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Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo sanz Jana Dziaková Javier Rodriguez-Cobos guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of Biochemistry and Molecular Biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of Biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for Biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care Biosensors

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Ambient air quality and the risk for Chronic Obstructive Pulmonary Disease among Metro Manila Development Authority traffic enforcers in Metro Manila:An exploratory study

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Chronic Diseases and Translational Medicine 2021年第2期7卷 117-124页

作者： Xerxes Seposo Audrey Lynn A.Arcilla Jose guillermo N.De Guzman III Enrico Miguel S.Dizon Andrea Nova R.Figuracion Christina Micaela M.Morales Pauleena Katriona A.Tugonon Geminn Louis C.Apostol School of Medicine and Public Health Ateneo de Manila UniversityDon Eugenio Lopez Sr.Medical Complex Ortigas Avenue 1604Pasig CityPhilippines School of Tropical Medicine and Global Health Nagasaki University1-12-4 Sakamot 1-12-4 SakamotooNagasaki852-8523Japan

Background::Air pollution and poor ambient air quality are significantly related to multiple health *** associated disease is chronic obstructive pulmonary disease(COPD),a preventable disease with several contributing factors and one of the leading causes of morbidity/mortality locally and globally.A potentially high-risk population are traffic enforcers who are constantly exposed to air *** the Philippines,the MMDA has the widest coverage in traffic *** study determined the risk of COPD among Metro Manila Development Authority(MMDA)traffic enforcers in relation to ambient air quality level,as well as identified other factors that increase the risk of developing ***::Fifty-two MMDA traffic enforcers deployed in PM 2.5 air quality sensor areas in Metro Manila from 2016 to 2018 were recruited through stratified *** International Primary Airways Guidelines(IPAG)questionnaire was utilized to measure risk of *** health and working history were obtained through *** of environment and natural resources provided PM 2.5 ambient air quality data which aided in the construction of the Exposure-Month *** logistic regression was used to examine the association of PM 2.5 together with the relevant factors and the risk of ***::We found statistically significant associations between PM 2.5 and COPD among high risk category[odds risk(OR):1.24,95%confidence interval(CI):1.07-1.44].Age(Moderate,OR:1.16,95%CI:0.98-1.38 and High,OR:10.06,95%CI:4.02-25.17)and chest pain(Moderate,OR:68.65,95%CI:1.71-2.75×103)were potential risk factors,whereas body mass index(BMI)(OR:0.05,95%CI:0.01-0.53)exhibited protective ***::Exposure to PM 2.5 was associated with an increased risk of COPD among high-risk category MMDA traffic *** and chest pain were potential risk factors to risk of COPD,whereas BMI exhibited a potential protective *** of this study can be used for cli

关键词： Chronic obstructive pulmonary disease Traffic enforcers Air pollution Occupational risk Philippines

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The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine

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Genes & Diseases 2019年第3期6卷 201-223页

作者： sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago MedicineChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Rosalind Franklin University Chicago Medical SchoolNorth ChicagoIL 60064USA SIR Program Illinois Math and Science Academy(IMSA)AuroraIL 60506USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL60208USA The Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL60616USA

Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological *** roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ *** of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP *** it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other *** effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of ***,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and *** review aims to summarize our current understanding of BMP9 across biology and the body.

关键词： Adipogenesis Bone morphogenetic proteins(BMPs) BMP9/GDF2 Mesenchymal stem cells(MSCs) Metabolism Osteogenesis Regenerative medicine Tumorigenesis

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侵袭

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作者： (美)吉尔莫·德尔·托罗(guillermo Del Toro) (美)查克·霍根(Chuck Hogan)

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Essential Oils as an Alternative to Antibiotics to Reduce the Incidence and Severity of Necrotic Enteritis in Broiler Chickens: A Short Review

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Food and Nutrition Sciences 2023年第3期14卷 233-257页

作者： Makenly E. Coles Brittany D. Graham Juan D. Latorre Victor M. Petrone-Garcia Xochitl Hernandez-Velasco Inkar Castellanos-Huerta Xiaolun Sun Billy M. Hargis saeed El-Ashram Awad A. Shehata guillermo Tellez-Isaias Department of Poultry Science University of Arkansas Agricultural Experiment Station Fayetteville USA Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma de Mexico (UNAM) Cuautitlan Izcalli Estado de Mexico Mexico Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia (FMVZ) UNAM Cd. de Mexico Mexico Programa de Maestría y Doctorado en Ciencias de la Producción y de la salud Animal FMVZ UNAM Cd. de Mexico Mexico College of Life Science and Engineering Foshan University Foshan China Prophy-Institute for Applied Prophylaxis Bönen Germany

