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Early prediction of growth patterns after pediatric kidney transplantation based on height-related single-nucleotide polymorphisms

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Chinese Medical Journal 2024年第10期137卷 1199-1206页

作者： Yi Feng Yonghua Feng Mingyao Hu Hongen xu Zhigang Wang Shicheng xu Yongchuang Yan Chenghao Feng Zhou Li guiwen Feng Wenjun Shang Department of Renal Transplantation The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Precision Medicine Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China

Background:Growth retardation is a common complication of chronic kidney disease in children,which can be partially relieved after renal *** study aimed to develop and validate a predictive model for growth patterns of children with end-stage renal disease(ESRD)after kidney transplantation using machine learning algorithms based on genomic and clinical ***:A retrospective cohort of 110 children who received kidney transplants between May 2013 and September 2021 at the First Affiliated Hospital of Zhengzhou University were recruited for whole-exome sequencing(WES),and another 39 children who underwent transplant from October 2021 to March 2022 were enrolled for external *** on previous studies,we comprehensively collected 729 height-related single-nucleotide polymorphisms(SNPs)in exon *** machine learning algorithms and 10-fold cross-validation analysis were employed for model ***:The 110 children were divided into two groups according to change in height-for-age *** univariate analysis,age and 19 SNPs were incorporated into the model and *** random forest model showed the best prediction efficacy with an accuracy of 0.8125 and an area under curve(AUC)of 0.924,and also performed well in the external validation cohort(accuracy,0.7949;AUC,0.796).Conclusions:A model with good performance for predicting post-transplant growth patterns in children based on SNPs and clinical variables was constructed and validated using machine learning *** model is expected to guide clinicians in the management of children after renal transplantation,including the use of growth hormone,glucocorticoid withdrawal,and nutritional supplementation,to alleviate growth retardation in children with ESRD.

关键词： Growth Machine learning Pediatric kidney transplantation Single-nucleotide polymorphism

Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 630-643页

作者： CHEN Lan xu guiwen DA xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang Chongqing University of Science and Technology Chongqing 401331China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of Sciences99 West Lincheng RoadGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059SichuanChina

The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰（relative to PDB）, which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events（T-OAE） in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity.

关键词： oil shales geochemistry palaeontology T-OAE northern Tibet Proto-Tethys

Jurassic Black Shales Facies from Qiangtang Basin (Northern Tibet): Rare Earth and Trace Elements for Paleoceanographic Implications

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Acta Geologica Sinica(English Edition) 2013年第2期87卷 540-554页

作者： CHEN Lan YI Haisheng TSAI Louis Loung-Yie xu guiwen DA xuejuan LIN Andrew Tien-Shun College of Petroleum Engineering Chongqing University of Science and Technology Institute of Applied Geology National Central University Institute of Geophysics National Central University Institute of Sedimentary Geology Chengdu University of Technology State Key Laboratory of Oil/Gas Reservoir Geology and Exploitation Chengdu University of Technology

The Biluo Co and Amdo 114 station, northern Tibet, cropping out the Early Toarcian and Middle-Late Tithonian （Jurassic） organic-rich black shales, have been a focus to petroleum geologists in discussing their oil-producing potential. This paper first reports the trace elements and rare earth elements to discuss the paleoenvironments, redox conditions and sedimentary mechanisms of those black shales. Both sections exhibit variation in trace element abundances with concentrations 〈0.1 ppm to 760 ppm, mostly enriched in V, Cr, Ni, Cu, Zn, Mo, Ba and U. Element ratios of Ni/Co, V/Cr, U/Th and V/（V＋Ni） plus U were used to identify redox conditions. The shale-normalized rare earth element （REE） patterns are characterized by the flat-shale type with instable Ce anomalies and very weekly positive Eu anomalies. Positive Ceanom values are significant with values varying between - 0.064 and 0.029 in Biluo Co, which may be interpreted as release of REE and input of riverine terrestrial matter with rich Ce （resulting in pH change） during the anoxic conditions. In the middle parts of Amdo 114 station, distinct negative Ceanom values are observed （-0.238 to -0.111） and associated surface water warming were interpreted as being related to a major sea level rise. In contrast, the formation of the black shales in the lower and upper part of the studied succession took place during a cooler （Ceanom values 〉-0.10）, lower surface water productivity, and lower sea-level stage. Thus, we emphasize the role of different factors that control the formation of local and regional black shales. The most important factors are sea-level fluctuations and increasing productivity.

