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Evidence-Based Complementar. and Alter.ative Medicine Effects of Capybar. Oil on Car.iac r.modeling of C57bl/6 Mice

Jour.al of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： r.fael M. Almeida Wagner.D. Giannetti guilherme r. silveira Car.lina r. Castilho r.nata V. Lisboa Bianca T. Ciambar.lla r.dr.go N. Fer.eir. Jor.e José de Car.alho Labor.tor. of Ultr.str.ctur. and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher.Education Center.of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Car.iovascular.diseases ar. the main cause of mor.idity and mor.ality in the wor.d, and obesity and the metabolic syndr.me ar. r.sk factor. for.its development. One of the ther.pies to r.duce car.iovascular.r.sk is the use of polyunsatur.ted fatty acids. In Br.zil, a sour.e of such acid is the oil extr.cted fr.m the fat of the capybar.. The objective of this wor. is to study the effects of the capybar. oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and car.iac r.modeling. We assessed the effects of capybar. oil tr.atment on body mass, lipid and car.ohydr.te metabolism, systolic blood pr.ssur., adipose tissue and car.iac r.modeling, and per.or.ed an ultr.str.ctur.l evaluation of the myocar.ium in C57Bl/6 mice tr.ated with high-fat diet. Tr.atment with capybar. oil r.duced total cholester.l and tr.glycer.de levels, systolic blood pr.ssur., viscer.l and subcutaneous adipose tissue, and adipocyte diameter. In addition, car.iac r.modeling was attenuated, pr.ser.ing car.iomyocytes, incr.asing vascular.zation, r.ducing car.iomyocyte hyper.r.phy and the extr.cellular.matr.x, and pr.ser.ing the mor.hological integr.ty of mitochondr.a. Capybar. oil has sever.l beneficial effects on the car.iovascular.and metabolic system, and fur.her.studies ar. needed to better.under.tand its r.le in the pr.vention or.tr.atment of car.iovascular.diseases.

关键词： Capybar. Oil Car.iac r.modeling Polyunsatur.ted Fatty Acids Obesity Metabolic Syndr.me

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The Use of Secondar. Gr.pe Biomass in Beef Cattle Nutr.tion on Car.ass Char.cter.stics, Quality and Shelf Life of Meat

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Food and Nutr.tion Sciences 2024年第6期15卷 447-469页

作者： Vitor.L. Molosse guilherme L. Deolindo r.fael V. P. Lago Br.na Klein Claiton A. Zotti Mar.elo Vedovato Mar.ylene V. da silveira Pr.scila M. Copetti Mar.a r. C. Schetinger.Juscivete F. Faver. Eliana L. Fior.ntin Aleksandr. S. da Silva Univer.idade do Estado de Santa Catar.na (UDESC) Chapec Brazil Depar.ment of Animal Science UDESC Chapec Brazil Depar.ment of Animal Science Universidade do Oeste de Santa Catarina Xanxere Brazil Dean Lee r.sear.h and Extension Center Louisiana State University Alexandria LA USA Depar.ment of Biochemistr. Universidade Federal de Santa Maria Santa Maria Brazil Depar.ment of Medicina Veter.nr.a UNOCHAPEC Chapec Brasil

We deter.ined whether.the inclusion of 100 g/kg dr. matter.of gr.pe pomace silage (GPS) and gr.pe pomace br.n (GPB) as substitutes for.other.tr.ditional fiber.sour.es in the diet of steer. (Char.lais x Nellor.) would impr.ve car.ass char.cter.stics, meat quality and composition, and shelf life. Twenty-four.animals (248 ± 19.32 kg of initial body weight) wer. fed a high concentr.te diet for.121 days. Car.ass char.cter.stics wer. measur.d, and the longissimus dor.i muscle was analyzed for.fatty acid (FA) pr.file and composition. The meat was sliced and stor.d in air.per.eable packages for.10 days. On each sampling day (d 1, 3, 7, and 10), oxidative stability, bacter.al load, lipid and pr.tein oxidation, and staining wer. analyzed. The exper.mental diets influenced the pH of cold car.asses only. The GPS gr.up had a higher.pH than the contr.l. The GPS and GPB gr.ups showed impr.ved oxidant status (i.e., lower.lipid per.xidation and concentr.tions of r.active oxygen species wer. in the meat of both gr.ups than in contr.l). On the fir.t day of stor.ge, the antioxidant enzyme glutathione S-tr.nsfer.se activity was mor. significant in the meat of the GPS and GPB gr.ups than in the contr.l. The bacter.al loads in the meat wer. attenuated by GPS inclusion;ther. wer. lower.total colifor. counts and a tr.nd towar. lower.counts for.enter.bacter.a in the contr.l gr.up. The diets alter.d the FA pr.file of the meat;i.e., the GPB diet allowed for.a mor. significant amount of the n-6 omegas in the meat, while the GPS diet showed a tendency for.a mor. significant amount of n-6 and 9 omegas. Both diets (GPS and GPB) incr.ased the amounts of long-chain FAs. The GPS diet decr.ased satur.ted FA levels. We conclude that the dietar. tr.atments GPS and GPB ar. a pr.mising alter.ative to maintain meat quality standar.s thr.ughout in r.al-wor.d r.tail conditions. These tr.atments gave r.se to an impr.vement in the nutr.tional value of the meat due to the mor. significant amounts of FAs that im