Due to the removal of antibiotic growth promoters (AGPs) and consumer pressure for antibiotic-free (ABF) or no antibiotics ever (NAE) poultry production, there is a need for sustainable alternatives to prevent disease in commercial poultry operations. Without AGPs, there has been a rise in diseases that were traditionally controlled by subtherapeutic levels of antibiotics in the diet. This has impacted the health of commercial poultry and has been a significant cost to poultry producers. To mitigate this, the industry has started to investigate alternatives to antibiotics to treat these forthcoming health issues, such as necrotic enteritis (NE). NE is an enteric disease caused by an over proliferation of toxigenic Clostridium perfringens (CP) in the gastrointestinal tract. Although CP is a commensal in the avian intestinal tract, dysbiosis caused by inflammation and impaired intestinal integrity facilitates uncontrolled replication of CP. Infectious agents, such as Eimeria maxima, appear to be a predominant predisposing factor that promotes NE. However, non-infectious stressors, including dietary changes, have also been associated with NE to some degree. As a result of increased pressure to restrict the use of antibiotics, there is a need for research evaluating the efficacy of alternatives, such as plant-derived essential oils, as potential tools to mitigate NE in commercial poultry flocks. The aim of this study is to review the effects of essential oils as an alternative to antibiotics to reduce the incidence and severity of necrotic enteritis in broiler chickens.

关键词： Necrotic Enteritis Essential Oils Chickens Clostridium perfringens Alternatives to Antibiotics

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让肾脏健康人人可享,处处可及——从预防到诊治

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肾脏病与透析肾移植杂志 2020年第1期29卷 1-7页

作者： Philip Kam Tao guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal saadi Luisa Strani Ifeoma Ulasi Kamyar Kalantar Zadeh 无 Department of Medicine and Therapeutics Carol&Richard Yu PD Research CentrePrince of Wales HospitalChinese University of Hong KongHong Kong Nephrology Service Hospital Civil de Guadalajara Fray Antonio AlcaldeUniversity of Guadalajara Health Sciences CenterGuadalajaraJaliscoMexico Division of Health System Policy and ManagementJockey Club School of Public Health and Primary CareThe Chinese University of Hong KongHong Kong James Whitcomb Riley Hospital for Children Indiana University School of MedicineIndianapolisIndianaUSA World Kidney Day Office BrusselsBelgium Tanker Foundation ChennaiIndia Division of Nephrology and Hypertension 1st Department of Internal MedicineAHEPA HospitalAristotle University of ThessalonikiThessalonikiGreece Nephrology Unit Department of Internal MedicineFaculty of MedicineCairo UniversityGizaEgypt Renal Unit Department of MedicineCollege of MedicineUniversity of NigeriaItuku OzallaEnuguNigeria Division of Nephrology and Hypertension and Kidney Transplantation University of California Irvine School of MedicineOrangeCaliforniaUSA the World Kidney Day Steering Committee

Around 850 million people currently are affected by different types of kidney *** to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly *** global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by *** CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney ***,CKD is a major cause of catastrophic health expenditure.

关键词： awareness detection kidney diseases prevention

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Photoluminescence Spectroscopy as a Tool for Quality Control of GaN Thin Film to Be Used in Solar Cell Devices

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Materials Sciences and Applications 2014年第5期5卷 267-270页

作者： guillermo santana-Rodríguez Adolfo Mejía-Montero Betsabeé Marel Monroy-Peláez Máximo López-López Yenny Lucero Casallas-Moreno Manolo Ramírez-López Gerardo Contreras-Puente Osvaldo de Melo-Pereira Centro de Investigación y de Estudios Avanzados-IPN México City México Escuela Superior de Física y Matemáticas-Instituto Politécnico Nacional México City México Facultad de Física-Universidad de la Habana Habana City Cuba Instituto de Investigaciones en Materiales-Universidad Nacional Autónoma de México México City México Instituto de Investigaciones en Materiales-Universidad Nacional Autónoma de México México City México Centro de Investigación y de Estudios Avanzados-IPN México City México

The use of III-V and semiconductor nitrides in solar cells has been of interest in the PV-community due to the wide variation range of the band gap in these materials. Particularly, the processing of hetero-junction structures of InGaN/GaN and Si(p)/GaN(n) has been of great interest recently. In this work, the quality of GaN and InGaN thin films grown by Molecular Beam Epitaxy (MBE) on different substrate and buffer layers has been studied by photoluminescence spectroscopy (PL). The PL measurements were processed as function of sample temperature and pump power. In the PL spectra it is possible to observe a strong near band-gap-edge emission and a broad blue, green and yellow luminescence (BL, GL, YL), which can be assigned to the presence of Ga and N vacancies, amorphous phases, deep level impurities and structural defects. The relative intensity between the different peaks of the bands related to defects or impurities was studied as a tool for quality control of the films.