关键词： Jurassic black shale facies rare earth and trace elements paleoceanography northern Tibet

CO_(2)催化加氢制备C_(1)产物的反应路径与催化剂研究进展

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低碳化学与化工 2024年第3期49卷 1-8页

作者：黄艳王贵文杨龙徐冬高腾飞国能锦界能源有限责任公司陕西神木719319 国家能源集团新能源技术研究院有限公司北京102209

通过二氧化碳(CO_(2))催化加氢制备碳基燃料和高值化学品是一种极具应用前景的碳减排技术,但其工业化仍面临许多挑战。针对CO_(2)催化加氢制备的C_(1)产物,包括甲酸(HCOOH)、一氧化碳(CO)、甲醇(CH_(3)OH)和甲烷(CH_(4)),从反应路径、... 详细信息

通过二氧化碳(CO_(2))催化加氢制备碳基燃料和高值化学品是一种极具应用前景的碳减排技术,但其工业化仍面临许多挑战。针对CO_(2)催化加氢制备的C_(1)产物,包括甲酸(HCOOH)、一氧化碳(CO)、甲醇(CH_(3)OH)和甲烷(CH_(4)),从反应路径、催化工艺等方面综述了相关研究进展。首先,总结了CO_(2)催化加氢生成不同C_(1)产物的反应路径及其竞争关系。随后,针对CO_(2)催化加氢催化剂的改性方式,讨论了不同催化剂的催化性能。最后,对CO_(2)催化加氢催化剂的未来发展方向进行了展望。

关键词： CO_(2) C_(1)产物催化加氢反应路径催化剂

Manganese Deposits and Environments Contaminated by Manganese Mine Tailings in Chongqing Area

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Manganese Deposits and Environments Contaminated by Manganes...

2011 IEEE International Conference on Waste Recycling,Ecology and Environment(ICWREE 2011)

作者： Minquan XIA* Lan CHEN Song XIAO xuejuan DA guiwen xu College of Petroleum Engineering Chongqing University of Science and Technology Chongqing 401331 P.R. China

The Chengkou and Xiushan Mn deposits of Chongqing area are hosted by organic-rich black shales with higher MnCO3 contents between 33.00% and 82.35%. According to the geological settings and geochemistry, the metallogenesis of Neoproterozoic manganese related to the oceanic anoxic events and a particularly sharp solubility gradient exists along oxic-anoxic interface. The manganiferous stromalite has highest MnCO3 content with 82.35%, which indicates biological assistance in precipitation of manganese. The manganese mine tailings contain heavy metals such as Cu, Pb, Zn, Cr, Ti, Sb and U and contaminate the air, soil, and water, therefore, the governments must take more attention to environmental contamination by manganese mine tailings.

关键词： manganese deposits metallogenesis mine tailings Chongqing area

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抗静电珊瑚绒毛毯面料的开发

针织工业 2014年第2期 15-17页

作者：黄雷崔运花王申涛徐贵文东华大学纺织学院上海201600 纺织面料技术教育部重点实验室上海201600 江苏苏美达轻纺国际贸易有限公司江苏南京210000 江苏常熟鸽球印染有限公司江苏常熟215500

通过对针织物嵌织不同比例的镀银长丝,分析镀银长丝含量对织物抗静电性能及耐久性能的影响。指出,当织物达到抗静电要求时,银纤维含量越低越好。在此基础上,以11.1 tex/144 f DTY涤纶复丝和11.1 tex/34 f的X-static镀银长丝为编链纱,8.3... 详细信息

通过对针织物嵌织不同比例的镀银长丝,分析镀银长丝含量对织物抗静电性能及耐久性能的影响。指出,当织物达到抗静电要求时,银纤维含量越低越好。在此基础上,以11.1 tex/144 f DTY涤纶复丝和11.1 tex/34 f的X-static镀银长丝为编链纱,8.3 tex/36 f DTY涤纶复丝为衬纬纱,16.7 tex/288 f DTY涤纶复丝和11.1 tex/34 f的X-static镀银长丝为毛绒纱,在GE288型双针床经编机上开发抗静电珊瑚绒毛毯面料,介绍了其编织、剖绒、预定形、上柔、起毛、梳剪摇粒等工序的工艺及注意事项,最后对成品进行抗静电性能测试。结果表明,产品经20次洗涤后,抗静电性效果依然极佳,具有耐久性抗静电性能。

