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World Journal of Diabetes 2017年第10期8卷 455-463页

作者： Dania Lizet Quintanilla-Flores JoséGerardo González-González guillermo garcía-de la cruz Héctor Eloy Tamez-Pérez department of Internal Medicine 'Dr. José Eleuterio González' University HospitalUniversidad Autónoma de Nuevo León Endocrinology Service 'Dr. José Eleuterio González' University HospitalUniversidad Autónoma de Nuevo León School of Medicine Universidad Autónoma de Nuevo León Research Division School of MedicineUniversidad Autónoma de Nuevo León

AIM To compare the safety and efficacy or 3 basal-bolus regimens of neutral protamine hagedorn(NPH)/regular insulin in the management of inpatient *** We randomized 105 patients with blood glucose levelsbetween 140 and 400 mg/dL to a basal-bolus regimen of NPH insulin given once(n = 30), twice(n = 40) or three times(n = 35) daily, in addition to pre-meal regular insulin. Major outcomes included were differences in glycemic control, frequency of hypoglycemia and total insulin *** NPH insulin given in a once-daily regimen was associated with better glycemic control(58.3%) compared to twice daily(42.4%) and three times daily(48.9) regimens(P = 0.031). The frequency of hypoglycemia was similar between the three groups(2.0%, 0.7% and 1.2%, P = 0.21). The mean insulin dose at discharge was 0.48 ± 0.14 U/kg in the once-daily group compared to 0.69 ± 0.28 in the twice-daily, and 0.65 ± 0.20 in the three times daily regimens(P lar rates of hypoglycemia compared to a twice-daily and a three times-daily regimen. Further studies are needed to evaluate whether this regimen could be implemented in all hospitalized patients with hyperglycemia.

关键词： Neutral protamine hagedorn insulin Hospital hyperglycemia Basal-bolus regimen Type 2 diabetes mellitus Inpatient care units

Game changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis mana

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio M Caballero-Mateos guillermo Arturo Cañadas-de la Fuente department of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain department of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancements in the treatment landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm shift in UC management by targeting key signaling pathways involved in inflammatory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to modulate immune responses and gene expression,potentially revolutionizing the treatment algorithm for *** trials have demonstrated the efficacy of JAKis in inducing and maintaining remission,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatments but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the management strategies of UC,offering timely relief for patients with active disease and facilitating personalized treatment *** safety concerns,including cardiovascular risks and infections,ongoing research and post-marketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC management.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

Optimal diet strategy of a large-bodied psittacine: food resource abundance and nutritional content enable facultative dietary specialization by the Military Macaw

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Avian Research 2019年第4期10卷 469-477页

作者： Sylvia Margarita de la Parra‑Martinez Luis guillermo Munoz‑lacy Alejandro Salinas‑Melgoza Katherine Renton departamento de Ciencias Biologicas Centro Universitario de la CostaUniversidad de GuadalajaraAv.Universidad No.203Delegacion IxtapaC.P.48280 Puerto VallartaJaliscoMexico Comision Nacional Para el Conocimiento y Uso para la Biodiversidad Liga Periferico‑Insurgentes Sur 4903Delegacion Tlalpan14010 Mexico CityMexico Facultad de Biologia Universidad Michoacana de San Nicolas de HidalgoCiudad UniversitariaMoreliaMichoacanMexico Estacion de Biologia Chamela Instituto de BiologiaUniversidad Nacional Autonoma de MexicoApartado Postal 21San Patricio‑MelaqueJaliscoMexico

Background:Dietary specialization should arise when there is a relatively high abundance of a particular resource,where animals may select food items to obtain an optimal diet that maximizes energy ***‑bodied psittacines frequently exhibit a narrow dietary niche with specific habitat use,but few studies have determined whether psittacines select food resources,and how this influences habitat ***:We established fruiting phenology transects to evaluate food resource availability for the large‑bodied Military Macaw(Ara militaris)in semi‑deciduous,deciduous,and pine‑oak forest at two sites along the coast of Jalisco,during the dry season when macaws are *** also determined Military Macaw diet by observations of foraging macaws along transect routes,and conducted bromatological analysis of the nutritional content of the most consumed ***:Military Macaws used six plant species as food items during the dry season,and had a narrow dietary niche(Levins’B=0.28),with 56%of foraging macaws consuming the seeds of Hura *** food resources were recorded in pine‑oak forest during the dry season,with food resources and foraging by macaws concentrated in tropical deciduous and semi‑deciduous forest,where *** was the most abundant fruiting tree *** considering the proportional availability of food resources,we determined a broad Hurlbert dietary niche breadth of H=0.67,indicating that Military Macaws consumed food resources according to their ***,the seeds of *** were an important source of protein,carbohydrates,minerals and moisture,and the hard fruitcasing means that these seeds are exclusively available for ***:By concentrating their diet on the most abundant resources,Military Macaws may increase foraging efficiency in the dry *** high nutrient content also means that concentrating the diet on seeds of *** may be an optimal foraging strategy for Military Macaws

关键词： Ara militaris Bromatological analysis Diet composition Food resource selection Fruiting phenology Hura polyandra Psittacidae Tropical dry forest

