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UroPrecision 2024年第2期2卷 65-72页

作者： guiting lin Run Wang Tom F.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology Uniersity of Texas MD Anderson Cancer CenterHoustonTexasUSA Division of Urology Department of SurgeryUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

San Antonio,May 3,2024—The 16th Annual meeting of the World Chinese Urological Society(WCUS)was successfully held in San Antonio,drawing together experts and scholars from around the globe in the field of Chinese *** conference served as a platform for academic exchange,as well as an occasion for medical professionals of Chinese descent to learn from,inspire,and motivate one *** events are crucial for advancing research and clinical practice in Chinese urology worldwide,and the success of this conference signals a bright and progressive future for the field.

关键词： World exchange witness

16th Annual Meeting of the World Chinese Urological Society:Reunion and sharing of global Chinese urological advances

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UroPrecision 2024年第2期2卷 62-64页

作者： guiting lin Run Wang Tom F.Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCaliforniaUSA Department of Urology MD Anderson Cancer CenterHoustonTexasUSA Department of Surgery Division of UrologyUniversity of Texas McGovern Medical SchoolHoustonTexasUSA

1|*** few years without in-person meeting during the American Urological Association(AUA)due to COVID-19 pandemic,the world's brightest Chinese urologists and urological researchers gathered *** May 3,2024,the 16th Annual Meeting of the World Chinese Urological Society(WCUS)was successfully held in San Antonio,*** conference attracted Chinese experts and scholars from the field of urology around the world to discuss and share the latest academic achievements and research *** significant event provided an important academic exchange platform for Chinese urology experts globally.

关键词： union globally World

Stem cells： novel players in the treatment of erectile dysfunction

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Asian Journal of Andrology 2012年第1期14卷 145-155,179页

作者： Haiyang Zhang Maarten Albersen Xunbo Jin guiting lin Minimally Invasive Urology Center Provincial Hospital Affiliated to Shandong University Jinan 250021 China Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA 94143 USA Laboratory of Experimental Urology Department of Urology University Hospitals Leuven Leuven 3000 Belgium

Stem cells are defined by their capacity for both self-renewal and directed differentiation; thus, they represent great promise for regenerative medicine. Historically, stem cells have been categorized as either embryonic stem cells （ESCs） or adult stem cells （ASCs）. It was previously believed that only ESCs hold the ability to differentiate into any cell type, whereas ASCs have the capacity to give rise only to cells of a given germ layer. More recently, however, numerous studies demonstrated the ability of ASCs to differentiate into cell types beyond their tissue origin. The aim of this review was to summarize contemporary evidence regarding stem cell availability, differentiation, and more specifically, the potential of these cells in the diagnosis and treatment of erectile dysfunction （ED） in both animal models and human research. We performed a search on PubMed for articles related to definition, iocalisation and circulation of stem cells as well as the application of stem cells in both diagnosis and treatment of ED. Strong evidence supports the concept that stem cell therapy is potentially the next therapeutic approach for ED. To date, a large spectrum of stem cells, including bone marrow mesenchymal stem cells, adipose tissue-derived stem cells and muscle-derived stem cells, have been investigated for neural, vascular, endothelial or smooth muscle regeneration in animal models for ED. In addition, several subtypes of ASCs are localized in the penis, and circulating endogenous stem cells can be employed to predict the outcome of ED and ED-related cardiovascular diseases.

关键词： adipose tissue-derived stem cells bone marrow stem cells erectile dysfunction mesenchymal stem cells stem cells

Role of Schwann cells in the regeneration of penile and peripheral nerves

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Asian Journal of Andrology 2015年第5期17卷 776-782,I0008页

作者： lin Wang Melissa T Sanford Zhongcheng Xin guiting lin Tom F Lue Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA USA Andrology Center Department of Urology Peking University First Hospital Peking University Beijing China

Schwann cells （SCs） are the principal gila of the peripheral nervous system. The end point of SC development is the formation of myelinating and nonmyelinating cells which ensheath large and small diameter axons, respectively. They play an important role in axon regeneration after injury, including cavernous nerve injury that leads to erectile dysfunction （ED）. Despite improvement in radical prostatectomy surgical techniques, many patients still suffer from ED postoperatively as surgical trauma causes traction injuries and local inflammatory changes in the neuronal microenvironment of the autonomic fibers innervating the penis resulting in pathophysiological alterations in the end organ. The aim of this review is to summarize contemporary evidence regarding：（1） the origin and development of SCs in the peripheral and penile nerve system; （2） Wallerian degeneration and SC plastic change following peripheral and penile nerve injury; （3） how SCs promote peripheral and penile nerve regeneration by secreting neurotrophic factors; （4） and strategies targeting SCs to accelerate peripheral nerve regeneration. We searched PubMed for articles related to these topics in both animal models and human research and found numerous studies suggesting that SCs could be a novel target for treatment of nerve injury-induced ED.