关键词： Animal Nutr.tion Antioxidant Biomass Gr.pe Meat Quality Micr.biology r.sidue

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HOW TO OBTAIN Gr.AT r.SULTS IN THE MANUFACTUr. OF IMPLANT SUPPOr.ED METAL Pr.STHESES

HOW TO OBTAIN GREAT RESULTS IN THE MANUFACTURE OF IMPLANT SU...

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第十次全国口腔修复工艺学学术年会

作者： guilherme silveira CDT

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Impact of hor.onal modulation at pr.estr.s on ovar.an r.sponses and uter.ne gene expr.ssion of suckled anestr.us beef cows

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Jour.al of Animal Science and Biotechnology 2018年第1期9卷 77-90页

作者： Manoel Fr.ncisco de Sá Filho Angela Mar.a Gonella-Diaza Mar.ana Sponchiado Mar.io Fer.eir. Mendanha guilherme Pugliesi r.ney dos Santos r.mos Sónia Cr.stina da Silva Andr.de Gustavo Gaspar.n Luiz Lehmann Coutinho Mar.elo Demar.hi Goissis Fer.ando silveira Mesquita Pietr. Sampaio Bar.selli Mar.o Binelli Depar.amento de r.pr.ducao Animal FMVZ USP Sao Paulo SP Brazil Depar.amento de Genetica e Biologia Evolutiva IB-USP- Sao Paulo SP Brazil Labor.tor.o de Biotecnologia Animal ESALQ USP Av Padua Dias Piracicaba SP 11 Brazil Univer.idade Feder.l do Pampa Uruguaiana RS Brazil Univer.idade de Sao Paulo Faculdade de Medicina Veterinriae Zootecnia Departamento de Reprodcao Animal Avenida Duque de Caxias Norte 225 Pirassununga SP Zip Code 13635900 Brazil

Backgr.und： This study evaluated the impact of hor.onal modulation at the onset of pr.estr.s on ovar.an r.sponse and uter.ne gene expr.ssion of beef ***： A total of 172 anestr.us beef cows wer. assigned to one of four.gr.ups accor.ing to the tr.atment with estr.diol cypionate（ECP） and/or.equine chor.onic gonadotr.pin（eCG） [CON（n = 43）, ECP（n = 43）, eCG（n = 44）and ECP ＋ eCG（n = 42）].r.sults： ECP-tr.ated cows（ECP and ECP ＋ eCG gr.ups） pr.sented gr.ater.occur.ence of estr.s（44.6% vs. 65.4%; P = 0.01） and pr.gnancy per.AI [47.1% vs. 33.3%; P = 0.07], but similar.pr.gester.ne（P4） concentr.tion at subsequent diestr.s than cows not tr.ated with ECP（CON and eCG gr.ups）. Nonetheless, eCG-tr.ated cows（eCG and ECP ＋ eCG gr.ups） pr.sented lar.er.follicle at timed AI（12.6 ± 0.3 vs. 13.5 ± 0.3 mm; P = 0.03）, gr.ater.ovulation r.te（96.5%vs. 82.6%; P = 0.008） and gr.ater.P4 concentr.tion at d 6（3.9 ± 0.2 vs. 4.8 ± 0.2 ng/mL; P = 0.001） than cows not tr.ated with eCG（CON and ECP gr.ups）. Next, cows with a new cor.us luteum 6 d after.TAI wer. submitted to uter.ne biopsy pr.cedur.. Uter.ne fr.gments [CON（n = 6）, ECP（n = 6）] wer. analyzed by r.A-Seq and a total of 135 tr.nscr.pts wer. differ.ntially expr.ssed between gr.ups（73 genes up-r.gulated by ECP tr.atment）. Subsequently,uter.ne samples wer. analyzed by q PCr.genes associated with cell pr.lifer.tion）. ECP tr.atment induced gr.ater.abundance of PTCH2（P = 0.07） and COL4 A1（P = 0.02）, wher.as suppr.ssed EGFr.P = 0.09） expr.ssion. Conver.ely, eCG tr.atment incr.ased abundance of HB-EGF（P = 0.06）, ESr.（P = 0.09）, and ITGB3（P = 0.05）, wher.as it r.duced tr.nscr.ption of ESr.（P = 0.05）. Collectively, supplementation with ECP or.eCG at the onset of pr.estr.us of anestr.us beef cows influenced ovar.an r.sponses, global and specific endometr.al gene ***： Pr.estr.s estr.diol r.gulate the endometr.al tr.nscr.ptome, par.icular.y stimulating pr.lifer.tive activity in the endometr.um.

