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The Beneficial Effects of Components of Garlic (Allium sativum L.) in the Poultry Industry

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Food and Nutrition Sciences 2024年第1期15卷 27-57页

作者： Alejandra Meza-Rios Gilberto Velazquez-Juarez Inkar Castellanos-Huerta Rocio Ivette lopez-Roa Luis A. Anguiano-Sevilla Xochitl Hernanez-Velasco Xochitl Hernanez-Velasco Saeed El-Ashram Ebtsam Al-Olayan Billy Hargis guillermo Tellez-Isaias Adelaida Sara Minia Zepeda-Morales Departamento de Farmacobiología CUCEI Universidad de Guadalajara Blvd. M. García Barragán Guadalajara México Laboratorio de Análisis Fisicoquímicos Externos Departamento de Química CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México Center of Excellence for Poultry Science Department of Poultry Science Dale Bumpers College of Agricultural Food and Life Sciences University of Arkansas Cumberland United States Laboratorio de Investigación y Desarrollo Farmacéutico Departamento de Farmacobiología CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia UNAM Mexico Mexico Zoology Department Faculty of Science Kafrelsheikh University Kafr El-Sheikh Egypt Department of Zoology College of Science King Saud University Riyadh Saudi Arabia Laboratorio de Análisis Clínicos y Bacteriológicos (vinculación) Departamento de Farmacobiología CUCEI Universidad de Guadalajara Boulevard Marcelino García Barragán Guadalajara México

Plant-based antimicrobial agents are readily available, cost-effective, and exhibit low toxicity, making them promising alternatives in combatting microbial infections. Among these plants, garlic (Allium sativum) stands out for its traditional medicinal use in effectively combating various microorganisms. In the poultry industry, preventing avian virus and bacterial infections is paramount for chicken husbandry. However, using conventional drugs poses potential risks to human health. Garlic, a widely used Asian plant in traditional medicine for various pathologies, has shown potential as an herbal prophylactic remedy against viral and bacterial infections. Recently, researchers explored garlic and its derivatives as a scientific strategy in veterinary practices for diverse purposes, such as improving poultry production characteristics and acting as antibiotic growth promoters. This comprehensive review delves into garlic and its derivatives as preventive and corrective treatments for viral diseases in laying hens and broilers. The paper highlights their potential effectiveness and safety as a natural means to enhance poultry health and welfare while mitigating the risks associated with conventional drug usage in the food industry.

关键词： Garlic Antiviral Veterinary Chickens Allium sativum

Nestling sex ratio is unaffected by individual and population traits in the griffon vulture

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Current Zoology 2023年第3期69卷 227-235页

作者： guillermo Gomez-lopez Felix Martinez Ana Sanz-Aguilar Martina Carrete guillermo Blanco Department of Evolutionary Ecology National Museum of Natural Sciences(MNCN)Spanish National Research Council(CSiC)Jose Gutierrez Abascal 228006 MadridSpain Escuela Internacional de Doctorado Universidad Rey Juan Carlos(URJC)Tulipan s/n28933 MostolesMadridSpain Animal Demography and Ecology Group Institut Mediterrani d'Estudis Avangats(IMEDEA)Miquel Marques 217020 EsporlesMallorcaSpain Applied Zoology and Conservation Group Universitat de les Illes Balears(UIB)Ctra.De Valldemossa km.7.507122PalmaSpain Department of Physical Chemical and Natural SystemsUniversidad Pablo de Olavide(UPO)Ctra.de Utrera km.141013 SevillaSpain

Variation in offspring sex ratios is a central topic in animal demography and population *** studies have focused on bird species with marked sexual dimorphism and multiple-nestling broods,where the offspring sex ratio is often biased due to different individual or environmental ***,biases in offspring sex ratios have been far less investigated in monomorphic and single-egg laying species,and few studies have evaluated long-term and large-scale variations in the sex ratio of nestling ***,we explore individual and environmental factors potentially affecting the secondary sex ratio of the monomorphic griffon vulture Gyps *** used information collected at three breeding nuclei from central Spain over a 30-year period(1990–2020)to analyse the effects of nestling age,parental age,breeding phenology,conspecific density,population reproductive parameters,and spatial and temporal variability on nestling *** ratio did not differ from parity either at the population or the nuclei *** significant between-year differences were detected,even under highly changing conditions of food availability associated with the mad-cow *** found that tree nesting breeders tend to have more sons than daughters,but as this nesting behavior is rare and we consequently have a small sample size,this issue would require additional *** further research is needed to assess the potential effect of breeder identity on nestling sex ratio,this study contributes to understanding the basic ecology and population dynamics of Griffon Vultures,a long-lived species with deferred maturity and low fecundity,whose minor deviations in the offspring sex ratio might imply major changes at the population level.