关键词：珊瑚绒毛毯面料 X-static镀银长丝纤维含量编织工艺抗静电

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钨纳米颗粒填充法制作X射线吸收光栅

半导体光电 2019年第6期40卷 786-788,890页

作者：李乔飞许桂雯李冀黄建衡雷耀虎深圳大学物理与光电工程学院光电子器件与系统(教育部/广东省)重点实验室

提出一种新颖、可避免高温过程的大面积吸收光栅制作方法,使用钨纳米粒子作为X射线吸收材料,利用有机溶剂和乳化剂作为吸收材料的载体,在负压下将它们填充到周期为42μm、深度为150μm的光栅结构中。此外,与通过微铸造技术制作的相同结... 详细信息

提出一种新颖、可避免高温过程的大面积吸收光栅制作方法,使用钨纳米粒子作为X射线吸收材料,利用有机溶剂和乳化剂作为吸收材料的载体,在负压下将它们填充到周期为42μm、深度为150μm的光栅结构中。此外,与通过微铸造技术制作的相同结构铋块体吸收光栅相比较,得到的X射线投影吸收对比度表明,钨纳米颗粒对X射线吸收性能低约15%,但纳米颗粒填充法可显著降低吸收光栅的制作成本,并利于实现大面积制作。

关键词： X射线相衬成像吸收光栅纳米颗粒钨

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头皮糜烂性脓疱性皮病一例

中国麻风皮肤病杂志 2021年第8期37卷 523-524页

作者：许桂文王玉坤王小坡鹿文静山东大学齐鲁医院(青岛)皮肤科青岛266035 山东大学齐鲁医院皮肤科济南250012 中国医学科学院北京协和医学院皮肤病医院病理科江苏南京210042

患者,女,50岁。头皮红斑、脓疱伴疼痛6个月。皮肤科查体:头皮弥漫性分布紫红色浸润性斑片,其上见脓疱,局部见斑片状脱发区。实验室检查:取脓疱疱液多次行细菌及真菌培养均阴性。组织病理:表皮角化过度伴角化不全;真皮浅中层弥漫性淋巴... 详细信息

患者,女,50岁。头皮红斑、脓疱伴疼痛6个月。皮肤科查体:头皮弥漫性分布紫红色浸润性斑片,其上见脓疱,局部见斑片状脱发区。实验室检查:取脓疱疱液多次行细菌及真菌培养均阴性。组织病理:表皮角化过度伴角化不全;真皮浅中层弥漫性淋巴细胞、浆细胞、中性粒细胞浸润。抗生素治疗效果不佳,口服糖皮质激素及外用他克莫司治疗后有效。诊断:头皮糜烂性脓疱性皮病。

关键词：脓疱性皮病头皮糜烂性红斑

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Cu基催化剂催化CO_(2)加氢研究进展

当代化工研究 2024年第4期 16-18页

作者：黄艳王贵文杨龙徐冬高腾飞国能锦界能源有限责任公司陕西719319 国家能源集团新能源技术研究院有限公司北京102209

二氧化碳(CO_(2))的捕集与利用是实现“双碳”目标的重要技术手段,其中CO_(2)催化加氢不仅可以减少碳排放,还能将其转化为甲醇等高价值的化工产品。催化剂和反应器设计是CO_(2)催化加氢的关键,其中,Cu基催化剂是最为常用的催化剂。本文... 详细信息

二氧化碳(CO_(2))的捕集与利用是实现“双碳”目标的重要技术手段,其中CO_(2)催化加氢不仅可以减少碳排放,还能将其转化为甲醇等高价值的化工产品。催化剂和反应器设计是CO_(2)催化加氢的关键,其中,Cu基催化剂是最为常用的催化剂。本文针对CO_(2)催化加氢现状,归纳了CO_(2)催化加氢的基本原理,重点从Cu基催化剂的结构特性与催化机制、催化反应器等综述了CO_(2)催化加氢研究进展,并展望了今后的发展方向。

关键词： CO_(2) 催化加氢 Cu基催化剂反应器