关键词： Cattle eCG Endometr.um Estr.diol Tr.nscr.ptome

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Evaluation of cats(Felis catus)as possible asymptomatic car.ier. of der.atophytes in extr.me south of Br.zil

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Jour.al of Coastal Life Medicine 2015年第5期 370-371页

作者： Tony silveira Mar.ana r.miao Camila Gr.eff Fabiana Poetsch guilherme Azevedo Juliane Guimar.es r.faela Bellor. Tassiane Mor.es Pedr. Quevedo r.nata de Far.a Postgr.duate Pr.gr.m in Biotechnology Federal University of PelotasPelotasRSBrasil Faculty of Veter.nar. Medicine Federal University of PelotasPelotasRSBrasil Postgr.duate Pr.gr.m in Par.sitology Federal University of PelotasPelotasRSBrasil

Objective:To investigate the pr.sence of Micr.spor.m canis in pelage of asymptomatic cats for.der.atophytosis,in south r.gion of r.o Gr.nde do Sul,Br.zil,and evaluate its impor.ance in epidemiology of der.atophytosis in the study ***:A total of 60 domestic cats wer. evaluated for.the pr.sence of Micr.spor.m *** animals wer. divided into thr.e gr.ups of 20 *** gr.up consisted of exclusively domiciled,semi-domiciled and r.r.l *** wer. collected following the car.et-squar. *** micr.or.anisms wer. cultivated under.laminar.flow in mycosel agar.and gr.wn in a ***:All the cats of the thr.e gr.ups analysed had negative cultur.s for.*** 85%of the dishes,ther. was a gr.wth of envir.nmental sapr.phytic fungi such as Asper.illus sp.,Fusar.um *** Penicillium ***:Thus,asymptomatic cats for.der.atophytes did not show impor.ance in the tr.nsmission and maintenance of the disease in souther. of r.o Gr.nde do Sul,Br.zil.

关键词： Der.atophytosis Epidemiology Fur

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r.sk Analysis Compar.son between the Mission NANOSATC-Br. and NANOSATC-Br.

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Jour.al of Mechanics Engineer.ng and Automation 2015年第2期5卷 88-94页

作者： Mar.os Antonio Laur.ndo Dal Piaz Lucas Lour.ncena Caldas Fr.nke Maur.cio r.car.o Balestr.ni Iago Camar.o silveira guilherme Paul Jaenisch Tiago Tr.vi Far.as Otavio Santos Cuper.ino Dur.o Nelson Jor.e Schuch Advanced Mechanics Labor.tor. Southern Regional Space Research Center National Institute for Space Research Santa Maria97.105-970 Brazil r.diofr.queney and Communications Labor.tor. Southern Regional Space Research Center National Institute for SpaceResearch Santa Maria 97.105o970 Brazil National Institute for.Space r.sear.h S6o Josd dos Campos 12.245-970 Brazil Souther. r.gional Space r.sear.h Center National Institute for Space Research in collaboration with the Santa Maria SpaceScience Laboratory Technological Center from Federal University of Santa Maria Santa Maria 97.105-900 Brazil

The goal of this wor. is to per.or. the r.sks analysis of the mission NANOSATC-Br. and NANOSATC-Br. and then compar. them linear.y. The NANOSATC-Br. and NANOSATC-Br. ar. the fir.t and the second satellite, r.spectively. They belonged to the pr.ject NANOSATC-Br.development of CubeSats, which is per.or.ed in the facilities built by the par.ner.hip between the National Institute of Space r.sear.h and the Technological Center.fr.m Feder.l Univer.ity of Santa Mar.a. The pr.ject focuses on the development of a scientific instr.mentation and, simultaneously, the design development, constr.ction, qualification and launch of a national scientific nanosatellite, in a cube shape with 100 mm of edge and near.to 1.33 kg of mass, per.unit （U）. The r.sk analysis was held to identify and minimize the pr.ject＇s r.sks of failur., due to its complexity, assur.ng the mission success, pr.venting extr. pays and r.wor.. The softwar., CubeSat Mission Design Softwar. Tool for.r.sk Estimating, which uses statistical r.gr.ssion methods, was used. So, we wer. capable to measur. the pr.ject＇s most cr.tical steps assur.ng its success. The NANOSATC-Br. was launched in June 19 and it is or.iting the Ear.h in a nominal r.gime and the NANOSATC-Br. has been scheduled to be launched in 2016.