关键词： offspring sex ratio nestling sex Gyps fulvus monomorphism mad-cow crisis demography

Properties of nuclear pastas

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Frontiers of physics 2021年第2期16卷 119-173页

作者： Jorge A.lopez Claudio O.Dorso guillermo Frank Department of Physics University of Texax at El PasoEl PasoTexas 79968USA Departamento de Fisica FCENUniversidad de Buenos AiresNunezArgentina Unidad de Investigacion y Desarrollo de las Ingenierias Universidad Tecnologica NacionalFacultad Regional Buenos AiresBuenos AiresArentina

In this review we study the nuclear pastas as they are expected to be formed in neutron star *** start with a study of the pastas formed in nuclear matter(composed of protons and neutrons),we follow with the role of the electron gas on the formation of pastas,and we then investigate the pastas in neutron star matter(nuclear matter embedded in an electron gas).Nuclear matter(NM)at intermediate temperatures(1 MeV≤T≤***),at saturation and and sub-saturation densities,and with proton content ranging from 30%to 50%was found to have liquid,gaseous and liquid-gas mixed *** isospin-dependent phase diagram was obtained along with the critical points,and the symmetry energy was calculated and compared to experimental data and other *** low temperatures(T≤1 MeV)NM produces crystal-like structures around satura-tion densities,and pasta-like structures at sub-saturation *** of the pasta structures were studied with cluster-recognition algorithms,caloric curve,the radial distribution function,the Lindemann coefficient,Kolmogorov statistics,Minkowski functionals;the symmetry energy of the pasta showed a connection with its *** star matter(NSM)is nuclear matter embedded in an electron *** electron gas is included in the calculation by the inclusion of an screened Coulomb *** connect the NM pastas with those in neutron star matter(NSM),the role the strength and screening length of the Coulomb interaction have on the formation of the pastas in NM was *** was found to exist even without the presence of the electron gas,but the effect of the Coulomb interaction is to form more defined pasta structures,among other ***,it was determined that there is a minimal screening length for the developed structures to be independent of the cell *** star matter was found to have similar phases as NM,phase transitions,symmetry energy,structure function and thermal *** in NM,pasta f

关键词： nuclear pasta neutron star matter nuclear symmetry energy molecular dynamics nuclear phase transitions

加夫列尔·加西亚·马尔克斯图书馆,巴塞罗那,西班牙

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世界建筑 2024年第5期 76-81页

作者：无 Elena Orte guillermo Sevillano Marta Romero Jesús lopez Luis Sierra Ana Patricia Minguito Pablo Corroto María Abellán Sara Contreras RitaÁlvarez Tabio MiguelÁngel Maure Jesús Granada(摄影) SUMA建筑设计事务所不详

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计... 详细信息

加布里埃尔·加西亚·马尔克斯图书馆是巴塞罗那的第40座图书馆,也是巴塞罗那30年计划的结晶。该计划旨在建立一个由优秀社区与区域设施组成的密集网络。这座图书馆位于圣马蒂德普罗旺斯区,为53,000人提供服务。关联式建筑图书馆被设计成一座雕塑式实体建筑,让人联想到堆叠的书籍及其折叠的书页。该馆坐落在一处高架广场上,方便周围行人来往。同时,它又在空地上悬挑而出,门廊由现有的树木环绕,形成了一座城市大厅。不同大小及结构的开口定义了其不同立面与周围环境的关系。

关键词：巴塞罗那普罗旺斯周围环境加布里埃尔加西亚·马尔克斯图书馆关联式西班牙

From Bench to the Clinic: The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines

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Nano-Micro Letters 2022年第3期14卷 1-31页

作者： Diana O.lopez‑Cantu Xichi Wang Hector Carrasco‑Magallanes Samson Afewerki Xingcai Zhang Joseph V.Bonventre guillermo U.Ruiz‑Esparza Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Division of Health Sciences and Technology Harvard University-Massachusetts Institute of TechnologyBostonMA 02115USA Division of Renal Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Tecnologico de Monterrey School of Engineering and Sciences64849 MonterreyNLMexico Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China Harvard T.H.Chan School of Public Health BostonMA 02115USA Tecnologico de Monterrey School of Medicine and Health Sciences64849 MonterreyNLMexico John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