A Solution for Municipal Solid Waste Treatment

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Journal of Environmental Science and Engineering(A) 2023年第2期12卷 77-80页

作者： Roberto Iñaki Ponce de la cruz Gerardo Ortigoza guillermo Hermida Pedro Javier garcía José Hernández Instituto de Ingeniería Universidad VeracruzanaAv.S.S.Juan Pablo II S/NZona UniversidadFracc.Costa Verde 91294Boca del RíoVeracruzMéxico Instituto Tecnológico de Veracruz MiguelÁngel deQuevedo 2779C.P.91860VeracruzVeracruzMéxico

This article describes MSW(Municipal Solid Waste)management with APG(Arc Plasma Gasification)***,a brief description of the process and reactor configurations is presented,listing some advantages and ***,alternatives for producing electrical energy with the residue of synthesis gas are ***,this technology is proposed as an alternative to face the significant problem of eliminating MSW on a large scale.

关键词： Municipal solid water APG synthesis gas.

Woody plant taxonomic,functional,and phylogenetic diversity decrease along elevational gradients in Andean tropical montane forests:Environmental filtering and arrival of temperate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： guillermo Bañares-de-Dios Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez Itziar Arnelas Carlos I.Espinosa Norma Salinas Luis Cayuela departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain departamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain departamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain departamento de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain departamento de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains are paramount for exploring biodiversity patterns due to the mosaic of topographies and climates encompassed over short *** research has traditionally focused on taxonomic diversity when investigating changes along elevational gradients,but other facets should be *** first time,we simultaneously assessed elevational trends in taxonomic,functional,and phylogenetic diversity of woody plants in Andean tropical montane forests and explored their underlying ecological and evolutionary *** investigation covered four transects(traversing ca.2200 m a.s.l.) encompassing 114 plots of 0.1 ha across a broad latitudinal range(ca.10°).Using Hill numbers to quantify abundance-based diversity among 37,869 individuals we observed a consistent decrease in taxonomic,functional,and phylogenetic diversity as elevation increased,although the decrease was less pronounced for higher Hill *** exception was a slight increase in phylogenetic diversity when dominant species were *** decrease in taxonomic and functional diversity might be attributed to an environmental filtering process towards highlands,where the increasingly harsher conditions exclude species and functional ***,the differences in steepness decrease between Hill orders suggest that rare species disproportionately contribute to functional *** phylogenetic diversity the shifting elevational trend between Hill orders indicates a greater than previously considered influence in central Andean highlands of tropical lowlands originated species with strong niche conservatism relative to distantly related temperate *** could be explained by a decreasing presence and abundance of temperate,extratropical taxa towards the central Andes relative to northern or southern Andes,where they are more prevalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of the Tropical Lowlands Functional rarity Tropical Niche Conservatism

Fagus sylvatica and Quercus pyrenaica:Two neighbors with few things in common

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Forest Ecosystems 2023年第2期10卷 162-175页

作者： Sergio de Tomás Marín Jesús Rodríguez-Calcerrada Salvador Arenas-Castro Iván Prieto guillermo González Luis Gil Enrique G.de la Riva department of Ecology Brandenburgische Technische Universität Cottbus-SenftenbergKonrad-Wachsmann-Allee 603046CottbusGermany Forest Genetics and Ecophysiology Research Group School of Forestry EngineeringUniversidad Politécnica de MadridMadridSpain Area of Ecology Botany DepartmentEcology and Plant PhysiologyFaculty of SciencesUniversidad de CórdobaCórdobaSpain Ecology department Faculty of Biology and Environmental SciencesUniversidad de LeónLeónSpain

Background:The Iberian Peninsula comprises one of the largest boundaries between Mediterranean and Eurosiberian vegetation,known as sub-Mediterranean *** ecotone hosts many unique plant species and communities and constitutes the low-latitude(warm)margin of numerous central European species which co-occur with Mediterranean *** of the main species found in this region are the Eurosiberian European beech(Fagus sylvatica L.)and the Mediterranean Pyrenean oak(Quercus pyrenaica Willd.).It remains unclear how the different physiological and adaptive strategies of these two species reflect their niche partitioning within a subMediterranean community and to what extent phenotypic variation(intraspecific variability)is driving niche partitioning across Eurosiberian and Mediterranean ***:We quantified functional niche partitioning,based on the n-dimensional hypervolume to nine traits related to resource acquisition strategies(leaf,stem and root)plus relative growth rate as an additional wholeplant trait,and the environmental niche similarity between Pyrenean oak and European ***,we analyzed the degree of phenotypic variation of both target species and its relationship with relative growth rates(RGR)and environmental *** recruitment was measured for both target species as a proxy for the average ***:Species’functional space was highly segregated(13.09%overlap),mainly due to differences in niche breadth(59.7%)rather than niche replacement(25.6%),and beech showed higher trait variability,i.e.,had larger functional ***,both species shared the environmental space,i.e.,environmental niches were *** plant traits were not related to abiotic variables or RGR,neither did RGR to plant ***:Both target species share similar environmental space,however,show notably different functional resource-use strategies,promoting a high complementarity that contributes to maintaining a high functiona