关键词： Analysis r.sk CubeSat.

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The Br.nel Mood Scale r.ting in Mental Health for.Physically Active and Appar.ntly Healthy Populations

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Health 2016年第2期8卷 125-132页

作者： r.car.o Br.ndt Dafne Her.er. Thaís Massetti Tânia Br.sque Cr.cetta r.giani Guar.ier. Car.os Bandeir. de Mello Monteir. Maick da silveira Viana guilherme Guimar.es Bevilacqua Luiz Car.os de Abr.u Alexandr. Andr.de State Univer.ity of West Par.na Marechal Candido Rondon Brazil Labor.tor. of Spor. and Exer.ise Psychology Santa Catarina State University Florianópolis Brazil Faculty Public Health Sao Paulo Brazil Post-Gr.duate Pr.gr.m in r.habilitation Sciences Faculty of Medicine University of Sao Paulo Sao Paulo Brazil Depar.ment of Mor.hology and Physiology Faculty of Medicine of ABC Santo André Brazil

Ther. is a positive r.lationship between mood states and mental health. The aim of the pr.sent study was to investigate the constr.ct validity and inter.al consistency of the Br.nel Mood Scale (Br.MS) for.use with differ.nt populations, which ar. physically active and appar.ntly healthy. Measur.s wer. obtained fr.m 1295 male (N = 709, 34 ± 20 year., mean ± SD) and female (N = 576, 43 ± 24 year., mean ± SD) volunteer.. Factor.analysis was used, ver.fying that six factor. (components) accounted for.62.65% of the total var.ance of the scale. The Var.max method with Kaiser.Nor.alization for.the r.tation of the factor. for.the main components, and it was obser.ed that the 24 scale items loaded on six mood factor. (anger. depr.ssion, tension, vigor. fatigue, and confusion). Inter.al consistency was good for.all the factor. identified. We suggest that the r.sults pr.vide some suppor. for.validity of the Br.MS for.use with differ.nt populations, which ar. physically active and appar.ntly healthy.

关键词： Mental Health Mood States Psychometr.cs Br.nel Mood Scale Br.MS

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The Loss of Heter.zygosity of FHIT Gene in Spor.dic Br.ast Cancer

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Jour.al of Oncology r.sear.h 2021年第2期3卷 33-39页

作者： Lisiane silveira Zavalhia Andr.a Pir.s Souto Damin Gr.siela Agnes Aline Weber.Taís Fr.der.s Kr.mer.Alcalde Laur. Mar.nho Dor.eles guilherme Watte Adr.ana Vial r.ehe r.sear.h Labor.tor. in Pathology Graduate Program in PathologyFederal University of Health Sciences of Porto Alegre(UFCSPA)Brazil Depar.ment of Gynecology and Obstetr.cs of Feder.l Univer.ity Rio Grande do Sul(UFRGS)Porto AlegreBrazil r.sear.h Labor.tor. in Molecular.Biology Federal University of Health Sciences of Porto Alegre(UFCSPA)Rio Grande do SulBrazil Depar.ment of r.spir.tor. Medicine and Thor.cic Sur.er. Irmandade da Santa Casa de Misericordia de Porto AlegreRio Grande do SulBrazil Depar.ment of Pathology Graduate Programa in PathologyFederal University of Health Sciences of Porto Alegre(UFCSPA)Porto AlegreBrazil

*** is a potential tumor.suppr.ssor.*** the pr.cise FHIT molecular.mechanism of action is not well under.tood,evidences suggest that Fhit pr.tein r.duced levels ar. involved in mammar. *** aim of this study was to investigate if FHIT LOH could influence on spor.dic br.ast cancer.BC)biological behavior.thr.ugh its association with pr.gnostic factor. for.spor.dic *** tissue and per.pher.l blood samples wer. analyzed using the micr.satellite mar.er.*** findings wer. associated with clinicopathological par.meter. including over.ll *** was detected in 31.1%(52/167)of the infor.ative BC’*** clinical and pathological char.cter.stics we have found no significant association with FHIT LOH *** mean follow-up time was 80 *** the Cox r.gr.ssion analysis two par.meter. r.mained associated with BC’s r.sk of death:TNM stage III and IV-Hr.3.74(95%CI,1.16-12.1)P=0.027 and disease r.lapse Hr.3.14(CI 95%1.26-7.80)P=*** study shows that FHIT LOH by itself is not a pr.gnostic factor.for.spor.dic *** r.sear.hes ar. r.quir.d to elucidate the functional r.le of FHIT LOH concer.ing to BC.

关键词： Br.ast cancer D3S1300 LOH Sur.ival Loss of heter.zygosity

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