching of electromagnetically induced transparency in phase change metasurfaces

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Advanced Photonics 2020年第5期2卷 74-83页

作者： libang Mao Yang li guixin li Shuang Zhang Tun Cao Dalian University of Technology School of Optoelectronic Engineering and Instrumentation ScienceDalianChina Southern University of Science and Technology Department of Materials Science and EngineeringShenzhenChina University of Birmingham School of Physics and AstronomyBirminghamUnited Kingdom

Metasurface analogue of the phenomenon of electromagnetically induced transparency(EIT)that is originally observed in atomic gases offers diverse applications for new photonic components such as nonlinear optical units,slow-light devices,and *** development of functional integrated photonic devices requires an active control of EIT in *** demonstrate a reversible switching of the metasurface-induced transparency in the near-infrared region by incorporating a nonvolatile phase change material,Ge2Sb2Te5,into the metasurface *** leads to an ultrafast reconfigurable transparency window under an excitation of a nanosecond pulsed *** measurement agrees well with both theoretical calculation and finite-difference time-domain numerical *** work paves the way for dynamic metasurface devices such as reconfigurable slow light and biosensing.

关键词： metasurfaces electromagnetically induced transparency surface plasmon resonance reconfigurable phase change material

304不锈钢局部干法水下激光填丝焊接工艺及焊缝性能研究

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精密成形工程 2024年第1期16卷 105-111页

作者：赵亮朱加雷赵志博赵友亮李桂新李松钊黄钰珊北京石油化工学院机械工程学院北京106217

目的采用自主研制的水下激光填丝焊接装备,在304奥氏体不锈钢板材表面进行U形坡口激光填丝焊接试验,为304不锈钢水下修复工作提供技术参考。方法在功率为5600 W、焊接速度为6 mm/s、送丝速度为205 cm/min、保护气体流量为15 L/min、排... 详细信息

目的采用自主研制的水下激光填丝焊接装备,在304奥氏体不锈钢板材表面进行U形坡口激光填丝焊接试验,为304不锈钢水下修复工作提供技术参考。方法在功率为5600 W、焊接速度为6 mm/s、送丝速度为205 cm/min、保护气体流量为15 L/min、排水气体流量为30 L/min的条件下进行焊接试验,并对空气和水下环境下的焊缝进行对比检测分析。通过光学显微镜分析2种环境下焊缝的显微组织;对2种焊缝进行拉伸、弯曲等力学性能测试;采用显微硬度计测试1 kg载荷下不同区域的显微硬度;使用VersaSTAT 3F电化学工作站测定在3.5%(质量分数)的NaCl溶液中2种焊缝的开路电位和极化曲线。结果2种环境下的焊缝均无明显裂纹、气孔等缺陷;显微组织主要由奥氏体和铁素体组成,但2种环境下焊缝的奥氏体晶粒大小和铁素体形状均略有差别,焊缝拉伸断口均为典型的韧性断裂形貌且抗拉强度符合304不锈钢标准。2种环境下焊缝的微观组织和晶粒大小不同,水下焊缝硬度高于空气的。通过分析2种环境下焊缝的开路电位和极化曲线,可知水下焊缝的耐腐蚀性略高。结论所开发的局部干法水下激光填丝焊接工艺可以满足实际工程中水下焊接维修的要求,其焊缝性能可以满足304不锈钢空气环境下的焊接质量标准。

关键词：局部干法激光焊接 304不锈钢水下焊接电化学腐蚀

The pathogenicity on legumes of Cucumber mosaic virus was determined by 243 nucleotides on 2a polymerase gene of viral RNA2

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Chinese Science Bulletin 2002年第9期47卷 748-750,794页

作者： TAO Xiaorong ZHOU Xueping li guixin YU Jialin Institute of Biotechnology Zhejiang UniversityHangzhou 310029China National Key Laboratory on Agrobiotechnology China Agriculture UniversityBeijing 100094China

We had isolated and identified two Cucumber mosaic virus (CMV) isolates, the CMV red bean (CMV-RB) isolate and the CMV pea (CMV-P1) isolate. CMV-RB induces necrotic local lesions on inoculated leaves of broad bean, pea, cowpea and bean, and could not infect these hosts systemically. However, CMV-P1 was able to infect these legumes systemically. To study the difference of pathogenic-ity on the legumes induced by these two CMV isolates, the full-length infectious cDNA clones of CMV-Fny, which induced similar symptoms as CMV-RB in the four legumes, were used. The 243 nucleotides fragment, which encodes highly conserved GDD amino acid motif on 2a replicase gene of CMV-Fny RNA2, was replaced with that of CMV-P1. The constructed chimeric virus FP could infect these legumes systemically. The exchange of this region changes the virus symptoms on the legumes, indicating that this 243 nucleotides fragment has major effect on pathogenicity of CMV on the legumes.

关键词： Cucumber mosaic virus legumes replicase gene patho-genicity.