关键词： erectile dysfunction growth factors prostatectomy

Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury

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Asian Journal of Andrology 2008年第1期10卷 54-59页

作者： Anthony J. Bella guiting lin Ilias Cagiannos Tom F. Lue Department of Surgery Division of UrologyUniversity of Ottawa Ottawa KIY4E9 Canada Department of Neuroscience Ottawa Health Research Institute University of Ottawa Ottawa KIY4E9 Canada Knuppe Molecular Urology Laboratory San Francisco CA 94143 USA Department of Urology University of California San Francisco CA 94143 USA

Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves （CNs）, as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction （ED） after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors （GDNF）, bone morphogenic proteins, immunophilin ligands, erythropoetin （EPO）, and stem cells.

关键词： erectile dysfunction prostate cancer radical prostatectomy postoperative complications neuroprotection nerve regeneration neurotrophins brain-derived nerve growth factor immunophilin ligands stem cells

Icariin on relaxation effect of corpus cavernosum smooth muscle

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Chinese Science Bulletin 2001年第14期46卷 1186-1191页

作者： XIN Zhongcheng Kim Euikyung TIAN Zhenji lin guiting QUO Yinglu Department of Urology The First HospitalPeking UniversityBeijing100034China Department of Life Science Pohang University of Science and TechnologyPohangKorea

NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5’ monophosphate (GMP) by phos-phodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4×10-4 mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection.

关键词： Icariin corpus cavernosm cGMP erection.

Recruiting endogenous stem cells： a novel therapeutic approach for erectile dysfunction

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Asian Journal of Andrology 2016年第1期18卷 10-15页

作者： Zhong-Cheng Xin Yong-De Xu guiting lin Tom FLue Ying-Lu Guo Andrology Center Peking University First Hospital Peking University Beijing 100034 China Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA USA.

Transplanted stem cells （SCs）, owing to their regenerative capacity, represent one of the most promising methods to restore erectile dysfunction （ED）. However, insufficient source, invasive procedures, ethical and regulatory issues hamper their use in clinical applications. The endogenous SCs/progenitor cells resident in organ and tissues play critical roles for organogenesis during development and for tissue homeostasis in adulthood. Even without any therapeutic intervention, human body has a robust self-healing capability to repair the damaged tissues or organs. Therefore, SCs-for-ED therapy should not be limited to a supply-side approach. The resident endogenous SCs existing in patients could also be a potential target for ED therapy. The aim of this review was to summarize contemporary evidence regarding：（1） SC niche and SC biological features in vitro; （2） localization and mobilization of endogenous SCs; （3） existing evidence of penile endogenous SCs and their possible mode of mobilization. We performed a search on PubMed for articles related to these aspects in a wide range of basic studies. Together, numerous evidences hold the promise that endogenous SCs would be a novel therapeutic approach for the therapy of ED.

关键词： endogenous stem cell erectile dysfunction homing niche

Interaction of hTCF4 by yeast two-hybrid system

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Chinese Science Bulletin 2000年第21期45卷 1973-1977页

作者： lin guiting ZHANG Zhiwen ZANG long XIN Dianqi CHANG Zhijie GUO Yinglu Urology Institute Beijing Medical UniversityBeijing 100034China Physiology Department Beijing Medical UniversityBeijing 100034China Biology Department Qinghua UniversityBeijing 100084China