During the last decades,the use of nanotechnology in med icine has effectively been translated to the design of drug delivery systems,nanostructured tissues,diagnostic platforms,and novel nanomaterials against several human diseases and infectious ***-enabled vaccines have been positioned as solutions to mitigate the pandemic outbreak caused by the novel pathogen severe acute respiratory syndrome coronavirus *** fast-track the development of vaccines,unprecedented industrial and academic collaborations emerged around the world,resulting in the clinical translation of effective vaccines in less than one *** this article,we provide an overview of the path to translation from the bench to the clinic of nanotechnology-enabled messenger ribonucleic acid vaccines and examine in detail the types of delivery systems used,their mechanisms of action,obtained results during each phase of their clinical development and their regulatory approval *** also analyze how nanotechnology is impacting global health and economy during the COVID-19 pandemic and beyond.

关键词： Nanovaccines mRNA Coronavirus SARS-CoV-2 COVID-19

Evaluation of curcumin and copper acetate against Salmonella Typhimurium infection,intestinal permeability,and cecal microbiota composition in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1019-1030页

作者： Anaisa ALeyva-Diaz Daniel Hernandez-Patlan Bruno Solis-Cruz Bishnu Adhikari Young Min Kwon Juan D.Latorre Xochitl Hernandez-Velasco Benjamin Fuente-Martinez Billy M.Hargis Raquel lopez-Arellano guillermo Tellez-Isaias Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y ZootecniaUNAM04510 Ciudad de MexicoMexico Laboratorio 5:LEDEFAR Unidad de Investigacion MultidisciplinariaFacultad de Estudios Superiores(FES)CuautitlanUniversidad Nacional Autonoma de Mexico(UNAM)54714 Cuautitlan IzcalliMexico Department of Poultry Science Center of Excellence for Poultry ScienceUniversity of Arkansas1260 W.MaplePOSC 0-114FayettevilleAR 72704USA Centro de Ensenanza Investigacion y Extension en Produccion AvicolaFacultad de Medicina Veterinaria y ZootecniaUNAMCiudad de MexicoMexico

Background:Interest in the use of natural feed additives as an alternative to antimicrobials in the poultry industry has increased in recent years because of the risk of bacterial *** of the most studied groups are polyphenolic compounds,given their advantages over other types of additives and their easy potentiation of effects when complexes are formed with metal ***,the objective of the present study was to evaluate the impact of dietary supplementation of copper acetate(CA),curcumin(CR),and their combination(CA-CR)against Salmonella Typhimurium colonization,intestinal permeability,and cecal microbiota composition in broiler chickens through a laboratory Salmonella infection *** recovery was determined on day 10 post-challenge by isolating Salmonella in homogenates of the right cecal tonsil(12 chickens per group)on Xylose Lysine Tergitol-4(XLT-4)with novobiocin and nalidixic *** integrity was indirectly determined by the fluorometric measurement of fluorescein isothiocyanate dextran(FITC-d)in serum samples from blood obtained on d 10 *** ***,microbiota analysis was performed using the content of the left caecal tonsil of 5 chickens per group by sequencing V4 region of 16S rRNA ***:The results showed that in two independent studies,all experimental treatments were able to significantly reduce the *** colonization in cecal tonsils(CT,P<0.0001)compared to the positive control(PC)***,only CA-CR was the most effective treatment in reducing *** counts in both independent ***,the serum fluorescein isothiocyanate dextran(FITC-d)concentration in chickens treated with CR was significantly lower when compared to PC(P=0.0084),which is related to a decrease in intestinal permeability and therefore intestinal *** effect of dietary treatments in reducing Salmonella was further supported by the analysis of 16S rRNA gene sequences using Li

关键词： Broiler chickens Copper acetate Curcumin Intestinal permeability Microbiota composition Salmonella Typhimurium

Gallbladder perforation with fistulous communication

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1191-1201页

作者： Alejandro Quiroga-Garza Neri Alejandro Alvarez-Villalobos Milton Alberto Muñoz-Leija Mariano Garcia-Campa Hermilo Jeptef Angeles-Mar guillermo Jacobo-Baca Rodrigo Enrique Elizondo-Omana Santos Guzman-lopez Human Anatomy Department Universidad Autonoma de Nuevo LeonSchool of MedicineMonterrey 64460Nuevo LeonMexico General Surgery Division Hospital de Traumatología y Ortopedia No.21Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico Plataforma INVEST Medicina UANLKER Unit Mayo Clinic Universidad Autonoma de Nuevo LeonSchool of MedicineMonterrey 64460Nuevo LeonMexico Family Medicine Division Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico Surgery Division Hospital General de Zona No.6Instituto Mexicano del Seguro SocialMonterrey 64000Nuevo LeonMexico

