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Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions

World Journal of Clinical Cases 2018年第15期6卷 922-930页

作者： Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez samantha Cabrera-Palma guillermo Cabrera-álvarez Liver Research Unit Medica Sur Clinic and Foundation Department of Gastroenterology Hospital "Juárez" of México Department of Molecular Biology in Me-dicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Department of Internal Medicine "Christus Muguerza "Super Specialty" Hospital" Monterrey Department of Gas-troenterology "University Hospital "Jose Eleuterio González" Monterrey Department of Gastroenterology "General Hospital of Mexico "Dr.Eduardo Liceaga" Department of Gastroenterology "Central Military Hospital" Faculty of Medicine and Nutrition Juárez University of the State of Durango Liver Clinic Regional General Hospital IMSS 1

AIM To investigate the main current etiologies of cirrhosis in *** We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico.

关键词： Alcoholic liver disease Hepatitis C virus Nonalcoholic steatohepatitis Liver cirrhosis

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Colorectal Cancer Surgery in Extreme Elderly Population

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Journal of Cancer Therapy 2015年第1期6卷 12-20页

作者： Javier Gallego Plazas Elena Asensio Juan C. Navalon Inmaculada Lozano Jose M. Navarro guillermo Ricote Montse Olcina Almudena Cotes Henry M. Ore Alejandra Magdaleno Maria C. Ors Maria J. Escudero Miguel A. Morcillo Servicio de Oncología Médica Hospital General Universitario de Elche-Hospital Vega Baja Alicante Espana Servicio de Cirugía General Hospital Vega Baja Alicante Espana

Background: Colorectal cancer surgery in extreme elderly population (380 years) is a growing problem and a subject in question. Experiences and results in this scenario are limited. Methods: Medical records of patients?380 years old hospitalized in General Surgery Department in Vega Baja Hospital between January 1st 2008 and December 31st 2012 were retrospectively reviewed. Patients diagnosed with colorectal cancer (CRC) were selected. Data regarding comorbidities, treatment performed, complications and survival were collected. Results: 95 patients (74 colon, 21 rectum) were identified: median age 83.0 years (80 - 93), 64.2% males. 93.7% of patients were operated on: median hospital and post-operative stay of 11 and 9 days, respectively;curative intention surgery 82.1%. 4.2% of patients were treated with interventionist procedures, and 2.1% of patients in a conservative way. 17.9% and 4.2% of patients came up with early and late complications, respectively. Early and late mortality occurred in 9.5% and 3.2% of patients, respectively. By March 2014, with a median follow up of 43.8 months, median overall survival for colorectal cancer patients was 2.7 years (95%IC, 2.0 - 3.2). Univariaye Cox Regresion analysis revealed the presence of cardiomyopathy (p = 0.024), the presence of chornic kidney disease (p = 0.025), the presence of comorbidities (vs absence) (0.026), the number of comorbidities (0.034), type of admission (p = 0.001), treatment with surgery (p = 0.001) and the incidence of early (p = 0.004) or late complications (p = 0.023) associated to overall survival with statically significance. Multivariate Cox Regression analysis showed number of comorbidities (HR = 1.104;95%CI: 0.851 - 1.431;p = 0.456), treatment with surgery (HR = 4.928;95%CI: 1.815 - 13.385;p = 0.002), programmed admission into hospital (HR = 2.316;95%CI: 1.298 - 4.133;p = 0.004), and the incidence of late complications (HR = 4.629;95%CI: 1.279 - 16.750;p = 0.020) independently associated with o

关键词： Colorectal Cancer Surgery Elderly

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牛羊瘤胃积食中兽医诊疗

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畜牧兽医科学（电子版） 2021年第21期 64-65页

作者：古丽艾再孜·热依木新疆昌吉市六工镇畜牧兽医站新疆昌吉831100

牛羊的瘤胃积食又被称为瘤胃停滞,该病是一种由于前胃体液调节和凝聚力减弱,进食大量不易消化的饲料或浓缩饲料在瘤胃内堆积引起的疾病。临床症状为瘤胃亚急性肿大、体积膨胀、内容物停滞和阻塞,瘤胃运动和消化吸收受阻,导致干燥和毒血... 详细信息