关键词： Photoluminescence Gallium Nitride Solar Cells

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Current situation of Giardia infection in Spain: Implications for public health

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World Journal of Clinical Infectious Diseases 2012年第1期2卷 1-12页

作者： David Carmena guillermo A Cardona Luisa P Sánchez-Serrano MRC Clinical Sciences Centre Faculty of Medicine Imperial College Hammersmith Hospital Campus London W12 0NN United Kingdom Livestock Laboratory Regional Government of álava 01520 Vitoria-Gasteiz Spain National Centre of Epidemiology CIBERESP Instituto de Salud Carlos Ⅲ 28029 Madrid Spain

Giardia is an enteric protozoan that infects a wide range of vertebrate hosts, being considered a major causative agent of gastrointestinal disease in humans in both developing and developed countries. Giardia infection has also a significant impact on livestock health, causing diarrhoea and resulting in significant economic lost. Transmission is either direct, through the faecal-oral route, or indirect, through ingestion of contaminated water or food. In this article, we review current knowledge about the epidemiology of giardiasis in different populations in Spain, including humans, livestock, companion animals, and wildlife. Environmental contamination of surface waters and raw foods by Giardia cysts is also addressed. Special relevance has been given to the data available on the molecular characterization of the Giardia isolates obtained from clinical and environmental samples, as determining thespecies/assemblages and subassemblages involved is essential for accurately identifying the parasite and assessing zoonotic transmission. The public health significance of these findings has also been thoroughly discussed.

关键词： Giardia Spain Epidemiology Human Livestock Pets Water Public health Transmission Genotyping

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有机太阳能电池的界面修饰

有机太阳能电池的界面修饰

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中国化学会第30届学术年会-论坛二：新型前沿交叉化学论坛

作者：周惠琼 Thuc-Quyen Nguyen guillermo C.Bazan Alan J.Heeger 国家纳米科学中心 Center for Polymer and Organic Solids University of California at Santa Barbara

由共轭聚电解质给体和富勒烯受体组成的有机异质结(BHJ)太阳能电池,具有价格低廉、质量轻和柔性可弯曲等优点[1]。除了新材料合成和形貌调控,界面修饰对于提高有机太阳能电池的器件转换效率和稳定性具有非常重要的意义[2]。为了提高电... 详细信息

由共轭聚电解质给体和富勒烯受体组成的有机异质结(BHJ)太阳能电池,具有价格低廉、质量轻和柔性可弯曲等优点[1]。除了新材料合成和形貌调控,界面修饰对于提高有机太阳能电池的器件转换效率和稳定性具有非常重要的意义[2]。为了提高电极的电荷选择性和减小电荷收集的能量势垒,具有电子阻挡能力的空穴传输层(HTL)常被插入到阳极和BHJ活性层之间,而具有空穴阻挡能力的电子传输层(ETL)则被插入到阴极和BHJ活性层之间。金属性的聚合物PEDOT:PSS是有机BHJ电池最常用的空穴传输层,因为其溶液可加工性,合适的功函数,良好的导电性,以及在可见-红外区的优良光学透过性[3]。然而,在基于碱性基团的有机活性层器件中,PEDOT:PSS本征的p H酸性特性会导致界面质子化现象,从而限制了器件的效率。我们将一种新型的,p H中性的,水/醇溶性的共轭聚电解质(简称CPE-K)作为空穴传输材料用于p-DTS(PTTh):PCBM器件中,其转化效率比PEDOT:PSS器件提高了60%,内建电场V得到了增强,串联电阻R得到了降低,从而增强了电荷收集。这些效应主要来源于CPE-K消除了界面质子化以及界面能量势垒。

关键词：有机太阳能电池界面修饰电子传输层空穴传输层

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New options for the management of hyperparathyroidism after renal transplantation

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World Journal of Transplantation 2012年第3期2卷 41-45页

作者： Walter guillermo Douthat Carlos Raul Chiurchiu Pablo Ulises Massari Bone and Mineral Metabolism Section Renal Service Hospital Privado Centro Médico de Córdoba Postgraduate School of Nephrology Catholic University of Córdoba Fundación Nefrológica de Córdoba

The persistence and severity of hyperparathyroidism(HPT) post-renal transplantation is relatively frequent and primarily associated with the timing and its magnitude in the pre-transplant period and with the presence of parathyroid adenomas. HPT after renal transplantation is clinically manifested with hypercalcemia, hypophosphatemia, bone pain, fractures, and in more serious cases with cardiovascular calcifications that affect the survival. The primary clinical objective for patients with secondary HPT after renal transplantation is to obtain a level of parathyroid hormone(PTH) adequate to the renal transplanted function and to normalize levels of calcium, phosphorus and vitamin D. In many cases during this period, the development of hypercalcemiaand/or hypophosphatemia makes it necessary to take different therapeutic measures. The use of vitamin D or its analogues has been extrapolated from the management of pre-transplant HPT obtaining variable outcomes, although its use is limited by its capacity to produce hypercalcemia. Calcimimetics are drugs that have proven be effective in reducing PTH levels in patients with HPT on dialysis and has been effective in reducing up to 50% PTH levels in moderate to severe HPT in post-renal *** HPT persists after renal transplantation and does not respond to medical treatment, invasive management by percutaneous ethanol injection therapy of parathyroid glands or parathyroidectomy should be considered. The emergence of new methods for the management of HPT expands the availability of therapeutic tools for transplant patients.

关键词： Hyperparathyroidism Renal osteodystrophy Renal transplantation Percutaneous ethanol injection therapy Parathyroidectomy Percutaneous ethanol injection therapy

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