BACKGROUND The management of gallbladder perforation(GBP)with fistulous communication(Neimeier type I)is *** To recommend management options for GBP with fistulous *** A systematic review of studies describing the management of Neimeier type I GBP was performed according to the PRISMA *** search strategy was conducted in Scopus,Web of Science,MEDLINE,and EMBASE(May 2022).Data extraction was obtained for patient characteristics,type of intervention,days of hospitalization(DoH),complications,and site of fistulous *** A total of 54 patients(61%female)from case reports,series,and cohorts were *** most frequent fistulous communication occurred in the abdominal *** from case reports/series had a similar proportion of complications between open cholecystectomy(OC)and laparoscopic cholecystectomy(LC)(28.6 vs 12.5;P=0.569).Mortality was higher in OC(14.3 vs 0.0;P=0.467)but this proportion was given by only one *** were higher in OC(mean 26.3 d vs 6.6 d).There was no clear association between higher rates of complications of a given intervention in cohorts,and no mortality was *** Surgeons must evaluate the advantages and disadvantages of the therapeutic *** and LC are adequate options for the surgical management of GBP,with no significant differences.

关键词： Gallbladder perforation Open cholecystectomy Laparoscopic cholecystectomy Fistulous communication

Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies

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Journal of Sport and Health Science 2021年第3期10卷 290-295页

作者： Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie guillermo F.lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith Department of Geriatric Medicine Bezmialem Vakif UniversityIstanbul 34093Turkey Institute of Neuroscience Newcastle UniversityNewcastle upon Tyne NE17RUUK Primary Care Department Azienda Usl Toscana Sud EstGrosseto 52100Italy Division of Psychology and Mental Health University of ManchesterManchester M139PLUK College of Health&Human Services University of North Carolina at CharlotteLong BeachCA 90815USA Department of Cancer Epidemiology and Prevention Research Alberta Health ServicesHoly Cross CentreAlbertaT5J 3E4Canada School of Health Sciences Institute of Mental Health SciencesUlster UniversityNewtownabbey BT151EDUK Research and Development Unit Sant Joan de Deu Health ParkCIBER of Mental Health(CIBERSAM)Barcelona 08003Spain ICREA Pg.Lluis Companys 23Barcelona 08010Spain The Queen Elizabeth Hospital King’s Lynn NHS Foundation Trust King’s Lynn PE304ETUK Faculty of Sport Sciences University of MurciaMurcia 30100Spain Institute for Evidence in Medicine Medical CenterUniversity of FreiburgFaculty of MedicineUniversity of FreiburgFreiburg 79085Germany Neuroscience Institute Aging BranchNational Research CouncilPadua 35122Italy The Cambridge Centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridge CB11PTUK

Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health ***:An umbrella review of systematic reviews with meta-analyses of observational studies was *** assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess *** graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 ***,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing *** associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as *** further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.

关键词： Handgrip strength Health outcomes Meta-analysis Umbrella review

An alternative to MINFLUX that enables nanometer resolution in a confocal microscope

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Light(Science & Applications) 2022年第9期11卷 2077-2085页

作者： LUCIANO A.MASULLO ALAN M.SZALAI LUCIA F.lopez MAURICIO PILO-PAIS guillermo P.ACUNA Fernando D.Stefani Centro de Investigaciones en Bionanociencias(CIBION) Consejo Nacionallde Investigaciones Cientificas y Técnicas(CONICET)Godoy Cruz 2390C1425FQD Ciudad Autónoma de Buenos AiresBuenos AiresArgentina Departamento de Fisica Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresGuiraldes 2620C1428EHA Ciudad Autónoma de Buenos AiresBuenos AiresArgentina Department of Physics University of FribourgChemin du Musee 3Fribourg CH-1700Switzerland

Localization of single fluorescent emitters is key for physicochemical and biophysical measurements at the nanoscale and beyond ensemble *** include single-molecule tracking and super-resolution imaging by single-molecule localization *** the numerous localization methods available,MINFLUX outstands for achieving a~10-fold improvement in resolution over wide-field camera-based approaches,reaching the molecular scale at moderate photon *** application of MINFLUX and related methods has been hindered by the technical complexity of the ***,we present RASTMIN,a single-molecule localization method based on raster scanning a light pattern comprising a minimum of *** delivers~1-2nm localization precision with usual fluorophores and is easily implementable on a standard confocal microscope with few *** demonstrate the performance of RASTMIN in localization of single molecules and super-resolution imaging of DNA origami structures.

关键词： resolution pattern enable