牛羊的瘤胃积食又被称为瘤胃停滞,该病是一种由于前胃体液调节和凝聚力减弱,进食大量不易消化的饲料或浓缩饲料在瘤胃内堆积引起的疾病。临床症状为瘤胃亚急性肿大、体积膨胀、内容物停滞和阻塞,瘤胃运动和消化吸收受阻,导致干燥和毒血症。该文主要论述牛羊瘤胃积食中兽医诊疗过程。

关键词：牛瘤胃积食诊断治疗

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种植体钛基台和氧化锆基台粘结冠修复体的抗折强度：无饰瓷全瓷冠和饰面瓷全瓷冠系统的比较研究

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中国口腔医学继续教育杂志 2015年第3期18卷 151-157页

作者： Francisco Martinez-Rus Alberto Ferreiroa Mutlu Ozcan Dr Med Dent Jose F. Bartolome guillermo Pradies 华泽乾汤春波不详北京瑞尔齿科北京市朝阳区酒仙桥路18号颐堤港LG100 100621 南京医科大学附属口腔医院种植修复科南京市汉中路136号 210005

目的：研究种植体钛基台和氧化锆基台上全瓷冠修复体的抗折强度。材料与方法：内连接式种植体修复右上中切牙，分别制作个性化钛基台30个和氧化锆基台30个。两组基台分别以以下全瓷系统进行修复。每组10个：①计算机辅助设计／计算机辅... 详细信息

目的：研究种植体钛基台和氧化锆基台上全瓷冠修复体的抗折强度。材料与方法：内连接式种植体修复右上中切牙，分别制作个性化钛基台30个和氧化锆基台30个。两组基台分别以以下全瓷系统进行修复。每组10个：①计算机辅助设计／计算机辅助制作硅酸锂（MLD）；②热压铸造硅酸锂（PLD）；③二氧化锆（YTZP）。其中PLD和YTZP底冠表面经氟磷灰石饰瓷完成修复体。各组修复体分别粘固于两组种植体基台，在万能测试机上以0．5mm／min的速度加载至断裂。数据采用双因素方差分析（ANOVA）和Tukey’stest检验（CX=O05）。结果：基台材料（P=0．0001）和全瓷冠系统（P=O．028）均对实验结果有显著影响．组间交互作用不显著（P=O，598）；Ti—MLD组平均抗折强度{558．54-35N）相比其他各组（340．3±62～495．9±53N）为最高（P〈O．05L钛基台各组的抗折强度（558．54-35～495．9±53N）远高于氧化锆基台各组（392．94-55～340．34-62N）（P〈O05）：无论是钛基台还是氧化锆基台的MLD组其抗折强度均高于饰面瓷全瓷冠组（P〈0．05）。在Ti—MLD组和Ti-PLD组断裂模式仅为冠破裂，无基台断裂；在Zr-YTZP组则发生基台断裂，无冠破裂；在zr—MLD组和Zr-PLD组既有基台断裂也有冠破裂：Ti—YTZP组仅表现为种植体颈部的形变结论：钛基台结合无饰瓷冠修复抗折强度最高．而钛基台结合氧化锆全瓷冠修复整体断裂模式最理想。

关键词：计算机辅助设计/计算机辅助制作硅酸锂陶瓷无饰瓷冠铸造陶瓷钛氧化锆

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The domestication of Cucurbita argyrosperma as revealed by the genome of its wild relative

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Horticulture Research 2021年第1期8卷 1287-1300页

