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Foreign exchange trading and management with the stochastic dual dynamic programming method

Financial Innovation 2023年第1期9卷 583-620页

作者： Lorenzo Reus guillermo alexander sepulveda‑hurtado Escuela de Negocios Universidad Adolfo IbanezDiagonal Las Torres2640 SantiagoChile

We present a novel tool for generating speculative and hedging foreign exchange(FX)trading *** solution provides a schedule that determines trades in each rebalancing period based on future currency prices,net foreign account positions,and incoming(outgoing)flows from business *** obtain such policies,we construct a multistage stochastic programming(MSP)model and solve it using the stochastic dual dynamic programming(SDDP)numerical method,which specializes in solving high-dimensional MSP *** construct our methodology within an open-source SDDP package,avoiding implementing the method from *** measure the performance of our policies,we model FX prices as a mean-reverting stochastic process with random events that incorporate stochastic *** calibrate this price model on seven currency pairs,demonstrating that our trading policies not only outperform the benchmarks for each currency,but may also be close to ex-post optimal *** also show how the tool can be used to generate more or less conservative strategies by adjusting the risk tolerance,and how it can be used in a vari-ety of contexts and time scales,ranging from intraday speculative trading to monthly hedging for business ***,we examine the impact of increasing trade policy uncertainty(TPU)levels on our *** findings show that the volatility of currencies from emerging economies rises in comparison to currencies from devel-oped *** discover that an increase in the TPU level has no effect on the aver-age profit obtained by our ***,the risk exposure of the policies increases(decreases)for the group of currencies from emerging(developed)markets.

关键词： FX trading FX risk SDDP Multistage stochastic programming Julia Trade policy uncertainty

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A Golden Touch in the Design of Multifunctional Porphyrin Metallacages:Host-Guest Chemistry for Drug-Target Interactions

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CCS Chemistry 2024年第7期6卷 1662-1671页

作者： Tamara Rodríguez-Prieto Darren Wragg Nicole Heiduk Mihyun Park Nicole Strittmatter Roland A.Fischer Angela Casini guillermo Moreno-Alcántar Chair of Medicinal and Bioinorganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Professorship for Analytical Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Chair of Inorganic and MetalOrganic Chemistry Department of ChemistrySchool of Natural SciencesTechnical University of Munich85748 Garching b.München Munich Data Science Institute(MDSI) Technical University of Munich85748 Garching b.München

The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great ***,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still *** this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and *** experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关键词： gold metallacages porphyrins G4stabili-zation host-guestchemistry anticanceragents

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Loss of Surround Inhibition and After Sensation as Diagnostic Parameters of Complex Regional Pain Syndrome

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Neuroscience & Medicine 2012年第4期3卷 344-353页

作者： Marie Wojcik Wolanin Robert J. Schwartzman guillermo alexander John Grothusen Department of Neurology Drexel University College of Medicine Philadelphia USA

Complex Regional Pain Syndrome (CRPS) is a severe chronic pain condition. Patients with CRPS experience allodynia, hyperalgesia, autonomic dysfunction, movement difficulties and dystrophic changes. However other characteristics that may be unique to the pain in CRPS require further study. This study evaluated pain parameters in ninety five subjects composed of three groups: healthy pain free controls, patients with radiculopathy and CRPS patients. Healthy subjects were tested in all four extremities, whereas radiculopathy and CRPS patients were tested only on the most affected extremity. All subjects were tested for the following pain parameters: thermal allodynia, mechanical static and dynamic allodynia, windup, and a hyperalgesic mechanical stimulus. All subjects were also evaluated for autonomic dysfunction, movement disorder and dystrophic skin changes. Statistically significant differences were found between both pain groups and the healthy control subjects as well as between the two pain groups. The finding that statistically differentiated CRPS from radiculopathy and normal controls was pain spread following an algesic mechanical and cold stimulus as well as after sensations to these stimuli. The study demonstrated a simple bedside test that discriminated between CRPS, radiculopathy and healthy control subjects.

关键词： CRPS Complex Regional Pain Syndrome Radiculopathy Pain After Sensation Spread Chronic Pain

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Neural EGF-like protein 1(NELL-1):Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine

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Genes & Diseases 2017年第3期4卷 127-137页

作者： Mikhail Pakvasa Alex Alverdy Sami Mostafa Eric Wang Lucy Fu alexander Li Leonardo Oliveira Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Tong-Chuan He guillermo A.Ameer Russell R.Reid The University of Chicago Pritzker School of MedicineChicagoIL 60637USA Laboratory of Craniofacial Biology and Development Section of Plastic and Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Rosalind Franklin University Chicago Medical SchoolNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Center for Advanced Regenerative Engineering Northwestern UniversityEvanstonIL 60208USA Department of Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA

Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects,two problems associated with significant *** differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth *** EGF Like-Like molecule 1(NELL-1)is a secreted glycoprotein that has proven,both in vitro and in vivo,to be a potent osteo-inductive ***,it has been shown to repress adipogenic differentiation and ***-1 can work synergistically with other osteogenic factors such as Bone Morphogenic Protein(BMP)2 and9,and has shown promise for use in tissue engineering and as a systemically administered drug for the treatment of *** we provide a comprehensive up-to-date review on the molecular signaling cascade of NELL-1 in mesenchymal stem cells and potential applications in bone regenerative engineering.

关键词： Bone tissue engineering Mesenchymal stem cells NELL-1 NEL-like protein 1 Osteogenic differentiation

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Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside

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Genes & Diseases 2019年第4期6卷 342-358页

作者： Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf guillermo A.Ameer Tong-Chuan He Russell R.Reid The University of Chicago Pritzker School of Medicine ChicagoIL 60637USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Key Laboratory of Diagnostic Medicine(Ministry of Education) College of Laboratory MedicineChongqing Medical UniversityChongqingChina Department of Orthopaedic Surgery Xiangya Second Hospital of Central South UniversityChangsha 410011China Student Inquiry Research Program Illinois Mathematics and Science Academy(IMSA)AuroraIL60506USA Department of General Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Department of Orthopaedic Surgery Chongqing General HospitalChongqing 400013China Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Surgery Northwestern University Feinberg School of MedicineChicagoIL 60616USA Center for Advanced Regenerative Engineering(CARE) EvanstonIL 60208USA

With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical *** requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven *** most promising potential treatment options rely on stem cellbased *** cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell *** approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing *** aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic *** the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care.

关键词： Chronic inflammation Chronic wounds Growth factors Personalized medicine Skin Stem cells Wound healing

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