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Chinese Medical Journal 2014年第7期127卷 1357-1364页

作者： guiming liu firouz daneshgari Urology Institute University Hospitals Case Medical Center and Department of Urology Case Western Reserve University School of Medicine Cleveland Ohio USA

Objective To review studies on diabetic bladder dysfunction （DBD）,a common and bothersome complication of diabetes *** sources We performed a search of the English literature through *** key words used were ＂diabetes＂ and ＂bladder dysfunction＂ or ＂cystopathy＂.Our own data and perspective are included in the *** selection Studies containing data relevant to DBD were *** of the limited length of this article,we also referenced reviews that contain comprehensive amalgamations of relevant *** The classic symptoms of DBD are decreased bladder sensation,increased bladder capacity,and impaired bladder emptying with resultant elevated post-void residual ***,recent clinical and experimental evidence indicate a strong presence of storage problems such as urge incontinence in *** studies of DBD in animal models of type 1 diabetes have revealed temporal effects of diabetes,causing an early phase of compensatory bladder function and a later phase of decompensated bladder *** pathophysiology of DBD is multifactorial,including disturbances of the detrusor,urothelium,autonomic nerves,and *** and hyperglycemia play important but distinctive roles in induction of bladder dysfunction in type 1 *** causes significant bladder hypertrophy in the early stage of diabetes,whereas oxidative stress in the bladder caused by chronic hyperglycemia may play an important role in the late stage failure of bladder *** DBD includes time-dependent and mixed *** pathological alterations include muscle,nerve,and *** and hyperglycemia independently contribute to the pathogenesis of *** for DBD are *** clinical studies on DBD in type 1 and type 2 diabetes should be investigated *** studies of DBD in type 2 diabetes are needed,from the natural history to *** understanding of the molecular mechan

关键词： diabetes bladder dysfunction cystopathy complications

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