作者： Josue Barrera-Redondo guillermo sa.chez-de la Vega Jonas A.Aguirre-Liguori Gabriela Castellanos-Morales Yocelyn T.Gutierrez-Guerrero Xitlali Aguirre-Dugua Erika Aguirre-Planter Maud I.Tenaillon Rafael Lira-saade Luis E.Eguiarte Departamento de Ecologia Evolutiva Instituto de EcologiaUniversidad Nacional Autonoma de MexicoCircuito Exterior s/n Anexo al Jardin Botanico04510 Ciudad de MexicoMexico Department of Ecology and Evolutionary Biology University of CaliforniaIrvineCA 92697USA Departamento de Conservacion de la Biodiversidad El Colegio de la Frontera SurVillahermosaCarretera Villahermosa‐Reforma km 15.5 Rancheria El Guineo 2ªseccion86280 VillahermosaTabascoMexico Genetique Quantitative et Evolution-Le Moulon Universite Paris-SaclayInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementCentre National de la Recherche ScientifiqueAgroParisTechGif-sur-Yvette 91190France UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoAv.de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEdo.de Mex 54090Mexico

Despite their economic importance and well-characterized domestication syndrome,the genomic impact of domestication and the identification of variants underlying the domestication traits in Cucurbita species(pumpkins and squashes)is currently *** argyrosperma,also known as cushaw pumpkin or silver-seed gourd,is a Mexican crop consumed primarily for its seeds rather than fruit *** makes it a good model to study Cucurbita domestication,as seeds were an essential component of early Mesoamerican diet and likely the first targets of human-guided selection in pumpkins and *** obtained population-level data using tunable Genotype by Sequencing libraries for 192 individuals of the wild and domesticated subspecies of *** across *** also assembled the first high-quality wild Cucurbita *** genomic analyses revealed several structural variants and presence/absence of genes related to *** results indicate a monophyletic origin of this domesticated crop in the lowlands of *** found evidence of gene flow between the domesticated and wild subspecies,which likely alleviated the effects of the domestication *** uncovered candidate domestication genes that are involved in the regulation of growth hormones,plant defense mechanisms,seed development,and *** presence of shared selected alleles with the closely related species Cucurbita moschata suggests domestication-related introgression between both taxa.

关键词： Cucurbita likely pump

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Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin

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阻断传染性法氏囊病传播的工具

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国外畜牧学（猪与禽） 2017年第7期37卷 7-11页

作者：万建美(译) 孙相俞(译) 邵建忠(审) 何闪(制图表) guillermo gonzalez carlos gonzalez miren arbe 中鲨动物保健品(厦门)有限公司山东质德农牧集团发展有限公司诗华兽医服务和诗华疫苗服务&设备法国诗华大药厂不详

家禽行业面临着巨大的技术变革,其中之一就是孵化场进一步引进胚蛋免疫技术并扩大其应用,以及开发更多的可以通过胚蛋途径接种的疫苗。

关键词：传染性法氏囊病接种技术工具传播注射系统注射免疫马立克氏病 1日龄雏鸡

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Control Modeling for Full Scope Training Simulators under a Graphic Development Tool

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通讯和计算机（中英文版） 2011年第1期8卷 43-57页

作者： guillermo Romero-Jimenez Edgardo J. Roldan-Villasana Victor Jimenez-sa.chez Department of Simulation Electrical Research Institute Av Reforma 113 Col. Palmira Cuernavaca 62490 Mor. Mexico

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EL CAMARIN迷你公寓

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现代装饰 2019年第2期 28-35页

作者： Luciano Intile Enrico Cavaglià Fermínlndavere Esteban Basili guillermo Mirochnic Rodrigo Perez de Pedro Cecile Elbel sabine Uldry TommasoPolli Fernando Schapochnik 彭佳 IR arquitectura

这间公寓由阿根廷IR arquitectura建筑设计事务所所设计,是上世纪50年代Chacarita社区房产的一部分。它位于建筑二层的一个角落,可以俯瞰下面的街道。设计师利用空间的特点,打造了一间明亮而又灵活的迷你公寓。

关键词：世纪空间建筑设计利用角落设计师设计事务所公寓

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“Chipiplexing”只用微控制器少量端口驱动多只LED

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电子设计技术 EDN CHINA 2009年第2期16卷 76-页

作者： guillermo Jaquenod 阿根廷La Plata

实际的微控制器都有强大的双向I/O端口,可以用不同的技术来充分利用这些功能。最近有个设计实例描述了一种"Charlieplexing"方法,它是只用N个双向I/O端口和N个电阻。

关键词：端口 Chipiplexing 微控制器微型控制器 LED

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