To investigate the interaction of hTCF4, the yeast two-hybrid system has been used for testing the interaction of mutants of hTCF4 with themselves. Mutants of hTCF4 (hTCF4 Ⅰ ) and hTCF4 Ⅱ) have been obtained by polymerase chain reaction (PCR). Bait (hTCF4 Ⅰ -pDBLeu and hTCF4Ⅱ-pDBLeu) and prey (hTCF4 Ⅰ -pPC86 and hTCF4Ⅱ-pPC86) have been constructed by DNA recombination for yeast two-hybrid. Interaction of hTCF4Ⅱ with itself is found in the reverse yeast two-hybrid system (GIBCOBRL Co.). However, no interactions are found in hTCF4Ⅱ with hTCF4 Ⅰ and in hTCF4 Ⅰ with hTCF4 Ⅰ . These results suggest that hTCF4 could interact with itself to form homodimer or homocopolymer and perform the transcriptional activating function through LZ or HLH motifs in nucleus of renal cell carcinoma.

关键词： Wnt/Frizzled hTCF4 yeast two-hybrid.

Recent advances in andrology-related stem cell research

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Asian Journal of Andrology 2008年第2期10卷 171-175页

作者： Ching-Shwun lin Zhong-Cheng Xin Chun-Hua Deng Hongxiu Ning guiting lin Tom F. Lue Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA 94143 USA Andrology Center Peking University First Hospital Beijing 100009 China Urology Department The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 China

Stem cells hold great promise for regenerative medicine because of their ability to self-renew and to differentiate into various cell types. Although embryonic stem cells （BSC） have greater differentiation potential than adult stem cells, the former is lagging in reaching clinical applications because of ethical concerns and governmental restrictions. Bone marrow stem cells （BMSC） are the best-studied adult stem cells （ASC） and have the potential to treat a wide variety of diseases, including erectile dysfunction （ED） and male infertility. More recently discovered adipose tissuederived stem cells （ADSC） are virtually identical to bone marrow stem cells in differentiation and therapeutic potential, but are easier and safer to obtain, can be harvested in larger quantities, and have the associated benefit of reducing obesity. Therefore, ADSC appear to be a better choice for future clinical applications. We have previously shown that ESC could restore the erectile function of neurogenic ED in rats, and we now have evidence that ADSC could do so as well. We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency. （Asian JAndrol 2008 Mar; 10： 171-175）

关键词： stem cells bone marrow stem cells adipose tissue-derived stem cells erectile dysfunction male infertility

Low-intensity pulsed ultrasound stimulates proliferation of stem/progenitor cells: what we need to know to translate basic science research into clinical applications

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Asian Journal of Andrology 2021年第6期23卷 602-610页

作者： Yan Tan Yang Guo Amanda B Reed-Maldonado Zheng Li guiting lin Shu-Jie Xia Tom F Lue Knuppe Molecular Urology Laboratory Department of UrologySchool of MedicineUniversity of CaliforniaSan FranciscoCA 94143USA Department of Andrology Renmin HospitalHubei University of MedicineShiyan 442000China Hubei Key Laboratory of Embryonic Stem Cell Research Hubei University of MedicineShiyan 442000China Department of Urology Tripler Army Medical CenterHonoluluHI 96859USA Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Low-intensity pulsed ultrasound (LIPUS) is a promising therapy that has been increasingly explored in basic research and clinical applications. LIPUS is an appealing therapeutic option as it is a noninvasive treatment that has many advantages, including no risk of infection or tissue damage and no known adverse reactions. LIPUS has been shown to have many benefits including promotion of tissue healing, angiogenesis, and tissue regeneration;inhibition of inflammation and pain relief;and stimulation of cell proliferation and differentiation. The biophysical mechanisms of LIPUS remain unclear and the studies are ongoing. In recent years, more and more research has focused on the relationship between LIPUS and stem/progenitor cells. A comprehensive search of the PubMed and Embase databases to July 2020 was performed. LIPUS has many effects on stem cells. Studies show that LIPUS can stimulate stem cells in vitro;promote stem cell proliferation, differentiation, and migration;maintain stem cell activity;alleviate the problems of insufficient seed cell source, differentiation, and maturation;and circumvent the low efficiency of stem cell transplantation. The mechanisms involved in the effects of LIPUS are not fully understood, but the effects demonstrated in studies thus far have been favorable. Much additional research is needed before LIPUS can progress from basic science research to large-scale clinical dissemination and application.

关键词： cellular signaling pathway low-intensity pulsed ultrasound mechanism mechanotransduction stem cells