关键词： Environmental niche European beech Forest dynamics Functional niche Hypervolume Pyrenean oak Species coexistence Sub-Mediterranean community

Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury

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Neural Regeneration Research 2019年第6期14卷 1060-1068页

作者： Elisa garcía Roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía de la cruz-Castillo laura Castillo-Carvajal Monserrat Rivas-Gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus Norte Centro de Investigación del Proyecto CAMINA A.C. Unidad de Investigación Médica en Enfermedades Neurologicas Hospital Especialidades CMN Siglo XXI Unidad de Rehabilitación Osteoarticular.Instituto Nacional de Rehabilitación. Luis guillermo Ibarra Ibarra Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of Medicine

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016.

关键词： fibrin glue mesenchymal stem cells glial scar protective autoimmunity neural derived peptides neural regeneration

Study of the Viability of Sargassum as a Substrate to Produce Biofuel

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Journal of Environmental Science and Engineering(A) 2022年第2期11卷 55-61页

作者： María Montes Alejandra Vásquez Jessica de la O Pedro garcía guillermo Hermida Miguel Hernández Sergio Zamora department of Environmental Engineering Institute for EngineeringUniversity of VeracruzBoca del RioVer.94294Mexico department Chemical Engineering Faculty of Chemical SciencesUniversity of VeracruzBoca del RioVer.94294Mexico department Dynamic of Systems Institute for EngineeringUniversity of VeracruzBoca del RioVer.94294Mexico Graduate department Faculty of Construction Engineering and HabitatUniversity of VeracruzBoca del RíoVer.94294Mexico

Sargassum is an indicator of progressive pollution in the seas because it causes lack of light and lack of *** arrives in the Mexican Caribbean between the months of April and September,causing a bad smell that it has after its decomposition,a heavy load of heavy metals,as well as being an inconvenience for the inhabitants because it causes losses for tourism in that *** are several ways to take advantage of these algae and one of them is to generate biomass to obtain a *** objective of this study was to determine the viability of sargassum(two varieties)as a substrate to obtain biogas in anaerobic co-digestion with sludge from a WWTP(Wastewater Treatment Plant).Two forms of drying were also applied to the two varieties of *** was obtained that sargassum is a good component to co-digest because it does not destabilize the process and good biogas production is achieved.

关键词： Sargassum co-digestion biogas

-592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 505-509页

作者： Guadalupe garcía-Elorriaga Leila Vera-Ramírez guillermo del Rey-Pineda Csar Gonzlez-Bonilla Unidad de Investigación Mdica en Inmunología e Infectología Hospital de InfectologíaCentro Mdico Nacional La Raza(CMNR)Instituto Mexicano del Seguro Social(IMSS)Mexico CityMexico Banco Central de Sangre CMNRIMSSand Departamento de Infectología.Hospital Infantil de Mxico Federico Gómez.Secretaría de Salud(SSA) Mexico City.Mexico

Objective:To determine the polymorphisms of Interleukin-10(IL-10)(-592,-1082) in pulmonary tuberculosis(PTB)with and without type 2 diabetes(T2D).Methods:We studied a Mexican mestizo population of 37 patients with TB in remission(TBr) and 40 with active pulmonary TB (PTB),21 patients with TB + T2D.47 blood donors accepted,and 13 healthy health-care workers with tuberculin skin lest *** of IL-10 polymorphisms was performed by real-lime Polymerase chain ***:IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically ***-10-1082A/A presented more frequently in the group of patients with both diseases,not being statistically significant in comparison with the group of healthy subjects. Conclusions:This study describes two important new ***,it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy ***,the study provides evidence that the(-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol these diseases.

关键词： Cytokines IL-10 Polymorphism Genotype Pulmonary tuberculosis

The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita

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Molecular Plant 2019年第4期12卷 506-520页

作者： Josue Barrera-Red on do Enrique Ibarra-laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte departamento de Ecologia Evolutiva Instituto de Ecologia Universidad Nacional Aut6noma de Mexico Circuito Exterior s/n Anexo al Jardin Bot合nico 04510 Ciudad de Mexico Mexico departamento de Estudios Moleculares Avanzados Instituto de Ecologia A.C. Carretera Antigua a Coatepec No. 351 Col. El Haya. C.P. Xalapa Veracruz 91070 Mexico Centro de Investigaciones en Biodiversidad y Conservacion Universidad Autdnoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos 62209 Mexico Campo Experimental Bajio Instituto Nacional de In vestigaciones Forestales Agricolas y Pecuarias (INIFAP) Km 6.5 Carretera Celaya-San Miguel de Allen de Celaya Guanajuato 38110 Mexico UBIPRO Facultad de Estudios Superiores Iztacala Universidad Nacional Autdnoma de Mexico Av. de los Barrios #1 Col. Los Reyes Iztacala Tlanepantla Edo. de Mex 54090 Mexico

Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes.

关键词： Cucurbita argyrosperma, comparative genomics molecular evolution neofunctionalization long noncoding RNA whole-genome duplication